Human Health and Diseases

1. Health
➢ It is a state of complete physical, mental and social well-being.
➢ Health increases the longevity of people and reduces infant and maternal mortality rate.
➢ Good health is maintained by balanced diet, personal hygiene, regular exercise, yoga,
vaccination against infectious diseases, proper disposal of wastes, control of vectors and
maintenance of hygienic food and water resources.
➢ Health is affected by
• Genetic disorders (defects inherited from parents from birth)
• Infections
• Life-style: (a) food and water we take in (b) rest (c) exercise (d) habits

2. Disease
➢ Any condition which interferes with the normal functioning of the body and causes disorder
of the mind or body is called a disease.
➢ The disease-causing organisms are called pathogens.
➢ All parasites are pathogens as they cause harm to the host by living in/on them. They enter
our body, multiply and interfere with vital activities, causing morphological and functional
damage. So, pathogens adapt to life within environment of host. For example, pathogen
living in gut must survive at low pH and resist digestive juices.
➢ Types of diseases: a) infectious diseases and b) non-infectious diseases.

S.NO. INFECTIOUS DISEASES NON-INFECTIOUS DISEASES

i. These are easily transmitted from one These are not transmitted from one person to
infected person to the other. the other.
Such diseases are due to extrinsic Extrinsic as well as intrinsic factors, like
factors, i.e., pathogens. deficiencies and hereditary factors, can cause
these diseases
Public health and personal hygiene Public health and personal hygiene are
reduce the probability of disease. ineffective.
For example, HIV, tetanus, hepatitis-B. For example, cancer.
➢ Types of infectious diseases based on pathogens: a) bacterial diseases, b) viral diseases, c)
protozoan diseases, d) fungal diseases and e) helminthic diseases.

3. Bacterial Diseases
(i) Typhoid
• It is caused by pathogenic bacterium Salmonella typhi.
• It is spread by contaminated food and water.
• It generally enters the small intestine and then migrates to other organs through
blood.
• Symptoms:
(a) Constant high fever (39°C to 40°C) (b) Weakness (c) Stomach pain (d) Loss of
appetite (e) Constipation (f) Headache (g) Intestinal perforation and death may occur
in severe cases.
 • Typhoid fever can be confirmed by Widal test.
• Mary Mallon, called Typhoid Mary, was a cook and a typhoid carrier who continued
to spread the disease for several years through the food prepared by her, before it
was discovered.
(ii) Pneumonia
• It is caused by Streptococcus pneumoniae and Haemophilus influenzae.
• They infect alveoli (air-filled sacs) of the lungs where the alveoli get filled with a fluid
resulting in the decrease of respiratory efficiency of the lungs.
• It is spread by inhaling droplets/aerosol from infected persons and sharing glasses
and utensils with an infected person.
• Symptoms (a) Fever (b) Chills (c) Cough (d) Headache (e) In severe cases, lips and
finger nails turn grey to bluish in colour.

4. Viral Diseases
(i) Common cold
• It is caused by a group of viruses called rhino viruses.
• These viruses infect the nasal epithelium and respiratory passage but not the lungs.
• Their attack lasts for about 3–7 days.
• It spreads by
(a) contaminated objects like pens, books, cups, etc.,
(b) cough and sneeze droplets from an infected person.
• Symptoms (a) Nasal congestion and discharge (b) Sore throat (c) Hoarseness (d)
Cough (e) Headache (f) Tiredness.
(ii) Dengue fever
• It is caused by virus Flavivirus.
• Dengue is transmitted by the bite of a mosquito infected with one of the four
dengue virus serotypes.
• It affects infants, young children and adults with symptoms appearing 3–14 days
after the infective bite.
• There is no vaccine or any specific medicine to treat dengue. People who have
dengue fever should rest and drink plenty of fluids.
• Symptoms (a) High fever (b) Severe headache (c) Pain behind the eyes (d) Muscle
and joint pain (e) Rash

(iii) Chikungunya

• It is caused by an alphavirus called Chikungunya virus.

