Locomotion and Movement

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Locomotion and Movement

© 2022, Aakash BYJU'S. All rights reserved.


Key Takeaway

Locomotion 1

2 Movements

Muscle 3

4 Structure of muscle

Structure of
5
contractile proteins

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6 Light and dark bands

Cross bridge cycle 7

Sliding filament
8
theory

Human skeletal
9
system

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Axial skeleton 10
Skull Appendicular
11
skeleton
Vertebral column
Pectoral girdle
Sternum
Bones of arms
Ribs
Pelvic girdle
Joints 12
Bones of legs
Synovial joints
Disorder of muscular
13
and skeletal system​

Summary
© 2022, Aakash BYJU'S. All rights reserved.
Locomotion

 Locomotion: It is the ability


of an entity or
organism to move from
one place to another.
Movement  Locomotion is a type of
movement, but not all
movements are locomotory.
 Locomotion is a special type of
Locomotion movement where the organism
changes its position.
 Examples:
o Limbs in humans for walking
o Cilia in Paramecium

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Movements

 It is the change of position Types of movement


in an organism. It is essential
for all living organisms
including humans.
 Examples: Amoeboid Muscular
o Pumping of blood E.g. Amoeba E.g. Jaws
o Breathing through lungs
o Mobility of vesicles
inside a vessel Ciliary
E.g. Cilia of trachea

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Movements

Amoeboid Ciliary Muscular


movements movements movements

 It occurs with the help of  This type of movement  It is the movement shown
pseudopodia. occurs in some by limbs, jaws, tongue, etc.
 Pseudopodia is formed by internal organs.  The contractile property
cytoplasmic streaming. o The organs that are of muscles is utilised for
o Cytoskeletal lined with ciliated this movement.
elements such as epithelium show this  Examples: Humans and
microfilaments aid in movement. majority of multicellular
cytoplasmic  Examples: organisms.
streaming. Trachea, female
 Examples: Amoeba, reproductive system
macrophage, etc.

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Movements

Types of movements
based on control

Voluntary movements Involuntary movements

 These movements can be  They are under the control of the


controlled consciously. autonomic nervous system.
 They are associated with  These movements are
skeletal components and involuntary, i.e., they cannot be
controlled voluntarily. controlled by our will.

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Muscle

Myocyte
 It is a type of specialised tissue
Length = l
originating from mesoderm.
 It is made up of cells
known as myocytes.
Myocyte
 Myocytes provide contractility
Length = l/2
and allow muscles to gain the
ability to contract.
Myocyte  The stimulus provided by a
myocyte spreads to the
Length = l neighbouring myocyte.
 Contractility: It is a property that
allows it to shorten and return
to its original state.

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Muscle

Unique properties of muscles

Contractibility Excitability Elasticity Extensibility

 It is the property  It is the ability of  It is the ability of  It is the ability of


that allows a a muscle to a muscle to a muscle to
muscle to respond to a recoil or bounce stretch itself.
shorten and stimulus. back to its
return to its original length.
original state.

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Muscle
Types of muscles

Smooth muscles Cardiac muscles Skeletal muscles

 Tapering ends: The  It is present only  It is closely associated with


cells taper at in the heart. skeletal components
both the ends.  It is a contractile tissue of the body.
 Striations are absent: that aids in the beating  Voluntary muscle: The
The altering light and of the heart. movements of this muscle
dark bands are  Cardiac muscle helps in are under the control of
absent, giving a maintaining the the nervous system.
smooth appearance cardiac cycle.  Muscle fibres have a
to the muscles. o It has continuous striated appearance
rhythmic heart under microscope.
movements:  It enables the movements
contraction and of body parts.
relaxation.

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Muscle
Types of muscles

Smooth muscles Cardiac muscles Skeletal muscles

 It is also known as the following:  It is also known as the  It is also known as the
o Visceral muscle: As it forms the lining of following: following:
hollow organs o Striated muscle o Striped muscle
o Non-striated muscle: As it lacks striation o Involuntary muscle o Striated muscle
o Non-stripped muscle: As it appears smooth o Voluntary muscle
o Involuntary muscle: As it is involuntary in
 Examples:
nature o Muscles of tongue
 It assists in: o Muscles of limbs
o Transport of food through digestive tract
o Transport of gametes through female
genital tract

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Structure of Muscle

Fascia

Skeletal muscle

Muscle fibre
Muscle fibre
bundle (fascicle)
Epimysium

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Structure of Muscle

Fascia Muscle bundle fibre


 The collagenous sheath  The muscle fibres are arranged
surrounding the muscle parallelly in the form of a bundle
which holds together known as a muscle bundle
muscle bundle fibres. fibre or fascicle.

