Professional Documents
Culture Documents
SSRN Id4771020
SSRN Id4771020
Programs Management
Valeriy Revo
Toronto - 2024
Preprint
valeri.revo@gmail.com
Acknowledgment
The author thanks his wife, Zoya Revo, for all possible support in the author’s work when
writing this article.
Funding
The author has not received support from any organization for the submitted work.
Competing Interests
ISBN 9781990242106
Abstract
Keywords: disease management, disease programs, researcher's bestiary, quantum level of the
organism, medicine of quantum processes, fundamental biological constant.
The doctor's main goal was to relieve the patient of pain and other disease
manifestations. However, this was often difficult or even impossible due to subjective and
objective circumstances.
Subjective circumstances are insufficient knowledge and skills of specialists. Objective
circumstances are, first of all, the use of an outdated natural philosophical paradigm, the basis
of which is the attitude towards illness as something initially harmful and external to the
organism. In this case, the doctor mainly paid attention to the symptoms. However, they are
only signs of a disease that do not reveal their content. However, more and more reasons have
accumulated to believe that diseases are one of the natural manifestations of the inherent
properties of living things [1, 2].
Another objective circumstance is the plurality of human diseases. This is his
phylogenetic inheritance. Indeed, disease programs arise at each stage of phylogenesis
simultaneously with the appearance of living beings at this level of systemic organization. The
number of disease programs that emerge at each stage of phylogenesis is constant [3]. Thus,
we can attribute this value to the fundamental biological constant for each stage of
phylogenesis. Living organisms that appear at the next stages of phylogenesis retain in their
phylogenetic memory all the disease programs of the previous stages.
Each disease has external manifestations in the form of its s patterns of symptoms. The
field of knowledge that studies them is pathology. This fundamental clinical discipline includes
pathological anatomy and pathological physiology. Today, some speculative constructs, such
as evidence-based medicine, deny the importance of pathological anatomy for the clinic. This
is a misconception that negatively affects the clinical thinking of practitioners [4].
Any phenomenon has a reason. As a phenomenon of Nature, disease also has an
objective reason for its occurrence both at the stage of phylogenesis and its manifestation in
the organism.
Until now, the study of disease has taken place at the phenomenological level, mainly
in the dimensional space of Newtonian physics. This approach did not allow us to understand
the nature of these natural phenomena for living things, the reason for their occurrence and the
causal mechanism. In addition, as clinical practice has shown, the presence of one disease can
block the development of another disease. Such relationships were called dystropies
(synonymous with “reverse comorbidity”). Alzheimer's disease, Parkinson's disease and
schizophrenia are some examples of dystropias [5]. In other cases, the presence of one disease
provoked and stimulated the development of another disease. For example, the clinical
manifestations of hypertension suggest that this patient also has coronary heart disease, etc.
[6]. Such relationships were called syntropic.
The noted circumstances served as the basis for attempts to use some diseases to treat
others, which were more dangerous to a given person's life. Among the most famous examples
of such “treatment” is the infection of syphilis patients with malaria. The results obtained
helped Julius Wagner-Jauregg, one of the apologists of this technique, receive the Nobel Prize
in 1927 [7].
Figure. System model of a human and a living organism of the previous stage of phylogenesis
[10]. For a system model of all stages of phylogeny, see [11].
Planck units
The dimensions of the elements of the organism and the processes occurring in it, which
are familiar to classical medicine, are within the range accessible to modern measuring
technology. However, many of them, such as spontaneous, reversible, ultra-high-frequency
conformational dynamics (hydration ⇄ dehydration) of living protein, the work of
consciousness, disease programs initiation in the phylogenetic memory organism, and other
fundamental phenomena occur in the intervals, which are designated by Planck units of
measurement. Among them are Planck time and Planck length.
Planck time (10-44 s) is the time during which light travels a path equal to the Planck
length (1,616·10-35 m). This is the shortest possible length of time during which light travels
the shortest possible distance. At this level, modern physical theories stop working. This is
especially true for biological theories since living things are always complex systems by
definition, with fuzzy properties and extremely high uncertainty [12].
As J. V. Goethe wrote (Goethe, J. W. von, 1749-1832): “… ein eingeschränktes
lebendiges Wesen teil an der Unendlichkeit oder vielmehr, es hat etwas Unendliches in sich,
wenn wir nicht lieber sagen wollen, daß wir den Begriff der Existenz und der Vollkommenheit
des eingeschränktesten lebendigen Wesens nicht ganz fassen können und es also ebenso wie
das ungeheure Ganze, in dem alle Existenzen begriffen sind, für unendlich erklären müssen”.
