AKANE SHIMIZU

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AKANE SHIMIZU
 SORRY
HERE'S R
TODAY'S ee me
OXYGEN y
DELIVERY!
aR
a
J Fa

(|ca =S LoNI
Fb
meal & \
om

"He
i
do
Eee
| Gr. TA <—s i

ST yey S |
 THIS PLACE
LOOKS
PRETTY
COMFORT-
ABLE.

PLENTY TO
EAT, BY THE
LOOKS OF
THINGS.
 BUT FIRST,
WE'VE GOTTA
CLEAN OUT
THESE PESKY
NATIVES!
e , Wis
a ¢.

oat
a <y

Lies
eee oo

= a) Nh é
aN i!oa Hl
2 _—
Sig
pe
& : ee. a
oe LL, <a
re a
 SEE/NG
1S THE
INSIDE OF
A HUMAN
BODY.

FOR CELLS
LIKE US, THIS 1S
JUST ANOTHER
CHEERFUL
DAY AT WORK,

THIS
18 WHITE
BLOOD CELL
NEUTROPHIL
White Blood Cell DIVISION,
(Neutrophil) u-1/46. 2
His main jobis to destroy
| foreign substances that
y enter the body from the
outside, such as bacteria and /
viruses. Neutrophils make up
SR, | ERADICATION
=~ OF THE GERM
more than half of all white
4 blood cells in the blood.
¥ fe \ INTRUDERS,
| Nea

te
 IF EVEN ONE DON'T LET
GETS AWAY, A SINGLE
WE'LL HAVE A BACTERILIM
REAL MESS ON GET AWAY!
OUR HANOSI! YOUGOT Ko
THAT?!

HE'S
coverep AT
ALL.
IN
BLOOD. :

| oives |
| ME THE |,
CHILLS...
 TH-THANK
YOU FOR
SAVING ME.
THAT WAS
REALLY
CLOSE...

Red Blood Cell

Her red color is due to the
chemical hemoglobin.
She transports oxygen and
carbon dioxide through
blood circulation.

NO NEED
TO THANK
ME.
JUST
DOING MY
JOB.

Se
ag Ome,
a, | i}
oo A
gr YOU. f }
aus
Nib
 OKAY, SO TO
GET TO THE
LUNGS, I NEED
TO TAKE THIS

a (7 THAT
CORRIDOR
'

{| Venous Valve
Me] These prevent
blood from flowing
backwards. They
force the blood traffic
in the veins to be
one-way, heading
i toward the heart.
$-SORRY,
I'M NEW
A Red Blood Cell’s Job |,
Red blood cells circulate
through the body,
delivering oxygen to cells
in every nook and cranny.
They also carry carbon
WANT TO dioxide backto the lungs.
| DELIVER
THIS TO THE
LUNGS AND
BE DONE.
 + n
Macrophage
# Atype of white blood cell, these catch and
B kill foreign substances like bacteria, and
: determine antigens andinformation on immune
i responses. They also act as cleaners who
| remove debris such as dead cells and bacteria.

"Th VAAL
Z
HUH?! S$-SO 7
SORRY, MY
MISTAKE!

Lymph Ducts
Et Kae!
; |oP
These serve as a drainage
system for collecting the bodily THIS IS A
“| fluid (interstitial fluid) that
exists between various tissues.
LYMPH DLICT!
RED BLOOD
CELLS CAN'T
COME IN, YA

OH, MAYBE
I CAN ASK *,
WHOEVER'S Fy
INHERE. t
|, \. 2 rie|
a N07} Sa
AN THEYRE HS?
“aw ALWAYS DOING
we (50 CONSTRUCTION
eARD Te AROUND
HERE.
 Cee
Se
A
&

DON'T YOU
ACT LIKE
NOTHING
HAPPENED!!
bX
 FOUND ME
, ALREADY,
4 DID YA,
WHITE
BLOOD
CELL?

