Defining neuronal spike pattern behaviours

by exploring associated parameters in

Hodgkin-Huxley model

Proposed by: Mr.Kanisorn Khuphiran

Advisor: Asst. prof. Dr. Udomsilp Pinsook

Co-advisor: Dr. Thiparat Chotibutr
Neuronal spike patterns

Conveys intrinsic neuro-

computational properties

The categorization is due to

morphology. So, it might not be
exhaustive. There could be many
subtypes left to be found.

Is there another way to define

them?
 The Hodgkin-Huxley model
Contain biophysical meaning

Have 3 parameters to be fitted: m, n, h. So,

a neuron’s response (the spike train, V-t
plot) can be simulated.

Do different parameters contribute to

different spike train patterns?

How can different spike train patterns be

C = membrane capacitance
defined by the parameters?
V = membrane potential
I = injected current
g = maximum conductance What is its biophysical meaning?
E = Nernst equilibrium potential
m, n, h are probabilities of the ion gates to be opening/closing
 Genetic algorithm: flow chart

Credit: https://www.kindsonthegenius.com/basics-of-genetic-algorithm-ga-explained-in-simple-terms/
 Planning
No 2023 2024
Process
. SEP OCT NOV DEC JAN FEB MAR APR

1 Literature review

Create appropriate parameters in genetic

2
algorithm for the choice of model

Fitting the model to the publicly available

3
data of electrophysiological recordings

Evaluate parameter space occupancies of

4
different spike patterns

5 Define spike pattern behaviours

6 Attempt to find a theoretical link

7 Write a report

8 Complete project examination

 Goal Budget
1. Solve Optimization problem in Hodgkin-
1. Books and journals
Huxley model using genetic algorithm
1500 Baht
2. Define neuronal spike pattern behaviours
2. Credits for cloud services
more precisely
2500 Baht
3. Computer parts
Benefits 1000 Baht
1. Development of a more detailed theory on
the causal link between neuronal level and
network level
2. Deeper understanding of the mechanism
behind emerging neuro-computational
properties
 References
1. Lynch, E.P., Houghton, C.J.: Parameter
estimation of neuron models using in-
vitro and in-vivo electrophysiological
data. Front. Neuroinform. 9, 10 (2015)
2. De Jong, K.A.: Evolutionary
computation: a unified approach. MIT
THANKS FOR
LISTENING
Press, Cambridge (2006)
3. Izhikevich, E.M.: Dynamical systems in
neuroscience. MIT Press, Cambridge
(2007)