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U4-Degree ARA Correction EN
U4-Degree ARA Correction EN
U4-Degree ARA Correction EN
CARBOHYDRATES
OUTLINE
4.1. Introduction.
4.2. Classification.
4.3. Monosaccharides.
Classification. Stereoisomers. Cyclic structures. Reducing sugars.
Sugar derivatives
4.4. Oligosaccharides. Disaccharides.
4.5. Polysaccharides
Homopolysaccharides: starch, glycogen, cellulose, chitin.
Heteropolysaccharides: peptidoglican, glycosaminoglycans,
glycoconjugates (Proteoglycans, Glycoproteins, Glycolipids).
4.6. Lectins.
4.1 INTRODUCTION:
• Polyhydroxyaldehydes or polyhydroxyketones.
• Biological roles:
- Nutrients and energy storage.
- Structural and protection roles.
- Bones lubricants.
- Cellular adhesion.
- Glycoconjugates: intracellular signalling, cell recognition.
4.2. CLASSIFICATON:
WHAT DO YOU HAVE TO KNOW?
2
2
3 3
4 4
5 5
6 6
D-Glucose D-Fructose
4.3. MONOSACCHARIDES:
Aldoses
4.3. MONOSACCHARIDES:
Ketoses
4.3. MONOSACCHARIDES:
- Which kind of enantiomers are the most frequent within the carbohydrates
group?
- How are the sugars represented by means of Fischer and Haworth projections?
4.3. MONOSACCHARIDES:
• Sugars with free anomeric carbon atoms that are reasonably good
reducing agents and will reduce hydrogen peroxide, ferricyanide or
certain metals such as Cu2+.
4.3. MONOSACCHARIDES: SUGAR DERIVATIVES
A variety of chemical and enzymatic reactions produce derivatives of the
simple sugars:
1) Reductions: alditols and deoxy sugars:
Alditols: carbonyl
group is reduced to
alcohol (-itol).
4.3. MONOSACCHARIDES: SUGAR DERIVATIVES
1) Reductions: alditols and deoxy sugars:
Aldonic
acids
Uronic
acids
Aldaric
acids
4.3. MONOSACCHARIDES: SUGAR DERIVATIVES
4) Sugar esters: Phosphate and sulphate ester of monosaccharides.
4.4. OLIGOSACCHARIDES.DISACCHARIDES.
Nonreducing
end
Reducing
end
Component of milk.
Reducing disaccharide.
Amylose Fragment
Branched point in
amylopeptin
4.5. POLYSACCHARIDES: HOMOPOLYSACCHARIDES. STARCH:
Glycogen granules
4.5. POLYSACCHARIDES: HOMOPOLYSACCHARIDES. CELLULOSE:
Cellulose microfibres
4.5. POLYSACCHARIDES: HOMOPOLYSACCHARIDES. GLYCOGEN:
• The polysaccharide is
joined to a tetrapeptide
(covalent bond).
• Lisozyme hydrolyze
the glycosidic bonds.
Oligosaccharides
O-linked Oligosaccharides
N-linked
4.5. POLYSACCHARIDES: GLYCOCONJUGATES: GLYCOPROTEINS:
• Glycoproteins structure is more complex that proteoglycans
structure.
• Localization:
• Biological advantages: