nnyst shen he wide meme Mi wo Be |. Magnesium Laonmostsbuncantcaton ie voly ‘apemelpcmacetuar cater tytn cect "46% (muscle, soft tissues), <1% (Blood) ene fe ~Protentound +e oompiexes | Functions of Magnesium Inge mani ccs of BM, uta ins contributor to bone strctre (For muscle contraction and heart rythm aStates eRe BAR RR ortiy tl Sone Ct mtn a et qui pore | Regulation of Magnesium ian € arin te a Pratyetnermene cei Sn Sent le Aldosterone and Thyroxine "= “* [| Hypomagnesemia nn a = Se ee eget sett a tea hint nada ghmsentg | Hypermagnesemia [Dinerease Intake (Medication, Magnesium sulfate therapy) ‘aHypoparathyrtasm ype aiderosteronism {aRtnattature (Decrease excretion) [Renal Ca/ Bonemetastases det meme 6 tore bes | Specimen considerations and Patient Preparation seit oe cae | hgdnchlovs QSerum, lthium heparinized-plasma or 24-hour beused — aved prug ‘OKs, EDTA nd etal shou DD Noto hemotsis causes {elie non ERED Wok sate ROC, | Methodologies of Magnesium Measurement wa naghial tov acc dena ‘eats teen! "Mg + Calgarite > Reclsh-voe (520.592 nm) 2 Formazan ayo (itros) 'Ma2+ + Dye > Colored comeex(S80nm) ‘9 Matnylnymot bie (lmension, DuPont aca) | Methodologies of Magnesium Measurement 4. Titan Yetlo/ Dye Lake Method/ Clayton Yotlow/ Thole allow ‘Ma + Titan Yellow > Fed Lake ColoidalPrecotate Mg + S-hyeroxyS-qnoine autre so > Fucrescence (380 = oem 6. Atom Absorption Spectrophotometry 7lomsolective slectrode Values to Remember Reference Vake; 0.830 LO mma. Conversion Factor: ImEg/LtommayL=0.5 Bicarbonate Laconpesed of unaenotea NaHCO, carbonate andcartamte AMahierane of hahaa Bewonate concentration occurs in aReterenoe Va: 2128 Ea. ANION GAP. ‘set ndoating an rereaes none of mots of fe anmeaered Formulas AG-Na~(Cl= HCOS) 0° AG= (Na+ K)=(Ci+ HCO) Clinical significance of Anion Gap Increased Anion Gap Urea Real Faure Yeetonciosis ” ‘Poisoning dus to ingestion of txt substances “sot aioe Sete denyration “srumenteror “MUDILES” Matnano “uremia -DIabetle Ketoacldoeie ron nalants,gorazi, buproten Lact acidosis -Etnyiene alycot poisoning, ethanol ketoacidosis -/Salcylates, Starvation ketoacidess, Sympatnomimaties Decreased Anion Gap vHypoalbuminemia vHypocalcemia Erroneous reporting vHypoatbuminemia vHypocalcemia