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    QC Basics

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    QC Basics

    Uploaded by

    nanipentesh2
    8 views15 pages

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    QC basics

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    8 views15 pages

    QC Basics

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    nanipentesh2

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    © All Rights Reserved
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    of 15
    a what i karl seer principe and reationseserbe it he fendenental peinesple behind {t is based on the Bunsen [se'tazuecn iodine and sulfur Glexide in an aqueous fre apoune. cf water present in the sample ig calcul Citeeping reaget ices, civer) and che amount of 1: Whe performing Mostar cont how oyu sty ony Methane rat with wt SoD gs mS mani Sarena ne wy Kf factor coming 0 pelea at tangent. think then be es should be My AE feree 2 the dittarence of sap of 100 teat and Karl Pircher titee.? ot io drag tolersie Bet in 200 deternie orgonie a condition hati prinipal of kar fiche instrument Present in custance by Knee ator what medium we can choos fo analsing aldehyde an ‘Ketone saimples by using KF reagent ‘SANPLES ARE XRT GROUPS.) hr Be ate pees naucralieation,s#ficion of next drop of WAH SpUPLSTAS" gC Eslucion will be above 6.2. for this reason ie'vas showing pink colour BS. soos. bor bese with ents? why ceeded pharm Soeimetaeectelceteae gad aotoue oF Sete we eka crande either in compariaon vith other stabllity oos-out of specifications and sot-out of trend Ri tho words Fegular Using all harms {RGi0Ery Lic, sver we gee ating con coring of ur austy ie and soipbetee “ weet ‘aeable at sh Serene ISSPaS ee, Setidgn temperatures sence iy in recommended to TeSr'bulehneee ash inevead of sitraces and chlorides ty we are ang 88 ml of concentrated HCI prepare 1X Soaion 5.0 ton / 2.10 0 36 » o6. ant sense 37 iae.s9 Af purity Ja 1008 bat fo HEL Petilfed volune ta prepare 2M olution 10.997100/362050 Gravity SeNC1)/ Bg. We. OF HL weece 10 12 multiplied to convert in normal soln. (2000 at) 2 ise 10+ 2.t9)/36.8 © 11.64 oR) wes ote, Caffeine = 238.600 26 297.500 (samaeel oe) dont ie eandardsaton do or retest or exp f Volumetric ain prepare inne ety cstandasdieation date ie decided based on the changes in nomality on testing everyday during pre seaniiine sees hats primary standard? Girectly used for standasdeat ion of seltmeee eo lone i eeitaiens afer comple consumption of C1 by N8OH aon of next dopo i wl pak colour with phenopianinckeaor Why ths pak eae aes ‘Why not ae black, green or anything ees Phenolpthalein indicator pH range = 8.2 To 10.0 tm this pit region only Phenolpthalein indicator ahowe pinie What difrence bern residue on ignition and sulphate ash? KIHAIEEATEEE “Het remeioe etter igntston és notniag nut ‘ids ton mean samp gna t igh ACID AND Suit HYDROGEN PTHALATE Is USED FoR PERCHLORIC ACIOAND NAOH. WHY ITIS USED FOR BOTH ACID amo eee Eger rverooen prema ety A1abIe én pure ‘What is boing point? & Explain. ‘What is the Defination of Tapdensity 2 ereegit iota MSE, o& teeta cates tng / vote ot aan att Salt centlty © taped asgt hee why we use vanilin in melting range elation std Tiuns eatddng aed fulbudoamtae eRaytet Teer ahaa enlabeatfGn te nacing point Spas vais the iaificant of pH in He? ‘what is reverse phase chromarography normal phase chromatography Pleas Eka" tobiiegnase te fonpsiae in chs type the non polar analytes elute irstshe polar analytes elute ater “The tne taken for 3 parte compound te ave ough the column fo he decors known #8 ‘vetenon me Teltctivy secolueton and late elution (itaatogensoy? rain prinesple ie adsorption. when wisture of componenete assed ehrough the colunn the componente thieh are nore Inceraction comenaste eluted first depend apon chet son Colleciant tna ot to samponnse havg the pnace (mobile phae-poler i stazionazy phase” toh polse) Erlgntay seaoep oo searionasy phase, ¢'t0 on welaced eubecance ceate are entabLighed after complete Nouriticn ana sngpectfied impurities ageinst Reference Sorantiearion method ‘vit i the diference Between BDS and ODS Columens and both are same oF not weit sauces Sg Se hdcapeed column 20°18 good cor “EStunonige acidic sitica it iz soe suitaple for basse {520 28 ser usp guideline =p ratio can be changedrevived so must be there for reason /juatification inclusion set (an be moaifisd — —— 4,108 1s acceptable , ut your internal Guldline/SoP should define the acceptable Limit /renge: But in general + 108 ie acceptabie Why we ure caffeine £08 WOLE extsbeation in Detector weve Pharmscopieas 45% gives » multiwavelength responce Like 205,245,273 am f SloccTIENMIMSRESS TRS oe ene ov range 4 To lthis caus ve can use Erbjon perchisesee taieh