SUMMER INTERNSHIP TRAINING

INTERNSHIP TRAINING REPORT

Submitted by

HEMA.S
Register No: 920221631018

In partial fulfillment for the award of the degree

Of

MASTHER OF BUSINESS ADMINISTRATION

In

DEPARTMENT OF MANAGEMENT STUDIES

PULIYUR C.F., KARUR DISTRICT- 639114

OCTOBER 2021
 Department of Management studies
INTERNSHIP TRAINING REPORT
AUGUST 2021
This is to certify that the internship training undergone at

“BIO TRANS PHARMACEUTICALS PRIVATE LIMITED, CHENNAI”

is the bonafide work done by

HEMA.S
Register No: 920221631018

of Master of Business Administration during the year 2021-2023.

--------------------- ------------------------
Guide Head of the Department

Submitted for the Viva-Voce examination held on _____________

----------------------------- ----------------------------
Internal Examiner External Examiner
 DECLARATION

I HEMA.S affirm that the Internship Training report undergone at BIO TRANS
PHARMACEUTICALS PRIVATE LIMITED, CHENNAI being submitted in partial
fulfillment for the award of Master of Business Administration is the original work carried out
by me. It has not formed the part of any other report submitted for award of any degree or
diploma, either in this or any other University.

Signature of the Candidate

HEMA.S

I certify that the declaration made above by the candidate is true

DATE: Signature of the Guide,

PLACE:
 ACKNOWLEGEMENT

It is my great feeling of happiness to place on record my deep sense of gratitude to our principal
Dr.A.PUNITHA, for having offering this type of program as a part of this curriculum.

I am very grateful and highly indebted to my guide and Head of Department of Management
Studies, Chettinad College of Engineering and Technology, for his valuable guidance to rendered
during the course of my training Dr.S. Dharmalingam.

I am happy to extend my sincere thanks to HR Manager of BIO TRANS PHARMACEUTICALS

PRIVATE LIMITED, CHENNAI, for providing this opportunity to work under them. I have to
pay my special tribute to them for their enlightened guidance provided to me during the training
program. It is my duty to express my sincere thanks to all the employees for their excellent co-
operation extended to me throughout the training program.

I wish to thank my parents and guide for their valuable support during my training.
 TABLE OF CONTENTS

S.NO CHAPTERS PAGE NO

1 INTRODUCTION 1

1.1 Profile of the Industry 2

1.2 Evolution Pharmaceutical Industry in India 3

1.3 Pharmaceutical Market – an overview 4

1.4 Profile of the Company 5

2 FUNCTIONAL DEPARTMENTS 6

2.1 Purchase Department 6

2.2 Sales Department 7

2.3 Finance Department 7

2.4 Human Resource Department 10

2.5 Quality Control Department 10

2.6 Production Department 14

2.7 Packaging Department 20

2.8 Research, Formulation & Development Department 24

3 ANALYSIS - SWOT 25

4 PRODUCT PROFILE 30

5 CONCLUSION 32
 ABSTRACT

The BIO TRANS PHARMACEUTICAL PRIVATE LIMITED is an organization which I had

done my institutional training is very useful for my carrier. And I had now known about the
operational process to exporting procedures from this organization.

Internship training is an integral part of MBA program, because it gives us the practical
knowledge of what we have learnt during our study period. But practical knowledge is also
necessary along with the theoretical knowledge. One can see how the theories and knowledge are
being practically implemented. This report is about a pharmaceutical company. This report
carried the information about all departments in the organization and necessary information’s of
the company.

Training is the process of learning a sequence of programmed behavior. It is an application of

knowledge. It gives people an awareness of the rules and procedures to guide their behaviour.
Development is a related process. It covers not only those activities which improved job
performance, but also those which bring development of their personalities to help individual’s
progress towards the actualization of their potential capabilities. Education is the understanding
and interpretation of knowledge. Education imparts qualities of mind and character and
understanding of basic principles and develops the capacities of analysis, synthesis and
objectives.
 CHAPTER 1
INTRODUCTION
The pharmaceutical industry plays a significant role in developing
vaccines and medications for prevention and reduction in disease incidence, treatment of
ailments and enhancement in quality of life by contributing to innovative research and engaging
in technological advancements to meet the complex healthcare demands of the population. The
main goal of this industry is to provide drugs to maintain health or prevent infections and cure
diseases affecting the global population. The pharmaceutical industry within the healthcare
sector comprises of different subfields of development, manufacturing or production and
marketing of medications by drug manufacturers or marketers and biotechnology companies.
The discovery, development, production and marketing of pharmaceutical drugs or vaccines as
medications administered to patients aims to prevent, cure or alleviate the symptoms of different
diseases. Health supplements reduce the chance of getting sick and meet daily nutritional
requirement of vitamins and minerals.