YOU WON'T
Ps CATCH ME
Zou) THAT EASY! /

LOSING CRAP! [
SIGHT
OF THE :
BACTERI-

A
POR

OF THIS
NICE AND
 oS A oy rh
Bacterial Capsule
A layer, foundin some types
of bacteria, outside thecell f
8 wall. It protects the bacteria &
~ | from attacks by white blood
==] cells and other threats.

INVADERS
GOT AWAY!
 | THEN THIS
BODY WILL
BE...!

IF WE DON’T
KILL HIM
Secor mrmrmrercsretin
QUICKLY,
Pneumococcus Secerenccees
HE’LL BEGIN
(Streptococcus pneumoniae) y DIVIDING!
A pathogen that causes
respiratory diseases such as
pneumonia. Possesses a cell dS
capsule and is highly virulent. Fy SA,

Sea RX
Orn

KNOW THIS
*) 1S A KIONEY, y Yi p= \\

IT'S NOT
JUST THE
THE GERM LUNGS
ESCAPED THAT'RE
INTO THE IN
BLOOD TROUBLE!
EAM.

THIS THING
ISN'T
UNTANGLED
 THERE'S
SOMETHING
CALLED PNEUMONIA
PNEUMO- ISN’T THE
COCCAL ONLY DISEASE
BACTEREMIA. CAUSED BY
PNEUMOCOCCUS.

THAT'S WHEN
PNEUMOCOCCUS
ENTERS THE
IT'LL EVEN BLOOD STREAM
OCCUPY THE AND ATTACKS
MENINGES VARIOUS
SURROUNDING ORGANS.
THE BRAIN AND,
IN THE END,
DESTROY THIS

BASTARDS
WORK FAST!
THEY CAN Pneumococcal Bacteremia
Acondition that occurs when
INVADE THE pneumococcus enters the blood
WHOLE BODY IN stream. Marked by a sudden
AS LITTLE AS high fever. Advanced bacteremia
24 HOURS. can lead to a dangerous disease
called bacterial meningitis.

RIGHT NOW,
uUsuALLy, THIS BODY
It HAS A
WOULDN'T WEAKENED
B IMMUNE
PROBLEM. RESPONSE.
 COULON 'T
HAVE COME
WP WITH ‘ ! ‘
A BETTER ; | mY Receptor
DES/GN ; Works like adetector

FOR THAT ag ZAR aes

HEY, DID
THAT THING
MENTION
ANYTHING?
DOING HERE,
ANYWAY?

I THINK
HE WAS
HEADED
FOR THE
 la .

, JUST
FOLLOW ME. ae
WE'RE HEADED [ered
TO THE SAME
PLACE. Bierew

%,

OH,
THANKS!

go
a
{

LN : hee
2 SURE. }, Vy" 4 ee THIS IS Wy RN ps z ae ih
i MelY aE 5 SOME |', Wit BO Gam Mt WN eet
et _ ‘ —: PLACE! NYtINRK A it Sr Nene da

rt x

Q foes Pi aTer,, \ Dendritic Cells

a ‘ Zz 3 4 AE These cells take fragments of bacterial
py | \ i, ~~ 8 cells and virus-infected cells, and present
i oa * £ them asantigens for other cells in the
- as i x Z immune system. As their name suggests,

\ smnS ; — .
they extend finger-like appendages. 6 u

‘ % on Liv) OWL? i KE Sn
 OH,
SORRY! THEY'RE
CALLED
WE'RE STILL
DOING SOME
CONSTRUC-
TION UP
AHEAD!

Platelet
These specialized blood
if cells collect wherever a
| blood vessel is damaged,
blocking the opening.
They are relatively
smaller than other cells.

DID
SOMETHING
HAPPEN?

TION WAS
DELAYED
BECAUSE
OF A
PROBLEM.

‘CAUSE, UM,
THE DELIVERY
PEOPLE MADE
: A CRITICAL
| MISTAKE, AND...
 THERE...
LUKE THis?

THIS IS
STRANGE.

BREAK? Z RECEPTOR'S

i xweRre’s
GING, 0 eee |
ious is
SRONG 4,
xu Wee \ cw,

\i
 WE'VE
RECEIVED WORD
THAT THERE'S A
PNEUMOCOCCUS
BACTERIA ON
| THE LOOSE IN
THE BLOOD
STREAM.