Epimysium Muscle fibre


 It is a dense connective  Each fascicle has many
tissue sheath muscle fibres.
surrounding a muscle.  Muscle fibres are arranged
parallel to each other.

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Structure of Muscle
Myofibril
 A muscle fibre contains many filamentous
myofibrils/myofilaments.

Sarcoplasm
 It is the cytoplasm of the striated muscle.
 Sarcoplasm contains lots of nuclei.
Hence, it is termed as syncytium
(multinucleated).

Sarcolemma
 Muscle fibres are covered by a layer of plasma
membrane known as sarcolemma.

Sarcoplasmic reticulum
 Sarcoplasm has the endoplasmic reticulum
known as a sarcoplasmic reticulum
that stores calcium.
 This calcium aids in muscle contraction.

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Structure of Muscle

Myofibril
 Each muscle fibre has many myofibrils.
Each myofibril contains many proteins.

Thick filament: Constitutes myosin


Thin filament:
Constitutes actin

 Myofilaments are made up of actin and myosin that are also known as contractile proteins.
 Myosin and actin both are rod-like structures arranged parallel to each other.
o They are longitudinal to myofibrils. The actin filaments are thinner than myosin filaments.

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Structure of Contractile Proteins
Structure of actin

G actin Tropomyosin
 Each F actin is a polymer of  It is the protein that runs
monomeric units known as close to F actin.
G (globular protein) actin.

F actin Troponin
 Each actin filament has two  It is the filament that holds the
filamentous actin known as tropomyosin and is present in regular
F actin helically wound intervals.
to each other.
 It blocks the active binding sites of actin.

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Structure of Contractile Proteins
Structure of myosin
Myosin
 Myosin is also known as the thick filament.
 It is the polymer of meromyosin. Monomeric proteins
are known as meromyosins.
 Each meromyosin has two parts: HMM and LMM.

HMM: Heavy meromyosin


 Globular head: It is an active ATPase enzyme. It has
binding sites for ATP and active sites for actin.
 It has a short arm.

Cross arm: The head and the short arm project


outwards at a regular distance and angle from
each other and from the surface of myosin.

LMM: Light memomyosin


 It is the tall.

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Light and Dark Bands

 Actin and myosin are


arranged in the myofibril in
such a way that they
appear as light and dark
bands. This gives the
skeletal muscles a
striated appearance.

Light band
Constitutes actin
Dark band
Constitutes myosin

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Light and Dark Bands
Sarcomere is the portion between the successive Z lines.
A sarcomere is a functional unit for contraction.

 I band  Z line
o The light band contains actin. o The I band is bisected by an
o It is also known as the elastic fibre known as the Z line.
I band or isotropic band. o The zigzag line cuts through
 M line the I band.
o It is a thin, fibrous membrane.  Dark band
o It holds the dark bands together. o The dark band has myosin. It is

 H zone overlapped by actin filaments at


o It is the central part of the thick
the periphery.
filament that has only myosin o It is also known as the A band or
or the thick filament. anisotropic band.
o The overlapping thin filaments o A band and I band are arranged
are not present in this region. alternately throughout the
myofibril.

