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Feature Article

The Effects of Holy Name Meditation on


Spiritual Well-being, Depression, and Anxiety
of Patients With Cancer
Jinsun (Sr. Julianna) Yong, PhD, RN ƒ Junyang (Fr. John) Park, STD ƒ
Juhu Kim, PhD ƒ Pyeongman (Fr. Justino) Kim, PhD ƒ Im-Sun Seo, PhD, RN ƒ
Hun Lee, BA

This study was conducted to evaluate the effects of the Program was thus effective in enhancing cancer patients"
Holy Name Meditation on cancer patients’ spiritual spiritual well-being and decreasing their anxiety and
well-being, anxiety, depression, and pain. Twenty-eight depression. Therefore, it is recommended that Holy Name
patients were enrolled in the control group, and Meditation be provided in clinical settings to reduce the
18 patients were selected for the experimental group. psychosocial and spiritual suffering of cancer patients.
Only the patients in the experimental group completed 5
weeks of the Holy Name Meditation Program. All
participants were surveyed to assess spiritual well-being
KEY WORDS
(Spiritual Well-Being Scale), anxiety and depression anxiety, cancer, depression, spiritual intervention,
(Symptom Checklist 90-R), and pain (numeric pain rating spiritual well-being
scale). There were no significant differences between the
two groups" general characteristics, but the baseline t is projected that there will be a continuous increase
survey revealed that anxiety and depression levels were
higher in the experimental group. Analyzing the results
after controlling the baseline scores of anxiety and
depression showed that spiritual well-being was increased
I in worldwide cancer incidence, further intensifying
global cancer burden.1 In Korea, for example, the
prevalence rate was 28 885.8 per 100 000 as of 2014.2
The overall experience of cancer elicits immense suffer-
(F = 4.80, P = .034), whereas anxiety (F = 4.98, P = .031)
and depression (F = 7.28, P = .010) were decreased after ing, causing cancer patients to experience cancer-related
the intervention. No difference in pain was found pain along with symptoms such as anxiety and depres-
between the two groups. The Holy Name Meditation sion.3-5 They also have to deal with spiritual and existen-
tial concerns.6 The number of cancer patients experiencing
this kind of comprehensive, multidimensional suffering is
Jinsun (Sr. Julianna) Yong, PhD, RN, is professor and director, The growing, pointing to a greater need to deliver holistic care
WHO Collaborating Centre for Training in Hospice & Palliative Care, that improves overall quality of life.
College of Nursing, The Catholic University of Korea, Seoul, South Korea. It has been demonstrated that the various symptoms ex-
Junyang (Fr. John) Park, STD, is professor, College of Theology, The perienced by cancer patients do not only co-occur but also
Catholic University of Korea, Seoul, South Korea.
interact. For patients with cancer, physical pain often ac-
Juhu Kim, PhD, is professor, Graduate School of Education, Ajou Uni-
versity, Suwon, South Korea. companies psychological and emotional distress such as
Pyeongman (Fr. Justino) Kim, PhD, is associate professor, Depart- anxiety and depression.7,8 These in turn increase fatigue
ment of Humanities and Social Medicine, College of Medicine, The and exacerbate overall suffering.9 The symptoms of anxi-
Catholic University of Korea, Seoul, South Korea. ety and depression especially act as factors that diminish
Im-Sun Seo, PhD, RN, is assistant professor, Department of Nursing, quality of life.10 These symptoms of cancer appear in differ-
Baekseok Culture University, Cheonan, South Korea.
ent dimensions of the person, and it is the mutual interac-
Hun Lee, BA, is coordinator, The WHO Collaborating Centre for Train-
ing in Hospice & Palliative Care, College of Nursing, The Catholic Uni- tion of such multidimensional symptoms that negatively
versity of Korea, Seoul, South Korea. impacts quality of life. Spiritual well-being, on the other
Address correspondence to Jinsun (Sr. Julianna) Yong, PhD, RN, College of hand, has been shown to enhance cancer patients" quality
Nursing, The Catholic University of Korea, 222 Banpodero Seocho-gu, of life while reducing their anxiety, depression, fatigue, and
Seoul, South Korea 137-701 (jyong@catholic.ac.kr).
desire for hastened death.11,12 Hence, spiritual well-being is
The authors have no conflicts of interest to disclose.
receiving increased attention as a mediating factor for
This study was financially supported by the Catholic Medical Center Re-
search Foundation in 2012. quality-of-life enhancement.
Copyright B 2018 by The Hospice and Palliative Nurses Association. Indeed, findings reveal that enhancing the spiritual well-
All rights reserved. being of cancer patients helps to promote well-being in
DOI: 10.1097/NJH.0000000000000451 other dimensions, thus improving quality of life and reducing

