1. ______, though it also acts as a genetic 7.

In a nucleotide, a nitrogenous base

material in some viruses, mostly acts as a 1) Is linked to the OH of I’C of pentose sugar
messenger. 2) Is linked to sugar through a N-glycosidic
1) DNA linkage
2) RNA 3) Is linked to sugar to form a nucleoside
3) Proteins 4) All of the above
4) Both 1 and 2
8. Find the correct statement regarding a
2. ________ is a long polymer of polynucleotide.
deoxyribonucleotides. 1) One end has a free phosphate moiety at
1) DNA 3’ end of sugar, which is referred to as 5’-
2) RNA end of polynucleotide chain.
3) Proteins 2) One end has a free OH at 5’C of sugar,
4) Both 1 and 2 which is referred to as 5’ end .
3) The backbone is formed of sugar and
3. The length of DNA is generally defined as phosphates.
1) Number of base pairs in it 4) All of the above.
2) Number of hydrogen bonds in it
3) Number of phosphodiester bonds in it 9. Find the false statement regarding RNA.
4) Number of glycosidic bonds in it 1) Every nucleotide residue has an
additional OH group present at 3’-
4. Haploid content of human DNA is position in ribose
1) 4.6 × 106 bp 2) 5- methyl uracil is absent
2) 5386 nucleotides 3) Acidic in nature
3) 48502 bp 4) Both 2 and 3
4) 3.3 × 109 bp
10. ‘Nuclein’ was first identified in 1869 by
5. ________ is a pyrimidine. 1) James Watson and Francis Crick
1) Cytidine 2) Maurice Wilkins
2) Uracil 3) Friedrich Meischer
3) Thiamine 4) Erwin Chargaff
4) All of the above
11. Flow of information from RNA to DNA is
6. Given below are two statements called
Statement I : Cytosine is present in both 1) Transcription
DNA and RNA, while thymine is present only 2) Translation
in DNA. 3) Reverse transcription
Statement II : Uracil is present in RNA at the 4) Transition
place of thymine.
In the light of the above statements , choose 12. Given below are two statements
the correct answer from the options given Statement I : In E.coli, DNA is scattered
below: throughout the cell.
1) Both Statement I and Statement II are Statement II : In E.coli, DNA is held by some
correct. proteins with positive charges in a region
2) Both Statement I and Statement II are called nucleoli.
incorrect. In the light of the above statements , choose
3) Statement I is correct but Statement II is the correct answer from the options given
incorrect. below:
4) Statement I is incorrect but Statement II 1) Both Statement I and Statement II are
is correct. correct.
 2) Both Statement I and Statement II are
incorrect.
3) Statement I is correct but Statement II is
incorrect.
4) Statement I is incorrect but Statement II
is correct.
13. Histones are rich in
1) Arginine
2) Histamine
3) Lysine
4) Both 1 and 3
14. Given below are two statements: one is
labelled as Assertion (A) and other is labelled
as Reason (R).
Assertion (A):- The negatively charged DNA
is wrapped around the positively charged
histone octamer to form nucleosome.
Reason (R):- A typical nucleosome contains
200 bp of DNA helix.
In the light of the above statements , choose
the most appropriate answer from the
options given below:
1) Both (A) and (R) are correct and (R) is the
correct explanation of (A)
2) Both (A) and (R) are correct and (R) is not
the correct explanation of (A)
3) (A) is correct but (R) is not correct
4) (A) is not correct but (R) is correct
15. Nucleosomes constitute the repeating unit of
a structure called
1) Nucleus
2) Chromatin
3) Nucleoid
4) Chromosome
16. Which of the following statement is wrong
regarding heterochromatin?
1) Densely packed
2) Stains dark
3) Transcriptionally active
4) Both 2 and 3
17. Given below are two statements
Statement I : Discovery of nuclein by
Meischer and the proposition of principles
of inheritance by Mendel were almost at the
same time.
Statement II : S strain of streptococcus
pneumoniae does not produce pneumonia.
In the light of the above statements , choose
the correct answer from the options given
below:
1) Both Statement I and Statement II are
correct.
2) Both Statement I and Statement II are
incorrect.
3) Statement I is correct but Statement II is
incorrect.
4) Statement I is incorrect but Statement II
is correct.
18. S strain of streptococcus pneumoniae
bacteria produce
1) Smooth shiny colonies
2) A polysaccharide coat over the cell
3) A mucous coating over the cell
4) All of the above
19. Given below are two statements
Statement I : Biochemical nature of genetic
material was defined from Frederick Griffith
experiments.
Statement II : The unequivocal proof that
DNA is the genetic material came from
Meselson Stahl experiment.
In the light of the above statements , choose
the correct answer from the options given
below:
1) Both Statement I and Statement II are
correct.
2) Both Statement I and Statement II are
incorrect.
3) Statement I is correct but Statement II is
incorrect.
4) Statement I is incorrect but Statement II
is correct.
20. What is the function of deoxyribonucleoside
triphosphates during DNA replication?
1) Act as substrate
2) Enzymatic action
3) Provide energy for polymerisation
4) Both 1 and 3
21. RNA is the genetic material in
1) TMV
2) OB Bacteriophage
3) HIV
 4) All of the above 3) 20,000
4) 30,000
22. Given below are two statements: one is
labelled as Assertion (A) and other is labelled 28. How many genes are present on
as Reason (R). chromosome I ?
