SCHOOL OF COMPUTING

COLLEGE OF ENGINEERING AND TECHNOLOGY

SRM INSTITUTE OF SCIENCE AND TECHNOLOGY
(Under Section 3 of UGC Act, 1956)

S.R.M. NAGAR, KATTANKULATHUR – 603203

CHENGALPATTU DISTRICT

21BTB102T- Introduction to Computational Biology

Topic- Neuroplasticity

SUBMITTED BY – Ananya Agrawal

SWASTIKA RAY

REGISTER NUMBER - RA2311003010974

RA2311003010992

CLASS / BATCH - N1 / 1

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 INDEX

I. Introduction …3
A. Definition of Neural Plasticity
B. Importance of Studying Neural Plasticity

II. What is Neural Plasticity? ..3

A. Adaptive Structural and Functional Changes
B. Clinical Implications
C. Major Mechanisms:
1. Neuronal Regeneration/Collateral Sprouting
2. Functional Reorganization

III. Historical Roots of the Concept …3

A. William James and Early References
B. Credited Origin of the Term Neural Plasticity

IV. Phases of Neuroplasticity ...3

A. Initial Damage and Secondary Neuronal Networks
B. Recruitment of Support Cells and Synaptic Plasticity
C. Brain Remodeling and Axonal Sprouting

V. Mechanisms of Neuroplasticity …4
A. Neuronal Regeneration/Collateral Sprouting:
1. Synaptic Plasticity
2. Adult Neurogenesis
B. Functional Reorganization:
1. Equipotentiality and Vicariation
2. Diaschisis

VI. Implications and Applications …5

A. Significance in Neuroscience, Clinical Practice, Education, and Rehabilitation
B. Practical Applications in Rehabilitation and Education
C. Clinical Integration and Future Directions

VII. Challenges and Future Directions …6

A. Methodological Limitations
B. Opportunities for Advancement
C. Translational Impact and Collaborative Efforts
D. Future Research Directions

VIII. Conclusion …7
A. Recap of Neuroplasticity's Significance
B. Summary of Key Points

References …7

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 I. INTRODUCTION

Neural plasticity, known also as neuroplasticity or brain plasticity, describes the ability of the
nervous system to adapt its behaviour in response to various stimuli by restructuring its
organization, functions, or connections.
Neurons possess the remarkable capability to adjust the strength and effectiveness of synaptic
communication through diverse activity-dependent processes, commonly termed synaptic
plasticity.
Over the course of the last century, research has consistently demonstrated that neural
plasticity is an intrinsic property of nervous systems across a wide spectrum of species.
Studies focusing on synaptic plasticity have not only advanced our understanding of
neuroscience but have also yielded insights with practical implications for societal well-
being, as this phenomenon is involved in numerous aspects such as learning and memory,
brain development, sensory training, and recovery from brain injuries.

II. WHAT IS NEURAL PLASTICITY?

Neuroplasticity, also known as neural plasticity or brain plasticity, is a process that involves
adaptive structural and functional changes to the brain. A good definition is “the ability of the
nervous system to change its activity in response to intrinsic or extrinsic stimuli by
reorganizing its structure, functions, or connections.”

Clinically, it is the process of brain changes after injury, such as a stroke or traumatic brain
injury (TBI). These changes can either be beneficial (restoration of function after injury),
neutral (no change), or negative (can have pathological consequences).
Neuroplasticity can be broken down into two major mechanisms:

• Neuronal regeneration/collateral sprouting: This includes concepts such as synaptic

plasticity and neurogenesis.

• Functional reorganization: This includes concepts such as equipotentiality, vicariation, and

diaschisis

III. HISTORICAL ROOTS OF THE CONCEPT

The first mention of the term plasticity in regards to the nervous system was by William
James in 1890. However, the term neural plasticity is credited to Jerzy Konorski in 1948 and
was popularized by Donald Hebb in 1949.

IV. PHASES OF NEUROPLASTICITY

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Neuroplasticity is traditionally thought of as occurring in 3 phases or epochs.
1. First 48 hours: Depending on the mechanism of the injury (such as stroke or TBI), there is
initial damage that cumulates as cell death with the loss of certain cortical pathways
associated with the lost neurons. The brain attempts to use secondary neuronal networks to
maintain function.

2. The following weeks: Recruitment of support cells occurs in this period as the cortical
pathways shift from inhibitory to excitatory. Synaptic plasticity and new connections are
made during this period.

3. Weeks to months afterward: The brain continues to remodel itself via axonal sprouting and
further reorganization around the damage.