368 www.jhpn.com Volume 20 & Number 4 & August 2018


Feature Article

death anxiety.13 In Pearce et al"s14 study on patients with ad- (spiritual dimension), depression and anxiety (psychoso-
vanced cancer, 91% of the participants had spiritual needs cial dimension), and pain (physical dimension).
and 67% reported a moderate or greater desire for the medical The conceptual framework for this intervention study
staff to support their spiritual needs. This is significant, for was based on Daniel Sulmasy"s26 biopsychosocial-spiritual
the same study found that unmet spiritual needs expose model. This model embraces a holistic view of the human
patients to risks of depression while reducing sense of spir- person, understanding the person as consisting of physical,
itual meaning and peace. As studies introduce interven- psychological, social, and spiritual dimensions. The model
tions that have positive effects on spiritual well-being also explains these dimensions as influencing one another
and quality of life,15,16 emphasis is being placed on the in mutual interaction. Accordingly, this study measured the
need to develop spiritual interventions that address spiritual Holy Name Mediation"s effects on the biopsychosocial and
concerns and needs. spiritual state of cancer patients.
However, the term spirituality is often used inconsis-
tently in each literature.17 The usage of the terms spiritual
and spirituality in this study is based on the definition METHODS
accepted at an international, interdisciplinary consensus
conference, where it was stated that: ‘‘spirituality is a dy- Design
namic and intrinsic aspect of humanity through which per- The study used a nonequivalent control-group pre-/post-
sons seek ultimate meaning, purpose, and transcendence, test design to examine the effects of the Holy Name Medita-
and experience relationship to self, family, others, com- tion on cancer patients" spiritual well-being, depression,
munity, society, nature, and the significant or sacred. Spir- anxiety, and pain. The intervention program was delivered
ituality is expressed through beliefs, values, traditions, and to the experimental group through a 5-week course com-
practices.’’18 This consensus-driven definition is in accord prising 50 minutes per week. The results of the interven-
with the people"s increasing tendency to seek beliefs and tion were then compared with data collected from the
practices that they find meaningful, rather than adhering control group.
to a certain religious tradition. However, despite grow-
ing emphasis at the global level that spiritual needs must Sample
be addressed to enhance quality of life, most patients The number of study participants was calculated using
are not receiving adequate spiritual care because of lack G*Power 3.1.3, which is a software used to compute statis-
of training and knowledge on the part of health care tical power for a variety of statistical tests. The calculation
professionals.19 was based on the results of Bormann et al"s21 study that
To address this issue, this study aimed to test the ef- applied mantram repetition to veterans with PTSD and
fects of a spiritual intervention on cancer patients. Called another randomized controlled trial study conducted on
the ‘‘Holy Name Meditation,’’ the intervention was devel- HIV patients.23 Considering that this study was the first to
oped from Eknath Easwaran"s 20 Eight-Point Passage apply an intervention not widely known in Korea to cancer
Meditation. Although there have been studies that ap- patients, the study sample was yielded based on a signifi-
plied a mantram-based meditation developed from the cance level of ! = .05, a statistical power of 0.80, and a
Eight-Point Passage to verify its positive effects on the medium effect size of f = 0.25. Although a total of 34 partic-
spiritual and psychosocial well-being of veterans with ipants were required on this basis, initial recruitment
posttraumatic stress disorder (PTSD)21,22 and HIV pa- targeted 46 people (23 per group) given the estimated at-
tients,23,24 no study has yet to apply such an intervention trition rate of 30%. The criteria for eligibility were that the
to cancer patients. The current study makes this attempt. person is a cancer patient between the age of 18 and 70
Holy Name Meditation mainly consists of silently re- years, does not take medication for depression or anxiety,
citing the Holy Name or the Holy Word that people have and has freely agreed to participate while understanding
chosen for themselves. The authors have already applied the research objectives. Participating patients who were
the Holy Name Meditation Program to middle manager included in the final experimental group and selected
nurses in a previous study, which verified that the interven- for analysis were those who took part in the intervention
tion enhanced their spiritual and psychosocial well-being.25 for 5 weeks, attending the sessions for more than three
On the basis of these results, this study sought to evaluate times.
whether the Holy Name Meditation Program, modified
to suit cancer patients, could show multidimensional effects
MEASURES
not only on health care professionals but also on patients
receiving cancer treatment. In short, the objective of this The effects of the Holy Name Meditation were measured
study was to apply Holy Name Meditation on cancer pa- using three tools, whose reliability and validity have al-
tients and examine its effects on their spiritual well-being ready been verified.

