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Current Practice Guidelines in Primary Care 2020 Joseph S Esherick Full Chapter
Current Practice Guidelines in Primary Care 2020 Joseph S Esherick Full Chapter
CURRENT
Guidelines in
Primary Care
2020
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Contents
Contributors xv
Preface xix
SECTION 1 SCREENING
6. GenltourlnaryDlsorden 51
Bladder Cancer 51
Cervical Cancer 52
Endometrial Cancer 62
Ovarian Cancer 63
Pelvic Examinations 65
Prostate Cancer 66
Testicular Cancer 70
7. Infectious DlsHses 71
Gonorrhea and Chlamydia 71
Herpes Simplex Virus (HSV), Genital 72
Hwnan Immunodeficiency Vrrus (HIV) 73
Syphilis 74
Trichomonas 74
8. Pulmonary Disorders 77
Chronic Obstructive Pulmonary Disease 77
Lung Cancer 77
9. R•nal Disordars 81
Kidney Disease, Chronic (CKD) 81
1O. SpKlal Populatlon: Chlldren and Adolescents 83
Alcohol Abuse and Dependence 83
Attention-Deficit/Hyperactivity Disorder 84
Autism Spectrum Disorder 85
Celiac Disease 86
Cholesterol and Lipid Disorders 87
Depression 88
Diabetes 89
Family Violence and Abuse 89
Hwnan Immunodeficiency Vrrus {HIV) 90
Hypertension (HTN), Children and Adolescents 91
Illicit Drug Use 92
Lead Poisoning 93
Motor Vehicle Safety 94
Obesity 94
Scoliosis 95
Speech and Language Delay 95
Suicide Risk 96
Tobacco Use 97
Tuberculosis, Latent 97
Visual hnpairment 98
11. Sp•clal Population: Newborns and Infants 99
Anemia 99
Critical Congenital Heart Disease 100
Developmental Dysplasia of the Hip (DDH) 100
Growth Abnormalities 101
Hearing Impairment 101
CONTENTS
vii
Hemoglobinopathies 102
Newborn Screening 102
Phenylketonuria {PKU) 103
Thyroid Disease 104
12. Special Population: Older Adults 105
Dementia 105
Falls in the Elderly 106
Family Violence and Abuse 107
Osteoporosis 108
Visual Impairment, Glaucoma, or Cataract 109
13. Special Population: Pregnant Women 111
Anemia 111
Bacterial Vaginosis 112
Bacteriuria, Asymptomatic 112
Chlamydia and Gonorrhea 113
Diabetes Mellitus, Gestational (GDM) 113
Diabetes Mellitus {DM), Type 2 114
Fetal Aneuploidy 115
Group B Streptococcal (GBS) Disease 116
Hepatitis B Virus Infection 116
Hepatitis C Vrrus (HCV) Infection, Chronic 117
Herpes Simplex Virus (HSV), Genital 118
Human Immunodeficiency Virus (HIV) 118
Intimate Partner Violence 119
Preeclampsia 120
Lead Poisoning 120
Rh (D) Incompatibility 121
Syphilis 121
Thyroid Disease 122
Tobacco Use 123
SECTION 2 PREVENTION
SECTION 3 MANAGEMENT
25. Behavloral HHlth Disorders 239
Adult Psychiatric Patients in the Emergency Department 239
Alcohol Use Disorders 240
Anxiety 241
Attention-Deficit Hyperactivity Disorder (ADHD) 241
Autism Spectrum Disorders 243
Depression 244
Eating Disorders 245
Opioid Use Disorder 246
Pregnancy, Substance Abuse 248
Posttraumatic Stress Disorder (PTSD) 249
Tobacco Abuse, Smoking Cessation 249
26. Cardiovascular Disorders 253
Abdominal Aortic Aneurysm (AAA) 253
Anaphylaxis 256
Atrial Fibrillation 257
Bradycardia 270
Carotid Artery Disease 271
Coronary Artery Disease (CAD) 274
Heart Failure 283
Hyperlipidemia 287
Hypertension 288
Peripheral Arterial Disease 306
Preoperative Clearance 308
Valvular Heart Disease 308
CONTENTS
Hematuria 463
Indwelling Urinary Catheters or Intermittent Catheterization 465
Infertility, Male 465
Ovarian Cancer Follow-Up Care 466
Pap Smear, Abnormal 467
Polycystic Ovary Syndrome 468
Prostate Cancer: Active Surveillance (AS) for the Management
of Localized Disease 468
Prostate Cancer Follow-Up Care 470
Urinary Incontinence, Overactive Bladder 471
Urinary Incontinence, Stress 472
Urinary Tract Symptoms, Lower 476
Urolithiasis 476
33. H•m•tologlc Disorders 481
Anemia 481
Anemia, Chemotherapy Associated 481
Anemia, Hemolytic (HA) 483
Anemia, Iron Deficiency 485
Anemia of Chronic Disease 487
Cobalamin (B12) and Folate (B,) Deficiency 488
Sickle Cell Disease 490
hnmune Thrombocytopenia (ITP) 493
Heparin-Induced Thrombocytopenia (HIT) 498
Thrombotic Thrombocytopenia Purpura (TTP) 502
Transfusion Therapy, Red Blood Cell (RBC) Transfusion 505
Transfusion Therapy-Alternatives to Red Blood Cell Transfusion 507
Transfusion Therapy, Platelet Transfusion 508
Transfusion Therapy, Fresh Frozen Plasma (FFP) 510
Transfusion Therapy, Cryoprecipitate 511
Transfusion Therapy, Prothrombin Complex Concentrate (PCC) 512
Neutropenia Without Fever 512
Hemophilia A and B 514
Von Willebrand Disease 515
Thromboprophylaxis 517
Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) 519
Thrombophilias 530
Multiple Myeloma/Monoclonal Gammopathy of Undetermined Significance 532
34. lnr.ctlous Diseases 535
Asymptomatic Bacteriuria 535
Common Cold 535
Diabetic Foot Infections, Inpatient Management 536
Human Immunodeficiency Virus (HIV) 537
Human Immunodeficiency Virus (HIV), Antiretroviral Therapy (ART)