V. MECHANISMS OF NEUROPLASTICTY

1. Neuronal Regeneration/Collateral Sprouting

Neuronal regeneration and collateral sprouting are integral components of neuroplasticity,

facilitating the brain's ability to adapt and reorganize in response to intrinsic and extrinsic
stimuli.
These mechanisms encompass both structural and functional changes within the nervous
system.

Synaptic Plasticity: Synaptic plasticity is a fundamental process underlying neuroplasticity,

enabling the modification of synaptic strength and efficacy in response to neural activity.
Initially described by Bliss and Lomo in 1973, long-term potentiation (LTP) exemplifies this
phenomenon. LTP involves the sustained enhancement of synaptic transmission following
repetitive stimulation of presynaptic fibers.
Mechanistically, LTP is mediated by the activation of postsynaptic receptors and subsequent
alterations in neurotransmitter release, leading to the strengthening of synaptic connections.
Factors influencing synaptic plasticity include exercise, environmental enrichment, repetition
of tasks, motivation, neuromodulators (e.g., dopamine), and medications.
Conversely, aging and neurodegenerative diseases may impair synaptic plasticity,
highlighting its dynamic nature.

Adult Neurogenesis: Adult neurogenesis, the generation of new neurons in the adult brain,
represents another facet of neuroplasticity.
While historically contentious, evidence from animal models supports the existence of adult
neurogenesis in specific brain regions, including the hippocampus and olfactory bulb.
However, its occurrence in humans remains debated, with challenges in identifying
definitive biomarkers.

Studies utilizing specific biomarkers have provided insights into the potential role of adult
neurogenesis in brain plasticity, although further research is needed to elucidate its
functional significance and therapeutic implications.

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 2. Functional Reorganization
Functional reorganization encompasses adaptive changes in neural circuits and functional
connectivity, facilitating the redistribution of cognitive and motor functions following injury
or environmental changes.

Equipotentiality and Vicariation: Historically, the concepts of equipotentiality and

vicariation posited that the brain could redistribute functions to compensate for damage.
However, empirical evidence has revealed a more nuanced understanding, with functional
reorganization occurring through a combination of neural plasticity mechanisms. Clinical
examples, such as brain reorganization after hemispherectomy or stroke, underscore the
dynamic nature of neural networks and their capacity for functional adaptation.

Diaschisis: Diaschisis refers to the phenomenon whereby damage to one brain region induces
alterations in distant but interconnected areas, influencing neural function. Initially proposed
by Constantin von Monakow, diaschisis reflects the complex interplay between neural
networks and functional connectivity.
Modern interpretations encompass diverse forms, including classic diaschisis, functional
diaschisis, connectional diaschisis, and connectome diaschisis, underscoring the multifaceted
nature of brain plasticity and its implications for neurological function.

VI. IMPLICATIONS AND APPLICATIONS

Significance of Understanding Neuroplasticity Mechanisms:

Understanding neuroplasticity mechanisms has wide-ranging implications for neuroscience,
clinical practice, education, and rehabilitation. It provides insights into brain function,
development, and adaptation, guiding targeted interventions for neurological disorders and
brain injuries.

Practical Applications:
Neuroplasticity-based rehabilitation strategies, such as constraint-induced movement therapy
(CIMT), harness the brain's adaptive capacity to promote recovery from stroke and traumatic
brain injury. Educational practices informed by neuroplasticity principles optimize learning
outcomes and cognitive development across the lifespan.

Clinical Integration:
Knowledge of neuroplasticity informs therapeutic approaches and pharmacological
interventions targeting synaptic plasticity mechanisms. Non-invasive brain stimulation
techniques offer promising avenues for modulating neuroplasticity and enhancing neural
repair in clinical populations.

Future Directions:
Continued research into neuroplasticity mechanisms holds promise for uncovering novel
therapeutic targets and advancing personalized interventions for neurological disorders.
Collaborative efforts across disciplines are essential for translating research findings into
effective treatments that enhance brain function and promote neurorecovery.

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 VII. CHALLENGES AND FUTURE DIRECTIONS

Methodological Limitations: Current research methodologies in neuroplasticity face

challenges such as reliance on animal models and interpreting complex neuroimaging data.
Addressing these limitations requires interdisciplinary collaboration and the integration of
innovative technologies.

Opportunities for Advancement: Advances in neuroimaging techniques and emerging

technologies offer opportunities for non-invasive visualization and manipulation of neural
activity. Longitudinal studies and investigations into individual variability are needed to
inform personalized therapeutic approaches.

Translational Impact: Integrating neuroplasticity principles into clinical practice holds

promise for optimizing treatment outcomes and promoting cognitive resilience. Collaborative
efforts between researchers, clinicians, educators, and policymakers are essential for
translating research findings into tangible clinical and societal benefits.