• It is generally spread through bites from A. aegypti mosquitoes.
• The best means of prevention is overall mosquito control and the avoidance of bites
by any infected mosquitoes.
• No specific treatment is known, but medications can be used to reduce symptoms.
• Symptoms (a) Fever up to 104°F (b) Severe joint pain (c) Muscle pain (d) Headache
(e) Nausea (f) Fatigue (g) Rash

5. Protozoan Diseases
(i) Malaria
• It is caused by a protozoan Plasmodium (P. vivax, P. malaria and P. falciparum).
 • P. falciparum causes the most serious and fatal malignant malaria.
• The vector of Plasmodium is female Anopheles mosquito which transfers the
sporozoites (infectious form).
• Treatment is by antimalarial drugs like quinine, chloroquin.
• Malaria can be prevented by killing mosquitoes by spraying DDT, BHC, etc., and using
insect repellents, mosquito nets, etc. Life cycle of Plasmodium
• Plasmodium requires two hosts to complete its life cycle—human and mosquito.
• The infected female Anopheles mosquito transfers the infectious form of
Plasmodium, i.e., sporozoites to the human body by biting.
• The sporozoites reach the liver cells, where they multiply.
• This is followed by their attack on red blood cells resulting in their rupture.
• The ruptured RBCs release a toxin called haemozoin, which is responsible for high
recurring fever, chills and shivering.
• Sexual stages (gametocytes) develop in red blood cells, from where these parasites
enter the female Anopheles mosquitoes when they bite an infected person.
• In the body of mosquitoes, they fertilise and multiply in the stomach wall.
• Sporozoites are now stored in the salivary gland of mosquito till it is again
transferred to human body by a mosquito bite. After entering the human body, all
the events are repeated.

(ii) Amoebic dysentery (Amoebiasis)

• It is caused by a protozoan endoparasite, Entamoeba histolytica, found in large

intestine of humans.
• Housefly acts as mechanical carrier and transmits the parasite from faeces of
infected person to the food.
• Infection takes place through food and water contaminated by faecal matter.
 • Symptoms (a) Abdominal pain (b) Constipation (c) Cramps (d) Stool with excess
mucous and blood clots.

6. Fungal Diseases
(i) Ringworm
• It is caused by fungi of genera Microsporum, Trichophyton and Epidermophyton.
• Human infection occurs either through contact with an infected person or from soil.
It also spreads through towels, clothes, combs, etc., of the infected persons.
• Heat and moisture help these fungi to grow that makes them thrive in skinfolds like
in groin or between toes.
• Symptoms (a) Dry and scaly lesions on skin, nails and scalp. (b) Lesions are
accompanied by intense itching.

7. Helminthic Diseases
(i)Ascariasis
• It is caused by an intestinal endoparasite of human, Ascaris lumbricoides, commonly
called roundworm.
• Eggs of parasite are excreted along with faeces of infected person, which
contaminates water, soil and plants.
• Infection takes place through contaminated vegetables, fruits and water.
• Symptoms (a) Abdominal pain (b) Indigestion (c) Internal bleeding (d) Muscular pain
(e) Fever (f) Anaemia (g) Nausea and headache (h) Blockage of the intestinal
passage.

(ii) Filariasis/Elephantiasis

• It is caused by filarial worms, Wuchereria bancrofti and Wuchereria malayi.

• Female Culex mosquito is the vector.
• Symptoms (a) Inflammation of organs in which they live (b) Blockage of lymph
vessels of lower limbs resulting in swelling. Lower limbs appear like legs of elephant,
thus the name. (c) Genital organs may also be affected, leading to deformation.

8. Prevention and Control of Infectious Diseases

➢ The following measures can prevent/control the infectious diseases:
A. For diseases transmitted through food and water like typhoid, amoebiasis, ascariasis.
(i) Maintenance of personal hygiene: By keeping the body clean, consuming clean
drinking water, food, vegetables and fruits.
(ii) Maintenance of public hygiene: Proper disposal of wastes and excreta, periodic
cleaning and disinfection of water reservoirs and pools, tanks, standard practice of hygiene in
public catering.
B. For Air-borne diseases like pneumonia, common cold:
(i) Maintain personal hygiene.
(ii) Maintain public hygiene.
(iii) Close contact with infected persons or their belongings should be avoided.
C. For vector-borne diseases like malaria, filariasis dengue chikungunya to above measures,
close contact with infected persons or their belongings should be avoided.
(i) Eradication of vectors and their breeding places.
 (ii) Use of mosquito nets.
(iii) Avoid stagnation of water.
(iv) Introduce fishes like Gambusia in ponds that feed on mosquito larvae.
(v) Spray insecticides in ditches drainage areas, swamps.
(vi) Wire mesh at doors and windows to prevent entry of mosquitoes.
D. Vaccination and immunisation programmes for diseases like polio, diphtheria, tetanus, etc.
E. Use of antibiotics and drugs to treat the infected person.