[13].
Among the fundamental biological phenomena, we should be interested in those that
determine the safety of life and its quality. These are, first of all, diseases that have been studied
so far at the phenomenological level.
A bestiary of transcendental experience in science (V. Revo, 2018) (from ancient Greek
δαίμων – spirit, divine power, reads as daimōn, + trans – through, on the other side, + from
Latin scandere – ascension, + … of experience in science) – definition of a hierarchical set of
transcendental entities possessing will and unlimited creativity in the area of their competence.
Since each person has in his phylogenetic memory programs of all diseases that have ever
arisen at the stages of phylogenesis, a number of fundamental questions arise regarding the
biological and physical nature of this part of existence [14]. However, researchers sometimes
do not have the opportunity to comprehend the content of the forms and principles of relations
of being for various reasons. One of them may be the lack of technical capabilities. Therefore,
they turn to a thought experiment with images of the imagination in the form of corresponding
visualized ideas and models that determine, according to I. Kant, “a priori conditions of
possible experience,” in other words, they turn to transcendental experience [15]. These
imageries are allegories of certain demons (according to J. von Goethe, 1811) [16].
I highlight thirteen of this kind's most famous thought experiments with different
hierarchical ranks [17]. These are nine demons of the inert world and four demons of the living
world. Seven demons of the inert world represent it in the quantum dimension, and two demons
represent it in the Newtonian physics dimension. Two demons of the living world represent it
in the quantum dimension, and one demon represents it in the Newtonian physics dimension.
The Leibniz demon has the highest rank among the demons of the inert world of
quantum dimension. (Leibniz G. W. von, 1710) [18]. The other demons in this group are
Laplace's demon (1814) [19], Einstein's demon (1935) [20], Schrödinger's demon (1935) [21],
Wigner's demon (1961) [22], Proietti's demon (2019) [23], and Pines' demon (1956) [24]. Two
demons of the inert world of the dimension of Newtonian physics represent Maxwell's demon
(1867) [25] and Szilard's demon (1929) [26].
Three demons represent the living world. These are two demons of the world of
quantum dimension: Revo’s demon of phylogenesis, synonymous with the demon of systemic
metamorphosis [17], which determines the transcendental imperative of the systemic
metamorphosis of the living at the stages of phylogenesis and Revo’s demon of diseases [17],
which determines the transcendental imperative, selecting from the population a specific
organism in which the program of a particular chronic disease is launched in accordance with
biopathotype [27].
Darwin's demon represents the world of living things in the dimension of Newtonian
physics. This is how Isaac Asimov (1963) outlined the transcendental imperative, which
determines the optimal conditions of natural selection according to his thought experiment [28].
Allegories of thought experiments with images of demons of various ranks contributed
to the knowledge of the fundamental principles of organizing relations in Nature at all stages
and levels of its development. The fact that the number of demons in the world of quantum
dimensions is greater than the number of demons in the world of dimensions of Newtonian
physics is the result of the work of the attractor of scientific thought in the direction of studying
Nature at the quantum level.
Already today, researchers have the opportunity to study the manifestations of life also
at its fundamental quantum level. In his works, for example, in the monograph “Prolegomena
to the Future Systemic Metamedicine” [17]. I showed that life began its development with the
appearance of protein-polypeptide complexes in narrow cracks (up to 300-600 nm) of the basalt
bottom of the warm, fresh, shallow waters of the land. It was in these first structures that an
ultra-high-frequency mechanism of spontaneous reversible conformational dynamics
(hydration ⇄ dehydration) of the protein molecule appeared. From now on, this fundamental
phenomenon became an attribute of the living, appearing at all subsequent stages of
phylogenesis. I called this mechanism the “Soul of Life” [30].
The frequency of this process (10-11-10-13 s) corresponds to the frequency of natural
vibrations of an individual water molecule near the equilibrium position. Water, which forms
the hydration shell of protein molecules, determines their electret state, generating an external
electric field (Maskarenhas S., 1975). From now on, this fundamental phenomenon has become
an attribute of living things that appear at all subsequent phylogenesis stages. I called this
mechanism the “The Soul of Life.” [30].
This feature of the hydrated form of the protein gave A. Szent–Gyorgyi grounds to
declare: “Water is life’s mater and matrix, mother and medium” [31]. Another statement of this
famous biochemist is also known: “Life is water dancing to the tune of solids” [32].
