KPATKA XAPAKTEPHCTHKA HA I 1. HAMMEHOBAHHE HA JIEKAPCTBEHHS NPOYKT Bucerrroa 400 mg/ 80 mg ta6aerKH Biseptol 400 mg / 80 mg tablets perpasonew RELEML A 19-8 tay 2, KAYECTBEH H KOAMYECTBEH CbCTAB Beaxa ra6nerka coabpaa 400 mg cymameroxcason(sulfamethoxazole) 1 80 mg TpHMeTonpHM (trimetoprim). Tinnent cicex Ha NoMomparre eutecTsa — ww TOUKA 6.1 3. JIEKAPCTBEHA ®OPMA TaGneren [Beat Ta0eTK € 2eHIITEHHKAB HIOGHC, KPEI'TH, ABYFIOCKOCTRM, C 1HAKA NOBEPXHOCT 6e3 paspoHeHH pavulia, oT extara crpania ¢ rpasupant sak "-" 4 Gykautre "BS" Haz Hero. 4. KIWHW4HH AHHH 4.1 Tepanentiuma noKkasanan © Ypomuexauas, npHauienn or syscranrenn mianone E. coli, Klebsiella spp., Enterobacter spp., Morganella morganii, Proteus mirabilis u Proteus vulgaris. BaGenexka: 3a npemlowMTane e HeNOABTIMBH YPOMHIPKUHH Ja Ce ACKYBAT c ED anraGaxTepialeH JJeKapCTBEH MPOZYKT. © Ocrop Otitis media, npwumicn or ypcreuremit mamose Ha Sir. pneumoniae w H. influenzae, » cayuaii, Ye seKapsT npenieHH, se mpHaaranero na Cotrimoxazole € 10-onpasjaHo OT RaBaHeTO Ha ene arm HoTHK. ¢ Bromapate ua xpomiann 6pouxiry, npHAnHeH OT 4yBCTBHTENHM maMose Ha Streptococcus pneumoniae lub H. Influenzae, axo neKapat npeueHM, He MpHlaraHcTO Ha KOMELICKCCH MCAHUMHCKH MPOLYKT € 10-GnaronpHaTHo OT MoHOTepATHA. © Cronanmo-spesnn andexaper, mpisaienn ot Gaxrepun Shigella, + Muxpo6ionorsio noranpaesia nesMoHi, npuauHeHa or Preumocystis jiroveci (P.carinil) Mpentassane of uidbexrupate © MuKpoBA MpU NaLWMeNTH C HaMane uMyHuTeT (Hamp. CTIHH).. © napus wa mtemectnenmxa npx ssspacti, npwsnnesa or exreponatorennn wamose E, coli. 4.2 Jlosmponka w nas na mpuaoxenne ‘Popwara wa cyenensia 3a nena ox 6 rome, Ypoundexuun, cromamuo-peonu audexuuy, npwsmnenu or GaxrepHu Shig Ha xponmun 6poHXHTH pH BBApACTHN O6uxtosermmr pest iia Aosupanie skOGBa MpHaraKeTo Ha 960 mg Cotrimoxai nnpes yorara ana noTH auesio. [Ip ypounipexuun sleKapcTBeHMsT mpoayKT OOHKHORor 1020 14 anu; px anowentt xponuaHH 6porncrn ~ 14 AHH pH CTOMaLLHO-4peBHH HINpeKIIEH, pusmuenn oT Gaxtepun Shigella — 5 MH. Ypoundexuuu, cromantio-"peann angecunu, npusnuenn or Gaxrepun Shigella 1 ocrsp Otitis media npy zena: ‘OGnuxuoneno 48 mg/kg Ha renecHo termo/seH Ha ABe oTReTHH NOI Ha ReexH 12 aca. He npunaraiire 1NO-BHLCOKH 203 OT MpeaIMucaHTe 2a BEspacTHH! Tipu ypounexxuin 1 ocrsp Otitis media nexapcrsenuar nponyxr ce mpunara 10 su; npH mnpexu, MpHuHHeHH oF 6axrepn Shigella — 5 