in Pediatrics 539
Human Immunodeficiency Virus, Antiretroviral Use in Adults 540
Identifying Risk of Serious Illness in Children Under 5 Y 541
Influenza 543
Neutropenia. Febrile (FN) 545
CONTENTS
xiii
Index 727
Contributors
Gabrielle Flamm, MD
Family Medicine Residency Program, Ventura County Medical Center,
Ventura, California
[Chapters 1, 13, 24, 25, 36]
Audrey Gray, MD
Faculty, Sea Mar Marysville Family Medicine Residency Program, Marysville,
Washington
[Chapters 1, 13, 24, 25, 36]
Neil Jorgensen, MD
Faculty, Ventura Family Medicine Residency, Ventura County Medical Center,
Ventura, California
[Chapters 2, 3, 5, 14, 15, 17]
Shadia Karim, MD
Family Medicine, Ravenswood Family Health Center, East Palo Alto, California
[Chapters 4, 7, 16, 19]
CONTRIBUTORS
Luyang Liu, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 2, 3, 5, 14, 15, 17)
Eric Monaco, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 30, 31]
Marina Morie, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 12, 23, 27, 29)
John Nuhn, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 8, 28, 37]
Carolyn Pearce, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 10, 11, 21, 22)
Magdalena Reinsvold, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 6, 9, 18, 20, 32, 38)
CONTRIBUTORS
xvii
James Rohlfing, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 33, 34)
Kristi M. Schoeld, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 4, 7, 16, 19)
Tanya Shah, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 26, 35)
Ian Wallace, MD
Family Medicine Residency Program, Ventura County Medical Center, Ventura,
California
[Chapters 30, 31)
Current Practice Guidelines in Primary Care 2020 is intended for all clinicians
interested in updated, evidence-based guidelines for primary care topics in both
the ambulatory and hospital settings. This handy reference consolidates informa-
tion from nationally recognized medical associations and government agencies into
concise recommendations and guidelines of virtually all ambulatory care topics.
This book is organized into topics related to disease screening, disease prevention,
and disease management, and further subdivided into organ systems, for quick ref-
erence to the evaluation and treatment of the most common primary care disorders.
The 2020 edition of Current Practice Guidelines in Primary Care contains
updates reflecting more than 150 new guidelines, and nearly 30 new sections on
topics including transgender health, opiate use disorder, systemic lupus erythema-
tosus, rotator cuff injury, and abortion. It is a great resource for residents, medical
students, midlevel providers, and practicing physicians in family medicine, internal
medicine, pediatrics, and obstetrics and gynecology.
Although painstaking efforts have been made to find all errors and omissions,
some errors may remain. If you find an error or wish to make a suggestion, please
e-mail us at EditorialServices@mheducation.com.
Population
-Adults older than 18 y of age.
Recommendations
~ CDC 2018, USPSTF 2018, ASAM 1997
-Screen all adults in primary care settings, including pregnant women,
for alcohol misuse.
-If positive screen for risky or hazardous drinking, provide brief
behavioral counseling interventions to reduce alcohol misuse.
Sources
-CDC. Alcohol Screening and Brief Intervention for People Who Consume
Alcohol and Use Opioids. 2018.
-USPSTF. JAMA. 2018;320(18):1899-1909.
-ASAM. Public Policy Statement on Screening/or Addiction in Primary
Care Settings. 1997.
Comments
1. Screen regularly using a validated tool such as the AUDIT, CAGE, or
MAST questionnaires.
2. The TWEAK and the T-ACE are designed to screen pregnant women
for alcohol misuse.
Population
-Children and adolescents.
SECTION 1: SCREENING
Recommendation
~ USPSTF 2018
- Insufficient evidence to recommend for or against screening or
counseling interventions to prevent or reduce alcohol misuse by
adolescents.
Source
-USPSTF. JAMA. 2018;320(18):1899-1909.
Comments
1. Screen using a tool designed for adolescents, such as the CRAFFT,
BSTAD, or S2BI.
2. Reinforce not drinking and driving or riding with any driver under the
influence.
3. While behavioral counseling has been proven to be beneficial in
adults, data do not support its benefit in adolescents.
DEPRESSION
Population
-Children aged 11 y and younger.
Recommendation
~ USPSTF 2016
-Insufficient evidence to recommend for or against routine screening.
Source
-USPSTF. Depression in Children and Adolescents: Screening. 2016.
Population
-Adolescents.
Recommendation
~ USPSTF 2016
-Screen all adolescents age 12-18 y for major depressive disorder
(MDD). Systems should be in place to ensure accurate diagnosis,
effective treatment, and adequate follow-up.