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Light and Dark Bands

I Band A Band I Band

Z Line

M Line

H Zone

Sarcomere

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Muscle Contraction
 When an electrical signal reaches the
neuromuscular junction, the neurotransmitter
molecules are released.
 The neurotransmitter molecules bind
to the receptors on the sarcolemma. This
generates an action potential in the muscle
fiber.
 Action potential - It is an electrical impulse
that propagates on the muscle fiber.
 The action potential spreads to both sides from
the neuromuscular junction.
 An action potential causes the sarcoplasmic
reticulum to release calcium ions.
 These calcium ions ultimately bring about the
contraction of the muscle, by means of the
cross-bridge cycle.
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Cross-Bridge Cycle
Myosin-binding site masked at resting state

Myosin-binding site Actin Troponin


Troponin

Actin filament

Tropomyosin
Myson-binding site Tropomyosin
Myosin filament
Actin

During action potential Ca2+binds to


Myosin-binding sites exposed troponin causing conformational change

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Cross-Bridge Cycle
Myosin head binds ATP Myosin head hydrolyses ATP and is full of energy

ATP ADP
P

Myosin head pulls actin filament


Myosin head binds actin

ADP
P
ADP
P

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Cross-Bridge Cycle
Myosin head releases ADP and P Myosin head binds fresh ATP

ATP

ADP

Myosin hydrolyses ATP Myosin detaches from actin filament

ATP
ADP
P

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Sliding Filament Theory
Thin filament (actin) Thick filament (myosin)

Z-line M-line Z-line

H-zone

I-band A-band I-band

Sarcomere
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Sliding Filament Theory
Relaxed state of muscle

Actin
Myosin
Z-line
M-line
M-line

Sarcomere
A
I H I

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Sliding Filament Theory
Contracting state of muscle

Z-line When the myosin head binds


M-line M-line Actin
Myosin and pulls at the actin filament,
the actin filaments come
closer to the M-line.
a. The Z-lines come closer
b. The length of the
sarcomere shortens.
c. The lengths of the
Sarcomere I bands shortens.
A d. The length of the A band
I H I remains the same.

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Sliding Filament Theory
Maximally contracted state of muscle
In this state of the muscle, the length of the sarcomere is the shortest.
Actin
Myosin
Z-line
M-line

Sarcomere
A
I H I

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Sliding Filament Theory

Relaxation of muscle

 After a muscle contracts, it has to come back to its original relaxed state.
 The steps of contraction are reversed as follows:
o Calcium ions are pumped back into the sarcoplasmic reticulum.
o Tropomyosin masks myosin-binding sites on actin once again.
o So, myosin is no longer able to bind the actin filament.
o Z lines go back to their original position.
o Hence, the sarcomere goes back to its original length.
 The lengthening of the sarcomere means the relaxation of the muscle.

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Tetanus or Tetanic Contraction
 In a normal condition, an electric impulse comes from
a motor neuron, the muscle contracts and then relaxes.
 When the electric impulses come too fast, the muscle
does not get the time to relax.
 It is then in a state of continuous contraction. This is
called tetanic contraction or tetanus.

Muscle Fatigue
 While exercising, the glycogen stored in the muscles is
readily converted to its monomer glucose, which then
undergoes cellular respiration in order to produce energy.
 Glycogen levels become depleted in the exercising
muscles after prolonged or strenuous exercise.

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Red and White Muscle Fibres

Every muscle of the body is composed of two types of muscle fibers:


red and white, named so because of their colors.

Red muscle fibre White muscle fibre


 More blood vessels - more oxygen  Less blood vessels - less oxygen
 More mitochondria - more aerobic  Less mitochondria - more anaerobic
respiration respiration
 Large amounts of myoglobin - stores  Less amount of myoglobin
oxygen - red in color
 Less sarcoplasmic reticulum - slow  Extensive sarcoplasmic reticulum -
release of Ca2+ - slow muscle contraction rapid release of Ca2+ - fast muscle
contraction
 Marathoners born with more red  Sprinters born with more white fibres
fibres

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Human Skeletal System

 The hard, supportive, or protective elements of the animal body constitute


the skeletal system or skeleton.
 It consists of a framework of bones (206) and a few cartilages.
 Functions
o It supports the internal softer organs.

o It protects the delicate parts.


o It helps in movement.
o It provides attachment for muscles.
o It gives the body its shape and form.
o It helps in the formation of blood cells in bone marrow.
o It helps in breathing (tracheal rings, sternum, and ribs).
o It helps in hearing as ear bones (middle ear) transmit sound vibrations.

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Human Skeletal System
On the basis of the position of the skeletal structures in
the body, the skeleton is divided as follows:

Appendicular
Axial (80 bones)
(126 bones)

Skull Pectoral girdle

Vertebral column Arm bones

Sternum Pelvic girdle

Ribs Leg bones

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Axial Skeleton
Skull

 It is the bony framework of the head.


