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    6 views8 pages

    Аналгин

    Uploaded by

    Iva Cvetkova

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    Download as pdf
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    TPHOKEHKE 1 KPATKA XAPAKTEPHCTHKA HA TIPOLYKTA OSWATERAR ATEHUMA 0 AEKAPCTBATA Kear xapanimepemnma na nope Tegogone 7 Kost P60. sss OO, C2736 Paspeusesue Ne eonany.,.63337 17 8-3 1, MME HA JIEKAPCTBEHMS IIPOJLYKT Analgin 500 mg tablets, Avast 500 mg raGreric. 2. KAMECTBEH H KOJIMYECTBEH CBCTAB Beaka Ta6serka Canepa axTHSHO BEUIECTBO MeTAMHGO; HATpHIl (metamizole sodium) 500 mB. Tlowomuo neutectuo: Beaka TaGiieTka charspxka 34 mg meno HAUECTE. 3a mbakua cnncox na noMOUNHTE neULECTBA BIEATE TONKA 6.1 3. JEKAPCTBEHA ®OPMA TaGnerxa Kppri, naoeku Tabnerku, ¢ Aeutrrenna YepTa oT emmiara crpana, aHaMersp 13 mm, Gea 20 noNTH Bea, 6¢3 Mupnc, Jleaureanata yepra e 3a pasenale Ha TaGaeTKaTa Ha Ade PaBHIN NOTOBHEH, 4. KIMBHYHH JAHHH THINK HOKAIAHHS 41 Teps 3a noannanane Ha yMepeHO 0 CHAHO HSpaseHH GoxKn OT pasaiicH NpoHIxos: raapoGomHe, 366060, HeopanrHi, HEBpHTH, MHAAITHE, TpaBHAH, HsTapAHA, NocrorepaTHONH Gosks, SaHtTOMEH GOTKK, AleMeHtopes, BO7KH MPH OHKOOTHYI SAGORABATTR, GBOPEUME 1 ATENI KOSEKH, Karo avruruperauno cpeacrao 8 KoMmneKciara Tepanis a paSTHSHM CBCTORHIIS, CpPOBOLIEH BUCOKA ‘Tewmleparypa, HenosaH@eamta ce or apyra Tepamus. 42 Hosmponxa u wat ua apwaomenne Dosuposxe Hosara ce onpesens oT HuTeHSTeTA Ha GonKATA HAH NOBMUICHATa TeNepaTypa WOT MHAMBNAyATHATA HyscraHTeTHOCT KEM MeTaMMsoz. BaxHO e Jia ce nabepe Hail-HMicKaTa A029, pit KORTO ce OBNAEBAT Goskara v tommmesata Temmepatypa, Brspacmuu u nodpacmeauu nad 15-coduuna srapacm Beapactun 1 tonoun na 15 rox wi mo-ronesn (> 53 ka) Morar aa npwessar Ao 1 000 mg Metamns07 karo equa 1032, KOTO MOE Za ce NPHeMa 0 4 METH AWdeBHO Npes MuTepBATH oF 6 - B ACA, KOeTO choTaeTcTBa Ha MaKcMManua AHesHa no3a 4.000 mg. Flono wapasei: ebext Moree a ce ovaxaa 30 10 60 MiKyTH czes NepopanHo npHLTOReHHe. B caejwamara TaG.smua ca HoKasaHi MpenopeulrTeslHitTe EAMHNNHM ROIH M MAKCHMAIHNTE AMERNH 03H 8 SaBieHMOCT OF TerTOTO HIM wRapacTra: Texecto tern0 Enuswsna 03a Maxcusamta awestia 2032 kg sespact ‘raGaeren mg raGineren > 33 2 1S rogum | 1-2 300-1000 [8 Teduampusina nonynayi feuz om I uit do 14-codrauea xspacm (2 mecno on 32 ky 20. TIpw aeua w ioxowM Ha sbapact Ao 14 roam 8-16 mg NeTaMHI0N Ha KiCIOTpAM TEHIECHO TerTO MOKE sla Ce npnaarar karo exunitia 2072. B ciysaii Ha nommutena Temmepatypa osa ot 10 mg MeTaMHIO: Ha xitiorpam TeslécHo Tero OGUKHOBEHO € NOCTATRAWHA 3a NEMA. ‘Alen napazeH exper More 1a ce o¥aKBa 30 fo 60 MMT cxea Hepopastio NpUTOXeHHe, B cnemsamara raGavua ca noKasann ripenoppynTerKHTe EAMKNYEH ROSH H MAKCHMAIHTE AMEBHM AOS 8 sasneMMoct OT Ter0T0 HA BEapacTra ‘TesecHo Tero Ennai 2038 Maxcumaria anesita 203.8 kg uspact ‘raGnerK mg ‘ra6inereit mg 32-53 | 10-14 41 250-500 [4 2.000 Hleua nod 10-20dinuna expacm Tasu nexapersena dbopma ne € noxXOnMMa sa npHTOXeHME Mput jet Tos, 10-romMIKa BApacT. Tipeanarar ce apyru slexaperseuu opma/KoaMecrBa Ha 2KTHAHOTO BEULECTBO A 030A EAL, KONTO More 2a G4aar nosxoaRuIo AOMpAHL pH MO-MaINKH EUR. Cheiuannu nonynayun Tonynayua 6 cmapwecka eespacm, wamowen nayuenmu u nayuenmu c nanaren xpeamuruios KtupeHe Horra TpsGea na ce uawam np naUNeNTH B crapsecka wApacr, Mp HITOMeNH NaMEETH Ht TpH MaUKeHTH C HAMAJIEH KpeaTHEMHOR KNMPLHC, Thil KATO CMMHMPAHETO Ha MeTABOAMTHHTE NPOTYKTH Ha MeTaMIA0n Morke Aa Ce ystWDI epuoopobno ten GeO perno yopeacdane Tei Karo ckopocrTa Ha EmMMMNNpale € HaMaeHa, Koraro OxOpewara WIM WepHoApOGUaTa dpyMKUNA € Mapymena, MHOrOKpATHH BHCOKK 403K TpxGEa fa ce WSGarBar. He ce HaTara HaMateBane Ha 2O3aTa, Koraro ce mpiiara camo 3a xparko spew. KeM ANCWHa Zeta HAMA JOCTaTSHHO ONKT ¢ AbITOCPONNATA ‘ynorpeba tia MeTaMi0c pH NaLMelITH c TEKO YepHORpOGHO H GeGPeUHO yapexaaHe JlevenneTo ¢ Merammsoa ne 1pxGsa 1a npombinkaaa tlowewe or 3 10 5 ni. YrorpeGara my a 110- pomDDKHTeTeH TepHOA OT BPCME NH B HO-BHCOKH 03H OT MOCOMCHHTE C BLIMOKHO CAMO CER KOHCY;TANLNR € neKYBANIE TeKap. 43° [porwponoxasanus, = Capaxsyscronrrentoct KEM MeTaMH02 UH KEM HAKOE OT TOMOUHHTE BEULECTBA. + Capexxyacraireanoct kos pyrH repasomoHOsH mponsBoRNH (BK. APH TaueHTH © ananmesa sa arpanyaoturTo%a, ciex NpeAXOxIAILIO MPANOACHNE Ha TAKMBA CyGCTAMUKH). = Ocrpa xepropo6ia nopéapra, = FmoKor0-6-bocdarexnaporesiasia reaocTarbantocr (onacHocT oF xemoaHsa). + Texxxat sepwompobnit w/in Os6peuHH saG0-tapaHi8, + Hapywena kocrwomoseania dytnus (nanpumep cea newenue c uutrocrarut) Hil 326 xewaTonoeTawiara cncTeMa (anlmacTiCaHa AHEMHR, arpaHy HOUMTOSA, eBKOTTEK HA). ‘Tpeta tpunectep ta Gpemertoctra. 44° Cneuna.am nperynpeagenna mpeanasun mepku mpa ynorpe6a = Hlexernero ¢ meramaso.t ce nposexsta camo 3a KpaTeK HlepHOM OF HEME, KOFATO HM NPY" anrepnaripen Merox tia newexne. > Metasnioa Moxe aa npeauspaka arpanysounTosa 4 tpoMGoumrronens (6x. TosKa 4.8). PasourHeTo Ha arpanyaouMrosa He 3aBHCH OT fO38Ta H HE MOME [a Ce MPEABHAN. MOXke Ja HACTBI CTEM MEpEHE NpILEM aM exe eHoroKpaTHO NPATOKEHMe. Thm NpHBHANH Ha arpany.rorueTOsE ca beSpumTeT, GoxKK FupsoTo, GonesHCHO