Leonillo, Leiza-mei L.

CAS 2-C
Jurial, Sherlyn P.
ABNORMAL HUMAN KARYOTYPE 2
JACOB’S SYMPTOMS
Jacob’s Syndrome, also known as XYY Syndrome, is a genetic
condition that occurs when a male has an extra copy of the Y
chromosome in each of their cells (XYY). Sometimes, this
mutation is only present in some cells. Males with XYY
syndrome have 47 chromosomes because of the extra Y
chromosome.

Some patients may show no symptoms, while others may develop mild symptoms. Below given
are some of the common signs and symptoms of XYY syndrome:

 Underweight
 Poor muscle tone
 Delay in reaching all the milestone
 Delayed in development of speech and language skills
 Widely spaced eyes
 Learning disability
 Lower IQ than normal
 Severe acne
 Behavioural problems like high temper, hyperactive etc.
 Involuntary muscle movement
 Taller than average height
 ABNORMAL HUMAN KARYOTYPE 3
TURNER’S SYNDROME
Turner Syndrome is a genetic disorder affecting some
females. It might cause problems with hearing, vision
and fertility. It does not usually affect intellectual ability.
Treatment with hormones can help manage some of the
problems.
In turner syndrome, cells are missing all part of an X
chromosome. The condition only occurs in females. Most
commonly , a female with turner syndrome has only 1 X
chromosome. Others may have 2 X chromosomes, but
one of them is incomplete. Sometimes, a female has
some cells with 2 X chromosomes, but other cells have only 1.
People with turner syndrome are often short in height. They sometimes have infertility. This is
due to their ovaries not developing properly.
Females with turner syndrome might also have some or all of the following health issues:

 Difficulty feeding in infancy

 Problems with hearing or eyesight
 Problems with coordination
 Puffiness of the hands and feet
 Slower sexual development
 Problems with the heart, liver, or kidneys