Future Directions: Future research should focus on bridging the gap between basic research
and clinical applications, elucidating the natural history of neuroplasticity, and promoting
public awareness of brain health. By fostering synergistic partnerships and promoting
innovation, the scientific community can drive transformative advances in neuroplasticity
research and its applications.

CASE STUDY: Neuroplasticity in Neurological Disorders

Neurological disorders encompass a broad spectrum of conditions characterized by

dysfunction in the nervous system, often involving disruptions in neuroplasticity
mechanisms.
Neuroplasticity plays a pivotal role in the pathophysiology, progression, and recovery of
various neurological disorders, influencing both structural and functional changes in the
brain.

Stroke: Following a stroke, neuroplasticity mechanisms are activated as the brain attempts to
reorganize and compensate for damaged areas. Synaptic plasticity, axonal sprouting, and
functional reorganization contribute to recovery processes, with rehabilitation strategies
leveraging these mechanisms to promote motor and cognitive rehabilitation.

Traumatic Brain Injury (TBI): Neuroplasticity mechanisms are mobilized in response to

traumatic brain injury, facilitating recovery and adaptation to injury-induced deficits. While
acute injury may result in widespread neuronal damage, subsequent neuroplastic changes,
including synaptic remodeling and cortical reorganization, contribute to functional recovery
over time.

Alzheimer's Disease: Alzheimer's disease is characterized by progressive neurodegeneration

and cognitive decline, with alterations in neuroplasticity implicated in disease pathogenesis.

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Disruptions in synaptic plasticity, neurogenesis, and functional connectivity contribute to
cognitive impairments, highlighting the potential therapeutic value of enhancing
neuroplasticity in Alzheimer's disease treatment.

Parkinson's Disease: Parkinson's disease involves dysfunction of dopaminergic pathways

and basal ganglia circuits, impacting neuroplasticity mechanisms involved in motor control
and learning. Therapeutic strategies targeting neuroplasticity, such as deep brain stimulation
and pharmacological interventions, aim to modulate circuitry function and alleviate motor
symptoms.

Psychiatric Disorders: Disorders such as depression, schizophrenia, and post-traumatic stress

disorder (PTSD) are associated with alterations in neuroplasticity, including changes in
synaptic connectivity and neuronal morphology.

Understanding the neuroplastic basis of psychiatric disorders may inform the development of
novel treatment approaches targeting neuroplasticity pathways.
Overall, elucidating the role of neuroplasticity in neurological disorders offers insights into
disease mechanisms and therapeutic strategies aimed at enhancing neural repair, functional
recovery, and symptom management.

VIII. CONCLUSION

In summary, neuroplasticity stands as a pivotal concept in neuroscience, illuminating the

brain's ability to adapt and rewire itself in response to various stimuli. From its historical
roots to contemporary applications, neuroplasticity has revolutionized our understanding of
brain function and holds immense promise for clinical interventions and rehabilitation
strategies.

REFERENCES

1. Maier M, Ballester BR, Verschure PFMJ. Principles of Neurorehabilitation After

Stroke Based on Motor Learning and Brain Plasticity Mechanisms. Front Syst
Neurosci. 2019;13:74. [PMC free article] [PubMed]

2. Mateos-Aparicio P, Rodríguez-Moreno A. The Impact of Studying Brain Plasticity.

Front Cell Neurosci. 2019;13:66. [PMC free article] [PubMed]

3. Brzosko Z, Mierau SB, Paulsen O. Neuromodulation of Spike-Timing-Dependent

Plasticity: Past, Present, and Future. Neuron. 2019 Aug 21;103(4):563-581. [PubMed]

4. Hara Y. Brain plasticity and rehabilitation in stroke patients. J Nippon Med Sch.
2015;82(1):4-13. [PubMed]

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 5. Berlucchi G, Buchtel HA. Neuronal plasticity: historical roots and evolution of
meaning. Exp Brain Res. 2009 Jan;192(3):307-19. [PubMed]
6. Miyamoto E. Molecular mechanism of neuronal plasticity: induction and maintenance
of long-term potentiation in the hippocampus. J Pharmacol Sci. 2006;100(5):433-42.
[PubMed]

7. Hotting K, Röder B. Beneficial effects of physical exercise on neuroplasticity and

cognition. Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2243-57. [PubMed]

8. Carrillo-Mora P, Alcantar-Shramm JM, Almaguer-Benavides KM, Macías-Gallardo

JJ, Fuentes-Bello A, Rodríguez-Barragán MA. Pharmacological Stimulation of
Neuronal Plasticity in Acquired Brain Injury. Clin Neuropharmacol. 2017
May/Jun;40(3):131-139. [PubMed]

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