1st edition

TM’S Pharmacology Qbank

BY NITHIN KOUSHIK & SHIVA SAI

 General pharmacology

LAQ:
• *****Explain various routes of drug
administration with their advantages and
disadvantages. Add a note on special drug
delivery system.
• *****Define biotransformation. Explain various
mechanisms of drug metabolism with examples.
• *****Define bioavailability. Explain the factors
affecting bioavailability.
• *****Describe the factors modifying drug action.
Mention their pharmacological and clinical
importance.
• Define receptor. Briefly describe the types of
receptors with examples.

SAQ:
• *****Transdermal therapeutic system with
examples
• *****First pass metabolism
• *****Apparent volume of distribution
• *****Plasma protein binding
• *****Prodrug: advantages with examples.
• ***Microsomal Enzyme induction and it’s
significance.
• ***Microsoft Enzyme inhibition and it’s
significance.
• ***First order and zero order kinetics with
examples.
• *****Define Therapeutic index. Add a note on
therapeutic drug monitoring with Indications.
• ***Fixed dose combinations( advantages and
disadvantages with examples)
 • *****Describe the methods to prolong the
duration of drug action.
• ***Ion channels
• ***G-protein coupled receptors
• *****Drug synergism with examples.
• *Management of a poisoning case.
• *****Drug antagonism with suitable examples.
• ***Define tolerance. Explain types of tolerance
with examples.
• ***Add a note on the dose response relationship.
• ***Add a note on clinical trials.
• *Drug interactions.
VSAQs:
• *Iatrogenic diseases.
• *Anaphylactic reactions.
• *Idiosyncrasy.
• ***Drug dependence.
• *****Teratogenicity and teratogenic drugs.
• *****Tachyphylaxis.
• *****Pharmacovigilance and its importance
• ***Phase III clinical trail.
• ***Good clinical practice
• *****Adverse drug effects and types.
• ***Rationale use of medicines.
• *****Plasma half life and its importance.
• ***Pharmacogenomics and pharmacogenetics.
• ***Saturation kinetics.
• *Hoffman elimination.
• *Redistribution of a drug with example.
• ***Define drug. Add a note on
pharmacokinetics and pharmacodynamics.
• ***OTC drugs
• ***Orphan drugs
• *****Concept of p drug.
 • *Placebo and its uses.
• ***Loading and maintenance dose.
• ***Mention few drug drug dosage forms.
• ***Essential medicines.
• *Schedule H drugs.
• *Mention the drugs that can be used in
pregnancy and lactation.

ANS pharmacology
LAQ:
• *****Classify sympathomimetics. Add a note on
mechanism of action of epinephrine on
cardiovascular system. Mention its uses and adverse
effects and contraindications.
• *****Classify muscarinic receptor antagonist write the
pharmacological uses of beta blockers with their
uses, adverse effects and drug interactions.
• *****Classify Anticholinergic drugs. Discuss
pharmacological actions and uses, adverse effects of
atropine. Mention about atropine poisoning and line
of treatment.

SAQ& VSAQs:
Cholinergic drugs.
• ***Pilocarpine- uses and adverse effects.
• *****Physostigmine- mode of action, uses& adverse
effects.
• *****Neostigmine- mode of action, uses.
• *****Differentiate neostigmine and physostigmine.
• *****Treatment myasthenia gravis.
• *****What are OP compounds- describe treatment
for OP poisoning.
• ***Pyridostigmine- MOA, uses and Indications.
• ***Pralidoxime- Indications and basis use
• ***Miotics with examples.

Anticholinergic drugs
• *****HYOSCINE butyl bromide -MOA, uses and
adverse effects
• *****Atropine substitutes with their uses.
• ***Contraindications of atropine. Explain Rationale.
• *****Mydriatic drugs and drugs causing mydriasis
with cycloplegia.
• *Name 6 ganglionic blocking agents.