WE'RE HEREBY HelperT Cell

DEPLOYING In the event of a foreign invasion,
THE KILLER these cells act as commanders. They
A determine the appropriate strategic
T CELLS/ response based on the intelligence on
the nature of the invaders. They issue
deployment orders for Killer T Cells.

NOW THAT THE

ELITE FORCES OF
I SWEAR ON US LYMPHOCYTES
ARE ON THE WAY,
THATWe WILL THERE'S NOTHING
ERADICATE TO FEAR.
THE THREAT!

COMMANDER,
YOU HAVE
CRUMBS ON
YOUR FACE
__ FROM THAT
GN COOKIE
(4) YOU HAD
A\S4) EARLIER...

=4 Lymphatic Valve
The entrance for Killer T Cells.

WHA?! GAH,
1 I DO CRAPS
OH, UM, SO
GOOD DAY,
EVERYONE/
 THEY'RE
NAME OF
AWFULLY THE KILLER
IMPOSING. 7 CELL
DIVISION...

THEY'RE 7wO
RELATED TO ANY _ SECONDS
us WHITE COWARD OF
BLOOD CELLS, THAT LETS . ;
ACTUALLY. 'T GET ee Killer T Cells (Cytotoxic T Cells)
7 Deployed on the orders of a Helper
AWAY WILL
BE SENT
; : ! T Cell.
Professional killers who recognize and destroy
Lymphocytes
Atype of white blood cell. foreign substances such as transplanted
TO THE cells, virus-infected cells, and cancer cells.
They make up 20-40% ofthe
white blood cell count in the | SPLEEN!
blood. They are responsible
for the body’s immune
response. Killer T Cells are
atype of Lymphocytes

OH WELL.
WE SHOULD
GET GOING,
TOO.

DON'T
YOU LOOK
JUST FINE

ESPECIALLY
FOR
SOMEONE
WHO
MIGHT BE
ABOUT
TO DIE.
 THEN
YOU MIGHT
AS WELL
LEARN Now.

Hemolysis
The destruction of §
red blood cells. PNEUMOCOCCUS
IS A HIGHLY
AUXOTROPHIC,
BACTERIUM.
IN OTHER

NUTRIENT-
CARRYING
RED BLOOD
CELLS ARE
ITS TARGET!

HE JUST
WANTS TO
SCARE
YOU. DON'T
WORRY
ABOUT
vwubHKEKAATS HIM.
 ARE THE
LUNGS?!

eee,

yy
=

WELL...
I
GUESS
TAKE THIS IS
IT GOOD-

| THINK WE / )
couLD i}

MUCH FOR
SHOWING
ME THE DISTURBANCES
YET.
il
 ff
i
ae

u Es
: AANlEERY RUNNING STRICT FORaeBNEN
ea
rt: cd

The Lungs
The organs responsible
for taking in oxygen from
the air and excreting
carbon dioxide. In other
words, the place where
respiration occurs.

GET BACK
ie SAFE.

yin ch
ARHERE
you’ RE
WALANG :
_
 NOW...
WHAT
7O DO?
ME I CAN'T

HERE IT IS!
THE
oe : |: CAPILLARIES.

CAPILLARY 095
OKAY, "BE Cr raTroe
COURTEOUS | THE CAPILLARY (S NARROW,

TO OTHERS, : SO ENTER ONE AT AA TIME.

BE COURTEOUS TO OTHERS,
ONE ATA ' > ONE ATA TIME! ¥
TIME," IT i>

HAVE TO GO
THROUGH THE
CAPILLARIES...
Capillaries
Very narrow
AND GET
blood vessels TO AN
connecting ALVEOLUS.
the arteries
| and the veins.
 THAT
(plural: Alveoli)
PNEUMO- The place where air is
COCCHS... exchanged between the
I SURE I WONDER S) air and the capillaries.
HOPE I WHERE /T There are approximately
300 million alvioli
|,

DON'T RLIN WENT. between both lungs.