Source
-USPSTF. Depression in Children and Adolescents: Screening. 2016.
Comments
1. Screen in primary care clinics with the Patient Health Questionnaire
for Adolescents (PHQ-A) (73% sensitivity; 94% specificity) or the
Beck Depression Inventory-Primary Care (BDI-PC) (91 % sensitivity;
91 % specificity). See Chapter 39.
BEHAVIORAL HEALTH DISORDERS
Population
-Adults, adolescents, and pregnant women.
Recommendation
~ USPSTF 2008
- Insufficient evidence to recommend for or against routine screening for
illicit drug use.
Source
- USPSTF. Drug Use, Illicit: Screening. 2008.
SECTION 1: SCREENING
TOBACCO USE
Population
- Adults including pregnant women.
Recommendation
AAFP 2015, USPSTF 2015
- Recommend screening all adults for tobacco use and provide tobacco
cessation interventions for those who use tobacco products.
Source
-USPSTF. Tobacco Smoking Cessation in Adults, Including Pregnant
Women: Behavioral and Pharmacotherapy Interventions. 2015.
Comment
1. Provide some type of SBIRT (Screening, Brief Intervention, and
Referral to Treatment) such as:
a. The "5-K framework is helpful for smoking cessation counseling:
i Ask about tobacco use.
ii. Advise to quit through clear, individualized messages.
iii. Assess willingness to quit.
iv. Assist in quitting.
v. Arrange follow-up and support sessions.
Population
-School-aged children and adolescents.
Recommendation
USPSTF 2013
- Recommends that primary care clinicians provide interventions
including education or brief counseling to prevent the initiation of
tobacco use.
Comment
1. The efficacy of counseling to prevent tobacco use in children and
adolescents is uncertain.
Source
- USPSTF. Tobacco Use in Children and Adolescents: Primary Care
Interventions. 2013.
Cardiovascular
Disorders
Population
-Men age ~65y.
Recommendations
~ USPSTF 2014, ACC/AHA 2006, Canadian Society for Vascular
Surgery 2006, Society for Vascular Surgery 2018
-Screen once before age 75, with ultrasound, if they have ever smoked.
~ Canadian Society for Vascular Surgery 2018
-Screen once between age 65 and 80 y with ultrasound, regardless of
smoking history.
~ ESVS 2011
-Screen once with ultrasound at age 65 y if have smoked > 100 cigarettes
lifetime or have a family history of AAA.
~ ESVS2014
-Screen with ultrasound all men >65 y of age.
~ ACRa/AIUM/SRU 2014
-Screen with ultrasound all men ~65 y (or ;::: 50 y with family history of
aneurysmal disease) and women 2:65 y with cardiovascular risk factors.
- Patients 2: 50 y with a family history of aortic and/or peripheral
vascular aneurysmal disease.
- Patients with a personal history of peripheral vascular aneurysmal
disease.
-Groups with additional risk include patients with a history of smoking,
hypertension, or certain connective tissue diseases ( eg, Marfan
syndrome).
SECTION 1: SCREENING
ATRIAL FIBRILLATION
Population
-Asymptomatic adults over age 65.
Recommendation
.... USPSTF 2018
- Insufficient evidence to recommend routine ECG screening for atrial
fibrillation to impact risk of stroke from untreated atrial fibrillation.
Source
-JAMA. 2018;320(5):478-484.
CARDIOVASCULAR DISORDERS
Population
-Asymptomatic adults.
Recommendations
~ ASN 2007, USPSTF 2014, AHNASA 2011, ACCF/ACR/AIUM/
ASE/ASN/ICAVUSCAl/SCCT/SIR/SVM/SVS 2011, AAFP 2013
- Do not screen the general population or a selected population based on
age, gender, or any other variable alone.
-Do not screen asymptomatic adults.
Sources
-l Neuroimaging. 2007;17:19-47.
-USPSTF. Carotid Artery Stenosis: Screening. 2014.
-l Am Coll Cardiol. 2012;60(3):242-276.
-Choosing Wisely: American Academy of Family Physicians. 2013.
-Stroke. 2011;42(2):e26.
Recommendation
~ ACR-AIUM-SRU 2016, ACC/AHNASNACR/SVS 2011
-Indications for carotid ultrasound: evaluation of patients with a cervical
bruit, not routine screening.
Sources
-Stroke. 2011;42(8):e464-e540.
-ACR-AIUM-SPR-SRU Practice Parameter for the Performance ofan
Ultrasound Examination of the Extracranial Cerebrovascular System.
2016. http://www.acr.org/-/media/ACR/Documents/PGTS/guidelines/
US_Extracranial_Cerebro.pdf
Recommendation
~ Society of Thoracic Surgeons 2013
-Do not routinely evaluate for carotid artery disease prior to cardiac
surgery in the absence of symptoms or other high-risk criteria.
Source
-Choosing Wisely: Society of Thoracic Surgeons. 2013.
Comments
1. The prevalence of internal CAS of ;:::70% varies from 0.5% to 8%
based on population-based cohort utilizing carotid duplex ultrasound.
For population age >65 y, estimated prevalence is 1%. No risk
stratification tool further distinguishes the importance of CAS. No
evidence suggests that screening for asymptomatic CAS reduces fatal
or nonfatal strokes.
SECTION 1: SCREENING
Population
-Asymptomatic adults 40-79 y.