Adrenergic drugs
• *****Dopamine-MOA, uses and adverse effects. State
reasons why is it preferred to Noradrenaline in
circulatory failure.
• ***Ephedrine-MOA, uses.
• *****Describe Dale’s vasomotor reversal.
• *****Nasal decongestants- MOA, uses and side
effects.
• *****Selective beta 2 agonist- uses, Indications and
adverse effects.
• ***Phenylephrine-MOA, uses and Indications.
• *****Adrenaline in anaphylaxis/ Treatment for
anaphylactic shock.
• *****Salbutamol/ terbutaline- MOA, uses and adverse
effects
 • ***Pharmacological basis of dopamine in cardiogenic
shock.
• *****Pharmacological basis of administering
lignocaine with adrenaline.

Antiadrenergic drugs.
• *****Selective alpha 1 blockers( prazosin)-MOA, uses,
adverse effects.
• ***Uses of phenoxybenzamine and proponolol in
preoperative preparation of patients with
Phaeochromocytoma.
• *****Therapeutic uses of alpha blockers.
• ***Advantages of atenolol over propranolol.
• ***Drug therapy for BPH.
• ***Labetolol- uses, Indications and adverse effects.
• *****Drugs used in glaucoma.

Autocoids and related drugs

LAQ:
• *****Classify NSAIDS. Explain the mode of action,
Pharmacological actions, Therapeutic uses and
adverse effects of Aspirin. Add a note on Acute
salicylate poisoning.

SAQ& VSAQ:
• ***Classify H1 blockers and mention their MOA,
Pharmacological actions, adverse effects and
Therapeutic uses.
• *****Advantages of 2nd generation H1-blockers.
• *Classify 5HT blockers
 • *****Drug therapy for migraine( ergot alkaloids and
triptans)
• *****Prophylaxis of migraine
• *****Prostaglandin analogues- Pharmacological
actions and therapeutic uses especially in
Obstetrics.
• *****Drug therapy for gout( both Acute and chronic)
• *****Allopurinol-MOA, uses, adverse effects and drug
interactions.
• *****Classify anti-rheumatoid drugs and add a note
on sulphasalazine.
• ***Diclofenac and indomethacin.
• *****Selective COX-2 inhibitors- Advantages and
disadvantages.
• ***Paracetamol – Advantages over Aspirin, uses and
Acute paracetamol poisoning.

Drugs for cough& bronchial asthma

LAQ’s:
• ***Classify the drugs used for bronchial asthma and describe
the mechanism of action, Pharmacological uses and adverse
effects of sympathomimetics (salbutamol). Add a note on
status asthmaticus.

SAQ&VSAQ:
• *****Describe the drugs used for wet and dry cough.
• *****Antitussives with examples
• ***Expectorants and mucolytics.
• *****Methylxanthines- MOA, uses, adverse effects,
drug interactions.
 • *****Leukotriene receptor antagonist( monteleukast
and zafirleukast).
• *****Mast cell stabilizers(Sodium cromoglycate)
• *****Explain the role of corticosteroids in bronchial
asthma.
• ***Describe the adverse effects and safety measures
to be followed during therapy with
budesonide( inhalational corticosteroids) in a
bronchial asthma patient.
• *Name 3 drugs to be avoided in bronchial asthma.
• *Name 3 anti-asthmatic combinations

Drugs acting on peripheral Nervous system

LAQ:
• ***Classify local anaesthetics. Describe the MOA,
pharmacokinetics and pharmacological actions, adverse
effects of lignocaine. Add a note on precautions and
interactions.

Note: This question can also be asked as SAQ.

SAQ&VSAQs:
• *****Mention the advantages, uses and complications of
spinal anaesthesia.
• *****Rationale the combination of adrenaline with lignocaine.
• *****Define EMLA and mention it’s uses.
• *****Differentiate between competitive and depolarising block
or d-TC and succinyl choline.
• *****Dantrolene- MOA, uses and side effects.
• *****Succinyl choline- MOA, adverse effects and uses.
• *****Describe briefly about succinylcholine apnoea.
• ***Compare the features of procaine and lignocaine.
• ***D-TC- MOA, uses and adverse effects.
• ***Write a note on Infiltration anaesthesia and mention 2
drugs used in this technique.
 • ***Describe the techniques of local anaesthesia with it’s uses.
• *Drug interactions of skeletal muscle relaxants.
• *Name 3 centrally acting skeletal muscle relaxants.
• *Pancuronium
• *A full term primigravida aged 28 years in labour presents for
delivery and demands relief of pain associated during labour
and delivery. O/E there are no contraindications to normal
vaginal delivery. So, which type of regional anaesthesia is
most suitable for her and explain why?

