Facial expressions help communicate our emotions

and connect us to others.

But over time, those smiles and frowns can be

recorded on our skin, in the form of mimic wrinkles.

SYN®-AKE is the needle-free solution to this type

of wrinkle. This unique tripeptide helps relax the
skin from within, for smoother skin and a younger-
looking complexion.

It visibly reduces deep wrinkles, and when used

earlier in time it helps delay their appearance with
an age freezing effect.

DISCOVER THE POWERFUL PEPTIDE

DESIGNED FOR MOTHERS AND DAUGHTERS

For internal use only. Products are for experimentaluse only and are not for sale.
 age treatment
reduce the signs of time
VISIBLY REDUCES DEEP WRINKLES B
Y
-20% IN JUST FOUR WEEKS*

For internal use only. Products are for experimentaluse only and are not for sale.
*Double blind and intra-individual in-vivo study, 15 volunteers per group (female, age 41-60), 28 days applied twice daily on face.Evaluation
of anti-wrinkle effect with Primos 3D®: effect of SYN®-AKE (4%) on smoothing (Ra) measured on the forehead after 28 days)

DE-AGING DAILY CREAM SPF 30
WITH 4% SYN®-AKE, HYALURONIC ACID-BT
It plumps with hydration and relaxes
skin, smoothing the appearance of deep
wrinkles for a youthful complexion.
SK-E-101544-3
For internal use only. Products are for experimental use only and are not for sale.
DSM is not responsible for final products claims
rewind & regenerate
RESTORATIVE NIGHT TREATMENT
WITH 4% SYN®-AKE, SYN®-COLL, PENTAVITIN®
This intensively nourishing formula
works overnight to relax skin and
restore moisture and elasticity.
SK-E-101456-12
EYE SERUM CONCENTRATED SERUM
WITH 4% SYN®-AKE, SYN-EYE®, PEPHA®-AGE, WITH 4% SYN®-AKE, SYN®-HYCAN, HYALURONIC ACID-BT
VALVANCE® Look 100
High-tech formula and targeted application
It reduces the appearance of to visibly reduce deep wrinkles.
crow’s feet, while its unique texture
SK-E-101480-4
provides an instant flawless look.
SK-E-101456-10
 age prevention
make time stand still
DELAYS THE APPEARANCE
OF WRINKLES WITH AN AGE
FREEZING EFFECT

For internal use only. Products are for experimentaluse only and are not for sale.
 time freeze
DE-AGING DAILY CREAM SPF 30
WITH 4% SYN®-AKE, HYALURONIC ACID-BT
Stop wrinkles before they appear!
This future-proofing wonder formula
helps relax skin to delay the
progression of mimic wrinkles, while UV
filters help prevent sun damage.
SK-E-101544-3
For internal use only. Products are for experimentaluse only and are not for sale.
DSM is not responsible for final products claims
TIME FREEZE EYE SERUM
WITH 4% SYN®-AKE, SYN®-EYE,
PEPHA®-AGE, VALVANCE® Look 100
Get the #nofilter look!
This serum works overtime to keep
mimic wrinkles at bay. Enriched with
soft-focus effect particles, it instantly
blurs imperfections for a radiant look.
SK-E-101456-10
TIME FREEZE PEEL-OFF MASK
WITH 4% SYN®-AKE, PENTAVITIN®
Relax, recline and pencil in some
serious ‘me-time’! This age-defying
mask transforms skin to unveil a
smoother and firmer complexion.
SK-E-101394-10
 REDUCE THE SIGNS OF TIME

De-aging Daily This Daily Cream is powered by SYN®️-AKE Peptide, proven to help relax skin and reduce mimic
wrinkles in just 4 weeks. Its light texture hydrates and plumps skin, smoothing the appearance

CreamSPF 30
of deep wrinkles for a youthful complexion, while SPF 30 protects from sun damage.
Procedure:
PHASE INGREDIENTS INCI Name %W/W SUPPLIER
1. Heat phase A to 85°C.

