DI and SIADH

Complications of DI

Hypernatremia (> 145)

Polydipsia

ADH Hypothalamus
+
Osmolality

H2O Na+
-
Hypovolemia Dehydration
*(Inadequate Hydration)*

H2O Polyuria
Loss
in Urine

Complications of SIADH
Cerebral Edema
Hyponatremia (< 135)
ADH
H2O
+
Acute or ICP +
< 120
H2O Na+ Osmotic Shift
+ + H/A N/V Herniation
Ac
< 1ute
20 or
+
Cortical
Seizures
H2O Loss Irritability
in Urine
 DI and SIADH
Diabetes Insipidus (DI) Central DI Nephrogenic DI
Pituitary Macroadenoma
Sheehan Syndrome Apoplexy
(> 10 mm)

Central DI
ADH

ADH
Vascular
Compression Compression
Nephrogenic V2-R
DI Infarction
+ H2O
V2-R -

H2O BV
ar ction Lithium Hypercalcemia
BP + Inf Transsphenoidal
Bipolar
Resection PTH
and
ADH Malignancy
DIC Hypokalemia
H2O V2-R GI Losses or Renal Losses
H2O ECG Changes +

SIADH
Ectopic ADH
Production Ectopic ADH Production
Pituitary
ADH release
Pituitary ADH Release
ADH
Intracranial Drugs
Diseases (M/C) SCLC
V2-R O2 SSRI’s
Stroke Carbamazepine
+ Pulmonary Paraneoplastic
H2O ICH/SAH TCA’s
+ Diseases Syndrome
TBI
COPD
PNA
ARDS
Intubated +
H2O H2O
+
ADH
ADH