Table 2

Overview of cytarabine regimens including cytarabine for lymphoid neoplasms in adults. Details concerning
doses in combination regimens should also be consulted.
Disease Phase Regimens Cytarabine Dosing and Additional Drugs References
Dose-intensive regimen: I.V.: 3000 mg/m2 over
Acute lymphocytic 2 h every 12 h days 2 and 3 (4 doses/cycle) of
induction Hyper-CVAD [54]
leukemia even numbered cycles (in combination with
methotrexate; alternates with Hyper-CVAD)
Early intensification phase: 75 mg/m2/dose
days 1 to 4 and 8 to 11 (4-week cycle; repeat
Larson
once) [67]
regime SubQ 2
Late intensification phase: 75 mg/m /dose days
29 to 32 and 36 to 39
induction, relapse 3000 mg/m2 over 3 h daily for 5 days (in
High-Dose [68]
or progression combination with idarubicin [day 3])
I.V.: 1000 mg/m2/dose over 2 h days 2 and 3
refractory or
Chronic lymphocytic every 4 weeks for up to 6 cycles (in
Richter’s OFAR [69]
leukemia combination with oxaliplatin, fludarabine, and
syndrome
rituximab)
Burkitt and Burkitt- Cycles 2, 4, and 6: 150 mg/m2/day continuous
induction CALGB 9251 [52,70]
like lymphoma infusion days 4 and 5
Adults ≤ 65 years: Cycles 2 and 4 (IVAC):
2000 mg/m2 over 3 h every 12 h days 1 and 2
CODOX- (total of 4 doses/cycle) (1000 mg/m2 if age >
[53]
M/IVAC 65) (IVAC is combination with ifosfamide,
mesna, and etoposide; IVAC alternates with
CODOX-M)
cytarabine 800 mg/m2 IV on days 2 to 4) every
Mantle cell
induction R-BAC 28 days for four to six cycles (in combination [57]
lymphoma
with rituximab and bendamustine)
I.V.: 2000 mg/m2 over 1 h every 12 h days 2
CNS lymphoma, and 3 (total of 4 doses) every 3 weeks (in
induction [66]
primary combination with methotrexate and followed by
whole brain irradiation) for a total of 4 courses
2000 mg/m2 over 3 h every 12 h day 2 (total of
Hodgkin and non- relapse or
DHAP 2 doses/cycle) for 2 cycles (in combination [62,71]
Hodgkin lymphoma progression
with dexamethasone and cisplatin)
2000 mg/m2 day 5 (in combination with
ESHAP etoposide, methylprednisolone, and cisplatin) [60,63]
every 3 to 4 weeks for 3 or 6 cycles
2000 mg/m2 every 12 h day 2 (in combination
DHAOX with dexamethasone, and oxaliplatin) every 3 [61]
weeks
transplant preparative regimen: 200 mg/m2