INTO /7T,
gy
 .--FOR
BRING/NG
ME ALL
THIS WAY.
 DAAAAAAAALS

| RAAAMPAAAAAAS
iAAAA IE BAAA
VAAAAAAAAAA
~

YOU THINK
I’O LET
YOU GET
AWAY?!

WN
ad Ce z

od
We
pits ” HEH
:
HEH
ane uy

| ¥ )
<— Mi... AtEH j
< oy
aa — : HEH... oo
la =
£ a é uatetey —s he
i

cK 2
Se

nes
Ve
»~oe
ee

EE CERt

YOU HAD NO
IDEA WHAT
YOU WERE
CARRYING.
 T
A PPOETRFHFEIOCNRG
S
AMSBLI LOOD
RED B

S I
GUES AS
MIGHT
TART
WELL S
.
A SNACK

RE
WELML, INHETHE ©
T A
ES.
CAPILLARI

wow , YOU
SORRY!, RE ARE
macamm.t \( SUcarevine
‘[|
oPONE
d IN “
stoprep By | Atot oF
THE SMALL //\ NUTRIENTS.
INTESTINES. | |

TEOUS,
BE COUR
.
ONE AT A TIME

s
a4Dyjy
(Y
"

ppl
)
\
 el ey
YOU MORON!
GO AHEAD,

YOUR
FRIENDS?!

NOT THAT
ANYONE WiLL
. \ BE ABLE TO
\ \GET THROUGH
SS\\ WITH THE
\\) CORRIDOR
BLOCKED
LIKE IT ISI

TALK
ABOUT A
WASTED

ABOUT TO
MASSACRE
YOU ALL!
Le
 IT'S CALLED
TRANSM/GRATION. | YOU HAVEN'T
WHITE BLOOD DONE YOUR
, ce CELLS LIKE ME... HOMEWORK.

IB
os

»-CAN SLIDE

N
BETWEEN
\N
\

NN THE WALLS OF

Vay
\\
BLOOD
VESSELS TO
REACH OUR
TARGETS.

Transmigrating Cells
Cells that move freely
inside an organ.
 ; I NOTICED
P W 5 THAT MY
T COULDN'T ' RECEPTOR
BELIEVE IT STOPPED
AT FIRST... aia a RESPONDING
AS SOON AS I
PARTED WAYS [A
THAT YOU'D | witd THe Rep
BE HIDING fi ‘@O)) BLOOD CELL. X
INSIDE THE RED Pa |
BLOOD CELL'S
PACKAGE.

WHITE
BLOOD
CELL,
GOING TO THAT
ATTACK THING
RED BLOOD SAID...
CELLS
CARRYING
NUTRIENTS!

I DIDN'T
COME ALL
THE WAY
HERE
TO DIE!
 NOTHING LIKE
THE GETAWAY
WITH A TRICK HE USED
CAPSULE THAT BEFORE! A MUCH
STRONG, I STRONGER ONE
CAN’T TOUCH THAT HE CAN USE
HIM WITH DIRECTLY AS A
CLOSE-RANGE SHIELD!
COMBAT!
 Tf =
See di fC SS
S WS BIN Sc
CH

CELL-SAN,
PLEASE’
LEAVE
AN IDIOT

\ wovent
 GET BACK
A LITLE
FURTHER.

SLIPPERY
LITTLE

YOU GIVE
uP? ALL OUT
AFTER YOU OF TRICKS?
WENT AND WHAT A
KILLED ALL MY SAD LITTLE
BUDDIES... ENDING.
I’M GONNA
MAKE You
SUFFER
JUST LIKE
THEY DID

anRes
E
Nese \
Ue
PSs
2
 aS fs
—

=| ‘ a
—_ = i a .

o& ate
—|

ee
wre

a ¢

a
~ 4 \
4

THE 0
BACTERIUM 0)
WILL NOW BE THE BACTERIUM R
AS BEEN
siacahiat SUCCESSFULLY Bl
APPREHENDED.

