22/04/2024, 13:23 (1) Vipin M.

Vashishtha on X: "#LongCOVID is believed to be an idiopathic disease resulting from chronic inflammation and …

Post

Vipin M. Vashishtha
@vipintukur

#LongCOVID is believed to be an idiopathic disease resulting from chronic

inflammation and an exaggerated immune response. Current evidence
indicates that COVID-19 has long-lasting effects on the nervous system. 1/

9:05 PM · Apr 20, 2024 · 92.9K Views

27 454 1.3K 861

Post your reply Reply

Vipin M. Vashishtha @vipintukur · Apr 20

A new study explores the mechanism of neurodegenerative diseases by
examining the main pathways of central nervous system infection of SARS-
CoV-2. 2/

1 18 138 4.5K

Vipin M. Vashishtha @vipintukur · Apr 20

Research has indicated that chronic inflammation and abnormal immune
response are the primary factors leading to neuronal damage and long-term
consequences of COVID-19. 3/

2 31 161 4.7K

Vipin M. Vashishtha @vipintukur · Apr 20

The nervous system plays a crucial role in the long-term effects of COVID-19.
Studies have shown that a significant percentage (30–80%) of COVID-19
patients have experienced neurological sequelae or changes in mental health
4/

https://twitter.com/vipintukur/status/1781745986211365057 1/4
22/04/2024, 13:23 (1) Vipin M. Vashishtha on X: "#LongCOVID is believed to be an idiopathic disease resulting from chronic inflammation and …

1 35 171 4.6K

Vipin M. Vashishtha @vipintukur · Apr 20

COVID-19 survivors with cerebrovascular or neurodegenerative diseases, such
as stroke, Alzheimer’s disease, or Parkinson’s disease, were about 40% more
likely to experience these sequelae compared to individuals without SARS-
CoV-2 infection. 5/

2 43 174 10K

Vipin M. Vashishtha @vipintukur · Apr 20

Cognitive disturbances and fatigue are particularly prominent and debilitating
symptoms of long COVID, which are also significant indicators in
neurodegenerative diseases. 6/

1 27 148 4K

Vipin M. Vashishtha @vipintukur · Apr 20

Two possible mechanisms of long-term effects on the nervous system
The SARS-CoV-2 enters human cells by interacting with specific membrane
cell receptors, such ACE2 transmembrane receptor, & activating SARS-CoV-2
spike protein through TMPRSS2) cleavage. 7/

https://twitter.com/vipintukur/status/1781745986211365057 2/4
22/04/2024, 13:23 (1) Vipin M. Vashishtha on X: "#LongCOVID is believed to be an idiopathic disease resulting from chronic inflammation and …

1 23 128 3.6K

Vipin M. Vashishtha @vipintukur · Apr 20

Evidence suggests the presence of the virus in the nervous system, with the
case of SARS-CoV-2-associated meningitis. Additionally, SARS-CoV-2 has
been detected in cerebrospinal fluid by other researchers 8/

1 26 132 3.4K

Vipin M. Vashishtha @vipintukur · Apr 20

There are 5 routes by which SARS2 enters the nervous system: through the
olfactory epithelium & spread through the olfactory nerve (1), can pass
through blood–brain barrier (2) and the lateral ventricular choroid plexus (3)
due to the interaction of inflammatory factors. 9/

4 28 136 3.2K

Vipin M. Vashishtha @vipintukur · Apr 20

Another possible route is through the microorganism gastrointestinal tract-
brain axis (4). Furthermore, the corneal epithelium of the optic nervous system
can also act as an entry point (5). 10/

https://twitter.com/vipintukur/status/1781745986211365057 3/4
22/04/2024, 13:23 (1) Vipin M. Vashishtha on X: "#LongCOVID is believed to be an idiopathic disease resulting from chronic inflammation and …

1 23 130 3K

https://twitter.com/vipintukur/status/1781745986211365057 4/4