su. Tnesnonna, npainnena or Presonocystis jiroveci (P. carinif) apa BespacTan ema: Tipenoposnteanara n0sa sa mannentTa ¢ noreepacsa anbexiwis € 90-120 mg Cotrimoxazole Ha xaIorpaM TelecHo Tero Ha jest Ha OTAEAHH 05H, MpHEMANH Ha aceKH 6 aca sa nepHOA oT 14 710 21 mu. Tipenentus ua uncpexuun, upw4unenn o Pneumocystis jiroveci (P. carinii): Buapactum: 960 mg Cotrimoxazole (2 raGeTEH) BcaHEA jNeBHO B NpOABTXeHHe Ha 7 HH. Tlewa: 900 mg Cotrimoxazole/tn? tenecta nour ita pe panHn OTHesHH OSH Ha BceKH 12 yaca B ‘postmmxenne wa 3 mocnexosaTenaH ZuWH OT ceaMHuaTa. Maxcumannara Hest jos © 1920 mg (4 ‘ra6nerxH). J[uapus wa irerenlectseuuka ups meapacrun, npHmuena OT eureponatorencu mam E. coli. [penopsuntemnara no3a ¢ 960 mg (2 ta6teTKH) Ha BCeKK 12 4aca. Hosuposxa npu nayueumu c 6ebpewna nedocmamynocm: Tlosara npx namuewH ¢ xpeaTunntion KaupBHc 15-30 ml/min cneawa na Goae HanosORMHa HaManeHA; Ko KpeaTHEMHOBHAT KAUpBHc e 0-HucEK OT 15 mi/min, we ce Npenopw4Ba NpHNAraHeTO Ha Cotrimoxazole. Hasun na npuraeane: TaGneviarre ne Gua na ce pasaensr, Jlexaperuentiar nposyEr ce mpuuiara nepopamo mo speme Ha xpaniene wim nezuara ene TOBA. B ‘TeveNHe Ha NeveHHETO MAUIMeHTET a MAE MHOTO TENHOCTH 43° Mporunonoxasanus = Capsxayscrantenioct xoM Cotrimoxazole (cyaipameroKcas0x ¢ TpHMeTONPHM), HAKOM OT exCUMTIHEHTHTe, CympouaMnLte aM TPHMETOIPHM; = Jlwariocruumpano yapexiaxe wa sepnoapoGins napa; — Teka Gs6peuna esoctaTssHoCT, KOreTO HNBOTO Ha AeKAPCTBCHNR NPOAYKT B Cepywa He MOxe na Grae onpeeneno; — Texky xewaToxornann emymienns; — MerasoSnactia anemus, npwsnaena OF NenocTHT na Gommeaa KuCENHHA = Hegoctur na rmoxos0-6-pochar aexnuporenasa (wpaMoxa XeMomM32); — Jena nog 2 mecena (puck or smpena arent. = Bpemenocr w epmene 44 Cneunaxay mpeaynpeayeuas a mpeqnasud MepkH pu ynorpe6a(Or6eamsann ca peak cnysaH Ha xMBOTO-SACTPAILABAILH YCOKMeHRA, CHEPIAHH C MpHNArAHETO Ha cynonaMHny, BRAOSHTENHO CHEApOM Ha CrHBsH-/[KOHCDH, CHHAPOM Ha JTalfpa, Ocrpa KeKposa Ha epi 106, armiacTicma akleMMA, arpaHyONHTOA, APYTH HapyUICHHMA B CCTABA Ha KPLATA Ht XUNepayBCrBHTeMHOCT Ha aMXaTemara cHcrema (GenoApobHa HeKpsLITpaL). B caysali, re newenncro c Cotrimoxazole ¢ npwapy>Keno OT: OOPHB, BEAITAMEHO TEPIO, BACOKA Temmeparypa, OONKH B CTaBIATe, KAILTHUA, 29AYK WIE XTTTCHML, TORS MOE NA € HHIMKALMS 38 POHKH, Ho MOTeHUAMHO BLSMOKHK HEAeGHH eheKTH K NpHeMbT Ha LexapcTBOTO TpaGRa Ja Goe pexpares. TIpwarantero xa