Journal of Hospice & Palliative Nursing www.jhpn.com 369


Feature Article

Spiritual Well-being on both groups before the program. Participants in the


The Korean version of Paloutzian and Ellison"s27 Spiritual experimental group completed the posttest survey after
Well-Being Scale developed by Cheung et al28 was used. their intervention, whereas those in the control group
The Cronbach"s ! for Cheung et al"s28 study was 0.89, filled out the same posttest survey at the end of the 5-week
whereas the Cronbach"s ! for this study was 0.85. intervention period. Five of 27 participants in the experi-
mental group were removed after the pretest survey for be-
Depression and Anxiety ing absent more than three times. Four participants were
Depression and anxiety were measured using Kim et al"s29 removed because of incomplete responses to the posttest
standardized Korean version of the Symptom Checklist 90-R survey. As a result, a total of 18 participants remained in the
(Cronbach"s ! = 0.77-0.90), a simplified psychometric instru- experimental group. In the control group, 6 of 34 partici-
ment developed by Derogatis.30 Of the nine psychometric pants were removed because of incomplete responses to
items, those measuring depression and anxiety were the posttest survey, leaving 28 participants for analysis. In
extracted. In the study by Kim et al,29 the Cronbach"s ! was short, participants included in the final analysis consisted of
0.76 for depression and 0.77 for anxiety. For the current study, 18 patients in the experimental group and 28 patients in the
the Cronbach"s ! was 0.88 for depression and 0.91 for anxiety. control group (Figure).

Holy Name Meditation Program


Pain
The spiritual intervention program used in this study was
Pain was measured using the numeric pain rating scale val-
based on Eknath Easwaran"s20 Passage Meditation and
idated by Paice and Cohen.31
was adopted from the authors" precedent study.25 A re-
search team comprising a nursing scholar, a meditation
PROCEDURES expert, a theologian, an educator, and nurses in clinical
leader positions worked to supplement the precedent
Recruitment and Data Collection study"s program to accommodate cancer patients. The
Data were collected from March 2012 to March 2013. Data modified Holy Name Meditation Program consisted of
collection began after the study had been reviewed and ap- five modules, whose contents are summarized in Table 1.
proved by the Institutional Review Board at The Catholic Session 1 introduced participants to spiritual care and
University of Korea. Recruitment took place through written guided them to choose their ‘‘Holy Name’’ (or ‘‘Holy
announcements within the university hospital. Partici- Word’’) from a list of spiritual words, phrases, or pas-
pants were chosen from inpatient and outpatient cancer sages. They were then trained to silently repeat the Holy
patients receiving operational and pharmacological treat- Name that they found meaningful as often as possible
ment at the hospital. The experimental group consisted throughout the day, and not just during their meditation
of patients who voluntarily participated in the study, and time. Session 2 involved practice using the Holy Name
the intervention program was individually provided to repetition to transform negative emotions such as fear
them. The intervention was delivered in the order in which and anger into positive emotions. Session 3 trained par-
they applied, because cancer patients experienced suffer- ticipants to calm the mind and reduce hurry, thus
ing and there was uncertainty as to when their conditions preventing stress and waste of energy coming from ev-
would deteriorate. It was thus assessed that there was not eryday life and relationships. This served the purpose
enough time to wait for all applications before applying the of enabling them to live a harmonious life. During ses-
intervention. The control group consisted of patients re- sion 4, participants practiced one-pointed attention to fo-
ceiving operational and pharmacological treatment after cus on the matter at hand while warding off diffusion of
cancer diagnosis. For convenience, patients in the control thoughts, in an attempt to attain a peaceful mind. In session
group were selected from those recommended by the 5, participants were trained to integrate all these skills into
nurses. The selected patients agreed to take part in the sur- their daily life through the Holy Name repetition.
veys that were intended for data comparison with the ex- Each session lasted 50 minutes, comprising 30 minutes
perimental group. All participants from both groups of didactic lecture, 10 minutes of question and answer
provided written informed consent. The content of the in- combined with sharing of experiences, and 10 minutes of
tervention was not exposed to the control group, because meditation practice. The program was provided through
the intervention was applied to the patients in the experi- individual encounters between participants and a re-
mental group on an individual basis, according to each par- searcher on a weekly basis, when the participant visited
ticipant"s schedule of hospital visits. the hospital for either outpatient or inpatient cancer treat-
A total of 61 participants were selected, with 27 pa- ment. As a weekly assignment, the participants were asked
tients in the experimental group and 34 patients in the to keep a daily record of the frequency of their Holy Name
control group. The same pretest survey was conducted repetition and reflective experiences thereof. The record