Modern technologies and scientific advances accelerate the discovery and

development of innovative pharmaceuticals with reduced side effects and improved therapeutic
activity. Most of the drugs investigated for use in humans undergo pre-clinical development,
clinical trials and safety surveillance or monitoring to determine the safety and efficacy before
approval and launch into the market. This industry includes number of regulatory bodies that
monitor patents, drug safety, quality and pricing of drugs. Many dynamic scientific, legislative,
regulatory, political, social and economic factors affect the pharmaceutical industry. Practicing
physicians and pharmacists; academic, government and industry scientists in hospitals, clinics,
pharmacies and private organizations can influence the pharmaceutical industry. Medicinal
chemists, molecular biologists and pharmacists can help increase potency and specificity to
improve the benefits associated with the pharmaceutical drugs.

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1.1 PROFILE OF THE INDUSTRY:
India is the largest provider of generic drugs globally and is known for its
affordable vaccines and generic medications. The Indian Pharmaceutical industry is currently
ranked third in pharmaceutical production by volume after evolving over time into a thriving
industry growing at a CAGR of 9.43% since the past nine years. Generic drugs, over-the-counter
medications, bulk drugs, vaccines, contract research & manufacturing, biosimilars, and biologics
are some of the major segments of the Indian pharma industry. India has the most number of
pharmaceutical manufacturing facilities that are in compliance with the US Food and Drug
Administration (USFDA) and has 500 API producers that make for around 8% of the worldwide
API market.

Indian pharmaceutical sector supplies over 50% of global demand for

various vaccines, 40% of generic demand in the US and 25% of all medicine in the UK. The
domestic pharmaceutical industry includes a network of 3,000 drug companies and 10,500
manufacturing units. India enjoys an important position in the global pharmaceuticals sector. The
country also has a large pool of scientists and engineers with a potential to steer the industry
ahead to greater heights. Presently, over 80% of the antiretroviral drugs used globally to combat
AIDS (Acquired Immune Deficiency Syndrome) are supplied by Indian pharmaceutical firms.
India is rightfully known as the "pharmacy of the world" due to the low cost and high quality of
its medicines.

India is the 12th largest exporter of medical goods in the world. Indian
drugs are exported to more than 200 countries in the world, with US being the key market.
Generic drugs account for 20% of the global export in terms of volume, making the country the
largest provider of generic medicines globally. Indian drug & pharmaceutical exports stood at
US$ 24.60 billion in FY22 and US$ 24.44 billion in FY21. Indian drug & pharmaceutical
exports stood at US$ 2,119.08 million in June 2022.

2
1.2 EVOLUTION OF PHARMACEUTICAL INDUSTRY IN INDIA:

India is a significant player in the global medicines industry. In addition,

the country holds a large number of scientists and engineers that can propel the sector forward to
even greater heights. In the manufacturing of generic medicines around the world, India takes the
first place. The Indian pharmaceutical business supplies 50% of global demand for a variety of
vaccines, 40% of generic demand in the United States, and 25% of all medication in the United
Kingdom. As of April this year, the moving annual turnover was Rs.1.52 trillion, up from
Rs.1.43 trillion in April 2020. The domestic pharmaceutical industry’s yearly revenue was Rs.1.3
trillion in April 2019.

Over the last few decades, the Indian pharmaceutical industry has
experienced rapid expansion, which may be divided into four stages. We can consider the time
before 1970 as the first stage of the pharma industry. At that time, the Indian market was
dominated by foreign companies. The second stage covers 1970 to 1990 when several domestic
companies began operations. 1990 to 2010 is the third stage, where liberalization led Indian
components to launch operations in foreign countries.

The introduction of the patent bill was one of the first advancements in the
pharma industry. The patent bill was proposed for the first time in 1970. The bill allowed the
Indian pharmaceutical sector to become less reliant on intellectual property laws in the United
States.

3
1.3 PHARMACEUTICAL MARKET – AN OVERVIEW:

The evident spread of several major infections and diseases will impact
the global pharmaceutical market with expected growth of $1.3 trillion by 2020. Some of the
trends visible in the pharmaceutical industry include greater pressure on healthcare budget
enforced by rising incidence of chronic diseases; demand for medicines in emerging economies
found more compared to industrialized economies; regulators have become more cautious about
approving new and innovative medicines; rising customer expectations continue to challenge
innovative medicines; increase in new clinically and economically feasible alternative therapies.
The growth in pharmaceutical market is seen in expansion of medical infrastructure; doubling of
disposable incomes among a number of middle-class households; greater penetration of health
insurance; rising prevalence of diseases; aggressive market penetration and adoption of product
patents driven by the relatively smaller companies.

