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I. Xem 2 bộ phim trên Studyphim và chuẩn bị 2 bài nói về nội dung phim, thích/không thích gì về bộ
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II. Dịch các bài báo sau sang tiếng Việt
5. A new digital screening tool may help fast track the diagnosis of children with autism
One out of every 36 children are autistic, according to recent estimates from the CDC. The prevalence, which has
increased in recent decades, is thought to be due to better recognition of symptoms and improved screening
procedures. Even so, families still face challenges, including a delayed diagnosis. And, for girls and children
of minorities, this delay is often longer due to an inability to access the right experts and the variability of symptoms
from child to child.
Currently, there is no medical test for autism. Instead, experts make the diagnosis by evaluating a child’s
developmental history and behavior.
“For the majority of kids, there’s no objective test other than observation of behavior,” says Geraldine Dawson, a
psychologist at Duke University, and the lead author of the research study. “We’re only relying on parent reports.”
For Black and Hispanic children, although their parents start noticing the signs of autism around the same time as
other parents, they are still diagnosed later than their peers, says Daniel Geschwind, a physician researcher at
University of California Los Angeles, whose research focuses on autism. As Geschwind notes, these children also must
be taken to more doctor’s appointments and are at a higher risk of receiving inaccurate diagnoses than their peers.
In a recent paper, published in the journal Nature Medicine, researchers describe a digital screening device that uses
machine learning to analyze various aspects of behavior to determine whether a child has a high probability of being
autistic or not. When they tested this screening tool—called the SenseToKnow app—in a sample of 475 children, they
found it had a high accuracy rate for predicting which children were eventually diagnosed as autistic.
Barriers to a timely diagnosis
As Dawson notes, parents are quite good at detecting if something is different about their child. But reporting those
concerns to their doctors poses significant challenges; whether its difficulty framing the context or finding the right
words to describe what they are observing. This is further complicated because autism manifests differently in each
child and the timing of early symptoms can also vary.
Given how variable these signs can be, even when parents report their concerns, pediatricians often don’t have the
right knowledge and training to pick up on the fact that it’s autism, rather than something else. “There aren’t enough
providers with expertise, and most general pediatricians don’t have the expertise to do this,” Geschwind says.
The main screening tool, which is called The Modified Checklist for Autism in Toddlers, Revised with Follow-Up, or M-
CHAT-R/F for short, is made up of a formal screening questionnaire that includes a number of questions about a
child’s behavior and developmental milestones. That is then followed up with further questions from a pediatrician.
The M-CHAT-R/F works well in a formal research setting, but when applied in a busy pediatrician’s office where
appointments can be rushed, this accuracy drops. This drop in accuracy disproportionately affects girls, as well as
Black and Hispanic children.
“Of those [children] who screen positive, only half are referred to early intervention,” says David Mandell, a professor
of psychiatry at the University of Pennsylvania, whose research focuses on racial, ethnic and socioeconomic health
disparities in access to autism resources. Mandell was not a part of the study.
How the SenseToKnow app works
The new screening tool works like this: parents have their child watch a 10-minute video while the camera records
various aspects of behavior. The test predicts whether the child has a high probability of being autistic based on
several factors—what they pay attention to in the video, what facial expressions they make, how they move their
head, and how they respond to their name.
“We found differences in face expression that are extremely subtle,” Dawson says. In practical terms, for parents
reporting these subtleties can be challenging. “It is very difficult for a parent to quantify and to even describe,”
Dawson says.
Of the 475 children who were screened with this app during a primary care visit, 49 of them were eventually
diagnosed with autism, while another 98 children were diagnosed with other developmental delays. This prevalence,
which is higher than average, was likely due to the opt-in nature of the study, which may have led the parents
concerned about their child’s development to enroll.
Sensitivity vs specificity
A good screening tool will reliably identify the kids who are autistic, while also identify the children who aren’t. These
aspects of a test’s accuracy are called sensitivity and specificity.
A test’s sensitivity is its ability to correctly detect autism when it is present; specificity is a test’s ability to correctly
detect when autism isn’t present.
If a test has poor sensitivity but high specificity, there is a high chance that the children with a positive result will be
autistic. However, there also will be a lot of autistic kids, which the test will falsely label: not autistic.