SPF 30 for SYN-AKE CI A PARSOL® 1789 BUTYL METHOXYDIBENZOYLMETHANE 3,00 100288 2. Heat phase B to 80°C.
Add phase B to phase A and homogenize.
PARSOL® 340 OCTOCRYLENE 8,00 100288 Let cool down under gentle stirring to room
With SYN®-AKE, HYALURONIC ACID-BT, AMPHISOL® K temperature.
and PARSOL® PARSOL® EHS ETHYLHEXYL SALICYLATE 5,00 100288 3. Add phase C and homogenize for 30 seconds.
Check the final pH should be between 7.0 and 7.5.
PARSOL® SLX POLYSILICONE-15 1,50 100288

PARSOL® Shield BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE 1,50 100288 Technical Data:

pH: 7.20
Dermofeel® BGC BUTYLENE GLYCOL DICAPRYLATE/DICAPRATE 2,00 100491 Viscosity (Brookfield RV4/10rpm): 4 470 mPa.s
SPF expected: 30
Montanov 202 ARACHIDYL ALCOHOL, BEHENYL ALCOHOL, ARACHIDYL GLUCOSIDE 1,60 100313
MONTANOX 60 DF POLYSORBATE 60 0,40 100313
Supplier:
Cetiol Ultimate UNDECANE, TRIDECANE 2,00 100037 100288 DSM NUTRITIONAL PRODUCTS LTD
100313 SEPPIC
AMPHISOL® K POTASSIUM CETYL PHOSPHATE 0,30 100288 100080 COSNADERM
Sepiplus 400 POLYACRYLATE-13, POLYISOBUTENE, POLYSORBATE 20 0,50 100313 101007 DROM FRAGRANCES GMBH & KO. KG
100491 DR. STRAETMANS
B WATER DEM. AQUA 55,40 100037 BASF
Edeta BD DISODIUM EDTA 0,05 100230 MERCK KGAA
100037
100400 CP KELCO
PARSOL® HS PHENYLBENZIMIDAZOLE SULFONIC ACID 2,00 100228
Tris(hydroxymethyl)aminomethane TROMETHAMINE 1,00 100230
Propanediol PROPANEDIOL 2,00

Keltrol CG-T XANTHAN GUM 0,15 100400

HYALURONIC ACID-BT SODIUM HYALURONATE 0,25 100288
Pentylene Glycol PENTYLENE GLYCOL 3,00 100080
Dermosoft® Octiol CAPRYLYL GLYCOL 0,20 100491
C SYN®-AKE GLYCERIN, AQUA, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4,00 100288
Ethanol abs. ALCOHOL 6,00 100230
Perfume Sail Away 49454695 PARFUM 0,15 101007
SK-E-101456-12
This information is for illustration purposes only and based upon our current knowledge and experience at the time of printing. We do not make
any representation or warranty of any kind, express or implied, including merchantability or fitness for a particular use, with respect to such
information or its application. Use of this information is at your discretion and risk. Nothing herein relieves you from carrying out your own
suitability determinations and tests. You are responsible for observing all laws and regulations relevant to your products, uses or processes.
We do not assume any liability in connection with your product and its use. The foregoing information and suggestions are also provided
without warranty of non-infringement as to the intellectual property rights of third parties, and shall not be construed as any
Global Regulatory compliance in EU, LATAM, AUS, APAC and USA inducement to infringe the rights of third parties.
for UV filters in composition DSM Nutritional Products, Personal Care, P.O.Box 2676, CH-4002 Basel, Switzerland
 REDUCE THE SIGNS OF TIME

Restorative This Night Treatment is powered by SYN®️-AKE Peptide, proven to help relax skin and reduce mimic wrinkles
in just 4 weeks. This intensively nourishing formula works overnight to restore moisture and elasticity.