Cotrimoxazole npu crpentroxokos aparHT ce oKasea Hi¢ycreuIHO B Ton Gpoli OT ‘caysante, Toi Karo Jlekapcruoto He yRUMLOMABa GaxTepHaTe, Cotrimoxazole He € TONXOAAI 38 e“eRHC Ha CTPeHTOKOKOB apHATHT WIM BEAITAACHNE Ha CAMBHILHTE. Cotrimoxazole rpa6xa na ce mpiutara ¢ BANMAHHe MpH NaNeHTH ¢ GLGpesHa HenOCTATS4HOCT (BIDK 4.2), c Henoctar wa osmena Kucera (HAND. NO-BKSPACTHH MaNMCHTH, ANKOXONMEM, MaLMCHTH, [RekyBAHH ¢ ANTHKOHBYACHBAN 1eKapCTRA, MPH MAUMEHTH Chc CHHAPOM Ha MasaBcopOUH HC HeyOxpanaane), pH NANHEHTH € TEKKH ANCPrHSHM PeAKIMH WM CTpadiaute oT GpOHKHAMHA ACTMA. Tlopnuier pick or Texku demenann eextn px mpunaraxeTo ua Cotrimoxazole, BKMOSHTesHO Gx6pera 1.14 sepHoapoGua HenocTaTssOcT, Ce MposBsBa NpH f10-BRspacrem naueHTH, Hali-aecto OTGeaNIBAHNTe TEKKH HEACHIAHM PeAKUHH, MORBARALIM Ce TIPH NO-Bb3PACTHH fauHEHTH CA TEKH ‘KOXHN PeaKUMW, HOATHCKaHe Ha KOcTHOMOSBUHUTE YHKUNE H TPOMOOUWTOTIEHE c HH Ge3 nypnypa. ExnospemeHwoTo mpremane Ha AMypeTHUM HOBHMaBA PHCKA OT MYPTYpA. Heaxenaun peaxui ce nposanar no-ecto mpi nauments, crpanams or CIIMH, nexysas ¢ Cotrimoxazole nopanu mibexttit, npumnentt ot Pneumocystis jiroveci (P. carinif). Taxswa HerKeTani peakupiHt Bkxs0WBaT OGPHB, BHCOKA TEMIIepaTypa, NleBKOMeH, TOBMTIEHHE B CepyMa HA apaneibepasnara akruauoct, xANepKAIHEMHA H xIMOHaTPHCMIL. Kakro v npa xpyra aurruGakrepHaniit neKapcTBa, 10 BpeMe Ha seyenuero c Cotrimoxazole Mowe Ja ce Ha6mogana HceBAOMEMOpaHo3eH KOMHT. Kypovr ua Gonecrra Moxe ja Oble OF sek 0 AusoTO-sacrpaurasant, CneOBaTEAHO € MHOTO BBKHO Goxectra fa € mpandio aMarHoctMuMpanta, KOraTo MpwsIarakieTo Ha aHTHGaKTepHaNHOTO NeKapCTBO ‘na 3a pesysrat auapua, Teparasra ¢ adrrHGakrepuanHoTo slekaperso Buse BLPXY dusHOROTHTHATA bop ta ncGenoro “epro M Mowe fla HMa 3a peayiTar sHautTeMHOTO NomauaBaNe Ha 6poa auacpoOnn GaxrepH. ToxcHuusTe, uportanexsaim or Clostridium difficile ca cpen OcHOBHHTE pisuirrena Ha Kom. Tipexparanakero Ha mpvema Ha nexapcTBOTO ¢ OGMKHOSEHO HOCTATSAHO B CKHTe CHY*AH HB icesxomemBpanoseu Kon. B cpenHo TexKHTe H TCKKH CHY'aH Wa naMHeHTa TpAOBa Aa My ce AABaT TeTHOCTR, CilekTpOmTH, NpOTeHHM 4 aMTTABakTepHATHAK ATeHTH ¢ Hen KOHTpON Ra Clostridium difficile (merpornnaiox wn panKomuant). Ha mrankexTa He Tpa6Ba na ce aBaT neKapeTHeHH TpORYKTH NOMTHCKALIH NepHCTATTHKATA HM TaKHBA ¢ KOHCTUNALAOHEH eeKT. Tipoaykrer chaepaka napaxnapoxcnSeroaTH, KOHTO MOraT a MpHEMHAT axeprHUTH PeaKUE (sssMOrxHH ca KBCHH peaKuMH). 