The average human lifespan is exposed to more infections and diseases that require preventive
approaches to maintain health and increased research to improve quality of life among the
population. Hectic daily schedules, lack of exercise and sleep, unhealthy eating habits and other
lifestyle choices has resulted in poor digestion, high obesity rates, breathing difficulties and other
health problems. Globalization and urbanization are major driving forces in the growing demand
for health supplements and improved medications. Rising number of chronic diseases have made
people become more dependent on health supplements and medications. The benefits of
therapies and diagnosis influence pharmaceutical companies towards research and development
to support patients with accurate dose, convenience and compliance to medication regimen with
increase in the incidence of chronic diseases and technological advancements.

4
1.4 PROFILE OF THE COMPANY:
Bio Trans Pharmaceuticals Private Limited is situated at Chennai, Tamil
Nadu is a manufacturer of pharmaceuticals products for more than 3 decades which is classified
as small medium enterprises and is registered under the registrar of companies, Chennai. The
company was established in the year 1989. The company is producing and manufacturing more
than 300 products.

Name of the company Bio Trans Pharmaceuticals Private Limited

Year of establishment 23 November 1989

Head Quarters Chennai

Ramakrishna Meda
Key People Meda Manjula Rao
Meda Malleswara Rao
Age of the company 32 years 8months 26 days

Class of the company Privately held company

Bio Trans Pharmaceuticals in Ayanambakkam, Chennai is known to

satisfactorily cater to the demands of its customer base. It stands located at new no 112, near
Kone Elevations, Vanagaram road, Ayanambakkam 600095. The company has earned stamps
like JdVerified, JdPay substantiating the credentials of the business. The business strives to make
for a positive experience through its offerings.

Customer centricity is at the core of Bio Trans Pharmaceuticals and it is

this belief that has led the business to build long term relationships. Ensuring a positive customer
experience, making available goods and services that are of top notch quality is given prime
importance.
5
 CHAPTER 2
FUNCTIONAL DEPARTMENTS

2.1 PURCHASE DEPARTMENT:

Purchasing or procuring is the formal process of buying the raw materials.
The process of purchase usually starts with a demand or requirements from the production
department.

Based on requirement of production department a request for proposal or

quotation raised to Suppliers and send their quotations in response to the request for quotation
and a review is undertaken before the purchase is being made. Purchase department is also
concerned with the function like evaluating suppliers, negotiate contracts and review product
quality.

The purchase department in the pharmaceuticals is concerned with the

procurement of raw materials, dilutes and packing materials. The maintenance of inward and
outward ledger for raw materials and raw material ledgers are also practiced in the company for
ease of calculating the inventories and inflow & outflow of the raw materials in stock. The
purchase department is concerned with commercial practice, however Good Manufacturing
Practice (GMP) requirement should be taken care by this department as follows,

 Vendor identification

 Procurement of the required material from the approved vendor list.

 Ensure material availability as per production planning.

 Communicate and coordinate with vendor audit and at the time of complaint regarding
the material or the product which is manufactured using the material supplied by the
vendor.

6
 Purchase departments help keep organizations financially healthy. They
procure goods and services designed to meet operational needs while providing the highest
possible value.

2.2 SALES DEPARTMENT:

The sales department in the company is responsible for selling products

for the company. A sales department is the direct link between a company’s product and its
customers. The sales department is responsible for the selling of the company’s products to the
clients and receiving the value for the products. The sales department is also concerned with the
certain functions like selling items to pharmacies and hospitals based on their needs and
delivering the samples to the entities that are serious about purchasing the company’s medicines.
In Pharmaceutical Sector, Sale is an important aspect like other businesses but methods and
customer type is different as compare to other sectors. In pharmaceutical Sector, Doctors are
primary customer and prescription is main source of sale.

2.3 FINANCE DEPARTMENT:

Finance department is the pivot of the organization as it is responsible for

obtaining and handling any monies on behalf of organization. The department controls the
income and expenditure in addition to ensuring effective business running with minimum
disruptions. It is the duty of the finance department to advice companies on the best financing
mix that could yield the company the best profit. Finance Department is the part of an
organization that is responsible for acquiring funds for the firm, managing funds within the
organization and planning for the expenditure of funds on various assets. It is the part of an
organization that ensures efficient financial management and financial control necessary to
support all business activities. The contributions of finance department to any company and how
these contributions positively affect organizational performance will greatly depend on factors
such as the extent to which the owner/ manager is involved in his company. The roles and
responsibilities of a finance department include but are not limited to:

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2.3.1 BOOK KEEPING:

This is the most basic function of the finance department. It involves the
day-to-day recording, analysis and interpretation of a company’s financial transactions. This will
include the tracking of all expenses (purchases, payments etc.) and sales of finished products. In
some startup companies, this role is often carried out by a bookkeeper who might be replaced by
more specialized payables and receivables clerks as the company grows or expands its
operations.