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Feature Article

FIGURE. Flow diagram of retention and attrition.

was used when they shared their experience with the marriage status, religion, duration of diagnosis, and type
researcher. Participants also received a CD produced as of diagnosis (Table 2). However, for study variables, the
an audiovisual aid containing the program content, en-
abling them to access the material at home. The control
group only received conventional care, without any other TABLE 1 Content of the Holy Name
intervention. Meditation Program
Week Content
STATISTICAL ANALYSES 1 Introduction to Spiritual Care

SPSS 12.0 was used for data analysis. The general charac- Choosing and Repeating a Holy Name
teristics of the participants were analyzed on the basis of
- Practice silent repetition.
real numbers, percentage, average, and standard devia-
tion. The general characteristics of the two groups and their 2 Harnessing Emotions
pretest homogeneity were examined using t test and # 2 test.
The analysis of the Holy Name Meditation"s effects on the - Transform any negative emotion into its
positive counterpart.
two groups was conducted using paired t test and one-way
analysis of covariance that had pretest depression and anx- 3 Slowing Down
iety scores as its covariates.
- Calm the mind to reduce hurry that causes
stress and wastes energy.
RESULTS
4 One-Pointed Attention
Homogeneity Test of Variables - Give full concentration to one thing at a time.
Upon reviewing the homogeneity of study variables and
the general characteristics between the experimental 5 Putting It All Together
group and the control group, no differences were iden-
- Integrate all elements with the Holy Name.
tified in the participants" age, sex, level of education,

Journal of Hospice & Palliative Nursing www.jhpn.com 371


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TABLE 2 General Characteristics of the Two Groups


Exp (N = 18) Cont (N = 28)

Characteristics Mean (SD) or n (%) t or # 2 (P)


Age, y 50.4 (15.2) 52.1 (10.7) j0.43 (.671)

Sex

Male 9 (50.0) 14 (50.0) 0.00 (1.000)

Female 9 (50.0) 14 (50.0)

Education

Middle 1 (5.6) 2 (7.1) 0.26 (1.000)

High 8 (44.4) 14 (50.0)

College 8 (44.4) 12 (42.9)

Missing 1 (5.6) 0 (0.0)

Marriage

Single 3 (16.7) 2 (7.1) 1.62 (.620)

Married 15 (83.3) 25 (89.3)

Bereaved 0 (0.0) 1 (3.6)

Religion

Yes 16 (88.9) 20 (74.1) 1.20 (.279)

No 2 (11.1) 7 (25.9)

Duration of diagnosis, y

G1 8 (47.1) 17 (60.7) 2.45 (.344)

e1 and G2 5 (29.4) 3 (10.7)

e2 4 (37.8) 8 (28.6)

Diagnosis

AML 4 (18.2) 0 (0.0) 10.59 (.148)

Ovary/uterine cancer 2 (9.1) 5 (16.7)

Stomach/liver cancer 1 (4.5) 6 (20.0)

Breast cancer 3 (13.6) 2 (6.7)

Colon/rectal cancer 3 (13.6) 6 (20.0)

Lung cancer 2 (9.1) 5 (16.7)


Other 3 (13.6) 4 (13.3)
Abbreviations: AML, acute myeloid leukemia; Cont, control group; Exp, experimental group.