Recommendations
..... ACC/AHA2013
-Perform 10-y ASCVD Risk Score.
-High-risk categories include:
•Primary elevation of LDL-C ~190 mg/dL.
•Diabetes (type 1or2) with LDL-C 70-189 mg/dL and without
clinical ASCVD.
• Without clinical ASCVD or diabetes with LDL-C 70-189 mg/dL
and estimated 10-y ASCVD Risk Score ~7.5%.
..... ESC2016
-Perform SCORE risk assessment tool available at: www.heartscore.org
-Secondary hyperlipidemia should be ruled out.
-Total cholesterol and LDL-C primary target: goal LDL :570 mg/dL in
patients with very high CV risk, LDL :5100 mgldL in patients with high
CV risk.
-Secondary targets are non-HDL-C and ApoB.
-HDL is not recommended as a target for treatment.
...,. Canadian Cardiovascular Society 2016
-Screen all men/women over age 40, or those of any age at high risk
(clinical evidence of atherosclerosis, AAA, DM, HTN, cigarette
smoking, stigmata of dyslipidemia, family history of early CVD or
dyslipidemia, CKD, BMI >30, inflammatory bowel disease, HIV,
erectile dysfunction, COPD, hypertensive diseases of pregnancy).
-Nonfasting lipid tests are acceptable.
-Repeat a risk assessment using Framingham or Cardiovascular Life
Expectancy Model every 5 y or as clinical circumstances dictate.
Sources
-Circulation. 2013;2013;01.cir.0000437738.63853.7a.
CARDIOVASCULAR DISORDERS
CHOLESTEROL GUIDELINES
Recommended
LIpoprotein Recommended
Measurements Upoprotein Recommended
for Risk Targets of Risk Assessment
Source Assessment Therapy Algorithm
National Cholesterol Fasting lipid panel Primary Identify number of
Education Program Calculation of non- target: LDL-C CH Drisk factors
AdultTreatment HDL-C when TG Secondary target: Framingham 10-y
Panel Ill >200mg/dl non-HDL-C absolute CHD risk
International Fasting lipid panel Non-HDL-C Lifetime risk of total
Atherosclerosis with calculation LDL-C is considered ASCVD morbidity/
Society of non-HDL-C alternative target mortality (by
of therapy Framingham, CV
Lifetime Risk pooling
project, or QRisk)
European Society of Fasting lipid Primary 10-y risk of total
Cardiology/European panel with target: LDL-C fatal ASCVD by the
Atherosclerosis calculation of Secondary targets: Systematic Coronary
Society non-HDL-C and non-HDL or ApoB Risk Evaluation
TC/HDL-C ratio in patients with (SCORE) system
ApoB or ApoB/ cardiometabolic
apoAl ratio risk
are considered
alternative risk
markers
Canadian European Society Primary 10-y risk of total
Cardiovascular of Cardiology/ target: LDL-C ASCVD events by
Society European Secondary targets: the Framingham
Atherosclerosis non-HDL-C Risk Score
Society andApoB
American Association Fasting lipid panel Primary Men: Framingham Risk
of Clinical Calculation of targets: LDL-C Score (10-y risk of
Endocrinologists non-HDL-C Secondary targets: coronary event)
isa more non-HDL-Cin Women: Reynolds
accurate risk patients with Risk Score (10-y risk
assessment ifTG ea rdiometa bol ic of coronary event,
is between 200 risk or established stroke, or other
and 500 mg/dl, CADApoB major heart disease)
diabetes, insulin recommended to
resistance, or assess success of
established CAD LDL-C-lowering
therapy
CARDIOVASCULAR DISORDERS
Population
-Adults at low risk of CHD events.•
Recommendations
~ AAFP 2012, USPSTF 2018, American College of Physicians
2012, American Society of Echocardiography 2013,
American College of Cardiology 2013
-Do not routinely screen men and women at low risk for CHD riskb with
resting electrocardiogram (ECG), exercise treadmill test (ETT), stress
echocardiogram, or electron-beam CT for coronary calcium.
-Do not screen with stress cardiac imaging or advanced non-invasive
imaging in the initial evaluation of patients without cardiac symptoms,
unless high-risk markers are present.
-Do not perform annual stress cardiac imaging or advanced
non-invasive imaging as part of routine follow-up in asymptomatic
patients.
Sources
-AAFP Clinical Recommendation: Coronary Heart Disease. 2012.
-Choosing Wisely: American College of Physicians. 2012. http://www.
choosingwisely.org/societies/american-college-of-physicians/
-Choosing Wisely: American Academy of Family Physicians. 2013.
http:/ /www.choosingwisely.org/societies/american-academy-of-family-
physicians/
-Choosing Wisely. American Society of Echocardiography. 2012. http://
www.choosingwisely.org/societies/american-society-of-
echocardiography/
-Choosing Wisely: American College of Cardiology. 2014. http://www.
choosingwisely.org/societies/american-college-of-cardiology/
-Ann Intern Med. 2012;157:512-518.
-JAMA. 2018;319(22):2308-2314.
•Increased risk for CHD events: older age, male gender, high BP, smoking, elevated lipid levels,
diabetes, obesity, sedentary lifestyle. Risk assessment tool for estimating 10-y risk of developing
CHD events available online, http://cvdrisk.nhlbi.nih.gov/calculator.asp, or see Appendices VI
and VIL
•AHA scientific statement (2006): Asymptomatic persons should be assessed for CHD risk.
