MCQ immunodeficiency

1. Definition of Immunodeficiency disorders ?

-They are conditions that weaken the immune system, making it easier for the body to catch
viruses and bacterial infections .

2. There are two types of immunodeficiency disorders: primary are inherited, and
secondary are acquired .

3. Mention some semptoms of Immunodeficiency disorders ?

 Frequent
 prolonged infections
 Inflammation
 infection of internal organs
 Pneumonia
 sinus infections
 ear infections
 Diarrhea
 Colds
 pink eyes.

4. Which of the following is a complication caused by a primary immunodeficiency

disorder?
A) Hypertension
B) Osteoporosis
C) Recurrent infections
D) Diabetes mellitus

answer: C)

5. All of the following are example of primary immunodeficiency disorders except :

a) CVID
b) SCID
c) CGD
d) AIDS

answer: D)
 6. What is the primary characteristic of Common Variable Immunodeficiency (CVID)?
A) High levels of protective antibodies
B) Increased susceptibility to infections
C) Enhanced immune response
D) Normal functioning of the immune system

answer: B)

7. Which body systems are commonly affected by infections in individuals with Common
Variable Immunodeficiency (CVID)?
A) Cardiovascular and urinary
B) Musculoskeletal and endocrine
C) Respiratory, ears, and sinuses
D) Digestive and nervous

Correct answer: C)

8. When is Severe Combined Immunodeficiency (SCID) typically diagnosed?

A) During adolescence
B) In infancy
C) In early adulthood
D) During childhood

Correct answer: B)

9. What are common treatment options for Severe Combined Immunodeficiency (SCID)?
A) Antibiotics
B) Chemotherapy
C) Stem cell transplantation
D) Immunoglobulin infusions

Correct answer: C)

10.In Chronic Granulomatous Disease (CGD), what is the primary defect in the immune
system?
A) Impaired production of antibodies
B) Inability of white blood cells to kill bacteria and fungi
C) Overproduction of immune cells
D) Weakness in bone marrow

Correct answer: B)
 11.What are the masses of immune cells that form and cause damage to organs in Chronic
Granulomatous Disease (CGD) called?
A) Tumors
B) Abscesses
C) Granulomas
D) Cysts

Correct answer: C)

12- When is prophylactic antibiotic therapy typically used in the management of

immunodeficiency disorders?
A) To stimulate the immune system
B) To replace missing antibodies
C) To reduce the severity of allergies
D) To reduce the frequency and severity of infections

Correct answer: D)

13- Which therapy aims to replace the missing or dysfunctional antibodies in patients with
immunoglobulin deficiencies?
A) Antimicrobial therapy
B) Gene therapy
C) Immunoglobulin replacement therapy
D) Stem cell transplantation

Correct answer: C)

14- What is the primary objective of gene therapy in the treatment of severe
immunodeficiency disorders?
A) To stimulate the immune system
B) To prevent infections
C) To correct the underlying immune defect
D) To suppress the immune response

Correct answer: C)

15- Which type of transplantation involves modifying the patient's genes to correct the
underlying immune defect?
A) Bone marrow transplantation
B) Stem cell transplantation
C) Organ transplantation
D) Gene therapy
Correct answer: D)

16- What does stem cell transplantation aim to achieve?

A) To boost the production of antibodies
B) To replace dysfunctional genes
C) To reconstitute the immune system
D) To prevent allergic reactions

Correct answer: C)

17- what other prophylactic therapies may be necessary in the management of

immunodeficiency disorders?
A) Antihistamines
B) Antivirals and antifungals
C) Corticosteroids
D) Chemotherapy

Correct answer: B)

18- Compare between AIDS and HIV ?

AIDS HIV
Acquired immunedeficiency syndrome Human immune deficiency virus
Medical condition Virus which attacks to immune system
humans

19- How is HIV primarily transmitted through sexual activity?

A) Sharing contaminated needles
B) Unprotected sex with an infected partner
C) Receiving unsafe blood transfusions
D) Exposure to infected bodily fluids

Correct answer: B)

20- When does perinatal transmission of HIV occur?

A) During adolescence
B) During pregnancy, childbirth, or breastfeeding
C) Through sharing needles
D) Via blood transfusions

Correct answer: B)
21- Which mode of transmission involves sharing needles, syringes, or other injection
equipment?
A) Sexual transmission
B) Perinatal transmission
C) Blood transmission
D) Airborne transmission

Correct answer: C

22- What is a common risk factor associated with blood transmission of HIV?
A) Unsafe sexual practices
B) Sharing personal hygiene items
C) Unsafe blood transfusions or tissue transplantation
D) Inhalation of infected droplets

Correct answer: C)

23- Which activity is most likely to result in the transmission of HIV through blood?
A) Sharing drinking glasses
B) Using shared bathroom facilities
C) Sharing needles for drug injection
D) Sharing food utensils

Correct answer: C)

24- Mention symptoms of acute and chronic HIV ?

Acute HIV Chronic HIV
fever coughing
Night weats High fever
Chills Wight loss
Headches Diarhea
Sore throat Fatigue
Muscle and joint pain
Swollen lymph nodes on neck
Mouth ulcer
25- Mention symptoms of AIDS ?
- High fever above 100 F (37.8 C)
- Weight loss
- Sever fatigue
- Sweats
- Sever chills & night
- Memory problems
- Pneumonia
- Headache
- White spot in mouth
- Regular coughing

26- Tested of HIV : RNA test 10 days , antibodies antigen test 2-4 week , antibody screening
test 2-8 week .

27- Which type of HIV test looks for antibodies to HIV in a person's blood or oral fluid?
A) Nucleic Acid Tests (NATs)
B) Viral Load Tests
C) Antibody Tests
D) CD4 Cell Count Tests

Correct answer: C)

28- What is a notable feature of antibody tests for HIV?

A) They are only used in clinical settings
B) They are less accurate than other testing methods
C) They can detect HIV antigens
D) They are rapid and FDA-approved

Correct answer: D)

29- Which component of the blood or oral fluid do antibody tests for HIV primarily detect?
A) Viral RNA
B) CD4 cells
C) HIV antigens
D) Antibodies to HIV

Correct answer: D)
30-What do Nucleic Acid Tests (NATs) detect in HIV testing?
A) Antibodies to HIV
B) CD4 cell count
C) Viral load
D) HIV antigens

Correct answer: C)

31- When can Nucleic Acid Tests (NATs) typically detect HIV after exposure?
A) 1-2 days
B) 5-7 days
C) 10-33 days
D) 50-60 days

Correct answer: C)