PHA 619: Pharmaceutical Dosage Forms, Drug Delivery Systems, And Medical Devices

LABORATORY: STARCH GLYCERITE

UNIVERSITY OF SANTO TOMAS - FACULTY OF PHARMACY (BS PHARMACY 2026 – 1BPH)

[PREP # 26] STARCH GLYCERITE

OVERVIEW FORMULATION
I Introduction
● Glycerites INGREDIENTS ORIGINAL COMPUTED
AMOUNT AMOUNT
II Non-Aqueous Liquids: Glycerites
● Glycerin Starch 10 g 0.30 g

III Preparation #26: Starch Glycerite Benzoic acid 2g 0.06 g

INTRODUCTION Purified water 200 g (200 mL) 6.00 mL

GLYCERITES Glycerin (ρ= 700 g (560 mL)

● Solution or mixture of medicinal substances in not 1.25g/mL) 1000 g 30.00 g
less than 50% by weight
● Most glycerites are viscous while some are jelly like
● Used to prepare aqueous and alcoholic dilutions of COMPUTATIONS
substances which are readily soluble in water or Starch:
10 𝑔
alcohol 1000 𝑔
𝑥 30 𝑔 = 0. 30 𝑔
● Protectant, emollient, pill excipient, substitute for fatty
ointment Benzoic acid:
● Hygroscopic → tightly closed container 2𝑔
1000 𝑔
𝑥 30 𝑔 = 0. 06 𝑔
NON-AQUEOUS LIQUIDS: GLYCERITES
Purified water:
200 𝑚𝐿
GLYCERIN 𝑥 30 𝑔 = 6. 00 𝑚𝐿
1000 𝑔
● Glycerol also called glycerine or glycerin, is a simple
triol compound
● It is a colorless, odorless, viscous liquid that is PROCEDURE
sweet-tasting and non-toxic. 1. Weigh and measure the required amount of each
● Reducing agent ingredient
● Should not be triturated with strong oxidzing agent 2. Triturate starch
like KMnO4, chromium trioxide or KClO3 - explosion 3. Add water and glycerin to the starch and stir until a
will likely to occur homogeneous mixture is produced. Transfer the
● It produces coloration with phenol, salicylates, tannin, mixture to the final container.
etc due to contamination with iron 4. Using a sand bath, apply heat and gradually raise to
● Strong HNO3 / H2SO4 converts glycerin into an 140°C not exceeding 144°C. Stir constantly until a
explosive nitroglycerin translucent, jelly-like mass is formed.
● Soluble in water; hygroscopic
LABEL
PREPARATION # 26: STARCH GLYCERITE ● Red Label

CATEGORY CONTAINER
● Glycerites ● 30mL Wide Mouth Amber Bottle

SYNONYMS REMARKS
● Glyceratum amyli, Starch Glycerin ● The heat ruptures the starch grains & permits the
water to reach & hydrate the linear & α and β subunit
DESCRIPTION OF FINAL PRODUCT and branched starch molecules which trap the
● Translucent, jelly like mass dispersion medium in the interstices to form a gel.
● Trituration is the method used for preparation
USES ● Should always be freshly prepared and stored in a
● This product is used as a topical vehicle and tightly closed container.
protectant

DE VILLA, GRIMALDO, OLAVE, RESMA, SALVATIERRA, TAN, TERO