TR
DING. Ly
an) /
TERRE, | ORS \\ «/, eg

a
 AND WE'RE
IN THE BE BROKEN
BRONCHIAL FROM THE
DOYOU TUBES... INSIDE.
KNOW
4 WHAT THAT
MEANS? A

WHY, YOU...!
WHAT THE HELL!
AREN'T YOU
ASHAMED OF
YOURSELF, US-
ING A TRICK LIKE

YOU WANT
SOMETHING,
 BOO
o

LF COUNT wee
ON : TWHS OF/ \
YOUR eet ae
HELPER ~~
uw
Pee
———

ri
Viron
hk meSOOG-eom<M
amo

WE'RE
H INTHE |
| BRONCHIAL
| TUBES. |
 ¥
fl
ia
PSY
ASZ \ Ty
=<
AES

ai“ \\
ratioAM

ae ii

TBAT ES

COMMENCING
COUNTDOWN.
 secur
nlerperer
nres onse ied sin OLN
4 ode
Rill;
eal OO BN

AURIEA oi
iy
tion, tickling

Ee
inhalation
iono epper
or exposure to sunli :

ama
on
fl| =
WL
 ae i OWA
LENG
| vir UG
I | i}
=|
aan
«.
[]QOQOO0O0*
 l]
A
éie i
Zoe *
ee
“eG te

YW
 ares
Se~

oy, a oz
4
 W-WILL
I SEE YOU
AGAIN?
 THERE ARE
LOTS OF US
WHITE BLOOD
CELLS...

1 Number of White

a)
Blood Cells oN

\ : R =e
So4 es THAT You P&S
MENTION BES

THERE
ARE EVEN
MORE OF US
RED BLOOD
CELLS...
 WELL,
WE WORK IN
THE SAME
WORLD.
I’M SURE
WE'LL RUN
INTO EACH
OTHER
SOMEDAY.

NGF
eu TROUBLE
AFOOT?!

yaa
O1 TER 41 s
a
s
y
i]
\

\;
INBOUN. 4

TIME TO
CONTAC a
TEN
SECONDS.

0.001 HL:=0.00001 MM = ONE BILLI IONTH OF, A‘METER

Helper
T Cell

invasion, these cells act

as commanders. They
determine the appropriate
strategic response based
on the intelligence on the
y CHAPTER e:
} CEDAR muses
N
7
=

HEY LOOK!I!
THERE'S
SOMETHING
OVER LAKE
MUCOSA...

FN a7 hf
REA unl,
coe
Cedar Pollen Allergen
An allergy is an excessive
immune response against
a specific causative agent,
or antigen. (In the case of
allergies, the antigen is called
n “allergen”.) The allergens
responsible for the cedar
pollen allergy are the proteins
Cryjl and Cry j2. These
proteins are named for the
species name for Japanese
cedar, Cryptomeria japonica.
 REPORT FROM
MACROPHAGES
, NEAR THE EYE
: : LICOSA!
an che . : Uo RO yay) MULTIPLE POLLEN
= ue | LANDED AT
a _ POINTS 135
AND K5O!

ALLERGENS
ARE
INFILTRATING
THE BODY b=
THROUGH THE |
DRAIN PORT!

TO ALL
EMPLOYEES
NEAR THE
EYE MUCOSA,
PLEASE BE
CAREFUL.

A FOREIGN
FOREIGN : ENEMY HAS
ENEMY? Red Blood cell = |_ |__ENTERED
chemicalhemogiebin. fet | THROUGH
She transports oxygen and THE NEARBY
carbon dioxide through DRAIN
blood circulation. PORT—
 BETTER
TAKE CARE
OF THIS
ASSIGNMENT
FAST...

UM, LET'S
SEE. THE
THERE'S A / DELIVERY
LANDMARK. ADDRESS
IS HERE?
 S- WHAT IS
SOME- THIS THING?!
ONE IT'S SAYING
\ |HEEELP! "CEDAR"?
v

ANTIGEN
DETECTED.
 i if
lites
White Blood Cell (Neutrophil)
OH His main job is to destroy foreign
e substances that enter the body from the
©] outside, such as bacteria and viruses.
Neutrophils make up more than half
of all white blood cells in the blood.