If a test has high sensitivity but poor specificity, then there will be a lot of children incorrectly flagged as being autistic
(false positives), but very few autistic children being overlooked.
When many autistic children are overlooked, it means a delay in receiving the services and accommodations that they
need; while a lot of children incorrectly flagged as autistic will lead to long waiting lists to see an expert who can carry
out a full evaluation.
“You want to balance your sensitivity and your specificity, to try to find as many of the true positives as you possibly
can, to get those kids started on intervention services, without clogging up the system with a lot of false positives,”
says Diana Robins, a psychologist at Drexel University, whose research focuses on autism. Robins, who is one of the
creators of the M-CHAT-R/F screening tool, was not involved in the Nature study.
The SenseToKnow app was shown to have a sensitivity rating of 87.8 percent, and a specificity rating of 80.8 percent.
More research is needed
Before the SenseToKnow app is ready for use in a primary care setting, it will need further studies, which includes
validating its accuracy in different groups of children.
“The next step is to test this in an independent population, to understand its generalizability more broadly,” says
Geschwind, who was not part of the study. “Can it predict outside of the sample that it learned on?”
Dawson and her collaborators are currently carrying out this research, testing the SenseToKnow app in a bigger, more
diverse set of patients, to see if it can still accurately predict autism. Although the SenseToKnow’s accuracy was
generally quite good, these results weren’t uniform among all groups of patients.
“The sensitivity in Black children was great,” Mandell says. “The specificity was not great.”
This lower specificity would mean a higher chance of a child receiving a false positive result—in which the test
predicts that a child is autistic when they are not. Given the relatively low numbers of Black children who were
enrolled in the study, this accuracy can most likely be improved with further testing.
“The next step,” Robins says, “is to test 5,000 or 10,000 kids at checkup and see how it works.”
6. Efforts to trace monkey that fled Scottish wildlife park intensify
Japanese macaque spotted eating bird food in Kincraig may be seeking respite from breeding season
Efforts to trace a monkey that escaped from a wildlife park in the Highlands of Scotland have intensified after the
primate was spotted by a member of the public after his second night of freedom.
Hopes had been raised on Monday night that the Japanese macaque, which jumped the perimeter fence of the
enclosure he shares with more than 30 others on Sunday, had grown tired of his solo adventure.
He was spotted headed in the direction of the Highland wildlife park in Cairngorms, and local people – who were advised
to report sightings to a dedicated monkey hotline – were being encouraged to remove potential food sources such as
bins and garden bird nuts.
But the macaque headcount on Tuesday morning confirmed that one was still missing, and there has since been another
sighting that a team from the Royal Zoological Society of Scotland, which runs the park, is responding to.
Keith Gilchrist, the living collections operations manager at Highland wildlife park, said: “Throughout the day our expert
team of animal keepers will be patrolling the local area using a variety of techniques to try to coax him in, as well as
using our thermal image drone contractor to aid with the search. Cairngorms mountain rescue has also kindly offered to
support with their thermal imaging drone.”
By happy coincidence, the brother of the leader of the Cairngorm mountain rescue team is a renowned expert in
macaque behaviour at Kyoto University.
Also known as snow monkeys, macaques are familiar with cold mountain habitats.
Carl Nagle, who lives in the nearby village of Kincraig, told BBC Scotland News that he was enjoying a “lazy Sunday
morning” when he read the monkey alert on a local Facebook group.
“I looked out the window and there he was, proud as punch, standing against the fence eating nuts that had fallen down
from one of the bird feeders.
“He hung out, he looked a bit shifty like he was where he wasn’t supposed to be, which was true. He wandered around
the garden a bit – we thought he’d gone but he came back and then he was up on the bird feeders trying to get into
them. He was having a really good go – he worked harder at it than a squirrel.”
One theory is that the monkey jumped the fence seeking respite from the tensions of breeding season – there are two
dominant males in the park’s macaque group and their awol counterpart is younger and less confident.
Though the missing macaque is not thought to pose a threat to humans or pets, the Royal Zoological Society of Scotland
has advised the public to not approach him and contact the hotline on 079339 28377 with any sightings.
