Drying Process Validation: Fig. No.

1
The study of drying process is to be done to verify the wet granules are dried to required level of
moisture. Collect the samples from 9 locations for determination of Loss on drying. 3 samples from
Top (T1, T2, T3), 3 sample from middle (M1, M2, M3) and 3 samples from Bottom (B1, B2, B3).

T1 T2
T3

M1 M2
M3

B1 B2 B3

Fig. No. 1

Abbreviations: T1: Top Left, T2: Top Middle, T3: Top Right B1: Bottom Left, B2: Bottom Middle, B3:
Bottom Right), M1: Middle Left, M2: Middle, M3: Middle Right.
Conta blender. Lubrication Process Validation: Fig. No. 2

To study the lubrication process and to ensure the uniform mixing is done in Conta blender.
Samples are to be drawn from 10 different sampling locations and one Composite Sample Test to
be performed as per in process specification.

A
F
C G

B
I D H

Fig. No. 2

Abbreviations: A: Front Top Left, B: Front Middle Left, C: Front Top Right, D: Front Middle Right,

E: Back Top Left, F: Back Middle left, G: Back Top Right, H: Back Middle Right, I: Center Middle

J: Bottom Center
9.3 SAMPLING LOCATIONS FOR OCTAGONAL BLENDER

After completion of mixing for the defined period of time, the samples shall be collected
from different locations as Shown in diagram.

 BS1-Top right
 BS2-Top middle
 BS3-Top left
 BS4-Middle right
 BS5-Middle middle
 BS6-Middle left
 BS7-Bottom right
 BS8-Bottom middle
 BS9-Bottom left
 BS10-Near Discharge Port

BS-2

BS-1` BS-3

TOP SAMPLING LOCATION

BS-4 BS-5 BS-6

MIDDLE SAMPLING LOCATION

BS-7 BS-8 BS-9

BOTTOM SAMPLING LOCATION

BS-10
SAMPLING LOCATIONS FOR RAPID MIXER GRANULATOR

After completion of mixing for the defined period of time, the samples shall be collected
from different locations as Shown in diagram.

 DS1-Top Middle
 DS2-Middle right
 DS3-Middle middle
 DS4-Middle left
 DS5-Bottom middle

Top position

S1

Middle position

S2 S4
S3

S5

Bottom position

Coating Process Validation: Fig. No. 3

To study the coating process and to ensure the uniform coating is done in Autocoater. Samples are
to be drawn from 5 different sampling locations and one Composite Sample Test to be performed
as per in process specification

T1

B1 C

T2
B2

Fig. No. 3

Abbreviations: T1: Top Left, T2: Top Right, B1: Bottom Left, B2: Bottom Right, C: Center