4.5 BsanMogelicroue c apyra xexapcreeuu npoayKTH H ApyrH (popMa Ha Bau) Tuasudyu duypemu Envospementioro mpwenatic wa Cotrimoxazole c makon sMYpeTHUH, OcoBeHO THaS picxa OF TpoMGomTONeHMA. Anmnumpo Comune sexapcmeaCotrimoxazole Moxe 1a mrensutpuuumpa e”pekta OT atrruTpoMGoTHMENTe ‘exapersa 10 cTeneH, amarama npomsiia Ha n03aTa. PDenumour Cotrimoxazole wonrucka MeraGomimca ua @oHHTOHN; NepHONBT Ha nomypasriay na dyerNTOHH MPH "RANHeHTH, NpHeMaLU jwBeTe neKapeTBa, ce yABMACABA cpemHO ¢ 39%, TOKATO (peHUTOHHOBAAT kampone ce namanspa cpesito ¢ 27%, Memompexcam Cotrimoxazole ysennvasa cepyMHoro Hia0 Ha caoGomNTe pax MeTOTpeKCaT, NopaAnHt WaMecTRaHieTO MY OT MpOTEHHOBH KOMIUICKCH. Tpowseodnu na eyxtponuaypen Tipu eanospemenien mpem Cotrimoxazole Moxe a nirrensuipuuupa JelicreMeTo Ha anTHsMAGeTHN JICKAPCTRCHE MPOAYKTH MPOHIBO,IHH Ha CysIPOHKTYPE H MOOKE a TIPHYRHH PUCK OT XMITOTAHKEMEA. Tucoxcun Cotrimoxazole nox a NOBHILH CepyMHOTO HBO Ha NHTOKCHH NH HAKOM T10-BbapAacTHH MAlHeHTH, Tpuyuxneinu anmudenpecanmu Cotrimoxazole moe sia Hamas eshukackoctTa Ha TpmUHoINSHNHTe axTTHENpecaiTTH, Hfuxnocnopun TIpa nauueurn ¢ rpaicraxtupan O66pex, nexyparm c Cotrimoxazole u umxocnopun, ce ov6ensanaT LBpeMCHEH CMYLICHILA BLB PyHKuUNTTe Ha TpaHIcrMaNTHpaHuT GLOpeK, KOHTO Ce H3passBaT B THOBHINEHO MBO Ha KPeATHUMM B CepyMa, KOCTO BEPORTHO € MpHNMHENO OF NeHCTAMETO Ha ‘TpHMeTONpHM. Tpumemavan Cotrimoxazole c mpxMcrami Moxe a upwuniN meraro6aacT#a axleMIEA. Ximamieckn cyaGonasmire ca NOxOGHH Ha RAKOW AHTHTHPOMIHH neKapeTBA, JMypeTHUH (aueromann THa3Hy) 4 nepopaTHM aHTHIHAGeTH NeKepCTBA, KOCTO MORE Jla MPH KPCTOCAHA aNepris. Anmmuxoazynanmmu Tlosmuicax ca eberrure na aneHoKymapo m Baphaputl. AnmuduaGemuutu cpedemea Tlosmuier espexr Ha cynbormrypeitnn npoaykTH. ACE wnxuGumopu Pyrex or Texka xumepKaMMent Amecmemuy Tlonuanar pucka or MerxemornoSmemns, Koraro cyaipouaMMtite Ce MpHEMaT ¢ MpHIOKAHH, Anmuapumsaiu cpedcmea Tlopuaten pack or KaMepHH apHTMHH MpH mpHem c amHonapox., TLiasMcHuTe HHBA Ha Jp on noperimaa ymomkanane Ha QT MitTeppaa M PACK OF ApH. AumuGaxmepuasu cpedcmea Copymanre mmBa wa arcon m TpHMeTompHO/cynpameToKCAGON € BEIMORHO Ja Of KOMOMHHpaHo rpHeManie. HeoGXonHMO e NOBHUICHO BHMAHMe NOPaH TOKCHIHOPHOaMMiuH Mone 4a AOBeNe 0 NOBHUICHU HiBA Ha padaMMMUNN H KBE TOMyACHBOT Ha ‘TpHMeTOMpHM. Anmuposamuu epedcmea ‘Ako ce mpiarar TaxuBa epencTBa e HeOGKOANMO