 The skull is composed of the following set of bones:

Cranial bones Cranial bones


Parietal (2)
 Cranium is the
skeleton of the head.
Frontal (1)
 It is the outer Ethmoid (1)
protective covering
of the brain.
 It is made of 8 cranial Sphenoid (1)
bones. Temporal (2)

Occipital (1)

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Axial Skeleton

Facial bones

 It forms the front


Facial bones
part of the skull.
Nasal (2)
 There are Palatine (2)
14 facial bones.
Lacrimal(2)

Zygomatic (2)

Maxilla (2)

Mandible (1)

Vomer (1)
Inferior nasal conchae (2)

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Axial Skeleton

Ear ossicles

 Ear ossicles are also known Ear ossicles


as auditory ossicles.
 They are the 3 bones
present in the middle part Incus
of human ears.
 So, there are a total of six Malleus
ear ossicles in the body.
 The ear ossicles are the Stapes
three of the smallest bones
in the human body.

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Axial Skeleton

Hyoid
Hyoid Bone
 It is a U-shaped bone.
 It is present at the base
of the buccal cavity
above the larynx.
 It is the only bone that is Hyoid
bone
not in contact with Hyoid bone
any other bone. Larynx
 It is also known as the
tongue bone.
 It acts as a point of
attachment for certain
tongue muscles and the
floor of the mouth.

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Axial Skeleton
Mnemonics

Bones of cranium Bones of face

Fluffy Puppies On Every Third Street Victor Can Not Make My Pet Zebra Laugh

Frontal Ethmoid Vomer Mandible

Parietal Temporal Conchae (inferior) Palatine

Occipital Sphenoid Nasal bone Zygomatic

Maxilla Lacrimal

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Axial Skeleton
Skull
Based on the number of articulations, skulls are of two types:

Monocondylic Dicondylic

 1 occipital condyle  2 occipital condyle


 E.g. - birds, reptiles  E.g. - humans

1 Occipital condyle 2 Occipital condyles

 Occipital condyles are bony  Humans have dicondylic skulls.


articulations that are  In the posterior end, there are these two
projections on the occipital rounded occipital condyles.
bone.
 They attach with the first vertebrae.
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Axial Skeleton
Vertebral column

 The vertebral column or the backbone Vertebral Column


is curved and lies dorsally in our body.
 It comprises 26 serially arranged
units called vertebrae.
Cervical
 It extends from the base of the skull
and forms the framework of the trunk.
 Functions
o It bears the bodyweight in the Thoracic
standing position and while
the body is in motion.
o It protects the spinal cord. Lumbar
o It supports the head.
Sacrum
o It serves as the point of
attachment for the ribs. Coccyx

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Axial Skeleton
Vertebral column

 The components of the vertebral


column are known as vertebrae. Posterior
 The anterior with a large disc-like
Centrum/ body
flattened part is known as the
body or centrum.
 The posterior portion is known
as neural arch. Vertebral foramen

 The neural arch forms a hole known


as vertebral foramen.
Neural arch
 The 24 vertebral foramen together
form vertebral canal/neural canal.
The spinal cord passes through this Anterior
neural canal.

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Axial Skeleton
Vertebral column

The vertebrae are grouped into five types, depending on the


level of the vertebral column where they are found:

Cervical (7)

 It is present in the neck.


C1 (Atlas)
 They are 7 in number in almost all
mammals. C2 (Axis)
 The first cervical vertebra C3
is the atlas. It articulates with C4
the occipital condyles and
supports the head. C5
C6
 The second vertebra is
C7
known as the axis.

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Axial Skeleton

Thoracic (12)
T1
T2
 They are present T3
in the chest level. T4
 They are 12 in number. T5
 They are larger and T6
stronger than cervical T7
T8
vertebrae.
T9
 They are joined T 10
with the ribs. T 11
T 12

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Axial Skeleton

Lumbar (5)

 Lumbar vertebrae are


present in the lower back. L1
 They are five in number.
L2
 They are the largest and
strongest of all vertebrae.
L3
 They have to bear the
weight of the whole body L4
when the body is in a
standing position. L5

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Axial Skeleton

Sacrum (1) (Fused)

 Five sacral vertebrae are fused, forming the sacrum.