9. Immunity
➢ It is the ability of an organism to resist or defend itself from the development of a disease.
➢ There are two types of immunity: a) innate immunity (inborn immunity) and b) acquired
immunity (adaptive immunity). It is of two types i) passive immunity and ii) active immunity.
(i) Innate immunity
• It is present from the birth and is inherited from parents.
• It is non-specific type of defence.
• It is accomplished by providing different types of barriers to entry of foreign agents 4
types of barriers are:
(a) Physical barriers These barriers do not allow pathogens and foreign agents to
enter the body, e.g., skin, mucous membranes of digestive, respiratory and
urinogenital tracts trapping microorganisms.
(b) Physiological barriers Sweat, tears from eyes, acid in the stomach and saliva in
mouth prevent microbial growth.
(c) Cellular barriers WBCs (polymorphonuclear leukocytes PMNL-neutrophils), and
monocytes (natural killer lymphocytes) and macrophages phagocytose and destroy
microbes.
(d) Cytokine barriers Proteins called interferons produced by virus-infected cells
protect non-infected cells from further viral infection.
(ii) Acquired immunity
• It is not present from the birth and develops during an individual’s lifetime.
• It is pathogen specific.
• It has the ability to distinguish diverse types of foreign molecules or antigens
(specificity).
• When the immune system encounters a pathogen for the first time, a primary
response is produced which is of low intensity. The memory of this encounter with
the same pathogen is also formed. On subsequent encounter with the same
pathogen, a secondary or anamnestic response is produced which is of very high
intensity because of memory of first encounter.
• Immune responses are produced by two types of lymphocytes:
(a) B-lymphocytes or B-cells produce an army of proteins called antibodies in blood,
in response to pathogens.
(b) T-lymphocytes or T-cells help B-cells to produce antibodies.
• Two types of acquired immune responses or immunities develop in the body:
(a) Humoral immune response or antibody mediated immunity (AMI): It is mediated
by antibodies in the blood and lymph (humor).
(b) Cell-mediated immune response or cell-mediated immunity (CMI): It is mediated
by T-lymphocytes. It is responsible for graft rejection in organ transplant because of
its ability to differentiate between ‘self’ and ‘non-self’. Tissue matching, blood group
 matching is thus essential before any graft/transplant and even after this, patients
are given immune suppressant all their lives.
S.NO. ACTIVE IMMUNITY
1. It is developed due to contact with pathogen
(dead or living) or its antigen, that leads to
production of antibodies in the host body.
2. It has no or only few side effects.
3. It is slow but long lasting.
4. It takes time to develop its response.
5. For example, vaccination for polio, etc.
6. Injecting microbes deliberately during
immunisation or infections organisms entering
body induce active immunity.
PASSIVE IMMUNITY
It is developed when readymade antibodies
are injected into the body to protect body
against foreign agents.
It may cause a reaction.
It is fast but lasts only for few days.
It is used when the immune response has to
be faster.
For example, administration of tetanus
antitoxins, antibodies in colostrum, etc.
Foetus receives some antibodies from their
mother through placenta during pregnancy,
which induce passive immunity.

10. Antibodies
➢ Antibodies are protein molecules called immunoglobulins (Ig) and are of 4 types— IgA, IgM,
IgE and IgG.
➢ An antibody has a Y-shaped structure.
➢ Each antibody molecule consists of four polypeptide chains, two are long called heavy (H)
chains while the other two are short called light (L) chains. Hence, an antibody is represented
as H2L2.
➢ IgG is the most prevalent antibody in the blood followed by IgA and IgM.
➢ IgA is present in breast milk (colostrum).

11. Vaccination and Immunisation

➢ Vaccination is the process of introduction of weakened or inactivated pathogens or proteins
(vaccine) into a person to provide protection against a disease.
➢ Vaccines are weakened or inactivated pathogens or proteins introduced into a person to
provide protection against a disease.
➢ Immunisation is the process by which the body produces antibodies against the vaccine
(primary response) and develops the ability to neutralise pathogens during actual infection
(secondary response).
➢ Vaccination provides immunisation after a time gap.
 ➢ Vaccination and immunisation are based on the property called ‘Memory’ of the immune
system.
➢ The vaccine generates memory B- and T-cells that recognise the pathogen on subsequent
exposure and produce an intense immune response.
➢ If a quick immune response is needed, as in tetanus infection or snake bite, preformed
antibodies or antitoxin is injected into the patient. This type of immunisation is called passive
immunisation.
➢ By recombinant DNA technology, vaccines have been produced on large scale, e.g., hepatitis-
B vaccine is produced from yeast.

12. Allergy
➢ The exaggerated or hypersensitive reaction of the immune system to certain antigens
present in the environment is called allergy.
➢ The substances/agents which produce an immune response in an individual are called
allergens, e.g., pollen grains, animal dander, dust, feathers, drugs like penicillin, etc.
➢ IgE antibodies are produced in response to allergens.
➢ Cause: Chemicals like histamine and serotonin released from the mast cells.
➢ Symptoms: (i) Sneezing (ii) Watery eyes (iii) Running nose (iv) Difficulty in breathing.
➢ Drugs like anti-histamine, adrenalin and steroids quickly reduce the symptoms of allergy.
➢ To determine cause of allergy, patient is injected with very small doses of suspected allergens
and the reactions are studied.
➢ Modern day lifestyle has lowered immunity and increased sensitivity to allergens.

13. Auto Immunity

➢ It is an abnormal immune response in which the immune system of the body starts rejecting
its own body cells or ‘self’ cells and molecules, hence body attacks self-cells thus damaging
the body.
➢ For example, rheumatoid arthritis, Addison’s disease.

14. Immune System

➢ Components of immune system:
• Lymphoid organs
• Immune cells
• Soluble molecules like antibodies
• Lymphoid tissues
➢ (i) Primary lymphoid organs
• The organs where lymphocytes originate and mature to become antigen-sensitive,
e.g., bone marrow and thymus, are called primary lymphoid organs where immature
lymphocytes differentiate into antigen sensitive lymphocytes.

(a) Bone marrow

• It is the primary lymphoid organ where all blood cells including lymphocytes
originate.
• Bone marrow provides the micro-environment for the development and maturation
of B-lymphocytes.

(b) Thymus
 • Thymus is a lobed organ located near the heart and beneath the breastbone.
• It is quite large at the time of birth but reduces with age.
• It provides the micro-environment for the development and maturation of T-
lymphocytes.
➢ (ii) Secondary lymphoid organs
• After maturation, lymphocytes migrate to secondary lymphoid organs.
• The organs where lymphocytes interact with the antigen and proliferate to become
effector cells, e.g., spleen, lymph nodes, tonsils, Peyer’s patches of small intestine
and appendix are called secondary lymphoid organs.

(a) Spleen

• It is a large bean-shaped organ and contains lymphocytes and phagocytes.

• It acts as a filter of the blood by trapping blood-borne microorganisms.
• It has a large reservoir of erythrocytes.

(b) Lymph nodes

• These are small solid structures present at different points along the lymphatic
system.
• They trap the microorganisms or other antigens that enter the lymph and tissue
fluid.
• Antigens trapped in the lymph nodes activate the lymphocytes and produce an
immune response.

(c) Mucosal associated lymphoid tissue (MALT)

• It is formed of masses of lymphoid tissue lining the mucosa of respiratory, digestive

and urinogenital tracts.
• 50 per cent of the lymphoid tissue in human body is formed by MALT.

15. Acquired Immuno Deficiency Syndrome (AIDS)

➢ It was first reported in U.S.A. in 1981 and in last 25 years, it has killed more than 25 million
people.
➢ It is caused by the Human Immunodeficiency Virus (HIV).
• HIV belongs to the group retrovirus.
• It has RNA genome enclosed in an envelope.
➢ Transmission of HIV occurs through following ways:
(i) By sexual contact with the infected person.
(ii) By transfusion of contaminated blood and blood products.
(iii) By sharing infected needles.
(iv) From infected mother to her child through placenta.
➢ It is not spread by more touch or physical contact. It only spreads through body fluids. Hence
the infected persons should not be isolated from family and society. High risk individuals (i)
Those having multiple sexual partners. (ii) Drug addicts taking the drugs intravenously. (iii)
Individuals who require repeated blood transfusions. (iv) Children born to an HIV infected
mother.
➢ Diagnosis is done by enzyme linked immunosorbent assay (ELISA).
➢ Incubation Period: Time gap between infection and appearance of AIDS symptoms is called
the incubation period. It may vary from few months to 5–10 years.
➢ Life cycle of HIV
• After getting into the body of a person, the virus enters the macrophages.
• Here, RNA is replicated to form viral DNA by enzyme reverse transcriptase.
• The viral DNA now gets incorporated into the host cell’s DNA and directs the infected
cells to produce viruses.
• The macrophages continue to produce virus particles and hence act like HIV factory.
• The virus particles enter helper T-lymphocytes (TH cells) in the blood, where they
continue to replicate and produce viral progenies.
• Thus, the number of helper T-lymphocytes progressively decreases in the body of
the infected persons.
• With the decrease in number of T-cells, the immunity also decreases. The person is
unable to produce any immune response even against common bacteria like
Mycobacterium, parasites like Toxoplasma, viruses and fungi.
• Infected cells can survive while viruses are being replicated and released.

➢ Treatment
• There is no permanent cure for HIV.
• Anti-retroviral drugs: They can only prolong life of patient but cannot prevent death.
➢ Preventive measures
• As no cure is there so prevention is best option. As it spreads due to conscious
behaviour so prevention is easy.
• National AIDS Control Organisation (NACO) established in 1991 and other non-
governmental organisations (NGOs) educate people about AIDS.
• WHO has started a number of programmes to prevent the spreading of HIV infection
that includes:
(i) making blood from blood banks safe from HIV.
(ii) ensuring the use of only disposable needles and syringes.
(iii) free distribution of condoms.
(iv) controlling drug abuse.
(v) advocating safe sex and promoting regular check-ups for HIV susceptible
populations.
16. Cancer
➢ Cancer is defined as an uncontrolled division or proliferation of cells without any
differentiation.
➢ Characteristics of cancer cells:
(i) The cells divide repeatedly with uncontrolled cell division.
(ii) The cancer cells do not require extracellular growth factors.
(iii) Cancer cells have lost the property of contact inhibition.
(iv) Due to repeated division, cells form a large mass of tissue called tumour.
(v) The cells pass out from the tumour to new sites for forming secondary tumours.
(vi) The invasion of cancerous cells from one part to the other parts by body fluid is
called metastasis.
(vii) Tumours are of two types—benign and malignant.
S.NO. Benign tumour Malignant tumour
1. It is a non-cancerous tumour. It is a cancerous tumour.
2. Benign tumour does not show metastasis It shows metastasis and thus invades other body
and is non-invasive. parts.
3. It stops growth after reaching a certain Malignant tumour shows indefinite growth as
size. proliferating cells, called Neoplastic or tumor cells,
grow rapidly, invade and damage other tissues.
4. Limited adherence occurs amongst cells of There is no adherence amongst cells. They tend to
benign tumour. slip past one another.
5. It is less fatal to the body It is more fatal to the body

➢ Oncogenic viruses have cancer-causing viral oncogenes.

➢ Normal cells have genes called cellular oncogenes (c-onc) or proto-oncogenes, which are
present in inactivated state but under certain conditions (like mutation) get transformed to
cancer-causing oncogenes.
➢ Causes of cancer
The cancer-causing agents are called carcinogens. These are of following types:
(a) Chemical agents: Aniline dyes, N-nitroso dimethylamine, benzopyrene, chemicals in
cigarette smoke.
(b) Physical agents: Ionising radiations like X-rays and γ-rays, non-ionising radiations like UV-
rays, damage DNA causing neoplastic transformation.
(c) Biological agents: Oncogenic viruses, some parasites.
➢ Types of cancer
(a) Carcinoma: It is cancer of epithelial tissue, e.g., skin cancer.
(b) Melanoma: It is cancer of melanocytes of skin.
(c) Sarcoma: It is cancer of mesodermal tissue.
(d) Leukaemia and lymphoma: It is cancer of haemopoietic cells (blood cells).
➢ Cancer detection
(a) Blood and bone marrow tests are done for increased cell count in case of leukaemia.
(b) Histopathological study or biopsy: In biopsy, a piece of the suspected tissue cut into thin
sections is stained and examined under microscope by a pathologist.
(c) Radiography: X-rays are used to detect cancer of the internal organs.
(d) Computed tomography: It uses X-rays to generate a three-dimensional image of the
internal of an object.
 (e) MRI (Magnetic Resonance imaging): non-ionising radiation and strong magnetic field are
used in MRI to accurately detect pathological and physiological changes in the living tissue.
(f) Monoclonal antibodies: Antibodies against cancer-specific antigens are also used for
detection of certain cancers.
(g) Techniques in molecular biology: Used to detect genes in individuals with inherited
susceptibility to certain cancers. Identification of such genes can help in prevention by
advising to avoid exposure to particular carcinogen to which they are susceptible like tobacco
smoke for lung cancer.
➢ Cancer treatment
• The common approaches for treatment of cancer are:
• (a) Surgery: The tumour cells are removed with the help of surgery to check the
spread of cancerous cells.
• (b) Radiation therapy: A lethal irradiation of tumour cell is done, taking proper care
of the normal tissues surrounding the tumour mass.
• (c) Chemotherapy: Cancerous cells are killed by several chemotherapeutic drugs.
These drugs exhibit side-effects like hair loss, anaemia.
• (d) Immunotherapy: In this method, biological modifiers like α-interferons are used
which activate the immune system and help in destroying the tumour as tumor cells
avoid detection and destruction by immune system. Majority of treatments require
combination of surgery, radiotherapy and chemotherapy.

17. Drugs and Alcohol Abuse

➢ When drugs and alcohol are taken for purposes other than medicinal or taken in amounts or
frequencies that impairs physical, physiological or psychological functions, it is called drug
abuse and alcohol abuse, respectively.
➢ Drugs belong to different categories which are as follows.
➢ (i)Opioids
• Heroin is a depressant and slows down body functions.
• Source: Morphine is extracted from the latex of poppy plant Papaver somniferum.
Heroin is obtained by acetylation of morphine, is a white, odourless, bitter,
crystalline compound; commonly called smack.
• Mode of intake: By snorting and injection.
• Mode of action: They bind to specific opioid receptors in the central nervous system
(CNS) and gastrointestinal tract.
• Effects: Heroin is a depressant and slows down body functions. Morphine is an
effective sedative and painkiller useful in patients who have undergone surgery.
➢ (ii) Cannabinoids
• Source: Obtained from inflorescence of the plant Cannabis sativa. Flower tops,
leaves and resins of C. sativa in various combinations produce hashish, charas,
marijuana and ganja.
• Mode of intake: By inhalation and oral ingestion.
• Mode of action: They interact with the cannabinoid receptors present in the brain.
• Effects: Effect the cardiovascular system of the body.
➢ (iii) Coca alkaloid or cocaine
• Source: Derived from the leaves and young branches of South American plant called
Erythroxylum coca (coca plant). Cocaine is commonly called coke or crack.
• Mode of intake: By sniffing and snorting.
 • Mode of action: It has a potent stimulating action on central nervous system and
interferes with the transport of the neurotransmitter dopamine.
• Effect: It is a strong stimulant of CNS and produces sense of euphoria and increased
energy. When taken in excess it causes headache, convulsions, hallucinations and
even death due to cardiovascular or respiratory failure.
➢ (iv) Hallucinogens
• Source: Obtained from plants like Atropa belladona and Datura sps. Lysergic acid
diethyl amide (LSD) is derived from the fungus Claviceps purperea. Plants with
hallucinogenic properties have even been used as medicines in religious ceremonies
and rituals.
• Mode of action: These drugs are called psychedelic drugs because of their effects on
the cerebrum and sense organs.
• Effect: These drugs effect thoughts, feelings and perceptions of an individual.
Medically these are given to patients to cope with mental illnesses like depression
and insomnia.
➢ (v) Tobacco
• Source: Tobacco plant.
• Mode of intake: It is smoked, chewed or used as a snuff.
• Mode of action: It has nicotine, an alkaloid, which stimulates the adrenal gland to
release adrenaline and noradrenaline which in turn increases the blood pressure and
heart rate.
• Effects:
(a) Smoking increases the chances of lung cancer, bronchitis, emphysema, coronary
heart disease, cancer of throat, gastric ulcer, cancer of urinary bladder, etc.
(b) Smoking leads to increase in carbon monoxide content of blood and reduces
concentration of haem-bound oxygen, as a result of which oxygen deficiency in the
body is created.
(c) Chewing of tobacco causes oral cancer which becomes fatal in extreme
conditions.
➢ Alcohol
• Mode of intake: Oral intake.
• Mode of action: Alcohol has an anaesthetic effect on nervous system affecting
cerebrum, cerebellum and other parts.
• Effect: It may cause euphoria, peptic ulcer, gastric carcinoma, hepatitis, liver failure,
liver cell carcinoma.

