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Proposal Print 4
Proposal Print 4
JUNE, 2023
Objectives: To assess the knowledge, attitudes, and practice toward electronic prescribing
adoption in the Debre Tabor comprehensive specialized hospital, north central Ethiopia from
June 1, 2023 to September 7, 2023
Method: A single center institutional based cross-sectional study will be conducted at DTCSH
on prescriber’s
Work plan and budget: This study will be conducted from June 1, 2023 to September 7, 2023
and different tasks will be carried out to do the research by each group members and it will need
a grand total cost of 3034 ETB.
i
Acknowledgement
First and foremost, we would like to thank our research adviser, Mr.denekew (MPH), for his
guidance, support, and encouragement throughout the entire process. His mentoring and
expertise were invaluable in helping us to shape the direction of our research and to bring our
ideas to fruition. We would also like to express our gratitude to the member of Debre Tabor
comprehensive specialized hospital staffs and also our research team, who provide valuable
input, insights, and assistance at every stage of the project. Their contribution is critical to the
success of this research, and we are deeply grateful for their hard work and dedication. Finally,
we would like to extend our heartfelt thanks to all of the participants in our study, who
generously shared their time, experiences, and insights with us. Their willingness to engage with
our research was essential to the success of this project, and we are deeply grateful for their
participation.
ii
Table of Contents
Summary......................................................................................................................................................i
Acknowledgement.......................................................................................................................................ii
Acronyms and abbreviation.........................................................................................................................v
1. Introduction.........................................................................................................................................1
1.1 Background..................................................................................................................................1
1.2 statement of the problem..............................................................................................................3
1.3 Literature review..........................................................................................................................4
1.4 Significance of the study..............................................................................................................6
2. Objective.............................................................................................................................................7
2.1 General objective.........................................................................................................................7
2.2 Specific objective........................................................................................................................7
3. Method and Material...........................................................................................................................7
3.1. Study area and period..................................................................................................................7
3.2. Study design................................................................................................................................7
3.3. population....................................................................................................................................8
3.3.1. Source population................................................................................................................8
3.3.2. Study population..................................................................................................................8
3.4 Eligibility criteria.........................................................................................................................8
3.4.1 Inclusion criteria..................................................................................................................8
3.4.2 Exclusion criteria.................................................................................................................8
3.5 Sample size determination and sampling procedure....................................................................8
3.6 Study variables............................................................................................................................9
3.6.1 Dependent variable..............................................................................................................9
3.6.2 Independent variables..........................................................................................................9
3.7 Operational definitions................................................................................................................9
3.8 Data collection procedure............................................................................................................9
3.8.1 Data collection instrument...................................................................................................9
3.8.2 Data quality management.....................................................................................................9
3.9 Data analysis procedures...........................................................................................................10
4 Ethical Consideration........................................................................................................................10
5. Dissemination plan................................................................................................................................10
6. Work Plan and Budget...........................................................................................................................10
iii
6.1 Work plan........................................................................................................................................10
6.2 Budget Break Down..................................................................................................................12
7. References.............................................................................................................................................13
8 Annex.....................................................................................................................................................15
8.1 questionnaire (Data Collection Instrument).....................................................................................15
iv
Acronyms and abbreviation
CDS-eP- clinical decision supporting electronic prescription
v
1. Introduction
1.1 Background
Electronic prescribing (e-Prescribing), is the most recent technological advancement in
medication. e-Prescribing is a computerized system that facilitates or speed up the interaction
between physicians and pharmacist by enabling physicians to create and transfer the medication
prescriptions electronically to pharmacists. (1) e-Prescribing is the process of transmitting a
prescription or prescription-related information electronically from a prescriber directly to a
dispenser, rather than using the traditional paper methods. Previously existing research indicate
that implications of electronic-health, and e-Prescribing, can provide great advantage to
information management, reallocated distributive functions, providing more available time for
counseling and providing improved delivery of pharmaceutical care. Errors especially due to
illegibility of handwritten prescriptions, the constant need for time-consuming clarifications or
discussion with patient and refill requests could also be reduced with e-Prescribing. e-
prescribing also means of increasing security, a potential for collaborative billing, enable to use
time efficiently, for patient safety, make complete patient profile availability(data), and a better
pharmacist patient relationship as reasons for preferring the electronic method. (2)
In general, healthcare in the world, unlike other industries, has slowed in developing innovations
in information technology; but it is apparent that this sector is currently well on its way for
developing. A few federal agencies are actively promoting health information technology; a lot
of vendor firms are emerging; degree programs are mushrooming; and professional organizations
are hopping on the attractive growing of technology. E-Prescribing technology has taken hold as
an advance sector over hand-written drug treatments orders; E-prescription, being one of the
earliest adoptions in CPOE, which get acceptance by certain physicians. Prescribing errors are
the most source of preventable errors in hospitals in the world. E-Prescribing can reduce the
number of errors and indeed impact health outcomes.(3)
Electronic systems for medicine prescribing and administration have been adopted more widely
in the United States. currently, this may because of the need for costing of medication
administration, in an insurance-based health system, and the need for risk management to reduce
clinical risk to a minimum effect, and to optimize audit trails in a highly litigious society. As a
consequence,
1
there are many proprietary electronic Prescribing systems, available in the United States.(4)
According to the United State national progress report on “e-prescribing, the total number of
transmitted e-prescriptions to community pharmacies increased by 27% from 2007 to 2012 in the
United States”.(1) for developing this infrastructure, the Federal Government supported the
national adoption of EHRs because of the promise that the adoption and use of health
information technology can increase health system efficiency, improve care quality, and reduce
medication errors.(5)
The electronic prescription system creates connection to information systems in health-care
organizations like in hospitals, health-care centers, and pharmacies sectors. The implementation
of this application can end many problems of paper prescribing process and will bring benefits,
including medication cost savings, reducing medication prescription errors, increasing
prescription legibility of handwritten, improving medication therapy outcomes, reducing
redundant paperwork, electronically accessing to updated pharmacopeia information, and also
hold patient medication history securely.(6)
Over many years, hand-written prescription has been a preferred communication method for
physicians in decisions relating to medication therapy and for transmitting prescription to
pharmacists to distribute medications to the patients. It is also considered as a valuable resource
for the patients counseling on how to use the medicine to achieve the maximum benefit of health
care. In the last decade, electronic prescription is start to adopted and considered as an interested
subject among other electronic health solutions to process the health-related data and record.(7)
ICT based innovations have proposed a wide range of new services for Heath care users and
providers at many health levels. However, “the digitalization process often is neither smooth nor
successful”. The difficulties that national health care systems across the Europe have been faced
creating electronic health becomes an interesting research topic pointing out the complexity of
the issues when ICT specialists, physicians, pharmacy specialists, health managers, lawyers and
politicians are interconnected.(8)
The technology would safely transmit prescription or prescription related information between
stakeholders (prescribers, dispensers, pharmacies, health plans, and health insurers and health
manager) either directly or through an intermediary (including an electronic prescription
network) using electronic media or software.(7)
2
Assessing physicians’ attitudes and behaviors that help to technology adoption has been an area
of ongoing research topic today. A few studies investigate attitudes toward electronic health
record adoption in inpatient and academic ambulatory care settings. Some have investigated
adoption readiness using statewide survey samples of medical practices, others have assessed
physicians’ perceptions of quality of care to the technology.(9)
Today, the necessity of using electronic prescription systems can be felt more than ever due to
their many benefits. Therefore, study on this system as a systematic institution based cross
sectional review will be done. However, since many countries, especially developing countries
including our country Ethiopia, still use manual traditional prescription systems, using the
experiences of leading countries is very necessary and useful to develop and design the
electronic prescription system in the developing countries. Taking into account the above
considerations, the aim of our study is to assess the knowledge ,attitudes and practice toward
electronic prescribing adoption in university of Gondar specialized hospital on prescribers and
staff.(7)
Research showing that handwritten prescriptions are unsafe and associated errors can lead to
tremendous inefficiency for patients and pharmacists. Handwritten prescriptions have several
associated potential dangers, including the potential for misinterpretation errors due to
illegibility.(11)
Not using information technology (IT health) will lead to unimproved the quality, safety, and
efficiency of health care delivery… In addition to the dangers associated with poor legibility, the
need for pharmacy clarification can result in significant extra work for pharmacists as well as
delays for patients in obtaining prescriptions. Not potential benefits include unimproved
efficiency for pharmacists and providers, increase need for pharmacy clarification of prescription
information phone calls, and increase patient wait time for prescriptions.(11)
3
There are many different types of errors related to e-prescribing they have been organized into
three broad categories:
Order entry errors from the provider side; for example:-Wrong drug, pharmacy, patient, incorrect
directions, conflicting information, wrong quantity errors Refill errors.(11)
Many barriers have hindered the adoption of EHRs and e-prescribing systems, including the
misalignment of financial incentives, the high cost of purchase, implementation and maintenance
of systems; the immaturity of software products and vendors; the lack of integration between
EHR systems(10)
4
prescribing (92%), and regarded e-prescriptions to be time-saving (91%) and to be safer (83%),
compared to handwritten prescriptions.
Although a majority (73%) of the physicians reported that they were always or often checking
the e-prescription the last time before transmitting, 25% declared that they were seldom or never
doing the last check. The respondents suggested several improvements, among others, to
simplify the drug choice and the cancellation of e-prescriptions.(12) Even if in Swedish
physicians had a good practice up on using electronic prescription they found a difference in
attitudes between physicians that were rare (< 5 eprescriptions/day), intermediate (5–10
eprescriptions/day) and extensive (> 10 eprescriptions/day) users of eprescribing. (12)
A study in Kuwait indicates that more than half (56%) reported having average computer
literacy, as a result of this physicians’ attitude and practice towards e-prescribing systems was
high (94%), with 94% indicating that they understood how to use the system. The vast majority
(95%) were currently using an e-prescribing system, with between 1–17 years of previous
experience. The number of daily prescriptions was between 15–54 prescriptions. The overall
weighted median score for the knowledge dimension of the questionnaire was 3, while the
median score for functionality was 2.3, respectively. (13)
In a cross-sectional survey among GPs in the West of Ireland 70% of the respondents believed
that CDS-eP can improve quality, while nearly 84% considered that using this new mechanism
may reduce prescribing error. 94% of GPs expressed their readiness to learn and use this new
mechanism. About one in five respondents were concerned that this mechanism may reduce their
decision-making power in prescribing.(14) However in another study, 45% of prescribers agreed
that using e-prescription means faster or easier prescribing, as well as another study from turkey
38% reported that e-prescribing was time-saving. (15, 16)
A pre-implementation cross-sectional study in India indicated that 70% claimed their
prescriptions to be legible and 60.7% liked paper prescriptions, only 40% were able to track the
continuity of their prescription. Around 70.8% had computer usage experience for more than 5
years, 23.7% for 1-5 years, and the restless than one year. 79% were comfortable with the use of
computers, and only 57.6% had self-assessed good knowledge of computers. Of the 70.5% who
have heard of e-prescriptions only 14% had hands-on exposure in generating it. In another study
from South Africa, approximately one-third of the responding physicians reported that they use
or have trialed e-prescribing systems. (16, 17)
5
In a similar study in India, only 30.4% were afraid that their work would be controlled while
sending e-prescriptions. Even though an almost equal number of participants agreed and
disagreed on the fact that storage of personal healthcare information in a database would be
unethical and would lead to data abuse, 79.4% agreed that this data could be used for research
purposes. More than 50% of the participants disagreed with the statement that e-prescribing
would decrease the economic burden of the healthcare system and also, more than fifty
percentage thought that e-prescribing would help in detecting medication misuse and diversion.
(16)
Attitude regarding the future introduction of e-Prescription in Jordan nearly all of the responding
physicians (98.7%) agreed that developing a computerized system that includes important
information about drugs such as medicines interaction, contraindications, and cost, would
improve the prescribing process. The implementation of an EP system would result in a more
efficient prescribing and dispensing process according to 92% of the responders. (18)
Indian study regarding the future practice of electronic prescribing shows that 71.6% of
prescribers were willing to adopt e-prescribing in the future and 65% felt that it would be the
gold standard for prescribing in the coming years but the practice of electronic prescription
depends on good computer knowledge, that was found to be predictors of positive attitude
towards usefulness of e-prescription.(16)
6
knowledge towards electronic prescription that is necessary to know whenever before the
implementation of electronic prescription in this hospital.
2. Objective
2.1 General objective
7
cross-sectional study
3.3. population
3.3.1. Source population
All prescribers enrolled in human resource in the Debre Tabor comprehensive specialized
hospital.
n= (Zα/2)2 P(1-P)/d2
n= (1.96)2(0.5) (1-0.5)/ (0.05)2
n= 384.16
10% of nonresponse rate.