NporTbiWaNe, BBITATEHHE Ha MMTaBHUATa Ha yCTATa, HOCA, dhaputikca, avopeKTamHara Fenurasiiara oGaacr, TIpH eHesanHo Bromanante Ha ODUIOTO CKETORHNE M TlomBA Ha MpHOHNLE a arpawy.101HrTo32, sleNerMeTo ¢ WeTaMH07 TPRGBA Ja Ce MeKpaTH Ma Ce Hac.TesBa KPRAHATA KApTH, = TIpt no-nposeunsitreaKo npHnoxeHe Ha MeTaNHs0x € KeoGxosuNMO KOHTTpONMpaHe Ha KPHAHATA kapriiia, sxuowrTenno andepentitaTto GpoeHe Ha GENTE KPHRAH KACTKH. - Metasiioa ce Ha3niaiasa ¢ siiManie MPH nauMentH, Crpanauu OT aneprMstin 3a6onABaHtNR, AUWeHTH Che CEPLXYYBCTBHTEZHOCT KBM AHAATETHINK M TPOTABOPEMMaTHNH nekapersa (HeTOHOCHMOCT eM ANANTH), KaKTO M KBM APYTH MeANKAMERTH WTH XpaHW THOPAAM MOBMULEN PACK OT aneprHs Peantuiit 4 acTwaTAHHK MpHereILA ~ _ Meramigzon Moxke Aa nposoKHpA xHMOTOMWIHH peaKuuAH (wx. ToKA 4.8). TesH peaKUMH ca ROZO.ABHCHIMU H ce HaBMIOMAKAT NPEANNHO TPH Taper TepaTO NpunoxkeHHe. BompeKH TOBA, eACHHETO € weTamHsion nog (popaara Ha tabxerKs TpAGea za ce NPoBEAIA ¢ NOBULEKO BHNMAKHE pH MaxHeHTH ¢ xufioToHi, oGeMen neOMUAT KAM AEXHApATALLUA, HecTAOKUIO xpuROOSpaMleNe. ~ __ TIpn eaxospenento npaoxente c ankoxos ce yaesnaka pHCKEE OT HeMesTaHH neKapcTseHH peakw. = Heobxonmmo e na ce mputara ¢ nnaMarie np nauMeHTH € HepHonpoGHM si GLOpeNH yopencarina (wx, To0HKH 4.2 4 5.2) ~ _Tlexaperseno nizyunpano sepoxpoGuo yapexuiante. CsoUEHN ca caly4an Ha OcTDp XenaniT, ApeAUMHO OF KenATOUCAYNAPEH THT, IPH MAWMENTH, NERYBAK C METAMHBON, € HAMBIO OT HAKOMKO 10H 20 Rakonko Mecewa caea saNoubane ta TeyeKHeTO, [pwaHaltiTe K CKMITOMHTE BKIONBAT NOBMUEHH epnoapoGnn eHauMitB cepyMa, Che Wan Ges xCEATEHIa, 4eCTO B KONTEKCTA Ha APYIK Peau a CapbxuyacrsuTeaHOct KbM JlexapeTsoTo (Han. KOKCH OOPHB, KPHEHH ANCKPAsHH, NOBMUICHA TeMMepaTypa hi cosuHoditana) HeH npwapy acer OT XapaKTepHCTHRH Ha ABTORMYHEH xeriaTHMT. Fopexero NaUMeHTH ca ce RMACTAHOBILTH NPM Npekpatauarie ta AeEHHETO C METAMM3OLT, BHNDEKH TOBA 8 OTACITEK cAysaH HMA ‘choSiieMis 38 nporpecns 20 ocTpa YepiospoGta HenoeTaTEHHOCT, HaNaraula Yep:oApOGHA ‘parienurantrauns Mexatnisyrsr 1a wityunpanioro oF MeTaNHI0n YepHOApOBHO YEpERTANe He € HIXCHEH HAMIHO, HO AaHTe TlOKaSBAT HMyHO-aTeprH4eH MexAHUTbM, Tauuewture rpaGva na Goaar unctpykcrupanit 2a ce CBEpHAT Che CBOR seKAD B estyHal Ha NORBA Ha emmTown, npesiostarauin 4epwoapoGHo yapexxaant. ITpH Taxwea MauewTH yrorpeGara Ma MeTaMisos “rpabpa 2a ce npeycranost Hm 1a ce ote 4epHompOGHATa ‘by KUNE Merawaoa ie pasa na ce Bobe:kria HOBTOPHO MpHt NaLINEHTH C ETLHIO Ha YepHOADOBHO yBpETAKE TO Bpeme Ha NeNeHHe ¢ MeTaMIO;, IPM KONTO He € ycraHoBena ApyTa NpMMHHA 3a