So A kee AS ws Q © % * 2 ° a e, ABSORPTION OF DRums aS NNR Absoyphon ig Movement of the Chg foe is ite of Odministevation Into the Cveslation- Pampertant Povameter le the Yosle ef, Absorption . Factors Of Fecting Absovptien +| Ajeous Dolobility : Bugs Oven In Kelick Porn Most Cliseolse In Olqeoos [Phase before Ub Ts Closerbect. Fer Preity Udcter Fooloble Clvog (eq: sprvin, grisenfalwin) Tlate of absovption is lous . kKeteonazole chssolves crt low pu (cacti PH) 5 Gastie Crete le Tlequivect for its Absor Phen . «| Concentration : Passive AvPPocion Clepends Opsn Concentration Chachient 5 roca) ren Os Concentratect Deletion is Absorbed! faster than Chitet= Bolten, - Atco 4 absorsing . Larger Dor Pace = Snore bsorptie Chea Dvifoce .| Vascolovity of the; teed block flow crtthe & Absorbing Aur faco GeleadREE Sion hastens Ow Clbsox P Hon . Roote of Administevatin + —_ AP fects alwg Caksorp tion Cs Cach Shoste hag Ibs Quon Peralarites .+ Absorption thyovgt Orat Iloote + —p The CPRective barrier $¢ Orally Ciclministovech =P? Fer Absorption to take place: PH aay =R Chie Is the Qpithelial lining of; Ger. Gita bay - Rika Blood Mosse) Drvy Cionizea) +/- Dry Conionized) (Non=polat) For at Chwg to be Cibsovbecl it Shevlel bo + Oniomzeck , lipich Botobta Ctack of Bmath Bie. &4 + Ethanol Non-ionvect lipid Soloble. Ores gets Yeactily absoiwect Porn Stomach Cls UDet Cle jn Intestine at Yates PrYopotonal +o lipid: udater Coefficient Ht mecliom in Which if ts Clissolvoe? (onionizeck Ohugd . Fox lomrect Chiog CPH dog Patimeckow) Cllosovption Claexnt take Place? Abtopicin Ps Jama Acidic chug = Addie Medion, * Acidic Obvgs Gy? Aatayelates, bayertoates Qe Preclorninantly Absorbed Pref? Clad Qastetc Seite in Stomach. * Rosie Chvogs rEg ¢ Morphine, joinine — Aare Absa kad Only Or Tleachtng “he ae —> Howeves Cver ex Cladie veg Clb sor pH | Prom Stomach ls Blower, pecase MuUcoss IS dick , Covereck Lith Mucus And Barface Osea isa — Poster see Crnptying Cleetevaten = Thes. Chawg Absorption | In Clenercal , + Dissolution |s A BunPace Phenornencn dt. [Por ticle Bire of Chwy in Acti Choe age fern Sfoverns Tato. of Chesolotion i) As Govern Yat of Clbsorption, sp Presence of cluge ford hlotes Chios rel Seterds Absorption Cinch form Insoleble CGomptaner USA cock Pestheles. és. Tetracycl nes USith Gar Preset teenie —b Exeption ; Fatty ‘feck Qabances lone Runtvine CibsovPtien . Drugs inehhective Uohen Gweo , Gentamicin, Neastigmnine 5 Orawy Penicuin Gi, insolin ; +] P- glyeprotem - : testinal epi. Cow Dro (Gi Cone+ >) hey ob fix KI Blood Luoven let pass mofabotism AS The Orel Clbserp-tien of Certain Clog lous becavse CL Lraction ef the Obeovecd “seg Is Cactvocledt ~ back Inte the Interstthret _ | by ote telan tere el P- g* Digoxin arch cyctes serine 3 higeters of P-gp: og Geinichire , Verapamil, exytrremyein, « Telece ve (cause vay Apiture) + Yifarnpicin, Gnel PhanotarkitoneLominesl ect + Absorption 64 Crug Can be aPPectech by Lerinel ebb! one ob es ingested drug ; foros insolube Complexes . Ey: ) Tetracyclines Usith G2, i) TYen PreParations USIt Cinlacids . ¥) Phenytoin USith Bverat Rte , abs Sach interaction Gin be Minirnizect (4 Celi nistering hw. Olvugs at 2-4 bv intervals. Got Udutt affects. + Drugs Gan Otter Absorption bye ) Altering TMotitity . Anticholinersscs, On ticles sgsants , ov" Opieids Yetamel Motility Udbile Meteclopramicde Cntances it. i) Guosing Mucosal damage + & Nearaycin, Mothctrexete | Vinblastine . “ (Se Crim) Tr] Absorption Aweogh Sobeutaneous nd Trivanuscules Yeate “= B, these Vootes Chiog Is Clepositect Chrectty tn the | Viainity of Capiuories. Capitasies have. fase | Pavocetuterr Space Ane Cloeesn't Obstvoct Goa large lipted insoloble Mclecotes . Very lage Melecoles alymph > Many Aregs Net abs erbect Otay Ave absevbqol | Pox enteraly. AosorPtion Se gite & Slower thar tm, Site oot both Cre Aeneraly Rister | Cons then Oval Teste . — Al pplication of heat Clack Miuscelers Crrevetss Ciceelerate Alvog Akserprion by Aring boloock, flow | Udhile Vasece netrictor lackvenatingy Tletord ates , Hyalu yenidase. F'sce Avog AbseyHen Ror S.csg by Inclecing Spread. €9: Benaathine PeniciUin , Pretaming Zine insotin Gla per Progestins Rte Can be Given by these vor6S BS) Absorptin toeah tapieel Ste: (Shan, Garon, macannoaen) a anh > Depends 1 Oo bpd Bolotstity of chugs. Diggs thal Gan -€q: Hyosine, errteiny| ) Nicotine, testosterone, GN cy lycoryl srinithate)” —> Corticosteroict Cippliccl Ovex Qctensive Cjswas of, Skin Can Case Systemic Okfects Ord Pitoilary — Ciclyenal oppression . - AlosorPton of chrog Gan be Promoted Qy Yobbing the Chreog incor porated iN An Olegenovs base —P Organopnosphate Insecticides Coming in Contact USHh the Guin Can Procloce Systomic toxtelty . ‘| Abradeck Cinjorect) Skin Gan Produce Systemic effects As they Are Sleactily Absorbect . Eg: Tainnic Cert Applied Over bornt Chees Skin hos Proclocact bopatic f\ecrosis. —b Cornea is Permeable to lipicl Dlobe Physoshymine Conionizch) bet Not to highly Toniadk Neostign ine . 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