Ciprofloxacin Hydrochloride DMF Open Part Shangyu Jingxin Pharmaceutical Co., Ltd.

3.2.S.2.2.3 Synthetic route for Ciprofloxacin Hydrochloride

Stage 1: condensation
O O
O O

F F
OH OH

+ HN NH + HCl
Cl N N N

HN

Name: Cyclopropyl carboxylic acid Piperazine Ciprofloxacin

Molecular formula: C13H11O3NFCl C4H10N2 C17H18O3N3F

M.W.: 283.5 86 331.1

Stage 2: salification

O O O O

F F
OH OH

+ HCl + H2O . HCl . H2O

N N N N

HN HN

Name: Ciprofloxacin Ciprofloxacin Hydrochloride

Molecular formula: C17H18O3N3F C17H21O4N3FCl

M.W.: 331.1 385.8

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