Optimization Technology And Screening Design By: SATHISH HT 24 Sem M PharmTypes of screening designs.... **Completely randomized designs “Randomized block designs **Factorial designs Full Fractional “Response surface designs “Central composite designs **Box-Behnken designs **Three level full factorial designsCompletely randomized Designs » These designs compares the values of a response variable based on different levels of that primary factor ® For example ,if there are 3 levels of the primary factor with each level to be run 2 times then there are 6 factorial possible run sequences. Randomized block designs >For this there is one factor or variable that is of primary interest. To control non-significant factors, an important technique called blocking can be used to reduce or eliminate the contribution of these factors to experimental error.Factorial Design These are the designs of choice for simultaneous determination of the effects of several factors & their interactions. Symbols to denote levels are: when both the variables are in low concentration. * a-one low variable and second high variable. + b- one high variable and second low variable * ab- both variables are high. » Factorial designs are optimal to determined the effect of pressure & lubricant on the hardness of a tablet >» Effect of disintegrant & lubricant cone . on tablet dissolution . > Itis based on theory of probability and test of significance. @)Response surface designs “This model has quadratic form “Designs for fitting these types of models are known as response surface designs. “If defects and yield are the outputs and the goal is to minimize defects and maximize yield»Two most common designs generally used in this response surface modeling are Central composite designs Box-Behnken designs Box-Wilson central composite Design >This type contains an embedded factorial or fractional factorial design with centre points that is augmented with the group of ‘star points’. >» These always contains twice as many star points as there are factors in the design>The star points represent new extreme value (low & high) for each factor in the design To picture central composite design, it must imagined that there are several factors that can vary between low and high values. Central composite designs are of three types >» Circumscribed(CCC) designs-Cube points at the corners of the unit cube, star points along the axes at or outside the cube and centre point at origin > Inscribed (CCI) designs-Star points take the value of +1 & -1 and cube points lie in the interior of the cube » Faced(CCF) —star points on the faces of the cube.Box-Behnken design >» Box-Behnken designs use just three levels of each factor. In this design the treatment combinations are at the midpoints of edges of the process space and at the center. These designs are rotatable (or near rotatable) and require 3 levels of each factor >These designs for three factors with circled point appearing at the origin and possibly repeated for several runs. It’s alternative to CCD. >The design should be sufficient to fit a quadratic model , that justify equations based on square term & products of factors. @)Three-level full factorial designs ¥It is written as 3k factorial design. » It means that k factors are considered each at 3 levels. »>These are usually referred to as low, intermediate & high values. >These values are usually expressed as 0, 1 & 2 >The third level for a continuous factor facilitates investigation of a quadratic relationship between the response and each of the factors @)SCREENING & OPTIMIZATION OF CPPs OF WURSTER COATING DRUG LAYERING PROCESSNUMBER OF FACTORS -4 NUMBER OF LEVELS -2 EXPERIMENTAL DESIGN- FRACTIONAL FACTORIAL DESIGNene Sy Co EE EL Air Volume (cfm) dn 100d aod Spreying Rate (m/min) 3 prin SS gn/tna 5 prin Atomization Presur(ber) aba bbor bor Product Temperature (') are 4 ot | (Goal for Indivbdual Res pores TTI Fis (wiv) Fes shoud NT SS Aggomerctet(‘ulw) Agere shold NT SA Avoyby HPLC (4) To ocheve te oc the roduc em 85 to 88 DEENExperimental dataCONTOUR PLOT RESPONSE — FINES (%W/W) 5 1 o ou 2 3 4 5 @) SPRAYING RATE3D PLOTOPTIMIZATION OF CRITICAL PROCESSING | PARAMETERS OF DRY MIXING PROCESS FOR JOLIO ORAL DOSAGE FORM DEVELOPMENT AS PER Qb0)Objective of the experiment and numbers of factors involved are the primary two most important factors required to be considered during selection of any design of experiment Objective- To optimise critical process parameters of dry mixing process PENT Teele) FACTORS Blending speed & 10 12 Blending time 5 10 15 @)(0,0) (0,1) (0,2) ee 6 “e 0 : 2 aEXPERIMENTAL DESIGN SELECTED 3 LEVEL FULL FACTORIAL DESIGN In Dry Mixing Process, 2 Processing Parameters were critical & required to be optimized >» Moreover, It was required to investigate interactive & quadratic relationship between factors & response to find out optimum ranges > Thus, 3 Level FFD is a time & cost effective best option for optimization of 2 factors. > However 3 Level FFD facilitates investigation of interactive & quadratic relationship of factors & response. @)CONTOUR PLOT RESPONSE — ASSAY (%6W/W) 20 o 5 10 15 20 @) BLENDING SPEED.ANY QUESTIONS ?