Hydration water (syn. water in the exclusion zone) is negatively charged, and the bulk
water region is positively charged [32].
The first living beings had a powerful negative charge of the hydration shell due to a
larger supply of electrons [33]. A. Chizhevsky established (1918-1920) that the conservation
of a negative charge is a fundamental attribute of life [17]. It provides energy to the primary
precellular forms of life, maintains the nonequilibrium structure of the molecular forms of the
first living beings, and prevents the clumping of protein molecules and their deposition. It also
creates its own electromagnetic field. When the first living forms appeared, those that had a
more powerful charge of the hydration shell due to a larger supply of electrons received an
advantage. Although this mechanism has been preserved in all phylogenetic subsequent forms
of life, it represents another “blind” field of biology and medicine.
In this field, other manifestations of quantum effects in the systemic organization of
living things are noted. For example, living protein molecules, when hydrated, receive energy
from the protons of hydration water; when dehydrated, this protein loses energy. These kinds
of effects are fundamental for all living organisms that appear at all subsequent phylogenetic
stages, including humans.
A. M. Gorky has a wonderful metaphor: “A hypothesis is a doggy with which they hunt
for the truth” (A. M. Gorky “The Life of Klim Samgin”, 1925–1936). This doggy led me to the
autowave hypothesis of the mechanism of intra- and inter-level interaction of complex systems
[37, 3]. This made it possible to understand the principles of the systemic organization of living
organisms and the nonlinear processes occurring in them, for example, chronic diseases.
Any living creature, which is an open nonequilibrium system, needs constant
consumption of energy, information and matter. The dynamics of energy processes are
manifested by autowaves, which are self-sustaining waves in a medium.
The systemic hierarchical structure of the internal environments of the human organism
consists of five levels, which represent the subject of studying the biodynamics of quantum
processes [36]. The activity of this environment provides a constant supply of energy. This
compensates for the loss due to its radiation into the external environment, i.e., dissipation.
These centers of excitation contribute to the release of energy stored in the environment, which
is necessary for similar processes in neighboring areas.
The propagation of an autowave through each point of the medium is ensured by the
energy available in it, so it is transmitted without attenuation and distortion. A secondary wave
that may come to this zone will not find the necessary energy in it. The same applies to
autowaves reflected from the boundaries of the medium. Unlike ordinary waves, the
characteristics of autowaves (length, amplitude, phase) depend only on the properties of the
medium of their propagation.
The systemic and subsystemic elements of any organism have wave content. This
applies to many processes in living organisms and, above all, to diseases.
Diseases, like some nonlinear processes, are capable of returning to their original, or almost
original, state.
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The organism's disease programs exhibit both informational and energetic content.
Mechanisms for ensuring security and reproduction have priority in access to energy among
all life processes in a tectologically hostile environment. The method of reproduction does not
matter.
It should be noted that during the development of the disease program, elements of the
organism of different dimensions manifest themselves differently. The unfolding of disease
programs in the organism as elements of quantum dimension has a negentropic effect. This
circumstance ensures the interests of the individual [3].
However, the development of the disease reduces its adaptive resource, which
dynamizes the trophic chain. In a tectologically hostile environment, these highlights weakened
individuals. So, at the level of the elements of the organism of the dimension of Newtonian
physics, the organism becomes a victim, and Nature excludes it from the reproductive potential
of a given species. This circumstance ensures the interests of the species.
Since the species had priority in accessing the resources of life before the advent of
man, Nature provided each chronic disease program with its own innate resource of energy,
which the organism cannot use for other purposes.
The development of civilization has changed the balance of interests of the species and
the individual in the development of chronic disease programs in favor of the individual. This
is the merit, first of all, of social institutions. Life expectancy has increased significantly, and
infant mortality has dropped sharply. However, the latter circumstance had an equally dramatic
impact on the quality of the reproductive material of the population. The change in the balance
of interests in favor of the individual has not yet reached critical levels. However, the
emergence of technologies capable of blocking the initiation and development of disease
programs will deprive the organism of access to this negentropic mechanism.
According to the second law of thermodynamics, all living things need energy in order
not to fall victim to a critical value of entropy. Therefore, when developing technologies that
will be able to block disease programs, it is necessary to proactively develop methods for
constantly monitoring the level of entropy of the organism and techniques that have
negentropic potential. They will have a physical nature and will work at the level of structures
and processes of the organism, which have a quantum dimension.
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Conclusion
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