Molecular Basis of Inheritance PYQs

Contact Number: 9667591930 / 8527521718

1. A gene encoding for polypeptide of 50 amino acids get 9. A nutritionally wild type organism which does not
mutated at 25 codon UAU becoming UAA. The result require additional biochemicals is
would be 1. Prototroph
1. Polypeptide of 24 amino acid 2. Auxotroph
2. Two polypeptides one with 24 amino acids and second 3. Phenotype
with 25 amino acids 4. Autotroph.
3. A polypeptide with 49 amino acid
4. A polypeptide of 25 amino acids 10. On which organism Beadle and Tatum worked to
propose one gene-one enzyme hypothesis
2. During transcription, RNA polymerase binds to DNA 1. Drosophila
site 2. Escherichia coli
1. Regulator 3. Neurospora crassa
2. Promoter 4. Nostoc
3. Enhancer
4. Receptor. 11. Protein synthesis in an animal cell occurs
1. On cytosolic ribosomes only
3. Degeneration of genetic code is due to 2. On ribosomes attached to E.R. and nuclear envelope
1. First member of codons 3. On ribosomes present in nucleolus as well as cytoplasm
2. Second member of codons 4. On ribosomes present both in cytoplasm as well as
3. Third member of codons mitochondria.
4. Entire codons.
12. During transcription, holoenzyme RNA polymerase
4. What does lac refer to in lac operon binds to DNA sequence and DNA assumes a saddle like
1. Lactase structure at that point. The sequence is called
2. 1,00,000 1. AAAT box
3. Lac insect 2. TATA box
4. Lactose 3. GGTT box
4. CAAT box.
5. In genetic code dictionary, codons used to code for all
the 20 essential amino acids are 13. Amino acid sequence in protein synthesis is
1. 20 determined by sequence of
2. 60 1. rRNA
3. 61 2. tRNA
4. 64 3. mRNA
4. cDNA.
6. In gene mutation, adenine is replaced by guanine. It is
1. Frame-shift mutation 14. Antiparallel strands of DNA molecules means
2. Transcription 1. One strand turns clockwise
3. Transition 2. One strand turns anticlockwise
4. Transversion 3. Phosphate groups of the two strands share the same
position their ends
7. In bacterial DNA replication, synthesis starting from 4. Phosphate groups at the start of the DNA strands are in
the site of origin of replication opposite position
1. Involves RNA primers
2. Requires telomerase 15. Okazaki fragments during DNA replication
3. Proceeds unidirectionally 1. Polymerise in 3’ → 5’ direction and form replication
4. Moves bidirectionally fork
2. Prove semiconservative DNA replication
8. DNA finger printing is related to 3. Polymerise in 5’ → 3’ direction and explain 3’ → 5’
1. Molecular analysis of profiles of DNA samples DNA replication
2. Analysis of DNA samples using imprinting devices 4. Cause transcription
3. Techniques used for molecular analysis of different
specimens of DNA
4. Techniques used in identification of finger prints of
different persons

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
16. A sequential expression of a set of human genes 23. The one aspect which is not a salient feature of genetic
occurs when a steroid molecule binds to code, is its being
1. mRNA 1. Ambiguous
2. DNA sequence 2. Universal
3. tRNA 3. Specific
4. Ribosome 4. Degenerate

17. The two polynucleotide chains of DNA are 24. Select the two correct statements out of the four (a-d)
1. Discontinuous given below about lac operon.
2. Antiparallel (a) Glucose or galactose may bind with the repressor and
3. Parallel inactivate it
4. Semiconservative (b) In the absence of lactose the repressor binds with the
operator region
18. In the DNA molecule (c) The z-gene codes for permease
1. The proportion of adenine in relation of thymine varies (d) This was elucidated by Francois Jacob and jacque
with the organism Monod
2. There are two strands which run antiparallel one in 5’ The correct statements are
→ 3’ direction and other in 3’ → 5’ 1. (a) and (c)
3. The total amount of purine nucleotides and pyrimidine 2. (b) and (d)
nucleotides is not run always equal 3. (a) and (b)
4. There are two strands which run paralled in the 5’ → 3’ 4. (b) and (c)
direction.
25. Satellite DNA is useful tool in
19. Which one of the following pairs of codons is 1. Sex determination
correctly matched with their function or the signal for the 2. Forensic science
particular amino acid ? 3. Genetic engineering
1. AUG, ACG – start/methionine 4. Organ transplantation
2. UUA, UCA – Leucine
3. GUU – Alanine 26. What are those structures that appear as beads - on -
4. UAG, UGA – stop string in the chromosomes when viewed under electron
microscope ?
20. What is not for genetic code 1. Genes
1. It is unambiguous 2. Nucleotides
2. A codon in mRNA is read in a non-contiguous fashion 3. Nucleosomes
3. It is nearly universal 4. Base pairs
4. It is degenerate
27. Removal of RNA polymerase III from nucleoplasm
21. Semiconservative replication of DNA was first will affect the synthesis of:
demonstrated in 1. t-RNA
1. Salmonella typhimurium 2. hn-RNA
2. Drosophila melangaster 3. m-RNA
3. Escherichia coli 4. r-RNA
4. Streptococcus pneumonia
28. Which one of the following is not a part of a
22. Removal of introns and joining of exons in a defined transcription unit in DNA?
order during transcription is called: 1. The inducer
1. Looping 2. A terminator
2. Inducing 3. A promoter
3. Slicing 4. The structural gene
4. Splicing

