WRITE THESE IN FORMAL NOTEBOOK

Sl.No. Name of the Scientist Contribution/s

1 George Gamow
2 Marshal Nirenberg
3 Har Gobind Khorana
4 Severo Ochoa

CHALLENGE 1
1)Following are the features of genetic code. What does each one indicates?
Stop codon; Unambiguous codon, Degenerate codon; Universal codon.

CHALLENGE 2
2)If following is the sequence of nucleotides in mRNA, predict the sequence of amino
acids coded by it (take help of the checkerboard).
AUG UUU UUC UUC UUU UUU UUC.
Now try the opposite. Following is the sequence of amino acids coded by the mRNA.
Predict the sequence of nucleotides in the RNA.
Do you face any difficulty in predicting the opposite?
Can you now correlate which two properties of genetic code you have learnt?

CHALLENGE 3
3) Given below are the sequences of nucleotides in a particular mRNA and amino acids
coded by it.
UUU AUG UUC GAG UUA GUG UAA
Phe - Met - Phe - Glu - Leu – Val
Write the properties of genetic code that can be and that cannot be correlated from
the above given data.

HOMEWORK

1. 1a) Name the scientist, who suggested that the genetic code should be made of a
combination of three nucleotides.
b) Explain the basis on which he arrived at this conclusion.
2. a) Why is tRNA called as an adaptor?
b) Draw and label a secondary structure of tRNA. How does the actual structure of
tRNA look like?