®

Zincidone
By Solabia

Physio-seboregulator

ASSOCIATION OF ZINC AND L-PCA BENEFITS, IDEAL FOR OILY SKINS!

 ZINC : UNIVERSAL AND OLIGO-ESSENTIAL ANTI-SEBORRHEIC AGENT WITH ANTISEPTIC

ACTIVITY LIMITING BACTERIAL PROLIFERATION

 L- P CA :

- PHYSIOLOGICAL VECTOR OPTIMIZING ZINC BIOAVAILABILITY

- SIGNAL MOLECULE TO STIMULATING EPIDERMAL DIFFERENTIATION AND

REINFORCING SKIN BARRIER FUNCTION

Raw material approved by ECOCERT GREENLIFE,

according to the Ecocert Standard for natural and organic cosmetics

V5
 ®
Zincidone
By Solabia
Physio-seboregulator

 Definition
® O
ZINCIDONE is the zinc salt of L-Pyrrolidone Carboxylic acid or L-PCA. Zn2+
C
L-PCA is obtained by the cyclization of L-glutamic acid, amino-acid from vegetal O N O
-
origin. H 2

 CTFA Name  Recommended dose  Preservative

Zinc PCA 0.1 - 1% None
 Regulatory status:
Raw material approved by ECOCERT GREENLIFE according to COSMOS Standard

 Performances (technical file available on request)

1- Anti 5 -reductase activity
In vitro study / Pre-incubation of human fibroblasts with ZINCIDONE® or Zinc Chloride / Add of tritiated testosterone and incubation
for 24h / Cell lysis and radioactivity dosage.

Anti 5 α-reductase inhibiting activity of

ZINCIDONE (65%) to a greater extent than zinc
5 α- (%)

70
anti activity

60 +65 chloride (45%)

reductase (%)

 ZINCIDONE cellular penetration facilitated with

50
-reductase

40
L-PCA
+45
Anti 5 Activité

30
20
10
“The +”: Stimulation of epidermal differentiation
0
thanks to the physio-active used as messenger
ZnCl2 10-7M Zn(PCA)2 10-7M signal, the L-PCA

2- Seboregulating activity
In vivo sebumetric study on 2 groups of 16 volunteers after 28 days application on the half forehead of a cream containing
ZINCIDONE® at 1% vs untreated zone.

Variation of cutaneous sebum level

Placebo vs untreated zone + 9µg/cm²

®
ZINCIDONE 1% vs untreated zone - 22 µg/cm²* * : Significant

 Significant decrease of cutaneous sebum level at a low concentration of ZINCIDONE 

3- Activity on bacterial proliferation

In vitro study / Determination of MIC (Minimum Inhibitory Concentration) on several strains.

MIC of ZINCIDONE® % (p/v)

Propionibacterium acnes between 0.1 and 0.25%
Staphylococcus epidermidis between 0.5 and 0.75%
Staphylococcus aureus, Pseudomonas aeruginosa,
Escherichia coli and Candida albicans 0.7%

 Strong inhibition of microbial activity at a low dose, limiting bacterial

colonisation at the origin of various cutaneous unbalances