9. Elon Musk’s $56bn Tesla pay package is too much, judge rules
Judge ruled his pay – six times larger than the combined pay of the 200 highest-paid executives in 2021 – was set
inappropriately
A Delaware judge on Tuesday ruled in favor of the investors who challenged billionaire Elon Musk’s $56bn Tesla pay
package as excessive, a court filing showed. The judge found that Musk’s compensation was inappropriately set by the
electric-vehicle maker’s board and struck down the package. If the decision survives any potential appeal, the Tesla
board will have to come up with a new compensation package for Musk.
“Never incorporate your company in the state of Delaware,” Musk responded on Twitter/X.
Tesla shareholder Richard Tornetta filed the lawsuit five years ago, accusing the company’s chief executive of improperly
dictating negotiations around the compensation package and claimed that the board acted without independence. The
court’s opinion directed Tornetta to work with Musk’s legal team on an order implementing the judge’s decision. The
ruling can be appealed to the Delaware supreme court.
Tesla’s agreement with Musk is by far the largest compensation deal ever for an executive and it contributes a significant
part of his fortune, which is one of the world’s largest. Musk testified during the compensation trial in November 2022
that the money would be used to finance interplanetary travel.
“It’s a way to get humanity to Mars,” he testified. “So Tesla can assist in potentially achieving that.“
Tesla directors argued during a weeklong trial that the company was paying to ensure that one of the world’s most
dynamic entrepreneurs continued to dedicate his attention to the electric-vehicle maker. Antonio Gracias, a Tesla
director from 2007 to 2021, called the package “a great deal for shareholders” because he said it led to the company’s
extraordinary success.
The judge said the defense was unable to establish that the “historically unprecedented compensation plan” was
necessary to ensure Musk remained dedicated to Tesla. She directed parties to confer on a final form of order to
implement her decision.
“Swept up by the rhetoric of ‘all upside,’ or perhaps starry-eyed by Musk’s superstar appeal, the board never asked the
$55.8 billion question: Was the plan even necessary for Tesla to retain Musk and achieve its goals?” Judge Kathaleen St J
McCormick wrote in her decision.
Tornetta’s lawyers argued the Tesla board never told shareholders that the goals were easier to achieve than the
company was acknowledging and that internal projections showed Musk was quickly going to qualify for large portions
of the pay package.
The plaintiff’s legal team also argued the board had a duty to offer a smaller pay package or look for another CEO and
that they should have required Musk to work full-time at Tesla instead of allowing him to focus on other projects. In
2022, he bought the social media company Twitter, which he renamed X, and he has founded several startups, including
brain implant company Neuralink, tunneling enterprise the Boring Co and SpaceX, a rocket venture.
The package grants stock option awards allowing Musk to buy Tesla stock at heavily discounted prices as escalating
financial and operational goals are met. He must hold the acquired stock for five years. Musk qualified for all 12 tranches
or performance targets in the plan. He was not guaranteed any salary.
The ruling will put the spotlight on Tesla’s next round of compensation negotiations with the CEO. Tesla’s value
ballooned to briefly top $1tn in 2021 from $50bn when the package was negotiated. The ruling also comes after Musk
reiterated his desire for 25% voting control of Tesla. Musk sold a big portion of his Tesla shares in order to buy Twitter
but said in a post on X in January that he was uncomfortable leading Tesla unless he had 25% of the voting control. The
billionaire owned around 13% of the company at the time.
Amit Batish at Equilar, an executive pay research firm, estimated in 2022 that Musk’s package was around six times
larger than the combined pay of the 200 highest-paid executives in 2021.
In July, Tesla’s directors agreed to return $735m to the company to settle shareholder allegations brought in a separate
lawsuit filed in 2020 that they overpaid themselves. The lawsuit challenged options that were granted to directors
starting in June 2017.
10.Wildfires are making their way east—where they could be much deadlier
We all know wildfires have been getting worse in the drought-stricken western U.S., but experts say the growing risk
on the east coast is concerning.
When we think of wildfires, we often think of western states like California where massive blazes, such as the 2018
Camp Fire, have been among the deadliest and most destructive in modern history. In 2020, California’s worst wildfire
year on record, 8,648 fires scorched 4.3 million acres of land.
