Classification: Antipsychotics, 1st Generation Route: PO, IM injection Does: PO: ◦Moderate disease, 0.5-2 mg q8-12hr initially ◦Severe disease, 3-5 mg q8-12hr initially; not to exceed 30 mg/day. IM injection lactate (prompt-acting): ◦2-5 mg q4-8hr PRN; may require q1hr in acute agitation; not to exceed 20 mg/day IM injection decanoate (depot): ◦Initial: IM dose 10-20 times daily PO dose administered monthly; not to exceed 100 mg; if conversion requires initial dose >100 mg, administer in 2 injections (eg, 100 mg initially, then remainder in 3-7 days) ◦Maintenance: Monthly dose 10-15 times daily PO dose. Action: block dopamine D2 receptors in the brain and exert its antipsychotic action. Indications: ◦Schizophrenia, psychosis/sedation ◦Tourette syndrome ◦Intractable hiccup ◦Persistent nausea ◦Behavioural disorders ◦Acute agitation Contraindications: Contraindicated in severe toxic central nervous system depression or comatose states from any cause and in individuals who are hypersensitive to this drug or have Parkinson disease. Do not use in patients with known hypersensitivity to phenothiazines. Side effects: ◦Anticholinergic effects ◦Sedation ◦Weight gain ◦Erectile dysfunction ◦Oligomenorrhea or amenorrhea Nursing implementation: ◦Assess patient level of conscious ◦Monitor patient blood pressure, heart rate and ECG rhythm ◦Supervise suicidal risk during early therapy Generic name: Quetiapine Brand name: Seroquel Classification: Antipsychotics, 2nd Generation Route: PO Does: Immediate release ◦Day 1: 50 mg/day PO divided q12hr ◦Days 2-3: Dose increased daily in increments of 25-50 mg q8-12hr to 300-400 mg by day 4; further adjustments can be made in increments of 25-50 mg q12hr at intervals ≥2 days ◦Dosage range: 150-750 mg/day Extended release ◦Day 1: 300 mg/day PO; subsequently, may be increased by up to 300 mg/day at intervals ≥1 day ◦Maintenance (monotherapy): 400-800 mg/day Action: It works by balancing the levels of dopamine and serotonin in your brain, hormones that help regulate mood, behaviors, and thoughts. Indications: ◦Schizophrenia ◦For the acute treatment of mania and for maintenance therapy following stabilization Contraindications: Hypersensitivity, Hypokalemia, Hypomagnesemia, Congenital QT prolongation, Arrhythmia hx, Avoid abrupt withdrawal Side effects: ◦Suicidal tendency ◦Exacerbation of depression ◦Extrapyramidal symptoms ◦Hyperthermia, hypothermia ◦Dizziness ◦Hypotension ◦Tachycardia ◦Constipation ◦Weight gain ◦Increased appetite Nursing implementation: ◦Assess motor function, and be alert for extrapyramidal symptoms ◦Monitoring electrolytes level ◦Instruct the patient to take the medication in evening without food or with light meal Generic name: Risperidone Brand name: Risperdal, Risperdal Consta Classification: Antipsychotics, 2nd Generation; Antimanic Agents Route: PO, IM injection Does: Schizophrenia PO: ◦2 mg/day initially; may increase in increments of 1-2 mg/day at intervals ≥24 hr ◦Recommended target dosage: 2-8 mg/day once daily or divided q12hr (efficacy follows bell-shaped curve; 4-8 mg/day more effective than 12-16 mg/day). IM injection: ◦25 mg IM q2Weeks initially ◦If unresponsive, may benefit from a higher dose of 37.5 or 50 mg ◦Not to exceed 50 mg every 2 weeks Bipolar Mania PO (Risperdal or Risperidal M-Tabs) 2-3 mg/day initially; may be increased if necessary in increments of 1 mg/day at intervals of 24 hours to 6 mg/day Bipolar Disorder IM (Risperdal Consta): Monotherapy or in combination with lithium or valproate: 25 mg IM q2Weeks; some patients may benefit from a higher dose of 37.5 mg or 50 mg Action: The primary action of risperidone is to decrease dopaminergic and serotonergic pathway activity in the brain, therefore decreasing symptoms of schizophrenia and mood disorders. Indications: ◦Schizophrenia ◦Aggressive behaviour ◦Attention deficit hyperactivity disorder (ADHD) ◦Tourette syndrome ◦Bipolar Mania ◦Autism Contraindications: Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants like alcohol, barbiturates and narcotics. Side effects: ◦Somnolence ◦Agitation ◦Anxiety ◦Akathisia ◦Agitation ◦Rhinitis ◦Parkinsonism ◦Dyspepsia ◦Constipation ◦Dry mouth ◦Fatigue ◦Weight increase. Nursing implementation: ◦Maintain seizure precautions, especially when initiating therapy and increasing dosage ◦Monitor patient regularly for signs and symptoms of diabetes mellitus ◦Monitor the patient If fever occurs, rule out underlying infection, and consult physician for appropriate comfort measures Generic name: Lithium carbonate