Analyze Analgesics use H.

pylori infection Alcohol

Opioids Non-opioids Toxic releasing Smoking

Stress Financial problem

Inflammatory response
Aspirin NSAIDs Paracetamol
Inhibit H+ detection
COX-1 inhibition @ antrum

Decrease gastric mucous production, Mechanism unclear

Decreased PGE
Increased HCl production

Acid-pepsin attack

Erosion of mucosa
Bleeding @ Upper GI
(Acute peptic ulcer)

Blood oxidized by HCl Epigastric pain

Irritation of visceral innervation
(Burning sensation)
Black & Tarry stool