Night Treatment PHASE INGREDIENTS INCI Name %W/W SUPPLIER

Procedure:
1. Mix all ingredients of phase A under stirring and heat
With SYN®-AKE, PENTAVITIN®, SYN®-COLL, up to 75-80°C.
dl-alpha-Tocopheryl Acetate and A Montanov 68 CETEARYL ALCOHOL, CETEARYL GLUCOSIDE 0,30 100313 Add Sepinov EMT at the end of the heating phase.
Mixed Tocopherols 95 Lanette O CETEARYL ALCOHOL 1,00 100037 2. Mix all ingredients of phase B under stirring and heat
up to 75°C.
Palmera A9818 STEARIC ACID 0,20 101047 3. Add phase A into phase B under stirring.
Homogenize for 2 minutes with
Dermofeel® Sensolv ISOAMYL LAURATE 3,00 100491 an ultra-turrax at 14 000 rpm.
Cool down to room temperature under stirring.
Tegosoft CO CETYL ETHYLHEXANOATE 3,00 100415 4. Add ingredients of phase D at room temperature
under stirring.
DUB PTIS PENTAERYTHRITYL TETRAISOSTEARATE 3,00 100327 5. Adjust the pH around 5.5 with phase E.
Homogenize again for 2 min with an ulta-turrax
dl-alpha-Tocopheryl Acetate TOCOPHERYL ACETATE 0,50 100288 at 14 000 rpm.
HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL
Sepinov EMT 10 0,60 100313
TAURATE COPOLYMER Technical Data:
pH: 5.50
VEGELIGHT 1214 LC COCONUT ALKANES, COCO-CAPRYLATE/CAPRATE 3,00 101277
Viscosity (Brookfield RV5/10rpm): 17 000 mPa.s
LexFeel D5 NEOPENTYL GLYCOL DIHEPTANOATE, ISODODECANE 2,50 100647
Mixed Tocopherols 95 TOCOPHEROL 0,10 100288 Supplier:
100313 SEPPIC
B WATER DEM. AQUA 66.69 100037 BASF
101047 KLK OLEO
Edeta BD DISODIUM EDTA 0,05 100037 100491 DR. STRAETMANS
100415 EVONIK
Glycerine CremerGLYC 86.5% GLYCERIN 2,50 101003 100327 STEARINERIE DUBOIS FILS
100288 DSM NUTRITIONAL PRODUCTS LTD
Dermosoft® Octiol CAPRYLYL GLYCOL 0,20 100491 101277 BIOSYNTHIS
100647 INOLEX CHEMICAL COMPANY
Pentylene Glycol PENTYLENE GLYCOL 3,00 100080 100080 COSNADERM
101003 CREMER OLEO GMBH & CO. KG
Biophilic H HYDROGENATED LECITHIN, C12-16 ALCOHOLS, PALMITIC ACID 2,00 100214 101007 DROM FRAGRANCES GMBH & KO. KG
100214 LUCAS MEYER
D PENTAVITIN® SACCHARIDE ISOMERATE, AQUA, CITRIC ACID, SODIUM CITRATE 1,00 100288
SYN®-COLL PALMITOYL TRIPEPTIDE-5, GLYCERIN, AQUA 3,00 100288
SYN®-AKE GLYCERIN, AQUA, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4,00 100288

Perfume Sail Away 49454695 PARFUM 0,30 101007

E Sodium Hydroxide 10% Solution SODIUM HYDROXIDE, AQUA 0,06

SK-E-101456-12
This information is for illustration purposes only and based upon our current knowledge and experience at the time of printing. We do not make
any representation or warranty of any kind, express or implied, including merchantability or fitness for a particular use, with respect to such
information or its application. Use of this information is at your discretion and risk. Nothing herein relieves you from carrying out your own
suitability determinations and tests. You are responsible for observing all laws and regulations relevant to your products, uses or processes.
We do not assume any liability in connection with your product and its use. The foregoing information and suggestions are also provided
without warranty of non-infringement as to the intellectual property rights of third parties, and shall not be construed as any
inducement to infringe the rights of third parties.
DSM Nutritional Products, Personal Care, P.O.Box 2676, CH-4002 Basel, Switzerland
 REDUCE THE SIGNS OF TIME

Concentrated This Concentrated Serum is powered by SYN®️-AKE Peptide, proven to help relax skin and reduce
mimic wrinkles in just 4 weeks. This high-tech formula leaves skin looking smoother and firmer.

Serum
With SYN®-AKE, SYN®-HYCAN
Procedure:
and HYALURONIC ACID-BT PHASE INGREDIENTS INCI Name %W/W SUPPLIER
1. Mix all ingredients of phase A under stirring.
A KF-96L-2CS DIMETHICONE 4,00 100637 2. Mix all ingredients of phase B under stirring
until totally uniform.
KSG-240 DIMETHICONE/PEG-10/15 CROSSPOLYMER, CYCLOPENTASILOXANE 3,00 100637 3. Sprinkle Hyaluronic Acid into phase B under
higher shear.
KSG-16 DIMETHICONE, DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER 1,00 100637 4. Slowly add phase B+C into phase A under stirring
with a tri-pale and a starting speed of 350 rpm.
KF-6028 PEG-9 POLYDIMETHYLSILOXYETHYL DIMETHICONE 0,20 100637 While adding phase A, the formulation thickens, then
gradually increase the speed up to 1500 rpm.
Perfume Sail Away 49454695 PARFUM 0,15 101007
Technical Data:
B WATER DEM. AQUA 75,68
Viscosity (Brookfield RV6/10rpm): 74 200 mPa.s
Edeta BD DISODIUM EDTA 0,02 100037
Supplier:
CremerGlyc Refined Glycerine 100637 SHIN-ETSU CHEMICAL CO. LTD.
GLYCERIN 5,00 101003
Organic 101007 DROM FRAGRANCES GMBH & KO. KG
101003 CREMER OLEO GMBH & CO. KG
Pentylene Glycol PENTYLENE GLYCOL 3,00 100080 100037 BASF
100288 DSM NUTRITIONAL PRODUCTS LTD
Dermosoft® Octiol CAPRYLYL GLYCOL 0,15 100491 100080 COSNADERM
100230 MERCK KGAA
Sodium Chloride Emprove exp SODIUM CHLORIDE 1,00 100230 100491 DR. STRAETMANS