Drugs acting on CNS

General Anaesthetics
LAQ:
• *****Classify drugs used in general anaesthesia. Mention the
characteristics of general anaesthetics. And describe briefly
about the MOA, uses, adverse effects and advantages of
Thiopentone Sodium.
SAQ&VSAQ:
• *****Propofol- MOA, uses, adverse effects.
• *****Compare and contrast the features of Halothane and
Nitrous oxide.
• *****Describe briefly about the dissociative anaesthesia and
mention the MOA, salient features, uses and adverse effects
of ketamine.
• *****Rationale the basis for combining halothane and nitrous
oxide. Add a note on second gas effect.
• *****Describe the OBJECTIVES and aims of pre-anaesthetic
medication with examples.
• ***Mention the uses, adverse effects of isoflurane.

Alcohols
SAQ&VSAQ:
 • *****Treatment of chronic alcoholism. Add a note on
disulfiram therapy.
• ***Management of methanol poisoning.
• ***Management of Acute alcohol intoxication
• *Therapeutic uses of Alcohols.

Sedative-Hypnotics
SAQ&VSAQ:
• *****Classify benzodiazepines and mention MOA,
Pharmacological actions and therapeutic uses, adverse
effects of diazepam. Add a note on treatment of
benzodiazepines overdose(Flumazenil).
• *****Classify sedative-hypnotics. Describe the MOA,
Pharmacological actions, uses, adverse effects of
phenobarbitone. Add a note on treatment of Acute
barbiturate poisoning.
• *****Mention Z group of drugs( Non-benzodiazepine
hypnotics) and add a note on MOA and uses of Zopiclone.

Antiepileptic drugs
LAQ:
• *****Classify anti-epileptics. Describe the MOA,
pharmacokinetics, uses, adverse effects of phenytoin.
Mention the advantages of fosphenytoin over phenytoin.
• ***** Classify anti-epileptic drugs and mention the MOA,
pharmacokinetics, Therapeutic uses and adverse effects of
valproic acid.
SAQ&VSAQ:
• ***** Carbamazepine-MOA, pharmacokinetics, adverse
effects and uses.
• *****Describe briefly about the newer anti-epileptics and
their uses, adverse effects.
• ***** Management of status epilepticus.
• ***Drug interactions of anti epileptics.
• *Ethosuximide
• *Divalproex
 Antiparkinsonism drugs
LAQ:
• ****Classify Antiparkinsonism drugs. Describe in detail about
the MOA, Pharmacological actions, pharmacokinetics, adverse
effects, drug interactions, Therapeutic uses of Levodopa. Add
an note on on/ off phenomenon.
SAQ&VSAQ:
• ***** Dopamine receptor agonist- MOA, uses, adverse effects.
• ***** Rationale the combination of levodopa with carbidopa.
• ***** Describe the MOA, uses, adverse effects of
Selegiline( MAO-B inhibitors).
• ***** Mention the importance of Central anticholinergics in
Parkinsonism.
• *****Add a note on drug induced Parkinsonism and it’s
treatment.
• *COMT inhibitors.

Antipsychotic drugs and antimanic drugs.

LAQ:
• *****Classify neuroleptic drugs. Describe the MOA,
Pharmacological actions, uses, adverse effects of
chlorpromazine.
SAQ&VSAQ:
• *****Atypical antipsychotic- advantages.
• ***** lithium carbonate- MOA, uses, pharmacokinetics,
adverse effects, drug interactions.
• ***Haloperidol- MOA, uses, adverse effects.
• ***Treatment of schizophrenia.
• ***Drugs used for bipolar disorders and mania.
• * lysergic acid diethylamide(LSD).