 The vertebrae are separate in the beginning,
but start to fuse during adolescence.
 The sacrum lies between the innominate or hip bones.

Coccyx (1) (Fused)

 The four coccygeal vertebrae fuse


to form the coccyx. 1
 The vertebrae separate in the beginning,
but start to fuse during adolescence. 2
 The coccyx is considered to be the 3
vestigial tail in humans. 4

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Axial Skeleton
Sternum

 The sternum is also known


as the breastbone.
 It is a flat dagger-shaped bone.
 It is present just under the skin in
the front and middle of the chest.
 It provides the point of
attachment for ribs.
Sternum
 It also protects the organs in
the thoracic region and helps
in respiration.

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Axial Skeleton
Ribs

 They are the thin, flat, and curved bones that


Rib form a protective cage around the organs of
Thoracic vertibrae the upper body.
 The ribs are composed of 24 bones arranged
in 12 pairs.
 They are dorsally connected to the vertebral
column (thoracic vertebrae) and ventrally to
the sternum.
 They have two articulations/attachment
Coastal surfaces on their dorsal ends. Hence, they are
cartilage known as bicephalic.
 Functions:
Sternum
Rib o They protect the organs present in the
thoracic cavity and the kidneys.
o They also help in the respiration process.

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Axial Skeleton
Ribs

Sternum

True ribs

False ribs
Floating ribs

L1 Vertebra

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Axial Skeleton
Ribs

True ribs False ribs Floating ribs

 The first seven pairs of  The eighth, ninth, and  The last two pairs (11th
ribs are known as true tenth pairs are known and 12th) of ribs are not
ribs. as vertebrochondral connected ventrally to
 They are dorsally (false) ribs. the sternum or the
attached to the thoracic  They do not articulate cartilage. Therefore,
vertebrae. directly instead they are known as
anteriorly connect floating ribs.
 They are ventrally
connected to the indirectly with the  Thoracic vertebrae, ribs,
sternum with the help of sternum by costal and sternum together
hyaline cartilage, known cartilage of the form the rib cage.
as costal cartilage. seventh rib.

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Appendicular Skeleton

 It lies along the transverse (side) axis.


Pectoral girdle  The bones of the limbs along
with their girdles constitute
Arm
the appendicular skeleton.
Pelvic girdle  It is called so because it gives support
to the appendages.
 It comprises 126 bones.
Leg

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Appendicular Skeleton
Pectoral girdle

Pectoral girdle
 Also known as the shoulder girdle
Scapula Clavicle
 Acts as a point of attachment for the
upper limbs and the arm muscles
 Made up of two halves
o Scapula
o Clavicle

 The scapula is a large triangular flat bone.


 It consists of a spine and a body.
 The slightly elevated ridge is
known as the spine.

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Appendicular Skeleton
Pectoral girdle
Scapula

Acromion
Flat, expanded  The spine projects as a flat expanded
process process known as the acromion.
 The scapula is situated in the dorsal
Spine
part of the thorax.
Sharpe  It lies between the second and
ridge the seventh rib.
 Below the acromion is a depression
Body known as the glenoid cavity.
Large o It articulates with the head of the
triangular
humerus to form the shoulder joint.
bone

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Appendicular Skeleton
Pectoral girdle
Clavicle

Superior view  Pectoral girdle has two clavicles.


 Each clavicle is a long slender bone
Acromial with two curvatures.
end
 This bone is commonly
known as the collar bone.
Inferior view
 The clavicle articulates with the
Collar bone
acromion of the scapula.

Clavicle
 The clavicle and the scapula
together make the pectoral girdle.

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Appendicular Skeleton
Bones of arms

 Each arm is made


of 30 bones

Humerus

Phalanges (14)
Digits (5)
Radius
Metacarpals (5) Ulna
Palm bones
Carpals (8)
Wrist bones
Bones of wrist Bones of arm

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Appendicular Skeleton
Pelvic girdle

 The pelvic girdle bones help in the


articulation of the lower limbs.
Ilium  It is formed by two innominate
bones. They are also known as the
coxal or hip bones.