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
29. Given below is the diagrammatic representation of one 33. The diagram shows an important concept in the
of the categories of small molecular weight organic genetic implication of DNA. Fill in the blanks A to C.
compounds in the living tissues. Identify the category
shown and the one blank component "X" in it.

1. A - translation B - transcription C - Erevin Chargaff

2. A -transcription B - translation C - Francis Crick
3. A - translation B - extension C - Rosalind Franklin
4. A - transcription B - replication C - James Watson

Category Component 34. Transformation was discovered by :

1. Cholesterol Guanin 1. Meseson and stahl
2. Amino acid NH2 2. Hershey and chase
3. Nucleotide Adenine 3. Griffith
4. Nucleoside Uracil 4. Waston and crick

35. Select the correct option:

30. Which one of the following represents a palindromic

sequence in DNA?
1. 5' - GAATTC - 3'
3' - CTTAAG - 5' Direction of
Direction of
2. 5' - CCAATG - 3' reading of
RNA
3' - GAATCC - 5' the template
synthesis
3. 5' - CATTAG - 3' DNA strand
3' - GATAAC - 5'
4. 5' - GATACC - 3'
3' - CCTAAG - 5' 1. 5' - 3' 3' - 5'

31. What is it that forms the basis of DNA Fingerprinting?

2. 3' - 5' 5' - 3'
1. The relative proportions of purines and pyrimidines in
DNA
2. The relative difference in the DNA occurrence in blood,
3. 5' - 3' 5' - 3'
skin and saliva
3. The relative amount of DNA in the ridges and grooves
of the fingerprints. 4. 3' - 5' 3' - 5'
4. Satellite DNA occurring as highly repeated short DNA
segments

32. Read the following four statements (A-D): 36. Commonly used vectors for human genome
(A) In transcription, adenosine pairs with uracil. sequencing are:
(B) Regulation of lac operon by repressor is referred to as 1. T - DNA
positive regulation. 2. BAC and YAC
(C) The human genome has approximately 50,000 genes. 3. Expression Vectors
(D) Haemophilia is a sex-linked recessive disease. 4. T/A Cloning Vectors
How many of the above statements are right ?
1. Two
2. Three
3. Four
4. One

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
37. In sea urchin DNA, which is double stranded, 17% of 44. DNA- dependent RNA polymerase catalyzes
the bases were shown to be cytosine. The percentages of transcription on the strand of the DNA which is called the
the other three bases expected to be present in this DNA
are : 1. Antistrand
1. G 17%, A 16.5%, T32.5% 2. Template strand
2. G 17%, A 33%, T 33% 3. Coding strand
3. G8.5%, A50%, T24.5% 4. Alpha strand
4. G 34%, A 24.5%, T 24.5%
45. If there are 999 bases in RNA that codes for a protein
38. Satellite DNA is important because it : with 333 amino acids, and the base at position 901 is
1. shows high degree of polymorphism in population and deleted such that the length of the RNA becomes 998
also the same degree of polymorphism in an bases, how many codons will be altered?
individual, which is heritable form parents to children. 1. 1
2. does not code for proteins and is same in all members 2. 11
of the population 3. 33
3. codes for enzymes needed for DNA replication 4. 333
4. codes for proteins needed in cell cycle.
46. DNA fragments are:
39. Which of the following is required as inducer(s) for 1. Positively charged
the expression of Lac operon? 2. Negatively charged
1. lactose and galactose 3. Neutral
2. glucose 4. Either positively or negatively charged depending on
3. galactose their size
4. lactose
47. During DNA replication, Okazaki fragments are used
40. A complex of ribosomes attached to a single strand of to elongate
RNA is known as: 1. The leading strand towards replication fork.
1. Okazaki fragment 2. The lagging strand towards replication fork.
2. Polysome 3. The leading strand away from replication fork
3. Polymer 4. The lagging strand away from the replication fork
4. Polypeptide
48. Spliceosomes are not found in cells of
41. Which of the following is not required for any of the 1. Plants
techniques of DNA fingerprinting available at present? 2. Fungi
1. DNA -DNA hybridization 3. Animals
2. Polymerase chain reaction 4. Bacteria
3. Zinc finger analysis
4. Restriction enzymes 49. The final proof for DNA as the genetic material came
from the experiments of
42. Which one of the following is the start codon? 1. Griffith
1. UAG 2. Hershey and Chase
2. AUG 3. Avery, Macleod and McCarty
3. UGA 4. Hargobind Khorana
4. UAA