While California and other western states face a high wildfire risk, the region’s wide expanses of wilderness are less
likely to threaten humans. Not so in the eastern and southern United States, where population density puts more
people and property at risk. According to the U.S. Census, 56 percent of the U.S. population lives in the eastern and
southern regions of the country, compared to just 24 percent in the West.
New research shows that there may be cause for concern in the East as well, where fire size, numbers, and total area
burned seem to be increasing.
Recently published in Geophysical Research Letters, researchers used data collected over a 36-year period to show
that large wildfire numbers doubled from 2005-2018, compared to the two decades prior. The biggest increases were
seen in the Southern Coastal Plains of Florida, portions of coastal Georgia, and South Carolina where the five largest
wildfires occurred. Significant wildfires were also common in the Central Appalachian Mountains of Tennessee, West
Virginia, and Virginia.
Conversely, wildfire numbers decreased in the northeastern U.S. as shifting climactic conditions led to more
precipitation.
Why fires are increasing
The goal of the study was to identify whether wildfires were growing in frequency and scope, not to show what was
causing this increase. But the authors speculate that warmer, drier conditions brought on by a changing climate
combined with a lack of prescribed fires has led to a proliferation of woodier plants, trees, and shrubs that provide the
fuel for fires to burn in greater strength and numbers.
“This makes for wildfire conditions that are much more difficult for us to suppress,” says Victoria Donovan, lead
author of the study and an ecologist at the University of Florida’s West Florida Research and Education Center in
Milton, Florida.
Invasive species like Cogongrass, a perennial weed capable of driving wildfires deeper into the forest, have also taken
over large swaths of the South, across Alabama, Mississippi, and Florida. The grass increases the instances of wildfires
because, once ignited, it burns hotter and faster and regrows more rapidly than native grasses.
Why wildfires in the East present greater risk
While the fires aren’t as large as they are in the West, the risk to humans is much greater.
“In the East we have a greater wildlife-urban interface, where we’ve seen more people intermingling with wild land
vegetation,” says Donovan.
The study points to examples like the 2016 Gatlinburg fire in Tennessee, which, although less than a tenth of the size
of the Camp Fire, destroyed nearly 2,500 structures and killed 14 people. When wildfires ignite in densely populated
areas, they not only increase the risk of a loss of life, but also become harder to defend.
Additionally, the danger of wildfire smoke extends much farther than just the immediate area of the fire and can
impact more people in the eastern U.S. Last year’s Canadian wildfires, for example, placed more than a third of the
U.S. population under air quality advisories.
The study also found that 85 percent of wildfires were caused by humans, a statistic which isn’t surprising to Volker
Radeloff, a forestry professor at the University of Wisconsin Madison who was not involved in the study. He says that
when fires happen in populated areas, the risk of human ignition increases. People can start fires for any number of
reasons, and in populated areas it puts the landscape at risk. They might be burning dead leaves in their backyard, and
it gets out of hand—or, in the case of the Gatlinburg fire, two teenage boys playing with matches set the land ablaze.
“In these areas where houses and wildlife vegetation intermingle it’s kind of a double whammy because when a fire
occurs lots of houses are at risk, you have to evacuate people, and there’s also more people to start fires either
intentionally or unintentionally,” says Radeloff.
Planning for the unknown
While the study did show that the number of wildfires in the past four decades have increased, it’s challenging to
point to trends because in the East, there’s still so much variability in the weather from year to year, says Loretta
Mickley, a senior climate research fellow at Harvard, who was not involved in the study. “There will be one huge fire
one year and then not much in the years to follow. You’re left wondering whether it’s a bad year or a trend,” she says.
While in the West you can see a clear upward trend in fires as precipitation decreases and temperatures increase, in
the East the weather is less predictable. In an El Niño year, for example, the distribution of rainfall in the South and
East may quell the risk of wildfires.
She says that the study is an “important first step” in showing us where we need to be taking care to protect the
landscape.
And no matter whether it’s a trend or not, the numbers are concerning. “Right now, it’s safe to say that in the Eastern
U.S. there are quite a few eco-regions that have had more fires in the last five to 10 years than in the decades before
that,” says Radeloff.