2.3.2 MANAGEMENT OF COMPANY’S CASHFLOW:

It is the duty of the finance department to manage all cash flows into and
out of a company and ensure that there are enough funds available to meet the day-to-day
running of the company. This area also encompasses the credit and collections policies for the
company’s customers, to ensure that vendors and creditors are paid correctly and on time; and
that the company is also paid correctly and as when due.

2.3.3 BUDGETS AND FORECASTING:

In this function, the finance department works with managers to prepare

the company’s budgets and forecasts and also give feedback with regards to the financial
standing of the company. This information can be used to fulfil the cash needs of each
department, Plan Company staffing levels, plan asset purchase and expansions at minimum cost
before they become necessary. The finance department can also use past records from respective
departments to make better budget and forecast over long-term and short-term time horizons.

2.3.4 ADVICING AND SOURCING OF LONG TERM FINANCE:

It is the duty of the finance department to advise companies on the best

financing mix that could yield the company the best profit and also help them source longer-term
financing at the lowest cost such that there is a profit level of liquidity. Some of the many varied
paths a company can source funds to finance their business as discussed in one of our articles
“10 Most Common Ways to Finance Your Business” include bank credit or private lender debt
or, share issues to private investors (where applicable).

8
2.3.5 MANAGEMENT OF TAXES:

Running a company involves paying tax, and it is the duty of the finance
department to handle tax issues. This includes creating good corporate relationships with
government by remitting PAYE (Pay As You Earn) to the relevant authority, and ensuring that
implementation of tax matters are done within the framed policies.

2.3.6 MANAGEMENT OF COMPANY’S INVESTMENTS:

Apart from analyzing and selecting new investments, it is also the duty of
the finance department to manage company’s existing assets. The finance department should be
concerned with current assets apart from fixed assets. The company’s working capital needs to
be managed efficiently in such a way as to maximize profitability relative to the amount of funds
tied up since it has more implication on the firm liquidity than its fixed asset.

2.3.7 FINANCIAL REPORTING ANALYSIS:

Financial reporting and analysis is the function that takes raw accounting
entries and transforms them into meaningful, usable and comparable financial statements. The
finance department contributes to organizational growth by measuring and reporting on regular
bases, key numbers that are vital to the success of the company. This will likely include a
summary of all funding sources, expenditures and reserves available for future use (excluding
those already committed and budgeted for current period) some non-financial information. And
are usually communicated to managers in a logical and understandable format.

2.3.8 ASSIST MANAGERS IN MAKING KEY STRATGIC DECISIONS:

The finance department provides company management with information

necessary to make strategic decisions such as which markets or projects to pursue, the payback
periods for large capital purchases, decision on what should be given out as dividend out of the
company’s earnings and what to plough back into the business, the best financing mix that could
yield the company the nest profit, decision on how to allocate funds to investment etc., thus,
making sure that money is being used in the best way.

9
2.4 HUMAN RESOURCE DEPARTMENT:

The human resource department in this company plays an important role

in the organization, as HR is dealing with employees. The basic functions of this department like,
maintain relation with personnel as a representative of management, to follow act and rules as
per factories act, lbour law etc. recruitment of manpower, to aware employee about personnel
hygiene, medical checkup of the employees, maintain a statutory record of the employee like
attendance, leave, PF, ESI, etc.

2.5 QUALITY CONTROL DEPARTMENT:

Quality control is one of the key departments in a pharmaceutical

company because before consuming any type of medicine, they need to be tested and approved
for consumption in prepared pharmaceutical laboratories, so that they can be sold and consumed
by the population. The main objective of the quality control in the pharmaceutical industry is to
test both the raw materials and finished products. The pharmaceutical quality control laboratory
serves one of the most important functions in pharmaceutical production and control as it ensures
the products manufactured are safe and consistent standard.

The quality will checked in two different stages:

Quality Control is concerned with sampling, specifications and testing as

well as the organization, documentation and release of the product procedures. This ensures the
necessary and relevant tests carried out for the release of products. The product to be released for
sale or supply should be carried out only after checking their quality. Quality Control is not
confined to laboratory operations, but it is involved in all decisions which concern the quality of
the product. The independence of Quality Control from production is considered fundamental to
the satisfactory operation of Quality Control. The steps of quality are:

 Sampling

10
  Specifications
 Testing
 Documentation
 Product release
The basic requirements of quality control are as follows:

(a) Adequate facilities, trained personnel and approved procedures must be available for
sampling, inspecting and testing starting materials, packaging materials, intermediate, bulk, and
finished products, and where appropriate monitoring environmental conditions for GMP
purposes should be done.

(b) Samples of starting materials, packaging materials, intermediate products, bulk

products and finished products are taken by personnel according to the methods approved by
Quality Control.