SYN®-AKE GLYCERIN, AQUA, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4,00 100288

GLYCERIN, AQUA, MAGNESIUM CHLORIDE, TETRADECYL

SYN®-HYCAN 2,50 100288
AMINOBUTYROYLVALYLAMINOBUTYRIC UREA TRIFLUOROACETATE

C HYALURONIC ACID-BT SODIUM HYALURONATE 0,30 100288

SK-E-101480-4

This information is for illustration purposes only and based upon our current knowledge and experience at the time of printing. We do not make
any representation or warranty of any kind, express or implied, including merchantability or fitness for a particular use, with respect to such
information or its application. Use of this information is at your discretion and risk. Nothing herein relieves you from carrying out your own
suitability determinations and tests. You are responsible for observing all laws and regulations relevant to your products, uses or processes.
We do not assume any liability in connection with your product and its use. The foregoing information and suggestions are also provided
without warranty of non-infringement as to the intellectual property rights of third parties, and shall not be construed as any
inducement to infringe the rights of third parties.
DSM Nutritional Products, Personal Care, P.O.Box 2676, CH-4002 Basel, Switzerland
 MAKE TIME STAND STILL. DELAY THE APPEARANCE OF CROW’S FEET

Time Freeze This formula is powered by SYN®️-AKE, our hero de-aging Peptide, proven to fight expression lines by helping
to relax skin. This Eye Serum is specifically formulated for the delicate eye zone. It reduces the appearance of

Eye Serum crow’s feet, while its unique texture provides an immediate glow for a flawless look. Enriched with PEPHA®-AGE
for blue light protection.
With SYN®-AKE, SYN-EYE®, PEPHA®-AGE
and VALVANCE® Look 100 Procedure:
PHASE INGREDIENTS INCI Name %W/W SUPPLIER
1. Mix all ingredients of phase A stirring until uniform.
A WATER DEM. AQUA 80,02 2. Add each ingredient of B and stirring until uniform.
3. Add phase C into phase AB stirring until uniform.
Edeta BD DISODIUM EDTA 0,02 100037 4. Adjust pH around 5.50 with Phase D.

Carbopol 980 CARBOMER 0,60 100435

Technical Data:
pH: 5.47
Blanose CMC 7HF PH CELLULOSE GUM 0,15 100662
Viscosity (Brookfield RV5/10rpm): 20 120 mPa.s
Glycerin 86.5% GLYCERIN 3,00
Supplier:
Viscarin PC 209 CARRAGEENAN 0,25 100500 100435 LUBRIZOL ADVANCED MATERIALS, IN
100037 BASF
Dermosoft® Octiol CAPRYLYL GLYCOL 0,20 100491 100500 FMC BIOPOLYMER
100662 ASHLAND SPECIALTY INGREDIENTS
Pentylene Glycol PENTYLENE GLYCOL 3,00 100080 100080 COSNADERM
100491 DR. STRAETMANS
B AQUA, PANTHENOL, PALMITOYL TRIPEPTIDE-5, HYALURONIC ACID, 100230 MERCK KGAA
SYN-EYE® PHENOXYETHANOL, SODIUM BENZOATE, POTASSIUM SORBATE, 100288 DSM NUTRITIONAL PRODUCTS LTD
1,00 100288
101007 DROM FRAGRANCES GMBH & KO. KG
ETHYLHEXYLGLYCERIN, CITRIC ACID, ALGAE EXTRACT

SYN®-AKE GLYCERIN, AQUA, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4,00 100288

PEPHA®-AGE SCENEDESMUS RUBESCENS EXTRACT, AQUA, PHENOXYETHANOL 1,00 100288
C Ethanol abs. ALCOHOL 3,00 100230

Perfume Sail Away 49454695 PARFUM 0,10 101007

VALVANCE® Look 100 SILICA, TITANIUM DIOXIDE 2,00 100288

Timiron® Halo White TITANIUM DIOXIDE, TIN OXIDE 1,10 100230

Gemtone Tan Opal G005 MICA, IRON OXIDES, TITANIUM DIOXIDE 0,20 100037
D Sodium Hydroxide 30% Solution AQUA, SODIUM HYDROXIDE 0,36 100230
SK-E-101456-10