Brand name: Lithobid, Lithium Classification: Antimanic agents (Mood stabilizers) Route: PO Does: ◦Immediate release: 900-2400 mg/day orally divided every 6-8 hours ◦Extended release: 900-1800 mg/day orally divided every 12 hours Action: It works to stabilize the mood and reduce extremes in behavior by restoring the balance of certain natural substances (neurotransmitters) in the brain. Indications: ◦Acute manic disorder ◦Bipolar disorder Contraindications: Use with caution in renal insufficiency, thyroid disease and adrenocortical deficiency. Do not prescribe unless monitoring available. Check blood pressure, electrolytes, renal and thyroid function before commencing treatment and 6 monthly thereafter. Side effects: ◦Fine hand tremor ◦Plyuria ◦Mild thirst ◦Nausea ◦General discomfort during initial treatment Nursing implementation: ◦Monitor for lithium toxicity and metabolic acidosis ◦Hypercalcemia and Hyperparathyroidism: Associated with long-term lithium use. Monitor serum calcium And thyroid function regularly ◦Encephalopathic Syndrome: Increased risk in patients treated with lithium and an antipsychotic. Monitor routinely for changes to cognitive function Generic name: Lorazepam Brand name: Ativan Classification: Benzodiazepines Route: PO Does: ◦Initial: 2-3 mg PO q8-12hr PRN; not to exceed 10 mg/day ◦Maintenance: 2-6 mg/day PO divided q8-12hr Action: Binds to benzodiazepine receptors on the postsynaptic GABA-A ligand-gated chloride channel neuron at several sites within the central nervous system (CNS). Indications: ◦Anxiety ◦Psychosomatic Disorders ◦Premedication ◦Insomnia due to anxiety ◦Acute panic attacks ◦Status epilepticus Contraindications: Lorazepam is contraindicated in patients with hypersensitivity to benzodiazepines or to any components of the formulation, in acute narrow-angle glaucoma, pre-existing CNS depression, coma, acute pulmonary insufficiency or sleep apnea. Encephalopathy may be precipitated in patients with severe hepatic insufficiency. Side effects: ◦Drowsiness ◦Dizziness ◦Tiredness ◦Muscle weakness ◦Headache ◦Blurred vision ◦Sleep problems (insomnia) ◦Loss of balance or coordination ◦Forgetfulness or amnesia ◦Difficulty concentrating ◦Nausea ◦Vomiting ◦Constipation ◦Changes in appetite ◦Skin rash Nursing implementation: ◦Periodically reassess the usefulness for individual patients ◦Monitor respirations q5-15min and before each repeated dose Generic name: fluoxetine Brand name: Prozac Classification: Anti-depressant, SSRIs Route: PO Does: ◦Initial: 25 mg/6 mg PO qDay in evening ◦If needed, may titrate with 25-50 mg fluoxetine/6-12 mg; not to exceed 75 mg/18 mg per day Action: Its effects by blocking the reuptake of serotonin into presynaptic serotonin neurons by blocking the reuptake transporter protein located in the presynaptic terminal. Indications: ◦Depression ◦Obsessive compulsive disorder Contraindications: Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) and pimozide is contraindicated. Also contraindicated in patients with a hypersensitivity to fluoxetine, hepatic or renal insufficiency. Side effects: ◦Anxiety ◦Headache ◦Nervousness ◦Drowsiness ◦Sedation ◦Insomnia ◦Dzziness ◦Fatigue Nursing implementation: ◦Assessment of depression and suicidal risk, particularly at the beginning of therapy or when doses are changed, anxiety/panic attacks, social functioning, mania/mood lability, and features of serotonin syndrome ◦Monitor blood glucose and liver function tests Generic name: Venlafaxine Brand name: Effexor Classification: Antidepressants, SNRIs Route: PO Does: Major Depressive Disorder -Indicated for treatment of major depressive disorder (MDD) Immediate-release tablets: ◦75 mg/day PO divided q8-12hr initially; may be increased by ≤75 mg/day not faster than every 4 days ◦Moderate: Up to 225 mg/day PO divided q8-12hr ◦Severe: Up to 375 mg/day PO divided q8-12h Extended-release tablets or capsules (HCl salt): ◦37.5-75 mg PO once daily initially; may be increased by 75 mg/day every 4 days; not to exceed 225 mg/day Generalized Anxiety Disorder -Indicated for treatment of generalized anxiety disorder (GAD) ◦Extended-release tablets or capsules (HCl salt) 37.5-75 mg PO once daily initially; may be increased by 75 mg/day every 4-7 days; not to exceed 225 mg/day Action: Venlafaxine works by increasing serotonin levels, norepinephrine, and dopamine in the brain by blocking transport proteins and stopping their reuptake at the presynaptic terminal. Indications: ◦Major depressive disorder ◦Generalized anxiety disorder Contraindications: Uncontrolled hypertension, high risk of serious ventricular arrhythmias. Side effects: ◦Nausea ◦Vomiting ◦Vnorexia ◦Dry mouth ◦Constipation ◦Dspepsia ◦Orthostatic hypotension ◦Tremor ◦Sweating ◦Anxiety ◦Dzziness ◦Ftigue ◦Headache ◦Syncope Nursing implementation: ◦Assess BP and compare to normal values ◦Assess heart rate, ECG, and heart sounds, especially during exercise Generic name: Amitriptyline Brand name: Elavil, Levate Classification: Anti-depressant, TCAs Route: PO Does: ◦Outpatient: 25-50 mg PO qHS initially; increase by 25 mg every 5-7 days to 100-200 mg/day (may divide doses throughout day or give at bedtime); if needed, may increase to 300 mg/day Action: Acts by blocking the reuptake of both serotonin and norepinephrine neurotransmitters. Indications: ◦Treatment of depression Contraindications: Do not use trazodone if you have taken a MAO inhibitor in the past 14 days; Hypersensitivity; Some young people have thoughts about suicide when first taking an antidepressant. Side effects: ◦Headache ◦Confusion ◦Dizziness ◦Dry mouth ◦Nausea ◦Vomiting ◦Fatigue ◦Constipation ◦Blurred vision Nursing implementation: ◦Notify physician or mental health professional immediately if patient exhibits worsening depression or other changes in mood and behaviour Generic name: Penelzine Brand name: Nardil Classification: Antidepressants, MAO Inhibitors Route: PO Does: ◦Initial 15 mg PO q8hr, increase not to exceed 20-30 mg q8hr ◦Dosage should be increased to at least 60 mg/day at a fairly rapid pace consistent with patient tolerance; may be necessary to increase dosage up to 90 mg/day to obtain sufficient MAO inhibition; many patients do not show a clinical response until treatment at 60 mg has been continued for at least 4 weeks ◦After maximum benefit from drug is achieved, decrease dose after maximum response (2-6 weeks) over 2-6 week period to maintain dose as low as 15 mg qDay or every other day Action: phenelzine irreversibly these enzymes, preventing serotonin, norepinephrine, and dopamine from being broken down, allowing these neurotransmitters to have a more prolonged effect on their target receptors. Indications: ◦Resistant depression ◦Panic disorder ◦Social anxiety disorder Contraindications: Phenelzine is contraindicated in patients who exhibit hypersensitivity to the drug or who have pheochromocytoma, congestive heart failure, severe renal impairment or renal pathology, abnormal LFTs, or a history of liver disease. Side effects: ◦Dizziness ◦Feeling light-headed ◦Drowsiness ◦Sleep problems ◦Headache ◦Feeling weak or tired ◦Muscle twitching ◦Dry mouth ◦Stomach discomfort ◦Constipation ◦Swelling ◦Weight gain Nursing implementation: ◦Monitor blood pressure, heart rate, mood (when treating depressive symptoms), weight, dietary considerations, and suicidal ideation (particularly when initiating therapy or implementing dose increases ◦Monitor blood glucose levels in patients with diabetes who take phenelzine Generic name: Lisdexamfetamine Brand name: Vyvanse Classification: Stimulants; ADHD Agents Route: PO Does: Attention Deficit Hyperactivity Disorder: ◦Starting/switching treatment: 30 mg PO qAM ◦Dose adjustment: Increase by 10- to 20-mg/day increments approximately qWeek ◦Not to exceed 70 mg qDay Binge Eating Disorder: ◦Indicated for moderate-to-severe binge eating disorder (BED) in adults ◦Starting dose: 30 mg/day PO, THEN ◦Target dose: Titrate in increments of 20 mg at ~1 week intervals to achieve the recommended target dose of 50-70 mg/day ◦Not to exceed 70 mg/day Action: It works primarily by inducing the release of the neurotransmitters dopamine and norepinephrine from their storage areas in nerve terminals. Indications: ◦Attention-deficit/hyperactivity disorder ◦Binge eating disorder Contraindications: Hypersensitivity to amphetamine products or any component of the formulation; concurrent use of MAO inhibitor, or within 14 days of the last MAO inhibitor dose. Known hypersensitivity or idiosyncrasy to sympathomimetic amines; advanced arteriosclerosis; symptomatic cardiovascular disease; moderate-to-severe hypertension; hyperthyroidism; glaucoma; agitated states; history of drug abuse. Side effects: ◦Insomnia ◦Xerostomia ◦Upper abdominal pain ◦Tchycardia ◦Hypertension ◦Palpitations ◦Irritability ◦Anxiety ◦Agitation ◦Hyperhidrosis ◦Skin rash ◦Weight loss Nursing implementation: ◦Prior to treatment, assess for presence of cardiac disease (eg, a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) ◦monitor for signs of abuse and overdose