Acetabulum
 Each hip bone is made by the
fusion of three bones:
Pubis
o ilium
Ischium o ischium
o pubis

Femur  At the point of fusion of the above


(Thigh bone) bones is a cavity known as
acetabulum, to which the thigh
bone articulates.

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Appendicular Skeleton
Pelvic girdle

The pubic symphysis is made of


fibrous cartilage that joins the
two coxal (hip) bones ventrally.

Pubis

Pubis
symphysis

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Appendicular Skeleton
Bones of legs

 Each leg is made of


30 bones.
Femur (2) (Thigh bone)
Longest and strongest in
Phalanges (14) the body
Digits (5)
Patella (2) Knee cap
Metatarsals (5) Cup-shaped bone

Fibula (2)
Shorter, thinner, deeper
Tarsals (7)
Ankle bones Tibia (2)
Longer, thicker, front

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Total Number of Bones

Bones Number Bones Number


Cranial bones 8 Ribs 24

Facial bones 14 Scapula 2

Ear ossicles 6 Clavicle 2

Hyoid 1 Arm bones 60

Vertebral column 26 Hip bones 2

Sternum 1 Leg bones 60

Total 206

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Joints

Joints (On the basis of structure


 Joints are the points of
contact between: and movement)
o Bones
o Bones and cartilages

 Functions of joints: Fibrous Cartilaginous Synovial


o Hold bones together
Slight Considerable
o Bear weight of the No movement
movement movement
whole body
o Allow movements in
coordination with muscles

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Joints

Fibrous Cartilaginous Synovial


 Fibrous joints do not allow  These joints permit  These joints allow
any movement. limited movements. considerable movement.
 Sutures are a type of  The bones are joined  They have a fluid-filled
fibrous joints in the skull. together with the synovial cavity between
 Skull bones are fused end help of a cartilage. the articulating surfaces of
to end with the help of  Example: The joint the two bones.
dense fibrous connective between the adjacent  Examples: Movement of
tissues to form sutures. vertebrae in the head, wrist movement etc.
vertebral column.

Sutures Synovial
cavity

Cartilage
Articular
cartilage

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Synovial Joints
Types of synovial joints

Pivot joint

 Also known as rotary joint


 A ring-like movement is seen
 E.g. - Joint between atlas and axis

Gliding joint

 Also known as the plane joint


 Characterised by smooth surfaces
that can glide over one another Pivot joint Gliding joint
 E.g. - Joint between the carpals

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Synovial Joints

Condyloid joint

 The condyloid joint allows


movement but not rotation.
 E.g. - Wrist joint

Saddle joint

 The saddle joint does not


allow rotation.
 It enables back-and-forth
and side-to-side movements. Condyloid joint Saddle joint
 E.g. - Joint between the carpals
and the metacarpals of thumb

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Synovial Joints

Ball and socket joint

 Permits movement in all directions


 E.g. - Shoulder joint, hip joint

Hinge joint

 Allows the opening and closing in one


direction, along one plane
 E.g. - Elbow joint, knee joint

Ball and Hinge joint


socket joint

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Disorders of Muscular and Skeletal System

Myasthenia gravis Muscular dystrophy

 Myasthenia gravis is a rare  It is a genetic-inherited disorder.


autoimmune neuromuscular
 It causes progressive degeneration of
disorder that causes weakness in
skeletal muscles.
skeletal muscles.
 It can also lead to paralysis.  Muscles are damaged in this disorder.
o An autoimmune disease is a  It causes difficulty in:
condition where the body's immune
system mistakenly attacks its own o Walking
organs. o Swallowing
 The most commonly affected muscles o Breathing
are those of the eyes, face, and the
ones involved in swallowing.

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Disorders of Muscular and Skeletal System

Tetany Arthritis

 Rapid spasms (wild contractions)  The articulating cartilage wears away


occur in muscles due to in this condition, leading to more
low Ca++ in body fluid. friction between the bones.
 Spasms are rapid contractions  Symptoms:
o Joint pain
o Stiffness

Osteoporosis Gout

 It is an age-related disorder,  It is the inflammation of joints


characterised by decreased due to the accumulation of
bone mass and increased uric acid crystals.
chances of fractures.