Total N=n= 425
N= the number of prescribers to be sampled (sample size).
8
3.6 Study variables
3.6.1 Dependent variable
Attitude, Knowledge, and practice of electronic prescription
Experience
Electronic prescription: is a prescription system with the utilization of electronic medical record
which is designed to facilitate medicines prescription service starts from the prescription writing
stage, prescription reading stage, and medicines preparation stage up to prescription hand over,
the medicine use process, monitoring process toward the taking out of prescribed medicines. (24)
Knowledge of electronic prescription:
9
day the collected data will be reviewed and checked for completeness and consistency of the
response.
4 Ethical Consideration
This research will be conducted after the ethical clearance obtained from the research and ethical
committee of department of clinical pharmacy, fekede egzi college before the collection of data
using formatted questionnaires. The verbal informed consent will be obtained from study
participant after the objective of the study made clear and permission for cooperation was asked
politely. The confidentiality of study participants will be maintained by using codes. Verbal
informal voluntary consent will be taken from a participant.
5. Dissemination plan
After the research is finalized, the result will be submitted to the department of clinical
pharmacy, fekede egzi college and this result would be disseminated to DTCSH administrative
offices and used when the hospital tried to implement an electronic prescription system.
10
pharmacy
Research
protocol Researchers
development
2. Proposal Researchers
development
and
Submission
3. Approval of Advisor
proposal
4. Pre–test Researchers
5. Designing of Researchers
the final
questionnaire
6. Obtaining Department
ethical of clinical
clearance pharmacy
7. Data Researchers,
collection data
collectors
8. Data Researchers
processing and
summarizing
(Data entry
into software)
9. Data Researchers
management
and analysis
10. Report writing Researchers
11. Developing Researchers
the final report
11
12. Research Department
defense and clinical
submission pharmacy
and
Researchers
2) Service costs
12
Description of the cost
No. Cost in Remark
ETB
2 Expenses for stationery and materials 2090 ETB
3 Service costs 650 ETB
Sub-total 2740 ETB
Grand total (10%) 3034 ETB
7. References
1. Tremblay MC. A review of the literature and proposed classification on e-prescribing: Functions,
assimilation stages, benefits, concerns, and risks. 2015.
2. Clauson KA, Alkhateeb FM, Lugo KD, Khanfar NM. E-prescribing: attitudes and perceptions of
community pharmacists in Puerto Rico. International journal of electronic healthcare. 2011;6(1):34-46.
3. Salmon JW, Jiang R. E-prescribing: history, issues, and potentials. Online journal of public health
informatics. 2012;4(3).
4. electronic Aat, care: paip, a survey of prescribers and stafGoundrey-Smith S. History and Context
of Electronic Prescribing in the US and UK. Principles of Electronic Prescribing: Springer; 2012. p. 25-
46.
5. Johnson C, Johnston D, Crowley P, Culbertson H, Rippen H, Damico D, et al. EHR Usability
Toolkit: A Background Report on Usability and Electronic Health Records. Rockville, MD: Agency for
Healthcare Research and Quality; 2011. 2018.
6. Farre A, Bem D, Heath G, Shaw K, Cummins C. Perceptions and experiences of the
implementation, management, use and optimisation of electronic prescribing systems in hospital settings:
protocol for a systematic review of qualitative studies. BMJ open. 2016;6(7).
7. Samadbeik M, Ahmadi M, Sadoughi F, Garavand A. A copmarative review of electronic
prescription systems: Lessons learned from developed countries. Journal of research in pharmacy
practice. 2017;6(1):3.
8. wide IactIbihpa, range of new services for Heath care users and providers. However tdpo, Europe
insnsTdtnhcsa, pointing hbfceheHbairt, out the complexity of the issues when ICT specialists p,
pharmacy specialists, health, managers lapai.
9. Devine E, Patel R, Dixon D, Sullivan S. Assessing attitudes toward electronic prescribing
adoption in primary care: a survey of prescribers and staff. Journal of Innovation in Health Informatics.
2010;18(3):177-87.
10. Tan KS. Internet‐based ICT adoption: evidence from M2009.
11. Abramson EL. Causes and consequences of e-prescribing errors in community pharmacies2015.
12. Hellström L, Waern K, Montelius E, Åstrand B, Rydberg T, Petersson G. Physicians' attitudes
towards ePrescribing – evaluation of a Swedish full-scale implementation. BMC Medical Informatics and
Decision Making. 2009;9(1):37.
13
13. Almutairi BA, Potts HW, Al-Azmi SF. Physicians’ Perceptions of Electronic Prescribing with
Electronic Medical Records in Kuwaiti Primary Healthcare Centres. Sultan Qaboos University Medical
Journal. 2018;18(4):e476.
14. Hor CP, O'Donnell JM, Murphy AW, O'Brien T, Kropmans TJ. General practitioners' attitudes
and preparedness towards Clinical Decision Support in e-Prescribing (CDS-eP) adoption in the West of
Ireland: a cross sectional study. BMC medical informatics and decision making. 2010;10(1):1-8.
15. Gіder Ö, Ocak S, Top M. Evaluation of electronic prescription implications in turkey: an
investigation of the perceptions of physicians. Worldviews on Evidence ‐Based Nursing. 2015;12(2):88-
97.
16. Palappallil DS, Pinheiro C. Perceptions of prescribers towards electronic prescription: A pre-
implementation evaluation. Journal of Young Pharmacists. 2018;10(3):313.
17. Cohen JF, Bancilhon J-M, Jones M. South African physicians' acceptance of e-prescribing
technology: an empirical test of a modified UTAUT model. South African Computer Journal.
2013;50(1):43-54.
18. El-Dahiyat F, Kayyali R, Bidgood P. Physicians’ perception of generic and electronic
prescribing: A descriptive study from Jordan. Journal of pharmaceutical policy and practice. 2014;7(1):1-
8.
19. Greenhalgh T. Drug prescription and self-medication in India: an exploratory survey. Social
science & medicine. 1987;25(3):307-18.
20. Velo GP, Minuz P. Medication errors: prescribing faults and prescription errors. British journal of
clinical pharmacology. 2009;67(6):624-8.
21. People Are Die Just Because Of Dr. Handwriting [Internet]. August 02, 2020. Available from:
https://www.wordmotive.com/2020/08/people-are-die-just-because-of-dr.html.
22. It’s time to totally ban handwritten prescription [Internet]. Oct 20, 2018, 2:28 am IST. Available
from: https://www.deccanchronicle.com/nation/in-other-news/201018/its-time-to-totally-ban-
handwritten-prescription.html.
23. Clark PA. Medication errors in family practice, in hospitals and after discharge from the hospital:
an ethical analysis. The Journal of Law, Medicine & Ethics. 2004;32(2):349-57.
24. Hahn A, Lovett A. Electronic prescribing: an examination of cost effectiveness, clinician
adoption and limitations. Universal Journal of Clinical Medicine. 2014;2(1):1-24.
14
8 Annex
8.1 questionnaire (Data Collection Instrument)
Questionnaires
Dear Sir, we are graduating pharmacy students of Fekede egzi College and we are conducting a research
in Debre Tabor comprehensive specialized hospital with the objective of assessment of knowledge,
attitudes, and practice to ward electronic prescribing adoption in Debre Tabor comprehensive
specialized hospital. Therefore, your genuine participation and honest response will help us to get more
information about the problem. The most important of your participation is based on your willingness.
Your responses are completely confidential.
Thank you in advance!
A survey of prescribers
Background information
participants study code: _________
Please read the question carefully and encircle the most appropriate response Scale
-1- Strongly disagree 2- Disagree 3-Neutral 4-Agree 5–Strongly Agree
Years of experience: <1 year 1-5 years 6-10 years 11-15 years 16-20 years >20 years
15
The pharmacists clear any doubts in my prescription 1 2 3 4 5
16
Computer Use –Personal experience
I have been using computers for : <1 year 1 -5 years 6-10 years 11-15 years >15 years
17
It is good that more and more data is available so that 1 2 3 4 5
Perceived fitness
I will accept e prescribing if it’s adopted in the institution 1 2 3 4 5
18
I think the facilities in the institution will need drastic 1 2 3 4 5
Modifications
19
Researchers;
1. Eyob terefe
2. Fasika wubneh
3. Bisrat nigussie
4. Birhanu amare
5. Meseret genet
6. Liyuneshi guadie
7. Betelihem mulualem
8. Danawit tadesse
9. Debie fenetaw
10. Belaynew workie
20