(c) The test method should be validated.

(d) Records are made, manually and/or by recording data on-line. This should
demonstrate that all the required sampling, inspecting and testing procedures were actually
carried out. Any deviations from the recommended norms should be recorded and investigated.

(e) The finished products contain active ingredients (a.i.) complying with the qualitative
and quantitative composition, their storage in proper containers must be done. The containers
must be labelled.

(f) Inspection and the date of testing of materials, intermediate, bulk, and finished
products should be formally assessed. The products deviations from specified procedures must
be checked.

(g) No batch of product is released for sale or supply prior to certification by a qualified
person, which is in accordance with the requirements of the marketing authorization.

(h) Sufficient reference samples of starting materials and products are retained to permit
future examination of the product, if necessary. The product is retained in its final pack unless
exceptionally large packs are produced.

11
 Once the raw materials enter the factory premises and before going to the stores the
quality of the material will be checked by the quality control department. If they are as per the
guidelines then the QC department approves the raw materials. The finishes product analysis will
be done after the product is manufactured.

The Quality Control department holds the major responsibility as it ensures the quality
and the guidelines that as to be followed while manufacturing the products.

2.5.1 QUALITY ASSURANCE:

Quality Assurance is a wide ranging concept which covers all matters

individually or collectively that influence the quality of a product. It is the sum or total of the
organized arrangements made with the object of ensuring the medicinal products are of the
quality required for their intended use.

Therefore, Quality Assurance includes GMP. In a pharmaceutical

production process, quality assurance is involved in several activities such as: purchasing,
dispatching, warehousing, operational protocols, manufacturing, training, quality control,
validation and packaging.

A quality assurance is considered by merging a series of actions. These

actions collectively ensure product quality. As a result, the quality assurance system must
establish specific activities before the start of production.

This also includes the control factors and product evaluation before
formation of final product. The system of Quality Assurance for the manufacture of medicinal
12
products should ensure that the products are designed and developed in a way that follows the
requirements of GMP and GLP.

The production and control operations are clearly specified and GMP has
been adopted. The managerial responsibilities must be clearly specified and arrangements made
for the manufacture, supply and use of the starting, and packaging materials should also be taken
care of. All necessary controls or intermediate products, and any other in-process controls and
validations must be carried out.

Finally, the finished product should be correctly processed and checked

according to the defined procedures. It is important to mention that the medicinal products are
not sold or supplied before a qualified person certified each production batch in accordance with
the requirements of the marketing authorization, and any other regulations relevant to the
production, control and release of medicinal products. The few activities of the quality assurance
department are:

 Equipment qualification
 Analyst qualification
 Instrument qualification
 Process validation
 Cleaning validation
 Change control
 Deviation control
 Approval of analytical method validation.

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2.6 PRODUCTION DEPARTMENT AND ITS CYCLE:

The production department is regarded as the heart of the organization as it is responsible

for the creation of the finished products to the company. The department consists of group of
functions within a business that is responsible for the manufacturing of the goods. In other words
the department is responsible for the conversion of raw materials into finished goods.

In a pharmaceutical company, Production should be performed and

supervised by competent people. All handling of materials and products, such as receipt and
quarantine, sampling, storage, labelling, dispensing, processing, packaging and distribution
should be done in accordance with written procedures or instructions and, where necessary,
recorded.

All incoming materials should be checked to ensure that the consignment

corresponds to the order. Containers should be cleaned where necessary and labelled with the
prescribed data.

14
 The process of drug manufacturing performed in production department in
pharmaceutical unit to series of unit operations. The process may differ from company to
company. At first at the order of requirement by the customers are obtained.

Then the job orders are prepared. Job order is simply an authorization used
in a business to construct goods. A job order typically triggered by the receipt of a customer
order and is then used internally to schedule the work resulting from the customer needs.

The prepared job orders are redirected to the production department and
the checking for the availability of the raw materials take place to ensure that the required raw
materials are available for the production of the demanded goods by the customers and after the
checking of the raw materials the production process commences.

The process carried out by the production department in order to produce a product is depicted
below:

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2.6.1 BLENDING:

Blending is the first step after the raw material procurement. For drug
blending, to begin with an already developed formulation. Of course, if the formulation has yet
to be developed, they have the commercial equipment and in-house expertise to develop a
formulation for the client. In Pharma industry blending is the vital part to ensure the product
quality. Suring this stage different ingredients are mixed together to form the final blend and the
main purpose of this step is to ensure the adequacy of the mixing of ingredients.

Mixing and blending capabilities are made possible by equipment and

facilities. With a wealth of experience and expertise with all types of materials and compound
properties, the quality control team work tirelessly to develop an effective, product-specific
blending process to optimize the blend and drug performance.