YOU'RE
THAT RED HEY.
TH-THAT’S BLOOD
RIGHT! WE Tere
REALLY WIthTHE
> DID MEET coccus. 3
AGAINI! :

UM...
IT wAS WHAT
SAYING IN THE
"CEDAR" WORLD
Phagocytosis OR IS THAT
: The process by which a , SOME- THING?
= cell engulfs and breaks K \e p f a } THING.
down bacteria and foreign \ S a
substances. Cells that can :
do this (such as monocytes, 68
macrophages, and neutrophils)
are called phagocytes.
 THIS IS AN en
ALLERGEN i a SuSS\ | taste...
FROM ay \
CEDAR
POLLEN.

NOT PAR-
TICULARLY
RARE THIS

.. BUT IT'S
A HARMLESS
THING. DOESN'T
CAUSE ANY
ILLNESSES OR
ANYTHING.

WELL, BUT
IT COULD
CAUSE
PROBLEMS,
TOO. WE'RE HARMLESS?
SUPPOSED
TO KILL IT
ANYWAY.

1S THAT
THING
A CEDAR
POLLEN
sa el
 yt fs s
i
/ \ VY Va

os

it

YOU'VE
GOTTA
BE
KIDCING
so mis “EL
1S WHAT
CAME /N
THROUGH “ns
THE MUCOUS
a
immune responses of antigens.
2 ae

WHAT'R
cevar
ALLERGEN
Youle.
worRIED
ISA IT?
HARMLESS ——
ANTIGEN,
ISN'T IT?

WHITE
arog chy,

BUT...
WE MEMORY
CELLS HAVE A \ ME! TMA
LEGEND THAT'S \ MEMORY
SEEN PASSED \,
DOWN FOR
GENERATIONS. \\“Sxo
A WALK.
 WHEN THE
THE METEORS OF
Pa a eee MISFORTUNE
THE
arinEARTH |X) RAIN SPACE...
FROM DOWN
AND THE i oS
SEAS SHALL y >
WRITHE. A

IN OTHER
WORDS, VOLCANIC
ERUPTIONS,
CRUSTAL
PERTURBATIONS,
AND MASSIVE
FLOODS—ALL
AT THE SAME
TIME. AN
UNPARALLELED
CALAMITY.

THOSE
THINGS?
0H LOOK,
ANOTHER
ONE!
vty
&

you'LL
SEE
SOON
ENOUGH

A
HARBINGER
BEEEP! 0
| CALAMITY...?
BEEEP!
 EMERGENCY!
AN ABNORMAL
THOSE NUMBER
OF YOU IN THE OF CEDAR
AFFECTED ALLERGENS HAVE
AREAS WHO CAN INFILTRATED
RUN, RUNS/ THE BODY.

| GAM! My
HOUSE!

WHAT'S
THE END "se WITH THIS
OF THE : NR OO Ge, CRAZY
WORLD /S (= : | NUMBER OF
= CEDAR
) |ALLERGENS?
 IS IT ME, OR
ARE THERE
MORE OF
THESE THINGS
EVERY YEAR?

MATTER.
WE HAVE
A SECRET
WEAPON,
AFTER ALL.

YOU GET
OUT OF
HERE, RED

JUST KEEP
COMING.
 ell
4 (Antibody-producing cell)
Atype of lymphocyte that
makes weapons called
“| antibodies to fight antigens
such as bacteria and viruses.

BUT ONLY THE HOLY :

TO OPEN MIST SHALL
THE GATES COVER THE
“UTR... OF HELL... EARTH...
AA ae
Y, THIS
CALAMITY... |
Is IT \
OSSIBLE TO |
\ PREVENT IT? /

HOLY...HUH?
WHAT'RE YOU
TALKING
ABOUT NOW? L
AND
 IgE Antibody
(Immunoglobulin E)
An antibody produced by B
Cells on the orderof Helper
T Cells to combat allergens.

HE WIPED
THEM OUT
ALL AT
 SEE...
THAT
HOLY MIST
YOU WERE
TALKING
ABOUT
LOOKS MUST BE
LIKE THAT THE ANTI-
SOMETHING TOOK CARE BODy.
WAY MORE OF EVERY-
TERRIBLE Is THING.
ABOUT TO
HAPPEN!

