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EXERCISE#10
EXERCISE#10
EXERCISE#10
Exercise No. 10
Pharmacokinetic Calculations
Single Dose Administration and
Continuous and Multiple Dose Administration
Single Dose Administration occurs when the next dose of the same drug is administered
only after the drug of the previous dose is completely eliminated from the body. Multiple Dose
Administration is when a drug is given repeatedly at intervals shorter those required to
completely eliminate the drug of the previously given dose.
3. A fifty-year old male patient weighing 235 pounds was given an oral dose of Doxycycline
(0.5mg/kg) every twelve hours for one week. From the pharmacokinetic profile of the drug, it is
about 90% bioavailable and has an apparent volume of distribution of of 1.8L/kg. The
elimination half life of the drug is 24 hours. The absorption rate constant is 1.0 1/hr. From this
information calculate
a. Cmax after the first dose