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Summary
Types of movement

Amoeboid Ciliary Muscular


E.g. - Amoeba E.g. - Cilia of trachea E.g. - Jaws

Types of muscles

Smooth muscles Skeletal muscles


Cardiac muscles
E.g. - Muscles of E.g. - Muscles
E.g. - Muscles of heart
digestive tract of limbs

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Summary
Structure of muscle fibre

Myofibril

Sarcoplasm

Sarcolemma

Sarcoplasmic reticulum

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Summary
Structure of skeletal muscle

Fascia

Skeletal muscle
Muscle fibre

Muscle fibre
bundle (fascicle)
Epimysium

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Summary
Structure of actin
Structure of actin

 Also known as the thin filament

G actin Tropomyosin

F actin
Troponin

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Summary
Structure of myosin

 Myosin is also known as the thick filament.


 It is the polymer of monomeric proteins called meromyosin.
 Each meromyosin has two parts: HMM and LMM

HMM: Heavy
meromyosin

Cross arm

LMM: Light meromyosin

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Summary
Thin filament(actin) Thick filament(myosin)

Z-line M-line Z-line

H-zone

I-band A-band I-band

Sarcomere

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Summary

Muscle contraction

 Neuromuscular junction- The place where the end-point of a motor neuron


meets the sarcolemma of the muscle is called a neuromuscular
junction or motor end plate.
 Action potential- Action potential is an electrical impulse that
propagates on the muscle fibre.

Tetanus/ Tetanic contraction

 When the electric impulses come too fast, the muscle does
not get the time to relax.
 It is then in a state of continuous contraction. This is called
tetanic contraction or tetanus.

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Summary

Cross-bridge cycle

A. Myosin-binding site masked at resting state.


B. During action potential Ca2+ binds to troponin causing conformational change.
C. Myosin-binding sites exposed.
D. Myosin head binds ATP.
E. Myosin head hydrolyses ATP and is full of energy.
F. Myosin head binds actin.
G. Myosin head pulls actin filament.
H. Myosin head releases ADP and P.
I. Myosin head binds fresh ATP.
J. Myosin detaches from actin filament.
K. Myosin hydrolyses ATP.
L. Myosin binding and releasing cycle continues as long as there is Ca2+.

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Summary

On the basis of the position of the skeletal structures in the


body, the skeleton is divided as follows:

Axial Appendicular

Skull
Pectoral girdle
Arm
Sternum Pelvic girdle
Ribs
Vertebral Leg
column

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Summary
Skull

Facial bones(14):

Cranial bones(8): Nasal


Lacrimal
Frontal
Parietal Palatine
Sphenoid Zygomatic
Ethmoid Inferior nazal concha
Temporal
Occipital

Vomer
Maxilla
Mandible

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Summary
Vertebral column Rib cage

True ribs (1-7)

Hyaline
cartilage
Thoracic True Sternum
vertebrae(12) ribs (1-7)

Thoracic
Lumbar vertebrae
vertebrae(5) False
ribs (8-10)
Sacrum(1)
Floating ribs
(11-12)
Coccyx(1)

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Summary

Clavicle
Hip bone
Scapula

Femur Femur

Patella
Radius
Ulna Fibula

Metacarpals Metatarsals
Phalanges
Phalanges

Bones of upper limb and Bones of lower limb and


pectoral girdle pelvic girdle

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Summary

Joints (On the basis of structure


and movement)

Fibrous Cartilaginous Synovial

No Slight Slight
movement movement movement

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Summary
Types of synovial joints

Pivot joint Ball and


socket joint

Hinge Saddle
joint joint

Condyloid Gliding
joint joint

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Summary

Disorders of muscular and


skeletal system

Autoimmune neuromuscular disease


Myasthenia gravis causing muscle weakness

Progressive degeneration
Muscular dystrophy of skeletal muscle

Rapid spasms in muscles


Tetany
due to low calcium ions

Arthritis Inflammation in joints

Decrease in the bone mass increases


Osteoporosis
the risk of fractures

Gout Inflammation of joints due to the


accumulation of uric acid crystals
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