Individuals found to be at low risk (<103 10-y risk) or at high risk (>20% 10-yrisk) do not benefit
from coronary calcium assessment. High-risk individuals are already candidates for intensive
risk-reducing therapies. In clinically selected, intermediate-risk patients, it may be reasonable to use
electron-beam CT or multidetector computed tomography (MDCT) to refine clinical risk prediction
and select patients for more aggressive target values for lipid-lowering therapies (Circulation.
2006;114:1761-1791).
SECTION 1: SCREENING
Comment
1. USPSTF recommends against screening asymptomatic individuals
because of the high false-positive results, the low mortality with
asymptomatic disease, and the iatrogenic diagnostic and treatment
risks.
Population
-All asymptomatic adults age ~20 y.
-Risk score assessment.
Recommendations
ACC/AHA 2013, ESC 2012
-ASCVD Risk Score has replaced the FRS in the United States for
patients age 40-79 y.
- Assess 10-y ASCVD Risk Score every 4-6 y.
- Framingham Risk Score (FRS), including blood pressure (BP) and
cholesterol level, should be obtained in asymptomatic adults age ~20 y.
- The SCORE Risk Score remains the screening choice in Europe.
- No benefit in genetic testing, advanced lipid testing, natriuretic peptide
testing, high-sensitivity C-reactive protein (CRP), ankle-brachia!
index, carotid intima-medial thickness, coronary artery score on
electron-beam CT, homocysteine level, lipoprotein (a) level, CT
angiogram, MRI, or stress echocardiography regardless of CHD risk.
Sources
-Circulation. 2007;115:402-426.
- l Am Coll Cardiol. 2010;56(25):2182-2199.
Population
-Adults at intermediate risk of CHD events.
Recommendations
ACC/AHA 2013, ESC 2012
- May be reasonable to consider use of coronary artery calcium
and high-sensitivity CRP (hs-CRP) measurements in patients at
intermediate risk.
- hs-CRP is not recommended in low- or high-risk individuals.
Sources
- Bur Heart f. 2007;28(19):2375-2414.
- Bur Heartf. 2012;33:1635-1701.
-l Am Coll Cardiol. 2007;49:378-402.
- Circulation. 2013;2014;129(25 Suppl 2):S49-S73.
CARDIOVASCULAR DISORDERS
Comment
1. 10-y ASCVD risk calculator (The Pooled Cohort Equation) can be
found at: http://tools.acc.org/ASCVD-Risk-Estimator/
Population
-Adults at high risk of CHD events.
Recommendations
~ AAFP 2012, AHA 2007, USPSTF 2012
- Insufficient evidence to recommend for or against routine screening
with ECG, ETT.
-In addition, there is insufficient evidence to recommend routine MRI.
Sources
-Arch Intern Med. 2011;171(11):977-982.
-AAFP Clinical Recommendations: Coronary Heart Disease. 2012.
-Ann Intern Med. 2012;157:512-518.
Population
-Men and women with no history of CHD.
Recommendation
~ USPSTF 2009
-Insufficient evidence to assess the balance of benefits and harms of
using the nontraditional risk factors to prevent CHD events (hs-CRP,
ankle-brachia! index [ABI], leukocyte count, fasting blood glucose
level, periodontal disease, carotid intima-media thickness, coronary
artery calcification [CAC] score on electron-beam computed
tomography, homocysteine level, and lipoprotein [a] level).
Source
- USPSTF. Coronary Heart Disease: Screening Using Non-Traditional Risk
Factors. 2009.
Comment
1. 10-y ASCVD risk calculator (The Pooled Cohort Equation) can be
found at: http://tools.acc.org/ASCVD-Risk-Estimator/
Population
-Women.
Recommendations
~ ACCF/AHA 2011
-Cardiac risk stratification by the Framingham Risk Score should be
used. High risk in women should be considered when the risk is ~10%
rather than ;:::20%.
SECTION 1: SCREENING
-An alternative 10-y risk score to consider is the Reynolds Risk Score,
although it requires measurement of hs-CRP.
Source
-! Am Coll Cardiol. 2011;57(12):1404-1423.
Population
-Adults with stable CAD.
Recommendation
~ CCS2013
-Risk assessment by Framingham Risk Score should be completed
every 3-5 y for men age 40-75 y and women age 50-75 y. Frequency
of measurement should increase if history of premature cardiovascular
disease (CVD) is present. Calculate and discuss a patient's
"cardiovascular age" to improve the likelihood that the patient will
reach lipid targets and that poorly controlled hypertension will be
treated.
Source
-Can f Cardiol. 2013;29:151-167.
Recommendation
~ AAFP 2009, AHA/APA 2008
-All patients with acute myocardial infarction {MI) to be screened for
depression at regular intervals during and post hospitalization.
Sources
-Circulation. 2008;118:1768-1775.
-Ann Fam Med. 2009;7{1):71-79.
Population
-Adults age >18 y.
Recommendations
~ USPSTF 2015, AAFP 2009, CHEP 2015, ESH/ESC 2013,
Canadian Task Force on Preventive Health Care 2013
-Screen for HTN.
-HTN is > 140/90 mm Hg on two or more BP readings.
-All adults should have their BP assessed at all appropriate clinical visits.
-Ambulatory BP monitoring {ABPM) is the standard to confirm
diagnosis.