sepHONpOGHOTO _yapenate. + Texsxn Koti peaxtin. Texkkit Konan Hexezan Peaxuunn (SCARS), BkmowTeaHo cHnUIpoM Ha Stevens-Sohnson (SIS), ToKcHIHa ‘enugepwannua nexponiaa (TEN) Ht stekapcToerta peakitna ¢ eosHHOpHAMA H cHcTeMM cHMNTOME (DRESS), onTo Morar aa Gbaav xwsoToseeTpaLIABAulH WAM neTAMHN, ca CEOOIMABAMM MH seNeNHE c MeTAMHSOA. Taxnestrure tpx63a 2a Gaaat nacbopwupans 2a npyiauanutre st CHAATTOMITE H 2a Guar HaBmIONARATH C ‘HOBHUICHO BHHIMAHHe 3a Kon peaKIIAH. Ako Ce HonBaT npHaFalgH H CHMNTOMH, KOHTO MpeAMORarar TesM PeaKUNK, NETAMHIO:T TPABES 1a Coste conpaw HesaGasHo H uHKOTA He TpAGEA Na ObAE NpANAraH OTIOBO (Ax, TOIKA 4.3). + Thuenoro wnwecre # Tosa nekaperso cuampxka caNO MHOTO MAKI KOAMMECTRA FYFE He MAIKO Reponriio sa nipecwisamKa npoS.Aewi, AKO HMATE LNSOsMEKHS (HEIOHOCHMOCT KM FIyTEHA). Equa TaSterka cbin.pa we nosexe oF 3,4 wiukporpava rayren. [ips anepraa Kew milena (CU PALIN or HBoaMAKHR), NauHeHTST He TpaOEA na NprteME TOBA NeKapcTBO. = Tos sexaperaen npoayxr eeampxa 32,7 mg warp wa TaOsierKa, exaunaleHTeH npenopowsanin or C30 waxcumanes awesen UpweM na 2 g HarpHii xa mbspacten 45° Busnmoselicrane ¢ apyri xekaperwenm mpoaykrn xpyrH SpopMe na nIaHt Kymapiiionn aitukoary rants. [pi enHonpemeHHo mpHAoxeHie NETAMH3OX MOKE J TIOHIOKHL aKTHBIOCTTA Ha KYMaPHHOBMTE aHTHKOArY.TAHTH B pesyATAT Ha eHSHOMK HHITYRUUER, HH ADYTH dbeHOTHASHHFOBH NpOHSpOMLH, TIpH eAHOBPEMeMHO MpHLAOKeUKE ¢ METAMHIO ewllecTayea puck oT Hompa Ha Texkka XHNOTEpMiA. O11 M PYTH MHETOTOKCHYHK NIPOAYKTH, [TpH eaOBpeMeHHO ipsoxeHe ¢ MeTAMHIO eutecrayna nowmuieH pHcK OT NoxBa Wa MnesIOCyNpeCHR Eqsunantte uuayxtops (GapSurypann, rayreTaMit, GenuaSyTasoM) Morar aa MaManAT edeKra Ha MeTaMHsor. ‘Henpecar ua UHC npn xow6unaivex ¢ merasirson sacnanar anaarernanna My eqpeKc. ZTielicranevo wa Tpauacanusn anrrivrenpecartra (nesxodophy, aMKTPHNTAsIKH), OpAHH KOHTpALLeMTTHEHH ‘epencraa, axaTreTHutM, ALONYPHHOA n aNKOXOA ce NoTeHUMpa MIpH emHoBpEMeHHO NIpHIOACHHE ¢ Meranison. 3a kctaca Na mmpasononopiTe NpoHsBOTH € HoBeCTHO, He MOXe sla MMAT BSAHMOReMiCTBNE € KatrronpHL nati, MevorpexcaT # TpHaMTepeH, KaKTO Ha MpOMeHAT e”pexTHBHOCTTA Ha ANTHXWTepTEHSHBAITE nponyKrH na aypetinorre, Jo Kakba crenie MeTaVi307 BOA AO TSH BIANMOAHICTENE He © apeeTH, Tipu equospeenest nphem MeTaMisom NOKe Aa aman e*eKTa Ha aueTHACaMMMMTORATA KHCEIEIA Bopxy TPoMGoUMTHaTa arperaumia. CzeqonaTeAHO, TasM KOMGHEAUNA TpABEA fa Ce HBNONIBA.C MOBHULCHO siusaHive pw naxicentrH, ApMeMa:ItN HACK J0%a ACTIMpH Ya KapAWOMOTEKTUAR. ‘DapMakoxHHeTH4HO BIaNMoaeMicTENe — MILIYLpANe Ha WeKapcTAO-MeTABOAMSKDALIM