THE MIST
mur TT SHALL BECOME
NO ID)

MEANS, A DARK CLOUD,

BUT SCARY, CALLING FORTH
RIGHT?! HEAVY RAINS TO
SOMETHIN G WASH AWAY
cRATN SS
GOING “8
WAPPENS,
‘ ea EVERYTHING...
Gn g)

SURE, IT
SOUNDS
SCARY...
BUT YOU'RE
RIGHT. NO
IDEA WHAT
IT COULD

WAY To
GO, B
CELL!
KEEP
GOING!!

WHAT'S
WITH
THESE HUGE
USAGE
NUMBERS
FOR THE
IgE?!
 pC.
a \
cet, LS
ESSENTIAL
7 /

BUT THE
MANUAL SAYS
TO PRODUCE
HISTAMINES
CORRESPONDING *
TO THE IgE
VALLES... Mast Cell
Releases chemicals such as
histamines and leukotrienes
in response to stimulus
from excessive production
of IgE. The “mast” in mast
cell comes from the German
word for “fattening”

y $0 YOU
THINK THAT
OVERUSING

YOU DON'T
WANT TO GO
OVERBOARD
WITH THAT
THING.
OR SOMETHING...
 Pa WEE h
VA dy! wll
heen)
Vas
WELL, IT’S |< \ WHAT? A
ALL OVER |} LEGEND?
ANYWAY.
SEE...
THAT'S
GOING TO
BLOCK THE
ALLERGENS
FROM NAM!
COMING THEY'RE
IN! 2 ABOUT TO
a : RELEASE EN HAHAHA. *
THE H/ISTA- I'M SURE
MINES! IT'S FINE!
SOUNDS
SULLY.

HM?
CHANGING WHY'S IT
THE NOZZLE, RETRACT-
PROBABLY. ING?

..- WHA?
 My
fill
4
/f i Yip”
Za na@
Z
4é
a

y;

Achemical mediator
released by mast cells
when they recognize
foreign substances or
damage to tissues.

OH! COULD
THIS BE THE
MASSIVE
FLOODS OF
LEGEND?!

BE...
GURBLE...
 THERE’S
NO END
TO THESE
THINGS...!!

THE USAGE
NUMBERS
FOR ANTI-
BODY WERE
OFF THE
CHARTS...

THEN
I'D BETTER BECAUSE
PUT OUT THERE WERE
EVEN SO MANY
MORE CEDAR
HISTA- ALLERGENS?!
MINES!!

THIS THE
UNPAR-
ALLELED
CALAMITY?!

THIS IS
The role of histamines
JUST THE
Histamines work to widen BEGINNING!
the space between vascular },-
endothelial cells, making
| it easier for white blood
cells to transmigrate.
E
 CAPTAIN,
WE'VE GOT
TROUBLE!!
WHAT?!
CALL THE HISATAMINES
MAST CELL! ARE POURING
HAVE HER OUT LIKE A
STOP IT AT

SHE SAID
SHE CAN'T
STOP IT
UNTIL THE
CEDAR
ALLERGEN
INVASION IS
STOPPED...

NO USE,
CAPTAIN!
THE
HISTAMINES
 THE
EMERGENCY
IMMUNE
RESPONSE
PROTOCOL
1/8 ABOUT
70 GO INTO
EFFECT!

DUE
EY Allergic reaction TO THE
due to histamines RELEASE
7| Excessive production of CENTER
q histamines can resultin ee BREAK-
allergic reactions such as
flushing, itching, edemas, DOWN...
pain, and constriction of
the bronchial tubes.
 THE NASAL
MUCOSA ARE
EXPANDING
LIKE CRAZY!!

Stuffy Nose
Histamines affect the blood
vessels of the nasal mucosa,
causing inflammation and other
symptoms. As a result, the nasal
mucosa become swollen and
bloated, causing a stuffy nose.