Antidepressants and antianxiety drugs

LAQ:
 • *****Classify antidepressants. Describe the MOA,
Pharmacological actions, pharmacokinetics, adverse effects
and contraindications of selective serotonin reuptake
inhibitors.
• ***** Classify drugs used in mental illness and describe the
MOA, Therapeutic uses, adverse effects, drug interactions of
TCA. Add a note on tolerance and dependence.
SAQ&VSAQ:
• ***** SNRIs- MOA, Therapeutic uses, adverse effects
• ***MAO-A inhibitors
• ***Atypical antidepressants.
• ***Cheese reaction.

Opioid analgesics and antagonist

LAQ:
• *****Classify opioid analgesics. Describe the MOA,
Pharmacological actions, pharmacokinetics, adverse
effects,Therapeutic uses, contraindications of MORPHINE.
Add a note on Acute morphine poisoning.

SAQ&VSAQ:
• *****Codeine-uses, adverse effects
• *****Opioid antagonist- examples, uses and adverse effects.
• *****Pethidine- uses and adverse effects.
• ***Compare the features of morphine and pethidine.
• ***Tramadol- Actions and uses, adverse effects.
• ***Pentazocine- actions and uses, adverse effects.

Miscellaneous topics of CNS

SAQ&VSAQ:
• Mention few CNS stimulants
• Name 6 cognitive enhancers
• Amphetamine
• Treatment of anxiety disorders.
 • Name 3 drugs used in neurodegenerative disorders.
• Explain, how drugs acting on cns can lead to Drug abuse.
• Describe the process and procedure of drug deaddiction.
• Mention the drugs used for Alzheimer’s disease

Drugs acting on CVS

Drugs affecting RAAS

LAQ:
• *****Classify drugs used in Hypertension. Write in detail
about the MOA,Pharmacological actions, therapeutic uses,
adverse effects and drug interactions of captopril(ACE
inhibitors).
• *****Classify antihypertensive drugs and mention briefly
about the MOA, uses, adverse effects of telmisartan (ARBs).
Add a note on combination of ACE inhibitors with ARBs.
• ***Classify diuretics and mention the MOA, adverse effects
and advantages of diuretics in a hypertensive patient.

SAQ&VSAQ :
• *****Clonidine-MOA, Therapeutic uses, and adverse effects.
• *****Add a note on clonidine withdrawal syndrome.
• *****Write the MOA, therapeutic uses, adverse effects of
alpha methyl dopa.
• *****Describe the management of a hypertensive crisis.
• *****Sodium nitroprusside-MOA, uses and adverse effects.
• *****Mention 3 advantages of ARBS over ACE inhibitors.
• ***Enlist 3 antihypertensive drugs used in pregnancy.
• ***Describe the role of sympatholytics in Hypertension.
• *Write about the direct renin blocker and it’s adverse effects,
uses.
• ***Mention why ACE inhibitors are contraindicated in
bilateral renal artery stenosis patients.
 Antianginal drugs
LAQ:
• *****Classify antianginal drugs. Describe the MOA, therapeutic
uses, adverse effects of glyceryl trinitrate ( Nitrates). Add a
note on combination therapy in angina.
• *****Classify calcium channel blockers and describe the MOA,
Pharmacological actions, therapeutic uses and adverse
effects of verapamil.

SAQ&VSAQ :
• *****Describe the Drug therapy in myocardial infarction.
• *****Nicorandil- MOA, uses, adverse effects.
• *****Treatment of cyanide poisoning.
• *****Therapeutic uses of Nitrates.
• ***Nifedipine- MOA, uses, adverse effects.
• ***Name 6 drugs useful in peripheral vascular diseases.

Drugs for heart failure

LAQ:
• *****Classify drugs used for congestive heart failure. Write in
detail about the MOA, pharmacological actions, therapeutic
uses, adverse effects and drug interactions of digoxin. Add a
note on Digoxin toxicity.

