CIRCULATORY SYSTEM

Contains loose CT including

elastic fibers and adipose
tissue

Contains cardiac muscle

throughout most of the heart

Consists of endothelial lining

and the underlying CT layers
BLOOD
 SERUM
PLASMA

BUFFY COAT
PACKED RED
CELLS RBCs

Composition of Blood: Serum Composition of Blood: Plasma

White Blood Cells / Leukocytes
• Functions for immunity and defence.
• Become active outside the circulation, specifically
leaving the microvasculature in a process involving
cytokines, selective adhesion, changes in the
endothelium, and transendothelial migration or
diapedesis.

Composition of
Blood: Blood cells
1. Granulocytes
• Possess two major types of cytoplasmic granules:
• lysosomes (often called azurophilic granules in
blood cells)
• specific granules that bind neutral, basic, or
acidic stains and have specific functions.
• They have polymorphic nuclei with two or more
distinct (almost separated) nuclear lobes.

Types of Leukocytes
 EOSINOPHIL
BASOPHIL

NEUTROPHIL
NEUTROPHIL
BASOPHIL

LYMPHOCYTE

Types of Granulocyte
2. Agranulocytes
• do not have specific granules, but they do contain
azurophilic granules (lysosomes), with affinity for
the basic stain azure A.
• The nucleus is spherical or indented but not
lobulated.

Types of Leukocytes
 MONOCYTE
LYMPHOCYTE

LYMPHOCYTE

LYMPHOCYTE
MONOCYTE
MONOCYTE

LYMPHOCYTE

Types of Agranulocyte
Red Blood Cells / Erythrocytes
• They are approximately 7.5 μm in diameter, 2.6 μm
thick at the rim, but only 0.75 μm thick in the center
which gives them the biconcave shape.
• They are terminally differentiated structures lacking
nuclei and completely filled with the O2-carrying
protein hemoglobin.
• Erythrocytes are normally quite flexible, which
permits them to bend and adapt to the irregular turns
and small diameters of capillaries.
NOTE: RBCs are the
Composition of only blood cells
whose function does

Blood: Blood cells not require them to

leave the vasculature.