CARDIOVASCULAR DISORDERS
Recommendation
JNC 8 2014
- Treatment thresholds:
• Age ~ 60: 150/90.
•Age < 60: 140/90.
• DM or CKD: 140/90.
Source
- JAMA. 2014;311 (5):507-520.
Comment
1. "Hypertension" and "pre-hypertension" are no longer defined.
Population
-Age > 65y.
Recommendation
ACCF/AHA 2011
-Identification and treatment of systolic and diastolic HTN in the very
elderly are beneficial in the reduction of all-cause mortality and stroke
death.
Source
-J Am Coll Cardiol. 2011;57(20):2037-2110.
Comments
1. Increased frequency of systolic HTN compared with younger
patients.
2. HTN is more likely associated with end-organ damage and more
often associated with other risk factors.
Population
-Asymptomatic adults.
Recommendation
USPSTF 2018
- Insufficient evidence to recommend for or against routine screening
with Ankle-Brachia! Index.
Source
-JAMA. 2018;320(2):177-183.
CARDIOVASCULAR DISORDERS
SLEEPAPNEA
Population
-Asymptomatic adults.
Recommendation
~ USPSTF 2017, AAFP 2017
- Insufficient evidence to recommend for or against routine screening.
Sources
-AAFP. Obstructive Sleep Apnea in Adults: Screening. 2017.
-JAMA. 2017;317(4):407-414.
TOBACCO USE
Population
-Adults.
Recommendation
~ AAFP 2015, USPSTF 2015, ICSI 2014
-Recommend screening all adults for tobacco use and provide tobacco
cessation interventions for those who use tobacco products.
Sources
-AAFP Clinical Preventive Service Recommendation: Tobacco Use. 2015.
-USPSTF. Tobacco Smoking Cessation in Adults, Including Pregnant
Women: Behavioral and Pharmacotherapy Interventions. 2015.
-ICSI. Preventive Services for Adults. 20th ed. 2014.
Comment
I. The "5-K framework is helpful for smoking cessation counseling:
a. Ask about tobacco use.
b. Advise to quit through clear, individualized messages.
c. Assess willingness to quit.
d. Assist in quitting.
e. Arrange follow-up and support sessions.
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Disorders of the
Skin, Breast, and
Musculoskeletal
System
BREAST CANCER
Population
-Women.
Recommendations
~ USPSTF 2016
-Age 40-49 y: Individualize assessment of breast cancer risk;
incorporate woman's preference and cancer risk profile to determine
whether to screen.
-Age ~50-75 y: Mammography every 2 y, with or without clinical breast
exam.
-Age >75 y: Inconclusive data for screening.
~ ACS2016
-Age 20-40 y: Advise women to report lumps or breast symptoms.
-Age 40-44 y: Allow women to begin annual screening if desired.
-Age 45-54 y: Mammography every year.
-Age ~55 y: Mammography every 1-2 y as long as overall health is good
and life expectancy is ~ 10 y.
-Do not use clinical breast examination for screening.
~ NCCN2018
-Age 25-40 y: Teach breast awareness.
-Age 40-80 y: Mammography and clinical encounter annually.
-Age >80 y: Do not screen.
Sources
-http://www.cancer.org
-Ann Intern Med. 2012;156:609.
-Ann Intern Med. 2014;160:864.
Another random document with
no related content on Scribd:
“Goblin?” I asked quickly; for, you see, he looked so old and ugly that
I thought he must be one of the underground faeries.
“I’m not a goblin,” he replied in an angry, shrill voice, like the wind
whistling through a keyhole. “It is very rude of you to call me a goblin
—a nasty thing who lives under the earth, and only cares for gold
and silver. I’m a faery—a very celebrated faery indeed.”
“But you wear a beard,” I said doubtfully; “faeries don’t wear beards.”
“Not all faeries,” he answered, with dignity, jumping down from his
swaying flower stem; “but I do, because I am the librarian of King
Oberon.”
“Dear me! I did not know he had a library. Do let me see it!”
“You see it now,” said the librarian, waving his hand; “look at all the
books.”
I looked round, but saw nothing except a circle of trees, whose great
boughs, meeting overhead, made a kind of leafy roof, through which
could be seen the faint, rosy flush of the sunset sky. The ground, as I
said before, was covered with daisy-sprinkled turf, and there was a
still pool of shining water in the centre, upon the bosom of which
floated large white lilies.
“I must say I don’t see anything except leaves,” I said, after a pause.
“Well—those are the books.”
“Oh, are they! Well, I know books have leaves, but I didn’t know
leaves were books.”
The faery looked puzzled.
“You must have some faery blood in you,” he said at length, “or you
would never have found your way into this forest; but you don’t seem
to have enough of the elfin nature to see all the wonders of
Faeryland.”
“Oh, do let me see the wonders of Faeryland!” I asked eagerly; “now
that I am here, I want to see everything.”
“No doubt you do,” retorted the faery, with a provoking smile; “but I
don’t know if the King will let you—however, I’ll ask him when he
wakes.”
“Is he asleep?” I said in astonishment; “why, it’s day-time.”
“It’s day-time with you, not with us,” answered the librarian; “the night
is the day of the faeries—and see, there’s the sun rising.”
Looking up through the fretwork of boughs and leaves, I saw the
great silver shield of the moon trembling in the dark blue sky, from
whence all the sunset colours had died away.