CHSHIME ‘Merasst30n Moxe 12 itiqyuunpa eKapcTeo-MeTaGomHMpan EHSHMH, BKUONNTEMKO CYP2B6 n CYP3A4 Equospeentioro mpistoxeHne Ha MeramH90 ¢ GynporHor, eqasMperty, MeTATOH, BasITPORT, unclocrtopit, TaKPOTHMYC HIM CepTpAsINH MOA Aa OBE 0 HAMATRBAHE Ha TIasMeNeTE KOMeNeTPALIE va TeSW stckapeTsa c NOTEHLMAITHO HaMATABAHE Ha KIMHICINATa e*pNKACHOCT. FTopann Toxa ce Npenopbiea THOBHU:CHO BHAMANKE TDH exHOBpeMeHKO NPILIONCHMe Ha NeTAMMSON; KIMKINKAT OTTOBOP W/m HHBATA Ma exapcTaara TpxOBA sta ce MpOcMeARMAT 1O TOAXONRI HEMT, 4.6 Deprusmrer, Cpemennocr # xupmene Bpemenniocr Hasan ca cano orpannuenn asin sa ynorpeGara Wa MeTaMH30N TPH BpeMeH HEH. Bus ocowa Ha myGaukyeanMTe saKHM OT BpeNeni Kei C eKCOSMUMS Ha MeTAMHON Mpe3 MpaHA ‘TpumecTep (n ~ 568) He ca ycranopenn TeparoreHMi Win eMOpuOTOKCHTHK exherTa. B OTAEAINM cay’, Koraro re CBIIIECTBYBAT APYTH BLIMOARHOCTH 32 eNeHHe, MpHAraHeTO Ha EIHKHYHK JOSH MeTAMEO Mone a ce onycHe npes mepana n sTopHR TpHMeCTEp. Ilo npHRUHN Ne ce Mpeflopeysa NpHAraHeTO Ha MeTaMH0. pes mapas 4 BTOpHs TPHMECTHP. VrlorpeGaTa Nlo BpEMe Ha TPETUR TPMECTHP & CHEPIAKA C eroroKcHHoct (GsGpeIHo yapeavtane M KOHCTPHKINER Ka JY KTYC apTepmosyc) M cxeoBATEAHO ynorpeGata Ha MeTaMITIO:| © MPOTHBOMTOKASAHA NO BpeMe Ha TPETHA TPHMECTHD Ha GpeMeMHOCTTA (WK. ‘rowKa 4.3), Hpi caysalino npistarane wa MeTaMH30. TO BPeME Ha TPeTR TpHMECTDP aMuOTITUIATA Teunloct m AyKTYC aprepwosyc TPAOBA ja Ce KOHTpOAMpaT pes YATPASBYK HW eXOKAPRHMOTPADHA, Meravison npemitiaga pes rutantenrapiara Gapwepa Tipu axtworma: meramysoa weayunpa penponyKTHBHa TOKCHHOCT, HO HE H Teparoreroct (BE. TONKA 5.3). Kepmenie Tipoaykrare or pasrpaxaateto Ha MeTaMH30/1 HpeMMHapaT B KbPMaTé B SHAMUTENHH KONMHECTRAH HE MOKE a Ce HRIMOAM HICK 3a KEpMayETO, ITopasit TOBA MIHOTOKPaTaTa YMOTPEGA Ha METAMIESOR TO BPEME Ha xupMente 1pa6aa ja ce nsbarsa. B ciryyali ta exHoKparko MpHmioxente Ha MeTaMMas, a MaliKitTe co nnpenopiusa na CLGUpAT H WOXBEPART KYPMATA B NPOAWMACHHE Ha 48 4ace Clea NpMsaratteTO Ka oaTa. 4.7 Exper sepxy cnocoSwactra 3a mopupane m paGora c mans Tipw npzemaxe ua sucoxn 0am Ananrun He ce nperlopLusa ynpasaenKe Ha MOTOPHH MpeR an paGora c MaILNHH, MSHICKBALIH aKTHBHO BRUMAHUE, Toil KATO € BE3MOKHO a ORM BHUMAEETO M fla HAPYlM peaKuMuTe lip HeowaKHaH CHTYAILAM. 4.8 Hexesaun sexapernenn peaxunu Herxenaniite peakuii4 ca wx6poenH o-0y Mo ecTeMa oprani-Knae H 10 NecToTa. Hecrorire ca tespnnpanit KATO: moro wectH (21/10), Necrs (21/100 x0 <1/10), HeweeTH 1/1 000 10 -<1/100), penxit 1/10 000 10

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