The importance of the blending in a pharmaceutical industry is to ensure

blend uniformity, content uniformity and proper lubrication.

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2.6.2 DRYING:

Drying is the process of removing the presence of solvents (water or other

liquids) in a formulation with the presence of heat on a certain temperature. The temperature will
be depending on the total quantity and quality of the blended mixture of the formulated product.
Drying prevents the growth and reproduction of microbial proliferation and also reduces the cost
of handling and transportation. Pharmaceutical application drying is used to granules for
capsules and tablets and also improves the stability and deterioration of the medicines. The
drying unit operation is widely used in the pharmaceutical industry, yet many factors, including
moisture environmental conditions and the drying process parameters, have an impact on the
quality of active pharmaceutical ingredients. This can cause challenges during product
development, manufacture, storage and usage.

For the purpose of overcoming common challenges facing

pharmaceuticals drying development, including material constraints for scale up studies and
equipment transfer to a variety of types and sizes.

Research and technology advances should be encouraged to improve the

drying process. To design and manufacture a dryer with minimal energy consumption, a low
acquisition and operating cost and optimum local content flexibility.

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2.6.3 PUNCHING OF TABLETS:

Punching generally refers to as pressing. In other words it is the shaping

the formulated mixture into tablet of definite shape and into uniform thickness and size.
Thickness of tablet is important because it affects the therapeutic effectiveness of tablets. The
punching of tablets is done by the tablet press. Tablet press also referred to as tableting machine,
pharmaceutical tablet press, tablet compressing machine, or tablet punching machine is a
mechanical device that compresses powders into tablets of uniform size, shape, and weight
containing approximately the same quantity of Active Pharmaceutical Ingredient (API) and
excipients. Apart from its use in the pharmaceutical industries for manufacturing varieties of
tablets, it can also be used to manufacture illicit drugs, cleaning products, and cosmetics.

All tablet press employs the same basic principle of compression. The
basic unit of any tablet press is tooling consisting of two punches and a die called a station. The
upper and lower punches come together in the die that contains the tablet formulation.

The development of tablet press has been a continuous process. In the

past, we have hand-driven tablet press which has been modernized to electrical driven tablet
press.
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2.6.4 COATING:

Coating is the process by which the tablets are given color and flavor. It
improves the taste, color and odor and ease to the patients to swallow them. Coating is of three
types. They are sugar coating, film coating and enteric coating. Tablet coating is the process
where coating material is applied to the surface of the tablet to achieve the desired properties of
dosage form over the uncoated variety. Various classes of pharmaceutical coating materials used
in tablet coating depending on the phase of coating are reached. Coating materials can be
categorized as follows:

 Binders (acacia, gelatin, cellulose derivatives)

 Fillers (calcium carbonate, titanium dioxide, talc)
 Colorants (dyes, iron oxides, titanium dioxide)
 Antiadhesives (talc)

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2.6.5 CAPSULE FILLING:

The company specializes in formulating different medicines and providing

the medications in the capsule form. The company generally uses an automated capsule filler
machines for efficiency and accuracy. The process of capsule filling relies on accurate
formulations and precise measurements. Capsule fillers significantly speed up the process and
they can count on to dispense accurate dosages for very capsule produced.

2.7 PACKAGING DEPARTMENT:

Packaging literally refers to the process of design, evaluation and

production of packages. Pharmaceutical packaging may defined as the economical means of
providing presentation, safety, identification and stability of the product. Pharmaceutical
packaging is the packages and the packaging processes for pharmaceuticals preparations. It
involves all of the operations from production through drug distribution channels to the end
consumer.

Pharmaceutical packaging is highly regulated but with some variation in

the details, depending on the country of origin or the region. Several common factors can
include: assurance of patient safety, assurance of the efficacy of the drug through the intended
shelf life, uniformity of the drug through different production lots, thorough documentation of all
20
materials and processes, control of possible migration of packaging components into the drug,
control of degradation of the drug by oxygen, moisture, heat, etc., prevention of microbial
contamination, sterility, etc.

Packaging is often involved in dispensing, dosing, and use of the

pharmaceutical product. Communication of proper use and cautionary labels are also regulated.
Packaging is an integral part of pharmaceutical product.

Blister packs are pre-formed plastic/paper/foil packaging used for formed

solid drugs. The primary component of a blister pack is a cavity or pocket made from a
thermoformed plastic. This usually has a backing of paperboard or a lidding seal of aluminum
foil or plastic film. Blister packs are useful for protecting drugs against external factors, such as
humidity and contamination for extended periods of time. Blister packing machinery is readily
available and is suited to validation processes.

21
 Aluminum packs are similar to the blister packs but the medicine is not
visible directly, and Strip packs are those in which the tablets are not visible and the embed
design on the packs will not be available.