SAQ&VSAQ :
• *****Describe the role of diuretics in a CHF patient.
• *****Describe the role of vasodilators in heart failure.
• *****Write the adverse effects of cardiac Glycosides in CHF.
• ***Depict the role of dopamine in CHF.
• ***Illustrate the pattern of clinical use of various classes of
drugs in different stages of heart failure.
 • *****Aldosterone antagonist- MOA, uses, adverse effects with
examples.
• *****Enumerate 6 drugs used in heart failure.
• *****Explain why intravenous lignocaine is the Drug of choice
in case of digoxin toxicity.
• ***Digibind
• ***PDE 3 inhibitors.

Antiarrhythmic drugs
LAQ:
• *****Classify Antiarrhythmic drugs. Write in detail about the
the MOA, Pharmacological actions, pharmacokinetics,
therapeutic uses, adverse effects, drug interactions of
Amiodarone.

SAQ&VSAQ:
• *****Quinidine- MOA, Pharmacological actions,
pharmacokinetics, therapeutic uses adverse effects and drug
interactions.
• *****Describe in detail about the Pharmacological actions,
pharmacokinetics, adverse effects and uses of lignocaine in
cardiac arrhythmia.
• ***Describe the role of verapamil in ventricular arrhythmia.
• ***Drugs for supraventricular arrhythmia.
• ***Adenosine- MOA, adverse effects, drug interactions and
disadvantages.
• *Procainamide-MOA, pharmacokinetics, adverse effects and
uses.
• *Name 3 drugs for paroxysmal supraventricular tachycardia.
• *Name 3 drugs for ventricular tachycardia and atrial
fibrillation.
Drugs acting on kidney
LAQ:
 • *****Classify diuretics. Describe briefly about the
MOA, Pharmacological actions, therapeutic uses and
adverse effects of loop diuretics. Add a note on its
drug interactions.

SAQ&VSAQS:
• *****Describe the MOA, Pharmacological actions,
pharmacokinetics, therapeutic uses and adverse
effects of thiazide diuretics.
• ***Osmotic diuretics - mannitol
• *****Spironolactone- MOA, uses and adverse effects
• *****Acetazolamide- MOA, uses and adverse effects
• ***Amiloride
• *****Rationale the combination of furosemide with
Spironolactone.
• *****Vasopression analogues- examples,
Pharmacological actions and uses with adverse
effects
• *****Treatment for Diabetes insipidus
• *Treatment for SIADH

Drugs acting on GIT

Drugs for peptic ulcer&GERD

LAQ:
• *****Classify the drugs used for peptic ulcer disease. Write in
detail about the MOA, uses, pharmacokinetics,
Pharmacological actions, adverse effects of proton pump
inhibitors.

SAQ&VSAQs:
• *****Rantidine- MOA, uses, pharmacokinetics & adverse
effects
 • *****Enumerate the anti-H.pylori regimens.
• *****Pantoprazole- MOA, uses, advantages, adverse effects.
• *****Differentiate between cimetidine and rantidine.
• *****Add a note on sucralfate.
• ***What are anatacids? Explain with examples.
• ***Describe the advantages and disadvantages of combining
antacids.
• ***Colloidal bismuth subcitrate
• ***Name 6 drugs used in GERD.
• ***Drugs for dissolving gall stones.

Antiemetic,prokinetic and digestant drugs

SAQ&VSAQs:
• Classify antiemetics. Write in brief about the mechanism of
action and adverse effects of Antiemetics.
• Metoclopramide- MOA, therapeutic uses, adverse effects.
• Ondansetron- MOA, therapeutic uses, adverse effects
• Mention the role of neuroleptics as antiemetics.
• Name 6 prokinetic agents.
• Name 6 antiemetics.
• Name 3 digestants.

Note- Read all questions

Drugs for constipation and diarrhoea

SAQ&VSAQS:
• Define laxatives and mention their MOA, therapeutic uses
and adverse effects.
• Classify drugs used for diarrhoea and mention the role of
probiotics in diarrhoea.
• Antimotility and antisecretory agents.
• Role of zinc in paediatric diarrhoea.
• Osmotic laxatives- MOA, therapeutic uses, adverse effects.
Liquid paraffin- MOA, therapeutic uses and adverse effects.
• Bisacodyl- MOA, uses and adverse effects
• Stool softeners
 • ORS- composition, preparation and Indications
• Pharmacotherapy for IBD.
• Treatment for diarrhoea

Note- Read all questions.