Assertion (A):- Both DNA and RNA have the 1) 231
ability to direct their duplication. 2) 30,000
Reason (R):- Proteins are not able to direct 3) 2968
their duplication. 4) 3164
In the light of the above statements , choose
the most appropriate answer from the 29. Human genome has _______ million bp.
options given below: 1) 231
1) Both (A) and (R) are correct and (R) is the 2) 30,000
correct explanation of (A) 3) 2968
2) Both (A) and (R) are correct and (R) is not 4) 3164
the correct explanation of (A)
3) (A) is correct but (R) is not correct 30. Commonly used hosts for cloning of DNA
4) (A) is not correct but (R) is correct fragments in HGP were
1) Bacteria and yeast
23. Find the statement that is not correct. 2) BAC
1) DNA is dependent on RNA for protein 3) YAC
synthesis 4) All of the above
2) The protein synthesis machinery has
evolved around RNA 31. Find the wrong statement regarding HGP.
3) First genetic material was DNA 1) Mega project
4) DNA replicates semiconservatively. 2) Started in may 2006
3) Closely associated with bioinformatics
24. An inheritable mutation observed in a 4) None of the above
population at high frequency is reffered to as
1) VNTR 32. _______ is a substrate for enzyme beta-
2) Mini-satellites galactosidase.
3) DNA polymorphism 1) Lactose
4) SNP 2) Repressor protein
3) Glucose
25. A VNTR is a 4) Fructose
1) Piece of RNA
2) Micro-satellite 33. All reference point while defining the
3) Mini-satellite transcription unit is made with
4) An enzyme 1) Template strand
2) Coding strand
26. How many SNPs have been identified in 3) Sense strand
human genome? 4) Both 2 and 3
1) 3164 million
2) 2.4 million 34. A transcription unit is defined primarlly by
3) 1.4 million which region in the DNA?
4) 2968 1) A promoter
2) A structural gene
27. Total number of genes in human genome are 3) A terminator
about. 4) All of the above
1) 80,000
2) 1,40,000
35. Which enzyme in prokaryotes catalyses 39. Genetic code is
polymerisation only in one direction ie. 5’ à 1) Triplet
3’. 2) Unambiguous
1) DNA polymerase 3) Universal
2) RNA polymerase I 4) All of these
3) RNA polymerase II
4) All of the above 40. CCC codes for
1) Phenylalanine
36. Given below are two statements 2) Glycine
Statement I : The promoter and the 3) Lysine
terminator flank the structural gene in a 4) Proline
transcription unit.
Statement II : Promoter is located at 5’ end 41. GGG codes for
of structural gene. 1) Phenylalanine
In the light of the above statements , choose 2) Glycine
the correct answer from the options given 3) Lysine
below: 4) Proline
1) Both Statement I and Statement II are
correct. 42. Which of the following will not cause a frame
2) Both Statement I and Statement II are shift mutation?
incorrect. 1) Insertion of 2bp
3) Statement I is correct but Statement II is 2) Deletion of 1bp
incorrect. 3) Insertion of 3bp
4) Statement I is incorrect but Statement II 4) Deletion of 2bp
is correct.
43. Which of the following reads the genetic
37. Which of the following is applicable to code on m-RNA?
prokaryotic genes? 1) Amino acids
1) Monocistronic 2) T – RNA
2) Split genes 3) Ribosome
3) Interrupted coding sequences 4) Severo Ochoa enzyme
4) None of the above
44. If two charged t-RNAs are brought close
38. Given below are two statements enough
Statement I : No complementarity exists 1) Formation of phosphodiester bond is
between nucleotides and amino acids. favoured energetically
Statement II : The process of transformation 2) Formation of peptide bond is favoured
requires transfer of genetic information energetically
from a polymer of nucleotides to synthesise 3) Formation of glycosidic bond is favoured
a polymer of amino acids. energetically
In the light of the above statements , choose 4) Formation of hydrogen bond is favoured
the correct answer from the options given energetically
below:
1) Both Statement I and Statement II are 45. The ribosome consists of
correct. 1) DNA
2) Both Statement I and Statement II are 2) RNA
incorrect. 3) Amino acids
3) Statement I is correct but Statement II is 4) Lipids
incorrect.
4) Statement I is incorrect but Statement II
is correct.
46. Even a fully processed mRNA has some
additional sequences that are not translated.
These regions are called
1) Exons
2) Introns Q. NO. Answer Q. NO. Answer
3) UTRs 1 2 26 3
4) Cistrons 2 1 27 4
3 1 28 3
47. Lac operon was elucidated by 4 4 29 4
1) Francois Jacob 5 2 30 1
2) Jacques monad 6 1 31 2
3) Alec Jeffreys 7 4 32 1
4) Both 1 and 2 8 3 33 4
9 1 34 4
48. _______ enzyme catalyses the hydrolysis of
10 3 35 1
lactose.
11 3 36 1
1) Lac z gene
12 2 37 4
2) Permease
13 4 38 1
3) Transacetylase
14 2 39 4
4) Beta-galactosidase
15 2 40 4
49. In prokaryotes, control of rate of _______ is 16 3 41 2
the predominant site for control of gene 17 3 42 3
expression. 18 4 43 2
1) Transcription 19 2 44 2
2) Translation 20 4 45 2
3) Processing of mRNA 21 4 46 3
4) All of the above 22 2 47 4
23 3 48 4
50. The lac operon consists of 24 3 49 1
1) 1 regulatory gene 25 3 50 1
2) 3 regulatory gene
3) 4 regulatory gene
4) 2 regulatory gene