18. Addiction and Dependence

➢ The psychological attachment to certain effects such as euphoria and temporary feeling of
well-being, associated with drugs and alcohol is called addiction.
➢ People take drugs/alcohol when not needed, but with repeated use, tolerance level of
receptions in body increases; receptors thus respond to higher doses, leading to greater
intake and addition.
➢ Reasons for alcohol abuse in adolescents:
(i) Social pressure.
(ii) Curiosity and need for adventure, excitement and experiment.
(iii) To escape from stress, depression and frustration.
(iv) To overcome hardships of daily life.
 (v) Unstable or unsupportive family structure.
(vi) Effects might be perceived as beneficial for relieving stress
(vii) Perception that it is cool or progressive to smoke and consume alcohol. TV, movies,
internet, newspapers promote this perception.
(viii) Pressure to excel in academics or exams.
➢ The tendency of the body to manifest characteristic and unpleasant withdrawal syndrome on
abrupt discontinuation of regular dose of drugs/alcohol is called dependence.
➢ Characteristics of withdrawal symptoms:
(i) Anxiety (ii) Shakiness (iii) Nausea (iv) Sweating
(v) Vomiting (vi) Diarrhoea (vii) Insomnia (viii) Muscular and abdominal cramps
(ix) Restlessness (x) Depressed mood (xi) Irritability
Withdrawal symptoms are at peak after 1–2 days of stopping the intake and slowly fade
away. They mostly disappear 3–4 weeks after abstinence.

19. Effects of Drug and Alcohol Abuse

➢ Alcohol has an anaesthetic effect on nervous system, affecting cerebrum followed by
cerebellum and other parts.
➢ It affects the nervous system in following ways:
(i) Loss of judgement, will power and self-control.
(ii) Loss of emotional control.
(iii) Loss of moral sense.
(iv) Visual problem.
(v) Staggering and incoherent speech.
(vi) Inflammation of axon of neuron leading to neuritis.
➢ Side-effects of drugs on males: Acne, aggressiveness, reduction in size of testicles, decreased
sperm production, premature baldness, enlargement of prostate gland, mood swings,
depression, breast enlargement, potential for kidney and liver dysfunction.
➢ Side-effects of drugs on females: Masculinisation, aggressiveness, mood swings, depression,
abnormal menstrual cycles, enlargement of clitoris and excessive facial and body hair;
deepening of voice.
➢ Warning signs of drug and alcohol abuse:
(i) Drop in academic performance.
(ii) Absence from school/college.
(iii) Lack of interest in personal hygiene.
(iv) Isolation, depression, fatigue, aggressive and rebellious behaviour.
(v) Deteriorating relationships with family and friends.
(vi) Fluctuation in weight, etc.
(vii) Loss of interest in hobbies.
(viii) Change in eating and sleeping habits and appetite.
➢ Those who take drugs intravenously develop a risk of AIDS and hepatitis-B.
➢ Use of alcohol during adolescence may lead to heavy drinking in adulthood.
➢ The chronic use of drug and alcohol damages nervous system and liver (cirrhosis) and the
alcoholism during pregnancy affects the foetus.
➢ May turn to stealing to get money for buying drugs/Alcohol.
➢ Becomes cause of mental and financial distress to one’s family.
➢ May manifest reckless behaviour, vandalism and violence.
20. Prevention and Control
➢ Avoid undue pressure: Every child has his own choice and personality and hence should be
respected and nurtured accordingly. They should not be forced to perform beyond their
threshold limits, be in sports or studies, etc.
➢ Educating and counselling: Children should be educated and counselled to face problems,
stresses, to accept disappointments and features as part of life. We should put in efforts to
channelise child’s energy into healthy pursuits like sports, reading, music, yoga etc.
➢ Seeking help from parents and peers: Parents and friends can guide appropriately to sort
out their problems and can thus help the youth to vent out their feelings of anxiety and guilt.
➢ Looking for danger signs: Parents and teachers should be careful enough to look for and
identify the danger signs and if there, it should be brought to the notice of parents so that
appropriate measures can be taken to diagnose the malady and underlying causes. This
would help in initiating proper remedial steps and measures.
➢ Seeking professional and medical help whenever required. Help from psychologist,
psychiatrists, deaddiction and rehabilitation programmes and with sufficient will power, one
can get rid of problem completely