PMID- 34689968

OWN - NLM
STAT- MEDLINE
DCOM- 20211104
LR - 20211104
IS - 1557-9832 (Electronic)
IS - 0272-2712 (Linking)
VI - 41
IP - 4
DP - 2021 Dec
TI - Red Blood Cell Transfusion.
PG - 611-619
LID - S0272-2712(21)00048-2 [pii]
LID - 10.1016/j.cll.2021.07.004 [doi]
AB - Red blood cell (RBC) transfusions are necessary to increase a patient's
oxygen
carrying capacity. The optimal transfusion trigger remains elusive, but a
restrictive transfusion trigger of 7 g/dL has been shown in studies to reduce
RBC
transfusions without adversely affecting patient outcomes. Patient blood
management programs have been shown effective at reducing RBC transfusions.
Hemoglobin-based oxygen carriers and induced pluripotent stem cell derived
RBCs
are being developed to help mitigate RBC shortages and RBC transfusion
limitations. Numerous challenges still exist that need to be overcome before
they
can have widespread clinical use.
CI - Copyright © 2021 Elsevier Inc. All rights reserved.
FAU - Tanhehco, Yvette C
AU - Tanhehco YC
AD - Division of Transfusion Medicine, Department of Pathology and Cell Biology,
Columbia University Vagelos College of Physicians and Surgeons, 622 West
168th
Street, Harkness Pavilion 4-418A, New York, NY 10032, USA. Electronic
address:
https://twitter.com/YTanhehcoPhDMD.
LA - eng
PT - Journal Article
PT - Review
DEP - 20210930
PL - United States
TA - Clin Lab Med
JT - Clinics in laboratory medicine
JID - 8100174
RN - 0 (Hemoglobins)
SB - IM
MH - Blood Transfusion
MH - *Erythrocyte Transfusion
MH - Erythrocytes
MH - *Hemoglobins
MH - Humans
OTO - NOTNLM
OT - Hemoglobin
OT - Induced pluripotent stem cells
OT - Oxygen
OT - Patient blood management
OT - Red blood cells
COIS- Disclosure The author has nothing to disclose.
EDAT- 2021/10/26 06:00
MHDA- 2021/11/05 06:00
CRDT- 2021/10/25 05:46
PHST- 2021/10/25 05:46 [entrez]
PHST- 2021/10/26 06:00 [pubmed]
PHST- 2021/11/05 06:00 [medline]
AID - S0272-2712(21)00048-2 [pii]
AID - 10.1016/j.cll.2021.07.004 [doi]
PST - ppublish
SO - Clin Lab Med. 2021 Dec;41(4):611-619. doi: 10.1016/j.cll.2021.07.004. Epub
2021
Sep 30.