This information is for illustration purposes only and based upon our current knowledge and experience at the time of printing. We do not make
any representation or warranty of any kind, express or implied, including merchantability or fitness for a particular use, with respect to such
information or its application. Use of this information is at your discretion and risk. Nothing herein relieves you from carrying out your own
suitability determinations and tests. You are responsible for observing all laws and regulations relevant to your products, uses or processes.
We do not assume any liability in connection with your product and its use. The foregoing information and suggestions are also provided
without warranty of non-infringement as to the intellectual property rights of third parties, and shall not be construed as any
inducement to infringe the rights of third parties.
DSM Nutritional Products, Personal Care, P.O.Box 2676, CH-4002 Basel, Switzerland
 MAKE TIME STAND STILL. DELAY THE APPEARANCE OF WRINKLES

Time Freeze This Peel-off Mask is powered by SYN®️-AKE, our hero de-aging Peptide, proven to fight expression lines by helping
to relax skin. Apply a generous layer to clean skin and allow it to dry for 20-30 minutes, until the special texture

Peel Off Mask transforms from white to silver. Then peel it away, for instantly firmer and smoother feeling skin.

With SYN®-AKE, PENTAVITIN®, PARSOL® 340,

PARSOL® 1789 and PARSOL® HMS Procedure:
PHASE INGREDIENTS INCI Name %W/W SUPPLIER
1. Heat Phase A to 85°C.
A WATER DEM. AQUA 63,25 2. When the temperature reaches 35-40°C, disperse B,
take care that it does not form any cluster.
Edeta BD DISODIUM EDTA 0,10 100037 When the temperature reaches 80°C, leave stirring
until B is totally dissolved. Cool down to room
CremerGlyc Refined Glycerine temperature under medium stirring.
GLYCERIN 6,00 101003
Organic 3. Add phase C under stirring.
4. Premix phase D and heat up to 40°C to help
Pentylene Glycol PENTYLENE GLYCOL 3,00 100080 dissolving Parsol®️ 1789.
Stir until it is homogenous, then add the premix to
Dermosoft® Octiol CAPRYLYL GLYCOL 0,20 100491 the formulation under stirring.
B GOHSENOL EG-40C POLYVINYL ALCOHOL 11,00 100666 5. Sprinkle Lecigel into the formulation under stirring.
6. Below 40°C, add the ingredients of phase F under
C Xiameter PMX-200 Sil Fluid 100 CS DIMETHICONE 2,00 100404 stirring.
Adjust the pH around 5.50 if needed.
D PARSOL® 340 OCTOCRYLENE 0,30 100288
Technical Data:
PARSOL® 1789 BUTYL METHOXYDIBENZOYLMETHANE 0,08 100288 pH: 5.79
Viscosity (Brookfield RV7/10rpm): 108 000 mPa.s
PARSOL® HMS HOMOSALATE 0,13 100288
Supplier:
E Lecigel SODIUM ACRYLATES COPOLYMER, LECITHIN 1,00 100214
101003 CREMER OLEO GMBH & CO. KG
F Perfume Sail Away 49454695 PARFUM 0,30 101007 100037 BASF
100491 DR. STRAETMANS
SYN®-AKE GLYCERIN, AQUA, DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE 4,00 100288 100080 COSNADERM
100404 DOW CORNING CORP
PENTAVITIN® 100666 NIPPON GOHSEI
SACCHARIDE ISOMERATE, AQUA, CITRIC ACID, SODIUM CITRATE 1,00 100288
100214 LUCAS MEYER
100288 DSM NUTRITIONAL PRODUCTS LTD
Timiron® Liquid Silver CI 77163, ETHYLHEXYL HYDROXYSTEARATE 2,65 100230 100230 MERCK KGAA
101007 DROM FRAGRANCES GMBH & KO. KG
Ethanol abs. ALCOHOL 5,00 100230
SK-E-101394-10

Global Regulatory compliance in EU, LATAM, AUS, APAC and USA
for UV filters in composition
This information is for illustration purposes only and based upon our current knowledge and experience at the time of printing. We do not make
any representation or warranty of any kind, express or implied, including merchantability or fitness for a particular use, with respect to such
information or its application. Use of this information is at your discretion and risk. Nothing herein relieves you from carrying out your own
suitability determinations and tests. You are responsible for observing all laws and regulations relevant to your products, uses or processes.
We do not assume any liability in connection with your product and its use. The foregoing information and suggestions are also provided
without warranty of non-infringement as to the intellectual property rights of third parties, and shall not be construed as any
inducement to infringe the rights of third parties.
DSM Nutritional Products, Personal Care, P.O.Box 2676, CH-4002 Basel, Switzerland