#VolumBooster #PNfiller

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Introduction of Renefil®

Rheological properties of Renefil®

Specificities of Renefil®

Clinical data

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1) Noh TK, Chung BY, Kim SY, et al Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide a Popular Wound Healing Booster. Int J Mol Sci. 2016;17:1448
2) Park KY, Seok J, Rho NK, et al Long-chain polynucleotide filler for skin rejuvenation efficacy and complication in five patients. Dermatol Ther.2016;29:37-40 8 /29
Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler (springer.com)

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Compound
G’ G”
No. Sample name viscosity
(Elasticity) (Viscosity)
(Pa.s)
1 20 mg/mL HA 402 80 65
2 20 mg/mL HA, 0.5 mg/g PN 436 111 72
Validated;
3 20 mg/mL HA, 1 mg/g PN 434 98 71
Optimal compound viscosity
4 20 mg/mL HA, 1.875 mg/g PN 506 119 83
20mg HA + 1.875mg PN 5 20 mg/mL HA, 2 mg/g PN 486 147 81
6 20 mg/mL HA, 3 mg/g PN 480 204 83
7 3 mg/g PN 0.048 0.011 0.008
8 Competitor A 375 61 61
9 Competitor B 374 277 74
10 Competitor C 278 39 45
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® Control (competitor A)

Elasticity Viscosity Composite Tack Test(N)

Injection Force
Sample Name factor factor viscosity(cP) Molding
(N)
G’(cP) G’(cP) Elasticity+Viscosity factor

® 203,000 83,000 1,724,000 10.12 0.90N

Control (competitor A) 87,200 142,500 1,330,000 17.20 0.52N

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150
PBS PN
100 140
120
50 100
80

0 60
40
0 1 2 3 4 5
20

PN 0
0 1 2 3 4 5

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 PN induced hydrophobic interaction between HA gel particles.
As a result, it is possible to have good cohesiveness, which is the advantage of biphasic and monophasic fillers
without mixing free-HA, and to maintain the properties of fillers that remain in their original shape for a long
time.

• The PN-only sample solution is close to zero in

elasticity, viscosity, and composite viscosity.
• When the HA crosslinked gel and PN were mixed,
the elasticity, viscosity, and composite viscosity all
increased .

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Ref.) Jong Hwan Kim, et al. , Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex DermalFillerScientific Reports, (2020) 10:5127.