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2.7.1 TYPES OF PACKAGING:

 Primary Packaging

 Secondary Packaging and

 Tertiary Packaging.

Primary packaging is the material that first envelopes the product and hold
it. This is usually the smallest distribution or use. Example: Aerosol spray cans etc.

Secondary packaging is outside the primary packing perhaps used to group

primary packaging together. Example: cartons and boxes etc.

Tertiary packaging is used to bulk packaging and shipping. Example:

Barrels, containers and edge protectors etc.

BATCH NUMBER PRINTING

Lot or batch numbers are distinctive number provided to a lot or batch.

The date of manufacturing and expiry dates are also printed during this stage. As we know that
expiry date is a date mentioned at label in form of a year and month after it is not recommended
to consume a medicine.

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REPORTING OF GOODS PRODUCED:

After the production of required goods (that is medicines) they are being
reported to the sales department for the shipment of the goods to the concerned clients.

2.8 RESEARCH, FORMULATION AND DEVELOPMENT DEPARTMENT:

This department is involved in research work, search for a new molecule,

synthesis and modification of known molecules or some methods to increase productivity by
adopting different techniques. This department is working on the development of product
formulation. Product development is an essential and first part of the product life cycle. This
department has to carry out the development of a stable product and transfer it to the production
department for routine commercial manufacturing.

WAREHOUSE (STORES):

Warehouse includes the storage of raw materials, packing materials,

ancillary materials, intermediate materials, engineering materials and finished goods. The basic
functions are as follows:

 Maintain good storage practice

 Receipt and verification of the material

 Segregation of the material at various stages like Quarantine, under test, approves and
reject.

 Maintain the recommended storage condition.

 Reconciliation of the material and stock maintenance.

 Dispensing of the material.

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 CHAPTER 3

SWOT ANALYSIS

STRENGTHS:

Efficient and experienced general officers:

This industry works on so many different levels that it is very hard for
inexperienced personnel to maintain any sub sector of it. So, in order to keep things running
smoothly the industry hires highly trained personnel as its executive officers. This in turn
maintains the high standard that the industry has set for itself.

Skilled staffs:

Any and all staff of the pharmaceutical industry is highly skilled. They are
employed only after they have spent a good amount of time on rigorous training. These staff are
the backbone of this industry. So having a skilled set of staff surely helps with the industry’s face
value.

Wide-spread base of buyers:

This industry has a large base of customers. It also produces some

common types of medicine, which actually helps support this base. This also ensures that this
industry will have enough buyers for their products.

Resource and Labor availability:

This industry needs a high amount of manpower and chemical resources.

The countries of Asia and Africa can offer up a nice amount of manpower at a very low price.
Then again, the countries of Europe and America have bountiful financial resources. They can
also buy necessary chemicals for their drugs.

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Setting the benchmark:

Pharmaceutical industry has set an awfully high benchmark for the

medical industry. It is a known fact that the pharmaceutical industry is a subsector of the medical
industry. So, by doing its job efficiently the industry is setting a good example of excellence for
the medical industry.

Noticeable market presence:

The pharmaceutical industry has quite an impressive presence in the

market. Its large and intimidating aura often scares away potential competition and lures in many
customers.

WEAKNESS:

Non availability of modern technology:

This industry lacks modern machinery. This makes it rather outdated and
dull as customers are always searching for new and improved health care materials. Not to
mention with modern tech support the production could be a lot faster.

Lengthy decision-making process:

This industry is quite vast and widespread. So, when taking a new and/or
revolutionary decision, it may take a while before it is properly executed. This slows down the
whole process. The main cause is the lengthy decision-making process of the industry. As the
companies have their own board of directors and chairmans they can hardly agree on anything in
a short period.

Low profitability and low profit margins:

As the price is quite high for the resources in this sector, profits are quite
low more often than not. And it’s not that it is only the case for some of the companies. Almost
all the companies have low profit margins. This causes the industry to fall behind on the ground
of wealth.

Low staff morale:

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 The staff in this industry doesn’t have much motivation. This is the reason
for low rates of production. Because many psychological articles suggest that if the morale is low
or non-existent the performance of humans takes a heavy blow. So low staff morale is an issue.

OPPORTUNITIES:

Government support:

This industry is often favored by the government. So, they get all the
support and help they need from the government. It is also the factor for which the industry is
flourishing to this day. The laws and taxes are often in their favor.

Growing space:

This industry is still in its growing phase, according to the Life Cycle of
an Industry. So, it can still go a long way and spread its wings further apart. So, it can still take
control over the market, given the right marketing and advertising.

Financial support:

Along with the government, many insurance companies are also favoring
this industry. They have reasonable conditions and rules for them to follow. Also, the interest
level is very low for them.