372 www.jhpn.com Volume 20 & Number 4 & August 2018


Feature Article

score for depression in the experimental group was 8.47 analysis on studies that verified positive effects of various
points higher (t = 3.44, P = .001) compared to the control spiritual interventions on cancer patients" spiritual well-
group. The score for anxiety in the experimental group being, meaning of life, depression, and anxiety. However,
was also 6.02 points higher (t = 2.83, P = .009) compared of the 15 studies included in the meta-analysis, only two
to the control group. It was ascertained that patients in addressed both the spiritual and psychosocial effects of
the experimental group chose to participate in the study the intervention. Most interventions, including the two,
because they were experiencing more psychosocial dif- were strongly religious in nature. Unlike these interven-
ficulties than those in the control group. However, there was tion studies, this study was unique in that it applied a
no difference between the two groups’ spiritual well-being self-applicable intervention that was transreligious and
and pain (Table 3). had multidimensional effects.
As increasingly more people strive to fulfill the spiri-
Effects of the Holy Name Meditation Program tual desires innate to human existence, a greater number
To address the differences in the two groups" pretest of cancer patients receiving treatment with conventional
study variables (ie, depression and anxiety), an analysis medicine are expressing their preference for integrative
of covariance was conducted. The covariates were the medicine.33 As a result, there has also been a rise in the
pretest scores for depression and anxiety (Table 4). number of reports in the literature measuring the effects
The results of this analysis showed that the overall score of spiritual interventions on cancer patients, where the in-
for spiritual well-being was higher (F = 4.80, P = .034, terventions are not necessarily tied to a specific religion.
)p2 = 0.10) in the experimental group than the control Examples include meaning-centered psychotherapy,15
group. There was thus a medium to large effect size in Meaning of Life Intervention,34 life-review intervention,35
the experimental group. The level of decrease in both and Dignity Therapy.36 Although authors use different
depression (F = 7.28, P = .010, )p2 = 0.14) and anxiety terms such as psychotherapeutic or psychospiritual to de-
(F = 4.98, P = .031, )p2 = 0.10) was more significant in note these interventions, ‘‘spiritual’’ interventions differ
the experimental group compared to the control group from the psychosocial in that their goal is to promote spir-
and showed a medium to large effect size in the exper- itual well-being and address spiritual distress. It has been
imental group. The level of pain was low in both the ex- suggested that the wide array of spiritual health interven-
perimental group (mean, 2.0) and the control group tions may be categorized into (1) therapeutic communica-
(mean, 3.05) before the intervention, and no difference tion techniques, (2) therapy, and (3) self-care.37 The Holy
was identified between the two groups after the inter- Name Meditation would be a form of meditation under the
vention. category of self-care.
Studies have noted that meditation-based spiritual in-
terventions are beneficial because they can apply to peo-
DISCUSSION ple of all religious backgrounds. However, according to
This study verified that the 5-week Holy Name Medita- a meta-analysis on mindfulness meditation interventions,
tion Program had positive effects on the spiritual well- most studies identified psychological well-being as the
being, depression, and anxiety of cancer patients. These primary effect of such mindfulness-based interventions.38
results were similar to those of Oh and Kim"s32 meta- Unlike these interventions, a mantram-based intervention

TABLE 3 Homogeneity Test of Study Variables Between the Two Groups


Exp (N = 18) Cont (N = 28)

Characteristics Mean (SD) or n (%) t (P)


Spiritual well-being 77.11 (13.28) 78.00 (9.10) j0.27 (.789)

Religious well-being 39.77 (6.91) 36.75 (5.73) 1.61 (.114)

Existential well-being 37.33 (7.77) 41.25 (5.86) j1.94 (.058)

Depression 21.22 (9.26) 12.75 (7.36) 3.44 (.001)

Anxiety 11.05 (8.15) 5.03 (4.81) 2.83 (.009)

Pain 2.00 (2.62) 3.05 (2.96) j1.15 (.259)


Abbreviations: Cont, control group; Exp, experimental group.

