C o n n e c t i v e T is s u e

a tn x th a t s u p p o rt s and
provide a m
• Connective tissues s u e ~ d n d c e ll s to g e th e r ,n
ohi,,icdl/ s o th e
,nnecr r t s
)f t,; in

---
--
 o f C o n n e c t i v e I
Composition

el

M
tra c e ll u la r m a t r ix
• Ex
• Fibers
la r
(Collagen, R e t ic u
& Elastic)
-------
-
nce
• Ground substa
(Proteoglycans,
Glycoprotems &
Gly c o s a m m o g ly c a ns) ·-
53

FUNCTIONS:
• Prov1s1on o f st ru ct u ra l su p
p o rt
• R ol e as m e d iu m fo r ex ch an
ge
R ol e in d e fe n se an d p ro te ct io
n of body
• S to ra ge o f fa t
 CTIVE TISSUE
ONNE
CELLS O F C
F i x e d c e ll s /:
e ll s (
Resident c
s
• Fibroblast
s
• Ad1pocy1e
• Macropha
ges
,__
• M e s
cells
e n c h y mal s t e m
-- --
M ig r
cells/:
a n t c e ll

• M a s i cells
• Plasma ce
s ( Trans

lls
ient

-
----
·--
I
s
• le u c o c y t e
 ADIPOCYTES
• Spherical
• Large cell 50-150
micrometer
• Signet ring appearance
• Functions: storage of
neutral fat, heat production
,cushion, insulation
• Unilocular fat cell-WHITE
ADI POSE TISSUE
• Mult1locular fat cells-
BROWN ADIPOSE TISSUE
 Mast cells
• 0 ... .11
• 7•20 micrometer
• Basoph1l1c secretory granules -
• Nucleu!o central f .\,
• ActdlC radical m sulfales GAGs ...
MCTACHROMASIA f

-
• metachromas,a, which means that .,-.
0
~~:;,C:;e~~=~g~o~~7d~~~ ~1:~~~: ·I!. .
olue to purole or red L9 ,_
• functions: Loe.al mflammatory 9"-
respons.e, innate immunity, tissue
 -
,...
- - }
•
I
,, \( 1'\
I
~I
.. l
..c.\
,,, J

' { I
,- =f!i~-,
 %mrtTW:

r U N C T I O N S :

g o c y to s 1s ( d e fe n s e )
• Pha
m o v a l o f c e ll d e b r is
• R P
• ,v r o k 1 n e s
• \ 11 g e n p
r e s e n ta ti o n
r MACROPHAGES
monocyte
ctentm oval nucleu~ kidney
raped
, In CT of organs- HISTIOCYTES
• Irregular surfaces -pleats,
protusions-pinocytic &
phagocytic
• MONOCYTES-in blood
MONOC YTE PHAG O CYTE S YSTEM
•
• Examples:
• KUPFFER cells: Liver
• M1croglial cells: CNS
• Langerhan cells: Skm
• Osteoclasts. Bone
FIBROBLASTS
Mo st com mo n CT Cells ,
Pro duc e & ma inta in EC
COMPONENTS
Collagen, elas tin, GAGs,
pro teo glyc ans ,
glyc opr ote ,ns
• Targets for Gro wth fact ors
• TYPES:

f
• Fib rob last s-a ctiv e
• F1brocvte-qu1escent

-·--
• wo und hea hng -
Myo fibr obla st.s -- ----
-~ ---
--- -