Patents:

The pharmaceutical industry develops new and effective medication. If

one company creates it, it can patent that product themselves and earn a handsome amount of
profit. This gives the industry a chance to grow.

Global market:

Globalization has made the world closer than ever. This includes all the
customers. The pharmaceutical industry is showing a promising future in the global market. If
this works out well, the deficiency of proper resources and low profit margins will be no more.

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THREATS:

Currency devaluation:

In the current society’s currency devaluation has taken a turn for the
worse. This is affecting the pharmaceutical industry in a grim manner. It makes the whole ordeal
a lot harder than it already is.

New competitors:

Since globalization, the rivaling industries are increasing. Many people are
interested in the Ayurvedic industry, homeopathic industry and many others instead of
medicines. This poses a great threat to the pharmaceutical industry.

Insufficient power supply:

The pharmaceutical industry requires a huge amount of power. However,

to supply this power on a large scale is a problem. As a result, many companies of the industry
don’t get enough power to carry out their necessary routines.

Inflation:

The inflation of prices is an undeniable evil that is ever present. Especially

in a sector is where raw materials are pricey to begin with, inflation of price just adds salt to the
wound. Suddenly the necessities are out of reach for many companies in the industry. This
causes the production cost to skyrocket and suddenly the profits are lower than ever.

The following recommendations will focus on improving the weaknesses

or neutralizing the threats to the pharmaceutical industry. However, there are some points that
could use some extra work:

 The industry needs to adjust its decision-making process so that it takes less time.
 They need to fix their budget so that there is more budget for marketing and research
purposes.
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 They need to be more staff-friendly to keep their morale high.
 The board of directors needs to be more engaged.
 They also need up the ante in the marketing department.

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 CHAPTER 4

PRODUCT PROFILE

ANTIBIOTICS:

An antibiotic is a type of antimicrobial substance active against bacteria. It

is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic
medications are widely used in the treatment and prevention of such infections. Antibiotics are
not effective against viruses such as the common cold or influenza drugs which inhibit viruses
are termed antiviral drugs or antivirals rather than antibiotics. The antibiotics manufactured by
Bio Trans Pharmaceutical is

Anti-cold – Paracetamol, Phenylephrine and Chlorpheriramine maleate tablet.

Anti-Hypertension – Amlodipine Besylate Eg

Amlodipine IP.

ANTACIDS:

An antacid is a substance which neutralizes stomach acidity and is used to

relieve heartburn, indigestion or an upset stomach. Some antacids have been used in the
treatment of constipation and diarrhea. The antacids manufactured by the company is

Tums smoothies – Calcium carbonate.

MULTI VITAMINS:

The main purpose of a multivitamin is to fill in nutritional gaps, and

provides only a hint of the vast array of healthful nutrients and chemicals naturally found in
food. It cannot offer fiber or the flavor and enjoyment of foods so key to an optimal diet. The
company produces

Paediatric – Montelukast Sodium Eg To

Monteulastl

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 Levacetitizine Hd IP Tablets.

INJECTIONS:

An injection is the act of administering a liquid, especially a drug, into a person's

body using a needle (usually a hypodermic needle) and a syringe. An injection is considered a
form of parenteral drug administration; it does not involve absorption in the digestive tract. This
allows the medication to be absorbed more rapidly and avoid the first pass effect.

Diabetic injection – Metformin HCL.

AYURVEDIC AND HERBAL TABLETS:

Ayurveda is a traditional, holistic approach to medicine that originated in

India. The system promotes mental, physical, and spiritual wellness through exercise, diet, and
other lifestyle changes. Ayurvedic Tablets are made from natural and herbal ingredients, and
they can be used in place of allopathic medicines. These tablets are used to treat a variety of
conditions, including arthritis, anxiety, asthma, pain, stress, and inflammation but are most
commonly used to treat symptoms of the common cold and flu.

PAIN RELIEF OINTMENTS:

Topical painkillers, or analgesics, are sprayed on, rubbed in, or applied as

patches onto the skin over painful muscles or joints. Although all are designed to relieve pain,
different products use different ingredients.

Counterirritants - menthol, methyl salicylate.

Salicylates - aspirin.

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 CHAPTER 5

CONCLUSION

The entire internship training proved to be of immense help in my learning

process. I came across the various practicalities existing in the Bio Trans Pharmaceuticals Private
Limited. This institutional training has helped me to know how various activities are being done
in an organization it enabled me to put a full stop to my imagination and question arose at the
time of studying all the function aspects. In all the subjects theoretically by having practical
vision of all such things in this organization is doing practical.

Hence I would like to conclude by mentioning that I have got to learn

many things related to vouchers, preparation of balance sheet, payment cycle, fund allocation,
supplier management. This institutional training taught me about the real time scenarios held in
the company & the reactions given to them by different departments.

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