Drugs affecting coagulation

, bleeding and thrombosis
LAQ:
• *****Classify Anticoagulants. Describe in detail about the
MOA, therapeutic uses, adverse effects and contraindications
of unfractionated Heparin. Add a note on heparin overdose.
SAQ&VSAQS:
• *****Add a note on low molecular weight heparins with
examples.Mention their advantages.
• *****Differentiate between heparin and warfarin.
• *****Write in detail about the MOA, pharmacokinetics,
adverse effects, drug interactions and therapeutic uses of
Oral Anticoagulants.
• *****Fibrinolytic agents- uses, contraindications, examples.
• *****Describe the MOA, therapeutic uses and adverse effects
of streptokinase.
• ***Anti-platelet drugs and their uses.
• ***Name 3 antifibrinolytic drugs.
• *Name 6 contraindications of thrombolytic therapy.
• *Alteplase and teneteplase.

Haematinics and erythropoietin

SAQ&VSAQ:
• *****Preparations of Iron and therapeutic uses of iron
• *****Parenteral iron preparations and Indications.
• *****Management of Acute iron poisoning.
• *Vit-B12 uses, preparations.
• *Folic acid- preparations, uses.
• *Haematopoietic growth factors.
 • *Erythropoietin- uses, adverse effects and preparations.

Hormones and related drugs

LAQ:
• *****Classify corticosteroids. Describe the MOA,
Pharmacological actions, adverse effects and Therapeutic
uses. Mention few relative contraindications for steroid
therapy.
• *****A) Classify different types of insulin preparations.
B) Describe the MOA, Pharmacological actions
C) Describe the Indications and complications of insulin
therapy. Add a note on insulin resistance.
D) Describe the treatment for DKA.

• *****Classify oral hypoglycaemic drugs

I) Describe the MOA, adverse effects and drug
interactions of chlorpropramide.
II) Write in brief about the metformin and its adverse
effects.
III) Describe the MOA of sitagliptin
IV) GLP-I analogues and alpha-glucosidase inhibitors.
SAQ&VSAQs:
• ***Drugs used in acromegaly
• ***GnRH analogues and its uses.
• *****Bromocriptine- MOA, Pharmacological actions, uses and
adverse effects.
• *****Thyroid hormone preparations.
• *****Propylthiouracil v/s carbimazole
• *****Radioactive iodine- preparations, uses, contraindications,
advantages and disadvantages.
• *****Treatment for thyrotoxic crisis.
• ***Anabolic steroids- examples, uses and adverse effects.
• *Antiandrogens- examples, uses and adverse effects.
• ***Therapeutic uses and adverse effects of oestrogens.
• *****Antioestrogens/SERMS.
 • *****Clomiphene citrate-MOA, pharmacokinetics, uses,
adverse effects.
• *****Tamoxifen v/s raloxifene
• *****Ormeloxifene/ centchroman
• *Aromatase inhibitors.
• *Synthetic progestins
• *****Mifepristone- MOA, uses, adverse effects.
• *****Oral contraceptive pills(Total)
• ***Minipill
• ***Emergency contraceptive pills
• ***Parenteral contraceptive measures.
• ***Adverse effects of hormonal Contraceptives
• ***Prednisolone
• *****Adverse effects of glucocorticoids
• *****Therapeutic uses of corticosteriods.
• *****Insulin preparations
• *****Insulin analogues
• *****Management of Diabetic ketoacidosis
• ***Complications of insulin therapy
• *****Sulphonylureas-MOA, uses, adverse effects, drug
interactions.
• *****Alpha glucosidase inhibitors
• ***Sitagliptin
• ***SGLT2 inhibitors.
• ***Calcitonin- Pharmacological actions, uses, preparations.
• *****Vit-D – preparations, therapeutic uses.
• *****Bisphosphonates- MOA, uses, adverse effects.