Journal of Hospice & Palliative Nursing www.jhpn.com 373


374
TABLE 4 Comparison of Spiritual Well-being, Depression and Anxiety, and Pain of the Two Groups at Posttest

www.jhpn.com
Exp (N = 18) Cont (N = 28)
Between Groups (Adjusted for
Within Group Within Group Depression and Anxiety)
a
Characteristics Groups Mean (SD) t P Mean (SD) t P F P )p 2
Feature Article

Spiritual well-being

Total score Pretest 77.11 (13.28) j1.64 .118 78.00 (9.10) j0.24 .806

Posttest 80.83 (5.36) 78.41 (8.50) 4.80 .034 0.10

Religious Pretest 39.77 (6.91) 0.14 .889 36.75 (5.73) j0.48 .634
well-being
Posttest 39.61 (3.27) 37.21 (5.17) 3.56 .066 0.07

Existential Pretest 37.33 (7.77) j2.77 .013 41.25 (5.86) 0.04 .966
well-being
Posttest 41.22 (3.82) 41.19 (5.79) 2.16 .149 0.04

Depression Pretest 21.22 (9.26) 4.70 .000 12.75 (7.36) 0.07 .945

Posttest 12.61 (7.14) 12.67 (8.11) 7.28 .010 0.14

Anxiety Pretest 11.05 (8.15) 3.26 .005 5.03 (4.81) j0.13 .895

Posttest 5.22 (5.45) 5.14 (5.21) 4.98 .031 0.10

Pain Pretest 2.00 (2.62) 0.62 .538 3.05 (2.96) 1.17 .252
Posttest 2.06 (2.36) 2.26 (2.39) 0.24 .627 0.00
Abbreviations: Cont, control group; Exp, experimental group.
Within-group difference was examined by paired-sample t test. Between-group difference in posttest values was examined by a one-way analysis of covariance (adjusted for pretest depression and
anxiety).
a
Partial )2 values for the analysis of covariance. Effect sizes: small, 0.01; medium, 0.06; and large, 0.15.

Volume 20 & Number 4 & August 2018


Feature Article

similar to the Holy Name Meditation has been shown to Holy Name Meditation"s effects on a more diverse patient
have both psychological and spiritual effects. But studies population, including noncancer patients, seems neces-
verifying such results were limited to veterans and HIV pa- sary. Second, the pretest results identified significantly
tients.21-24 This research is notable for being the first study higher scores of depression and anxiety in the experimen-
to apply a transreligious spiritual intervention to cancer pa- tal group, meaning that a randomized controlled trial is
tients and verify its effects on both their spiritual and psy- needed to reinforce the study results. Last, there is a need
chological well-being. to construct and validate a conceptual model to closely
Stein et al,39 on the other hand, argued that psychoso- examine the implied relationship between spiritual well-
cial interventions should be given priority over spiritual being and the biopsychosocial states. This would help ex-
and/or existential interventions, on the grounds that can- plain the mechanism through which spirituality enhances
cer patients who consider themselves spiritual place the overall quality of life, contributing greatly to the devel-
greater importance to psychosocial interventions. The opment of spiritual interventions.
Holy Name Meditation, however, had positive effects
on spiritual well-being, as well as both depression and CONCLUSION
anxiety. This shows that spiritual interventions can have
multidimensional effects, encompassing both the psy- The results of this study present initial evidence that Holy
chosocial and spiritual dimensions. Study results showing Name Meditation enhances cancer patients" spiritual well-
that spiritual well-being mediated the reduction of depres- being while reducing their depression and anxiety. Be-
sion and anxiety support the results of this study.11,12 More- cause the Holy Name Meditation is a transreligious spiritual
over, a path analysis by Bormann et al40 suggested that intervention in the form of self-care that has multidimensional
enhancing the existential, spiritual well-being of veterans effects, it can provide an effective means to relieve cancer
with PTSD may mediate the alleviation of their symptom patients" total pain and improve their overall quality of life.
severity. A similar study may be conducted on cancer pa- With the cancer prevalence rate on the rise, there is an ur-
tients to identify a mechanism for the relationship between gent need to address the psychological and spiritual issues
the spiritual and psychosocial effects found in this study. faced by cancer patients in addition to managing their
The potential mediating role of spiritual well-being also physical symptoms. As an intervention that can be applied
corresponds to Sulmasy"s26 conceptual model that illus- clinically to enhance the well-being of cancer patients, the
trates how changes in the patient"s spiritual dimension in- Holy Name Meditation offers a useful way to address this
fluence the biopsychosocial dimension, thus having a contemporary challenge.
multidimensional impact on the overall quality of life. It
can be stated therefore that spiritual interventions can sub- References
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