Aa ce OCEAN JOMBIMHNTeNeH NpHeM Ha oxaTH. Anmumanapwon nexapemea Puck or MeranoGxacTHa aHeNHs MpH O34 Ha IIMpHMeTaMMH, HARBMiasaMK 25mg comMOTIHO, Anmusupycnu cpedcmea Tlosmmasat ce THNAGMeHUTe —KONIEHTpauN §=—-H_—=«RAMMBYZEH, —BUCOKH OSH aphMcronpun/eyacbaMeToKcas0n TpsGea a ce HaGsreaT. EaoBpeMetto neYeHHe Che 3HOByAHH Moe a TIOBHILIM.»pwcKa OT _~=—=«XEMETONOTWNHH §=—-HEKENAHH = peak KLM ‘spumeronpun/cyapameroxcasom. [LnaaMeHitTe KOHteNTpAlIN Ha SAmUITAGHH € BSMOXHO sa ce noBumar or tpumeronpHm/cymbameToKcason, Kamuonu npu pbusuonoewsmo pH Tinasmemire KonmeHTpauin 1a TPHMETONPHM WHLIH MpoKaHHaMAT WHI AMANTAAHH MOFaT 18 Ce TOBKIMAT ENHOMOCONHO WAH ABYTOCONHO. Kroxanun 7a ce woGarea equonpemenna ynorpeGa, nopaith NOBMUICH pHOK oT arama arpamryAoWHTOsa, Kawes asunobensoam Tlorucka expexra na cyadonasanire. TaGopamopru mecmose ‘CroGimana ce, He TpuMeTONpHM H cyMboHAMMTHTe MOBMHABAT AMAPHOCTHIEHTC TECTOBC, BKC. (Copynitit Hitpa na MeTOTpeKcaT K KpeaTHHIH, Ypes, FmOKo3a B YPHHATA H TECTOBETE 3 ypobiumnoren. Caarenjenar Yeunmar eynponaunauoro xeiicrone. Anmuaryudnu npodyrma Hasasssar pesop6nnaTa Ha cymbameToKcasoa. BapOumypamu ‘Ycunear ToKcHuHoctra Ha TpHMeTONpAM. lpi envoapemestio npHeNante c uiuiomeratunnt ca HaGmonana flOBMLICHO HHBO Ha cY.paMeToKCasor, Brusviue eepxy pesyamamu om aaGopamopnu uscredaatun: — Tpiiwerompins MOxe a MpOMeH peaynTaTiTe OT aiainsa Ha CepyMHMH MeTOTPEKCaT spes HAHAH METOWL, HO He BIKKE BEPXY Pesy:TATHTe OT ANANIISH, MSBEPUIBAKH pes PANHOHMYHONOrHSOK MeTOI. Cotrimoxazole moxe Ja nosmim cpeato ¢ 10% pesymrarHre OF akianisa Ha KpeaTHHHA no Meroaa Ha Sipe (c ankanen maxpar). 4.6 Bpemennocr u xmpmene Bpemennocr kucenuna.Hama mpenain 4 n06pe KouTpommpaxn mpoysRaus Ha ynotpeGara Ha Cotrimoxazole mpi Gpemennn xen, Bucenras ne Gua Ja ce womonyBa no BpeMe Ha GpemennocT, OcOGEHO B MEPEULA TPUMCETHP, OCBEH px a6comorua Heo6xommmocr. JloGaska Ha omar ce uastavasa, axo Bucenron ce npaara mpH Gpenenm, Kupmene Kaxro Tpameronpim, Taxa x cyadaneroxcazon npenmmanat » KepMara, He ce mpenoppana pwesanero na Cotrimoxazole mpu kepeictc. 4.7 Banaue pppxy cuocoGuoctta 3a wodupane w paGora ¢ Mammut Jlexapernenrr nposyicr oSUKHOReHO He oKa38a RIMSHE BBPXY NeHXOdASHIHOTO CHCTORHHE, enocoSniocrra 2a mioipapanie H paGora c MALIIANH B sIBIPKCHHE. Bompexn ona, ako ce NosBAT NeKenAHM peaKtIHMM KATO rnaBOGOnHe, KONBYNCHH, HEPBHOCT, yMOpA, ‘TpaGsa 1a ce BHHMABA Nlo BpeMe Ha Mo*Hpavle WH paGora c MAKIN. 