Chemotherapy
Antimicrobials-general considerations
SAQ &VSAQs:
• Antimicrobial resistance
 • Super infections
• Advantages and disadvantages of antimicrobial
combinations.
• Prophylaxis of surgical site infections.
• Add a note on chemoprophylaxis

Sulphonamides ,cotrimaoxazole,quinolones
SAQ&VSAQS:
• *****Classify Sulphonamides and write about its
MOA, uses, antibacterial spectrum and adverse
effects.
• *****Cotrimoxazole- MOA, spectrum of action,
adverse effects and therapeutic uses.Add a note on
its preparations.
• *****Ciprofloxacin- MOA, pharmacokinetics,
therapeutic uses and adverse effects.
• ***Drug therapy for typhoid fever.
• ***Ofloxacin

Beta lactam antibiotics

LAQ:
• *****Classify beta lactam antibiotics. Describe briefly
the MOA, pharmacokinetics, adverse effects and
therapeutic uses of penicillin.
• *****Classify cephalosporins. Describe the MOA,
adverse effects, Therapeutic uses of cephalosporins.
SAQ&VSAQS:
• *****Third generation cephalosporins
• ***Differentiate between Ampicillin and Amoxicillin.
• *****Beta lactamase inhibitors and their uses
• *****Benzathine penicillin G
 • *****Treatment of anaphylactic shock
• *****Amoxicillin
• *****Rationale the combination of Amoxicillin with
clavulanic acid.
• ***Cilastatin
• ***Uses of carbepenems

Aminoglycoside antibiotics
LAQ:
• *****Describe the properties of aminoglycosides and
write in detail about the MOA, adverse effects,
Therapeutic uses.
SAQ&VSAQS:
• *****Gentamicin- therapeutic uses and adverse
effects
• *****Streptomycin
• ***Neomycin
• ***Soframycin

Tetracycline and chloramphenicol

SAQ&VSAQS:
• *****Tetracycline- MOA, Pharmacological actions,
pharmacokinetics, therapeutic uses and adverse
effects.
• *****Doxycycline
• *****Advantages of doxycycline over tetracycline
• *****Chloramphenicol- MOA, pharmacokinetics,
therapeutic uses and adverse effects.
 • *****Effect of tetracycline on bones and teeth of
children

Macrolides,lincosamide,glycopeptide and other

antibacterial agents.
SAQ&VSAQS:
• *****Erythromycin- MOA, pharmacokinetics, adverse
effects and therapeutic uses.
• *****Azithromycin- MOA, antibacterial spectrum and
therapeutic uses.
• *****Clarithromycin- MOA, therapeutic uses, adverse
effects.
• ***Vancomycin
• *****Name 3 urinary antiseptics
• ***Nitrofurantoin
• *****Treatment for UTI
• ***Drugs used to treat gonorrhoea
• ***Drug therapy for syphilis
• ***Antipseudomonal agents
• ***Drugs used in anaerobic infections
• ***Drugs acting on MRSA
•
Anti-tubercular agents
LAQ:
• *****Classify anti-tubercular Drugs. Describe the
MOA, Pharmacological actions, pharmacokinetics,
therapeutic uses and adverse effects of INH. Add a
note on short course chemotherapy of TB
• *****Classify drugs useful in treating TB. Describe the
MOA, pharmacokinetics, uses and adverse effects of
rifampicin. Add a note on DOTS
SAQ&VSAQS:
 • ***Pyrazinamide
• *****Treatment of MDR-TB
• *****RNTCP guidelines of Treatment for TB
• ***Chemoprophylaxis of TB
• ***Treatment regimens of TB
• ***Newer anti-TB Drugs

Antileprotic drugs
SAQ&VSAQS:
• *****Classify Antileprotic drugs. Describe the MOA,
pharmacokinetics, therapeutic uses and adverse
effects of Dapsone.
• *****Clofazimine- MOA, therapeutic uses and adverse
effects
• ***Treatment schedules for leprosy
• ***Multi-drug therapy of leprosy
• *****Lepra reactions