“But that’s the moon,” I cried, laughing.
“The moon is our sun, stupid,” he said tartly. “I think the King will be
awake now, so I’ll ask him if you can see the books.”
He vanished,—I don’t know how; for, though I did not take my eyes
off him, he seemed to fade away, and in his place I saw the green
leaves and slender stem of a flower, with the Canterbury bell
nodding on the top.
The only thing I could do was to wait, so I sat down again on the
fallen tree, and amused myself with looking round to see what kind
of creatures lived in Faeryland.
The night was very still,—no sound of cricket or bird, not even the
whisper of the wind, or the splash of water,—all was silent, and the
moon, looking down through the leaves, flooded the glade with a
cold, pale light, turning the still waters of the pool to a silver mirror,
upon which slept the great white lilies.
Suddenly, a bat, whirring through the glade, disappeared in the soft
dusk of the trees, then I heard the distant “Tu whit, tu whoo” of an
owl, which seemed to break the spell of the night, and awaken the
sleeping faeries; for all at once, on every side, I heard a confused
murmur, the glow-worms lighted their glimmering lamps on the soft
mossy banks, and brilliant fireflies flashed like sparkling stars
through the perfumed air.
Then a nightingale began to sing; I could not see the bird, but only
heard the lovely music gushing from amid the dim gloom of the
leaves, filling the whole forest with exquisite strains. I understood the
nightingale’s song just as well as I did that of the cricket, but what it
sang was much more beautiful.
Asleep!—asleep,
In slumber deep,
Are maid and boy;
And grief and joy,
And pleasures—pains
Are bound—fast bound in slumber’s chains.
Ah, slumbers keep
The maid who sighs,
The boy who cries,
The bee that flies,
In charmèd sleep.
’Tis I!
Who in the darkness cry;
The nightingale who sings, who sings on high.
I call the elves
To show themselves;
They creep from tree, from grass, from flower;
In forest-bower
At midnight hour,
They dance—they dance,
All night so bright—so light;
While I the woods with song entrance.
Singing—Singing,
My voice is ringing
Thro’ the still leaves,
Till all the dark night heaves
With pain—with pain
Again—oh, sing again;
Bring joy—bring tears,
Till o’er the lawn
The red, red dawn
Appears—appears—appears.
Poor Gillydrop was now in a dreadful plight, and, folding his weary
wings, he dropped to the ground, where he sat in the hollow of a
buttercup, which was like a large golden basin, and wept bitterly. He
could never return to Faeryland until he had done some kindly deed,
but, as there was no one to whom he could do a good deed, he did
not see how he could perform any, so cried dreadfully at the thought
of living for evermore in the desolate Giants’ Country. So you see
what his disobedience had brought him to, for, instead of dancing
merrily with his friends in the Forest of Faeryland, he was seated, a
poor, lonely little elf, in a dreary, dreary land, with no one to comfort
him.
While he was thus weeping, he heard a sound like distant thunder;
but, as there were no clouds in the sky, he knew it could not be
thunder.
“It must be a giant roaring,” said Gillydrop, drying his eyes with a
cobweb. “I’ll go and ask him where all his friends have gone.”
So he flew away in the direction from whence came the sound, and
speedily arrived at a great grey castle, with many towers and
battlements, perched on the top of a very high hill. At its foot rolled
the Sea of Darkness, and round the tall towers the white mists were
wreathed like floating clouds. There was a wide road winding up the
steep sides of the rock to the castle door, which was as high as a
church; but Gillydrop, having wings, did not use the road, so flew
right into the castle through an open window.
The giant, whose name was Dunderhead, sat at one end of a large
hall, cutting slices of bread from an enormous loaf which lay on the
table in front of him. He looked thin,—very, very thin,—as though he
had not had a good dinner for a long time; and he thumped the table
with the handle of his knife as he sang this song, taking a large bit of
bread between every verse:
As the sun grew stronger, the beam shot farther and farther across
the Sea of Darkness, until it quite bridged it over, and you may be
sure Gillydrop ran as hard as ever he could, so as to reach earth
quickly. It was lucky he did make haste, for, just as he alighted on a
green lawn near a village, the sun hid himself behind a cloud, and of
course the beam vanished.
Having thus arrived, Gillydrop began to look about for two naughty
children to take to the Giants’ Country for Dunderhead’s supper. He
was very tired, both with his journey across the Sea of Darkness,
and with being up all day, which was just the same to him as staying
up all night would be to us. As he was anxious to get back to
Faeryland, there was no time to be lost, so, instead of going to sleep,
he searched all through the village for two naughty children.
Now, in one of the pretty cottages there lived a poor widow, who had
two children called Teddy and Tilly, of whom she was very fond, as
they were all she had in the world to love. I am sorry to say, however,
that Teddy and Tilly were not worthy of their mother’s love, for they
were very naughty indeed, and never so happy as when engaged in
some mischief. Dame Alice, for that was the name of the poor
widow, tried very hard to improve them, but it was really a waste of
time, for the harder she tried the worse they became. They tore their
nice clean clothes, worried the cat, destroyed the flowers, ate up
everything they could lay their hands on, and altogether were a great
trouble to their poor mother, who often wondered why her children
were so much worse than any one else’s. Dame Alice, however, had
still some hope that they would improve, for, having a few friends
among the faeries, she had learned that some day both Teddy and
Tilly would receive a severe lesson, which would make them the best
and most obedient children in the world.