4.8 Hemerann ehexra Haii-uecro nposnananutre ce nepasnonoxcHit ca TeaK Ha CTOMAILIIO-4peBHIA TpaKr (rajleHe, nonpeutanc) H KoxHH npouct (O6puHB, ypruKapHia). Caeqyiara npacruxa ¢ Hanox3eaHa MpH KiacHduKaunsTa Ha HexenatttTe PeaKUNH NO OTHOMIEHHE Ha ‘ectoTata: MHoro secTH (21/10); yectH (21/100 <1/10); xeectu (21/1 000 <1/100); pemKn (21/10 000 <1/1 000); sstioro pens (<1/10 000); HenaBecrn (ne MoraT 1a GwnaT MpeucHeHH wa Gas Ha HAMWIHATe aH). ‘Hapymenus wa xposra t ammduara cuctema Penxit: neskorienita, Heyrponentix, TpONGouMToNeH HA, Muoro peki: arpanynoumrosa, MeranoGnacTHa aHeMus, aflactsita aHeMus, XeMOaHTHTIHA anemia, MeTXeMOrNOGHREMHE, COSHHODKHS. Hevasecri: xxmonporpomOnneMis, Hapyutenne na umynuara cucrema Yeors: aneprusmmn opus Muoro pest: cnnpom a cepymia Gomecr, anapwaaknHsnu peaKtun (SKMOSHTEAHO TERKH H >kHBOTO-2aCTpaMTapallMy), BHCOKA TeMleparypa To MpHuHHa MEKAPCTBOTO, aHTHOCHIEMS, aNepTHTICH Macoxapar, flypnypa Ha Xcxiox-Libonsatin, aprepmirc Hox03a, nonOGeH Ha yMYC CHEAPOM, CuMATTOMH Ha CBPERYYBCTBATEMHOCT na ANKaTemtaTa cHcTeMa. HewspecTam: KoHBY.CHH, KOHIOHKTHBHa H CKNepaHa XHTIepeMHS. Hapymenus wa KOxHMTe H NOAKOAHN TEKAWH eer: Kowa peaktuan (Hanpumep OGpie, ypraKapns, cEpGex) Muoro penku: borosyscramrensocr, exciponmaTHBen nepMarirr, epHTeMa MYATTHDOPMC, CHHAPOM Ha Cramsx-J>koncou, cHHnpou na Jlaifon (Toxcasmta enunepwarua Hexposa). Hapyurenns na meTaGormama M xpaneneTo Teaxauan napyurenus Mnoro peaxt: aenpecus, xamoummaunn. ‘Hapyurenua wa nepsnara encrena ecru: rapoGomue.‘Mutoro penki: enevospTex:, ACeNTHeH MEHMHTHT, KOHBY.ICHH, NepuibepeH HEBPHT, ATAKCHA, MYM B yuuure. Henspecra: aneras, wepsiocr. Pecnuparopua, topakaamu m MeauacTasaann napyulenns Moro pemku: aaayx, Kaitaia, Genonpodia ungusrpanns. (Cromanmno-spesnn napyuienns Yecta: rantene, nospeinake, enki: AMapHA, rOcHT, CTOMATHT. Muoro pent: nccpiomenGpavioseu Konat, manKpeaTHT. Hewspectitn: xopenmt GomkH, ‘XenaTo$uimapau Hapymenua Muoro peski: nomMuleHa axTHEHOCT Ha YepHOApOGHHTe EHSHAE, XeTATHTH, NOSLAKOTA NPHAPYACH Or XonecrarHutia AcbsTTeHHIla HIM HeKpO3a Ha HepHA p06. (CkeneTwo-yckyAHM HApyUIeHHa W HApyWeHHsl Ha CLeNMHATeMHATA TEKAH Muoro peau: Gomi » crasure, Gonkn B MycKynMTe, Hapyuresma na GeOpenwte a muxo4naTa cucresa Muoro penn: xpicraaypna, GuOpesna HefocTarByHocT, MHTepCTAUMANCH He>pHT, HOBHLIeHE Ha vBoTO Ha HeGenTS4HA 2907, TlOBMUIaBAHE Ha KPeaTHHHHOBHTE HHBA, BAOWIaBAHE Ha AMYpC2aTa. HeaspecriH: ToxcHien Hed)poTHeH CHHAPOM ¢ aHypH HTK ONUTYPHA. (OGum paserpoiicrea w crpannanH ehextu pa npuem Henssecram: cnaGoct, ymopa, Gexceaie. 