wita ran he whote range 200-am'ta eo en ie is Sebi dng Hieeie comery-but aor silly avellable is Sanne anhat is the meaning of PURITY AND POTENCY hat i the difference between PURITY and POTENCY arity i2\the.Quistseative’# Roteney gat egt ve Purity iso qualicative analysis method. in this we estimate ESL sehen is Magners poter aoetonseriie dinethyl formamide methanote tetsanyarosucane buftar solution eterence standatd'then mean of aos Gans ain eeeaREL SE, why weare adjusting the pis eration preparation ‘better peak bands with sharper resolution aid area are” chesrved if ph is najuetes Sscordin to epecitiserions QYHICH PRESSURE IS HIGH EITHER INJECTOR OR DETECTOR IN GAS cmomaToGRAPHY ‘injector progsure iz than detector injector pressure high because injector side using septun what the detain acerncy & presen? Accuragy, Accuracy a, show u gestae of repraducthiticy by rrciglon, trasigion is show & tow practeice 16 us meth ‘what ler you ean alae for aide nature. pte and how t or an acidic nature compound u should use only acid pt butters only why because Acid compounds are showing woe hydrofopieity in acid pH, if the sample ie having Sots ‘Hydrotebicity st Fetaine on colum and it gives good peak ‘shape and advisabie retention time, s Swe Go acid samples in basic pil butfers the sample undezgoss. ionisation meanwhile incresses’ the hraseepiic ature dueto thie hydrophilic nature the gample-ncr retains on the column. u mist select a acid pice analyse tes acid fon what basis S0P's can be changed? IF mobile phase ratio Ss 70:30 to how much 8 can we change the ration in HPLe obi te phase bonded ghase will lore becuse now’ polar se soe variation in hple and go with sane Set GIS Wovking based on syageeeishtechaisus co the veriaticn cont tis itrene Between asa and purity in ple? PUriey Ts darocninstion oF iepurities Pr \ EMop tieey spéezasce cide mit. Wo ref. eta. will be winere at purtty by using chromatography ealys =" °° Wheisiy!ascay will be colciuated for BT'S. where content in this aliculdtion we wee in ocity eetiog we ertinae che analyte cofcentzation tn ‘atten etnen Primary and scary aference standart? A primary eeandara 18 reagent that ig axtranly pure Reamrotand} standard sa 2 standard that sa propered in che Taboratory for a specitie analysts, it is usualy “tow a prepare working standard im ou aerator gant reference standard? working sCandarars are prepared agetnat reference standasd MPLe ce: explain? tration was done ia Reverse Phase but notin normal phase why everse phase ond tornai phate claasification is based on the sobile phase and etatonaty phase, featasn) gue'se’ Phase and Yomal phase related co the mobile phase fon-it {9 equally suitable eo heceal ‘what i diference bw ailing fator® asymmetry Telling Pactor: S= snows ux tailing of peak egation ia 7 wooelar ae *oreeTaey cane of Pak egatin te a = tea we use pda detector in bp instead of uv detector SIRS ttows 00,2 teagee)aotmensroms stevens 5-2£ you dont now the exact lanbda maxing of the material v gE ge toe Pon, ae oe os ia ot Bonesble by ‘OV in sing] injection. we can do it by Giaraly for Normal Phase HPLC stationary phase is Poartn place of polar itwe ‘ke non-polar means what happened & why? HPLC {there any material ther than calfene to ea Fate hple detector Semtophenone, makina at 254 on Wis rsd fn and explain SEIELg S.tgbereHome She deviation “hvu thane SPdSSE,t00e How to establish pKa fora new APL molecule? what the reasons to get peak telling? : why lineriey not use in GC but use in HPLC? steps ne Normal phasor Reverse Phase HPLC method Conditions forgiven sampl UNIGH PRESSURE 1S HIGH EITHER INJECTOR OR DETECTOR IN Gas Injestor pressure 4e chan getector STUN a EE INCA OF sePaRATION oF voLaTiLe COMPONENTS PRESENT A 4 SIRTURE BETWEEN TWO PHASES MOVING MOBILE ASE GS wee Support Detector Type Supe Sse Deby Pzami Flame ionization Mase ow Hrdogen 7 Ft andair Mostorganicepds. 100pg 10 Thermal conductivity Concentration Reference Univers 7 creo) Ing 1 lectron aides, nates, apie Congentation Maktyp tiles, peroxides, 7 we Maloun onvdrdcs, 50 fe 10" ‘organometallics Nitouen Hydrogen hosphorus Massilow SUMOR" Nirogen phosphorus 10pg gr Hydrogen Sulphur, phosphorus Photonic Mass ow ait tn, boom arsenic : Topps Masefiow Tosi germans 100pg ap oxygen selenium, chromium Aliptatis, aromatics, Photo: ketones, esters, ‘nization “Concentration Make-up aldehydes, amines, 7 (eID) P eteroyclcs, 2 PB o ‘organosulprs, eiectoytic Mass flow Eondvtiiy nats peak purity 22 YEAO. OF ABSORBANCE B/\ THE ROOT OF UP store Axo Wr aMEhEle SF ABSORRRICE faz ncor OF SOM SEOSE aa apex Hydrogen, Halide, nitrogen, ‘oxygen nittossmnine sulphur rach faTa" BIST, S0 Potatinaer and be seaging shows how Toeecfapi sovesieed FEgte TET 224 ts cousin ‘pcicat 280%0p8

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