There was a wood, not far from the village, which was said to be
enchanted, and Teddy and Tilly were told never to enter it, but this
command only made them the more anxious to disobey, and they
constantly wandered about the wood, never thinking of the faeries,
nor of anything else, except their own pleasure. On the day Gillydrop
arrived, they had been in the wood all day, gathering nuts and
chasing the squirrels. Now, as it was sundown, they were coming
home to their supper, quarrelling dreadfully all the way, which was
very naughty of them after spending a pleasant day.
Gillydrop heard them calling each other names, so he peeped out
from behind the leaf of a tree, where he was hidden, and, seeing
their cross faces, he immediately guessed that they were two
children who would do capitally for Dunderhead’s supper, so at once
made up his mind how to act.
It was now night, and, as the faeries say, night is caused by the
overflowing of the Sea of Darkness, which rises and rises when the
sun goes down, until it rolls all over the earth, and any one abroad
during the night is in danger of being lost in its black waves. At dawn,
however, the sea subsides, and vanishes altogether when the sun
appears; but when he sets in the west, it rises once more and
spreads over the earth.
Gillydrop had brought with him a withered leaf from the Giants’
Country, which, being enchanted, would expand into a boat, and sail
across the Sea of Darkness to the Giants’ Country, for, having come
from there, it was bound to return to the tree upon which it had
grown.
The Red Elf took this leaf out of his pocket, and immediately it
spread out into a great brown carpet, which he placed under a tree in
the darkest part, and then went away to entice the children on to it.
Teddy and Tilly came through the wood, quarrelling in a noisy
manner, and calling each other ugly names; not a bit afraid of the
dark, although they certainly ought to have been.
“You’re eating all the nuts,” bellowed Teddy.
“Well, I gathered them,” shrieked Tilly.
“No, you didn’t; I got most,” whimpered her brother crossly.
“Oh, you story! You didn’t,” retorted Tilly.
And then they called each other more ugly names, and fought and
scratched until the whole wood resounded with their noise, and the
birds trembled in their nests with fear.
Suddenly, in front of them, they saw a small red ball, glowing like a
scarlet coal, and it kept dancing up and down like a restless will-o’-
the-wisp.
“Oh, Teddy,” cried Tilly, “look at that pretty ball!”
“It’s mine!” roared greedy Teddy, rushing forward. “I’ll have it.”
“You shan’t!” cried Tilly, running after him. “I’ll get it.”
But the red ball—which was none other than Gillydrop—rolled and
rolled in front of the children through the dark wood, and led them
deeper and deeper into the forest, until it bounded right on to a
brown carpet lying under a great tree, where it lay glowing like a red-
hot coal. Teddy and Tilly jumped on to the brown carpet with a
scream of delight, thinking they would now seize the ball, when
suddenly the sides of the brown leaf curled up, and it lengthened out
into a long boat. The darkness under it grew thicker and thicker, the
foliage of the tree above vanished, and the two naughty children
found themselves in a boat, rolling and tossing on the black waves,
with a gloomy, starless sky above them. Away at the end of the boat
sat Gillydrop, who had now unrolled himself, and was guiding the
magic skiff across the Sea of Darkness towards the Country of the
Giants.
“Oh, I want to go home!” cried Tilly, now very frightened.
“And so do I!” roared Teddy, sitting close to her.
As they said this, they both heard a mocking ripple of laughter, and
saw the Red Elf dancing with glee at the end of the boat.
“You’ll never go home again,” he cried mockingly, “because you have
been naughty, and must be punished.”
“I’ll never be naughty again,” sobbed Tilly.
“No more will I,” echoed Teddy; and they both wept bitterly.
“It’s too late now,” said Gillydrop, shaking his head. “Naughty
children always get punished.”
He might have said the same thing about himself; but then he was a
faery, and felt ashamed to tell two human beings that he had been
as naughty as themselves.
Teddy and Tilly cried dreadfully as they thought of their poor mother
waiting for them at home, and of the nice supper of bread and milk
which she had prepared for them; but their tears were all of no avail,
for the magic boat sailed on and on, though how it moved without
sails or oars they could not tell.
At last they saw a faint silver light away in the distance, and a cool
breeze blew steadily against them. The light grew larger and larger
until it spread everywhere, and they saw the shores of the Giants’
Country, with Dunderhead’s great castle hovering above them. The
boat ran right up on to the beach, and then, suddenly turning into a
leaf, contracted to a small size and flew away to another beech, but
this time the beech was a tree.
The Red Elf vanished as soon as the leaf, and Teddy and Tilly,
finding themselves alone in this dreary land, began to cry loudly. It
would have been better for them if they had held their tongues, for
Dunderhead, hearing two children crying, knew at once that the elf
had brought them for his supper, and came down to seize them
before they could get away.
“Ah! this is the supper my friend the elf has brought me,” he roared,
picking up the children. “I’m so pleased! Now I’ll boil them.”
You may be sure that Teddy and Tilly were in a dreadful fright on
hearing this, as they did not want to be boiled; but, in spite of all their
cries, Dunderhead took them up to the great hall of his castle, and
set them down on the table.
They were so fat and juicy that the Giant cried tears of joy at the
prospect of having a good supper, and as his tears gushed out in a
great torrent, Gillydrop, who had been waiting for this, plunged into
the torrent to get his clothes cleaned again. Much to his dismay,