4.9 Tpexosmpane He ce atiae Kaxna ¢ >xupoto-sactpaniasamtsra 03a Cotrimoxazole, Tipexosupantero exe cyspowamnan npwsntxsa: saryGa Ha ancrat, cromalunH 6O1KH, race, HOBpbuIAHe, cBCTOREPTEX, ranOGONMe, CBFLTHBOCT, sary6a Ha CesHAHHe, Mome 2a Ce OABH BHLCOKA ‘TeMmepatypa, Kpbs WI KPMCTANH B ypuHaTa. Ha O-KECeH ETA MOXe a ce NOABH NONTHCKANE HA KOCTHOMOSBSITITe YNKUHM H icusTreHMuIa, OcTpOTO MpeTOsMPAHE C TPEMETORPHM MOXE La MPHTMHH Tadeue, nospLuiane, cpeToREpTex, rano6onle, Aenpecis, pasctpolicrsa Ha Cb3HaHNCTO, HOTACKAHE Ha KocTHoMombunuTe yHxuit. TIpoueaypara, KOTO TpsGRa Ja Ce Cea, BIUTIONBA OTCTPANABAHE Ha exapcTaoTo OT CTOMALIHO-"peBHHa Tpakt (CTOMaIa NPOMHBKa HK TOBPBMAHe) H AABAHe 1a THanMeHTa Ha FosleMH KoaHecTRa TeSHOCTH, AKO AMypesaTa ¢ HezOCTaTHHa M GLOpCwHATA GpYHRIDAR € vopwanua, OxHesABaxeTo Ha YpHHara YnecHapa enuMHHauATa Ha TPHMETONPHM, HO MOE 1a YBeuHYK pHCKa OT KpucTANHAGUNEs Ha cyonawna B O.OpeuutTe. TpaGsa na ce cneM KpLeHaTA Kapruiia, ci.cTaba ita enekTpONUTIETe B CepyMa H UPYTHTe CHOXHMUNHH NapaMeTpH Ha NALMEHTa. Ceorserute npouenypH TpaGea na ce cie/lBar, aKO Ce MORBH KOCTHOMOSBHNO YBPCANIANC WIM axnsrrenutta, Expukactocrra or xeMonvanwsara c cpema, a nepHToHeaiHara 2uamita ¢ HeedbeKTHBHA. Xponmano orpansiic: npomwnxiresmoro npuemane a ronemn 03H Cotrimoxazole once 7 MpH4HHH NOATHCKAHE Ha KOCTHOMOSbUHATA bYHKUHR, KOCTO Ce MposBaBa Karo TPOMOOUTONCHHA, nenxortentin tat MeranoGaactia antents. B citysall, We Ce MORBET CHMITTOMM HB KOCTHOMOSBSIE YepexWaHMs, rpaGwa 2a Ce NPHAOKH sJBKOBOPHE, KATO CHOPE!| HAKOM ABTOPH nosa ¢ 5-15 mr/yen, §, @APMAKOJOFH4HH CBOACTBA ( 5.1 Dapmaxoqunamayau ewoiicrsaapwaxorepanesTima rpyna: KOMGHHANHH OT CyspoHaMHLiM H TpHMETONPHM, BRAOGHTENHO ‘npowsaonHn. ATC xo: JOIEEOL Bucerrron 400 mg/80 mg cbmepxxa cyaonamua ~ cystpaMeToKcasoa - W TpAMeTONPHM. Kom6unayuara 8 cbotHoutenue 5:1 or cbeaquHenHata HoH HMeTo Cotrimoxazole. 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Pietik6w, ul, M, Adamkiewicza 6A 05-152 Czosnow Honma 8 HOMEP(A) HA PA3PEIJEHHETO 3A YIOTPEBA 20000049 9, {ATA HA IUPBO PA3PEIUEHHE /T10(HOBABAHE HA PA3PEIUEHHETO 04.02.2000/29.03.2006/27.05.2017 10. JATA HA W3MEHEBHE HA TEKCTA 08/02/2019