43. Taylor conducted the experiments to prove

semiconservative mode of chromosome replication on

1. E. coli
2. Vinca rosea
3. Vicia faba
4. Drosophila melanogaster

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
50. What will be the sequence of mRNA produced by the 53. Which scientist experimentally proved that DNA is the
following stretch of DNA? sole genetic material in bacteriophage ?

3' ATGCATGCATGCATG 5' TEMPLATE STRAND 1. Beadle and Tatum

5' TACGTACGTACGTAC 3' CODING STRAND 2. Messelson and Stahl

1. 3' AUGCAUGCAUGCAUG 5' 3. Hershey and Chase

2. 5' UACGUACGUACGUAC 3' 4. Jacob and Monod

3. 3' UACGUACGUACGUAC 5'

4. 5' AUGCAUGCAUGCAUG 3' 54. In the process of transcription in Eukaryotes, the RNA
polymerase I transcribes -

1. mRNA with additional processing, capping and tailing

2. tRNA, 5 S rRNA and snRNAs

51. Match the following RNA polymerases with their
transcribed products: 3. rRNAs - 28 S, 18 S and 5.8 S

Column-I Column-II 4. Precursor of mRNA, hnRNA

(a) RNA polymerase I (i) tRNA

55. What initiation and termination factors are involved in
transcription in prokaryotes ?
(b) RNA polymerase II (ii) rRNA
1. σ and ρ , respectively

(c) RNA polymerase III (iii) hnRNA 2. α and β , respectively

3. β and γ , respectively
Select the correct option from the following:
4. α and σ , respectively
1. (a)-(i), (b)-(iii), (c)-(ii)

2. (a)-(i), (b)-(ii), (c)-(iii)

3. (a)-(ii), (b)-(iii), (c)-(i)

4. (a)-(iii), (b)-(ii), (c)-(i)

52. From the following, identify the correct combination

of salient features of Genetic Code

1. Universal, Non-ambiguous,Overlapping

2. Degenerate, Overlapping, Commaless

3. Universal, Ambiguous, Degenerate

4. Degenerate, Non-overlapping, Non ambiguous

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
56. Match the following genes of Lac operon with their 59. Expressed Sequence Tags (ESTs) refers to:
respective products :
1. Novel DNA sequence
(a) i gene (i) β -galactosidase
2. Genes expressed as RNA

3. Polypeptide expression
(b) Z gene (ii) Permease
4. DNA polymorphism
(c) A gene (iii) Repressor

60. Which of the following features of genetic code does

(d) Y gene (iv) transacetylase
allow bacteria to produce human insulin by recombinant
DNA technology?
Select the correct option 1. Genetic code is specific
(a) (b) (c) (d) 2. Genetic code is not ambiguous

1. (iii) (iv) (i) (ii) 3. Genetic code is redundant

2. (i) (iii) (ii) (iv) 4. Genetic code is nearly universal
3. (iii) (i) (ii) (iv)

4. (iii) (i) (iv) (ii) 61. Choose the correct pair from the following :
Break the DNA
1. Polymerases -
into fragments
57. Under which of the following conditions will there be 2. Nucleases Separate the two
-
no change in the reading frame of the following mRNA? strands of DNA
Make cuts at
5'AACAGCGGUGCUAUU 3' specific
3. Exonucleases -
positions within
1. Deletion of GGU from 7th, 8th and 9th positions DNA
2. Insertion of G at 5th position Join the two
4. Ligases -
DNA molecules
3. Deletion of G from 5th position

4. Insertion of A and G at 4th and 5th positions

respectively

62. If the distance between two consecutive base pairs is

0.34 nm and the total number of base pairs of a DNA
58. Purines found both in DNA and RNA are: double helix in a typical mammalian cell is 6. 6 × 10 bp,
9

then the length of the DNA is approximate:

1. Cytosine and thymine
1. 2.5 meters
2. Adenine and thymine
2. 2.2 meters
3. Adenine and guanine
3. 2.7 meters
4. Guanine and cytosine
4. 2.0 meters

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
63. Which of the following statements is correct? 67. In the polynucleotide chain of DNA, a nitrogenous
base is linked to the –OH of:
1. Adenine pairs with thymine through one H-bond
(1) 2'C pentose sugar
2. Adenine pairs with thymine through three H-bonds
(2) 3'C pentose sugar
3. Adenine does not pair with thymine
(3) 5'C pentose sugar
4. Adenine pairs with thymine through two H-bonds
(4) 1'C pentose sugar

64. The first phase of translation is:

68. Which is the basis of genetic mapping of the human
1. Recognition of DNA molecule genome as well as DNA fingerprinting ?
2. Aminoacylation of tRNA (1) Polymorphism in the DNA sequence
3. Recognition of an anti-codon (2) Single nucleotide polymorphism

4. Binding of mRNA to ribosome (3) Polymorphism in hnRNA sequence

(4) Polymorphism in the RNA sequence

65. Name the enzyme that facilitates opening of DNA

helix during transcription.
69. The term 'Nuclein' for the genetic material was used
1. DNA helicase by :

2. DNA polymerase (1) Franklin

3. RNA polymerase (2) Mischer
4. DNA ligase (3) Chargaff

(4) Mendel

66. E.coli has only 4.6 × 10 base pairs and completes the
6

process of replication within 18 minutes; then the average

rate of polymerization is approximate-

(1) 2000 base pairs/second

(2) 3000 base pairs/second

(3) 4000 base pairs/second

(4) 1000 base pairs/second

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
70. Complete the flow chart on central dogma 73. Identify the correct statement.

1. The coding strand in a transcription unit is copied to an

(b) (c)
mRNA.
(a) → mRN A → (d)

2. Split gene arrangement is characteristic of prokaryotes.

1. (a) - Replication; (b) - Transcription;
3. In capping, methylguanosine triphosphate is added to
(c) - Translation; (d) - Protein the 3' end of hnRNA.

2. (a) - Transduction; (b) - Translation; 4. RNA polymerase binds with the Rho factor to terminate
the process of transcription in bacteria.
(c) - Replication; (d) - Protein

3. (a) - Replication; (b) - Transcription;

74. If Adenine makes 30% of the DNA molecule, what
(c) - Transduction; (d) - Protein will be the percentage of Thymine, Guanine and Cytosine
in it?
4. (a) - Transcription; (b) - Replication;
1. T:30 ; G:20 ; C:20
(c) - Transcription; (d) - Transduction
2. T:20 ; G:25 ; C:25

3. T:20 ; G:30 ; C:20

71. What is the role of RNA polymerase III in the process
of transcription in eukaryotes? 4. T:20 ; G:20 ; C:30

1. Transcribes precursor of mRNA

2. Transcribes only snRNAs 75. Which of the following RNAs is not required for the
synthesis of protein?
3. Transcribes rRNAs (28S, 18S and 5.8S)
1. rRNA
4. Transcribes tRNA, 5s rRNA and snRNA
2. siRNA

3. mRNA
72. DNA fingerprinting involves identifying differences in
some specific regions in DNA sequence, called as 4. tRNA

1. Single nucleotides

2. Polymorphic DNA 76. Which is the "Only enzyme" that has "Capability to
catalyze Initiation, Elongation, and Termination in the
3. Satellite DNA process of transcription in prokaryotes?

4. Repetitive DNA 1. DNA Ligase

2. DNase

3. DNA dependent DNA polymerase

4. DNA dependent RNA polymerase

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 Molecular Basis of Inheritance PYQs
Contact Number: 9667591930 / 8527521718
77. Which one of the following statements about Histones
is wrong?

1. Histones are rich in amino acids - Lysine and Arginine.

2. Histones carry a positive charge in the side chain.

3. Histones are organized to form a unit of 8 molecules.

4. The pH of histones is slightly acidic.

78. Statement I: The codon 'AUG codes for methionine

and phenylalanine.

Statement II: AAA' and 'AAG are both codons that code
for the amino acid lysine.

In the light of the above statements, choose the correct

answer from the options given below.

1. Statement I is correct but Statement II is false

2. Statement I is incorrect but Statement II is true

3. Both Statement I and Statement II are true

4. Both Statement I and Statement II are false

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