Anti-fungal drugs
LAQ:
• *****Classify anti fungal drugs. Describe MOA,
pharmacokinetics, therapeutic uses, adverse effects
and drug interactions of Amphotericin B. Add a note
on treatment for Systemic mycoses.
SAQ&VSAQS
• *****Ketoconazole- MOA, adverse effects and
therapeutic uses.Add a note on its drug interactions.
• *****Fluconazole- MOA, therapeutic uses and adverse
effects.
• *****Itraconazole- MOA, adverse effects and uses
• *****Terbinafine
 • *****Clotrimazole
• *****Topical Anti-fungal agents.
• ***Whitefield’s ointment

Antiviral drugs
SAQ&VSAQS:
• ***Classify anti viral drugs
• *****Acyclovir- MOA, uses and adverse effects
• ***Name 6 Antiherpes agents
• ***Name 6 Anti hepatitis drugs
• *****Classify anti retroviral drugs
• *****Nucleoside reverse transcriptase inhibitors
• *****Zidovudine- MOA, therapeutic uses and adverse
effects
• *****Protease inhibitors
• *****Post exposure prophylaxis of HIV infection.
• ***Describe briefly about HAART
• *Treatment of a HIV positive pregnant women.

Antiparasitic agents
LAQ:
• *****Classify antimalarial drugs. Write briefly about
the MOA, adverse effects and therapeutic uses of
Artemisinin. Add a note on artemisinin based
combination therapy (ACT)
• *****Classify antimalarial drugs and describe the
MOA, adverse effects, therapeutic uses of
chloroquine. Add a note on treatment for
chloroquine resistant malaria.
• *****Classify anti ameobic drugs and describe the
MOA, therapeutic uses, drug interactions and
adverse effects of metronidazole. Name few
nitroimidazole drugs.
SAQ&VSAQS :
• *****Pyrimethamine-MOA, preparations, therapeutic
uses and adverse effects.
• *****Primaquine- MOA, pharmacokinetics, adverse
effects and therapeutic uses.
• ***Treatment of malaria during pregnancy
• *****Diloxanide furoate
• ***Treatment of amoebic Dysentery
• *****Classify antiheminthic drugs
• *****Mebendazole-MOA, pharmacokinetics, uses and
adverse effects
• *****Albendazole- MOA, pharmacokinetics, adverse
effects and uses.
• *****Explain the advantages of albendazole over
mebendazole.
• *****Diethylcarbamazine citrate-MOA, adverse
effects and uses.
• *****Ivermectin- MOA, therapeutic uses and adverse
effects
• ***Praziquantel- MOA, therapeutic uses and adverse
effects.

Anticancer drugs
SAQ&VSAQS:
• *****Classify anticancer drugs.
• *****Alkylating agents-MOA, pharmacokinetics,
adverse effects and uses.
• *****MESNA
• *****Cisplatin
• *****Methotrexate- MOA, adverse effects and uses.
• *****Purine antagonist
• *****Vinca alkaloids
 • *****Describe the drugs used to ameliorate toxicities
due to anticancer drugs

Miscellaneous
SAQ&VSAQS:
• *****Dimercaprol- MOA, therapeutic uses and
adverse effects
• ***Classify immusuppresants.
• *****Cyclosporine- MOA, uses and adverse effects
• *****Chelating agents with examples
• *****Desferroxamine
• ***D-pencillamine
• ***Tacrolimus
• ***Azathioprine
• *****Cyclophosphamide
• *****TNF-Alpha inhibitors
• *Interferon alpha
• ***Name 3 immunostimulants
• ***Name 6 antiseptics and disinfectants
• *Metallic salts uses
• *****Vit D analogues
• *Name 3 live vaccines and 3 Inactivated vaccines es
• ***Astringents
• ***Name 3 drugs used for psoriasis
• *Name the drugs used in skin disorders
• ***Mention 6 drugs used for acne
• ***Drug therapy for Scabies
• *Retinoic acid
• *Name 6 drugs useful in pregnancy without any side
effects
• *Name few drugs used for criminal offences
• *****Name 3 plasma expanders
• *Name few pesticides harmful to man
• *Add a note on food adulteration
• ***Name 6 herbal medicines
• ***Add a note on good clinical Practice.