Sneeze
Histamines stimulate the sensory
nerves in the nasal mucosa. When
this stimulus reaches the sneezing
center, it causes repetitive sneezing.
 | AND THE |
| MASSIVE

.1 Histamines stimulate the

sensory nerves in the eye
“y to cause inflammation
h| (congestion and itching).
(| This produces an
excessive amount of tears.
Tae

AND THE
CRUSTAL
PERTUR- |,
BATIONS!
 THIS 1S
THE CEVAR
POLLEN
LLERGY
OF
DAMN /T!
HOW OID
THIS
HAPPEN?’
“y]| Cedar Pollen Allergies
“| Allergic symptoms—such as sneezing,
runny nose, stuffy nose, itchy
eyes—caused by the cedar pollen
acting as an antigen (allergen).
 DAMN IT!
HOW DID
THEM! =D Tile
THEIR or
FAULT.

I-IT’S NOT MY
FAULT!!! SHOULDN'T
YOU BE BLAMING
THE HISTAMINES?!
ALL THAT
ANTI/-
BODY!

YOU THINK
YOU'RE
DOING?!

IT'S NOT
MY FAULT!
IT WAS
THE IgE!
NO! IT’S
DEFINITELY : ee“lan
BECAUSE YOU ACCORDING
RELEASED TO THE
TOO MUCH MANUAL!
HISTAMINE!! ;
 THIS IS
GETTING
OUT OF
CONTROL...

TO THINK
THAT ALL THIS
HAPPENED...

JUST BECAUSE
EVEN IF EVERYONE DID
WE'D KNOWN, THEIR JOBS
WE STILL PROPERLY...
| woutp've HAD |
NO CHOICE
BUT TO DO
EXACTLY WHAT
WE DID.

NO MATTER
WHAT THE
CIRCUMSTANCES,
WE CANNOT
ABANDON OLR
DUTIES.

oo
 °
Neresiess :

fone eh “tee, ;
7 \ aha A Std ame.

WY A NatANY VAAL \
\ \ : K\\\ \
\ WA aN
\ i \) mA\GeeNS
 WELL,
I DON'T
REALLY
WHAT'S KNOW
WITH THE WHAT
UPROAR?! BUT THE THIS IS,
IS EVERY- DELIVERY EITHER!
THING ADDRESS
OKAY?! IS RIGHT
HERE!

YOU HAVEN'T
SEEN IT
BEFORE, EITHER,
MEMORY
CELL-SAN?

ARRIVED AT
DESTINATION.
PROCEED.
WITH.
REMOVAL.
ee
en
=

Se

IS THAT?!
WHY [6 IT
ATTACKING
 I've Y
HEARD OF
THIS. 3]

(i Lia J —oa¢ WHEN

, 5 CALAMITY
(6) | 4B STRIKES
\“ y THE
UA WORLD...

IT

Ame —Buencne
COMES TO

RYON
NAME THAT WAS —
lIs— INVOLVED IN af Tae’
ra THE DISTUR- : =
BANCE.
 NN.
HN
yy

Steroid (Adrenocortical Hormone)

Medicine that suppresses allergic reactions
and various symptoms triggered by
) histamines. It is extremely effective. In the
case of pollen allergies, it can be administered
orally, by nasal or eye drops, or via injection.

Y
GH
O
 I DON'T
UNDERSTAND
WHAT'S
GOING ON,
BUT I'M
SORRYYY! f

CAPTAIN,
~# MORE TROUBLE!
SOME STRANGE
THING—

SORRY!
WE'RE SORRY,
B CELL AND
MAST CELL! ,
 you GuYS
MUCH
Ld MORE f=:
CIVILIZED —_ [op
THAN THAT >
THINGI! 4:
On
4%
intl eg

HOW LONG
1S THIS
GONNA GO
ON,
ANYWAY?!

; TIN 4 Sex
Fes oe
 THE
STEROID
RAN OUT OF
BATTERIES
AND
STOPPED.

AND IN
THE END, THE
Wet, WERE ABLE ALLERGIC hf ALLERGENS
EveRy- 10 COME TO REACTION | (74 DISAPPEARED
THIN AN UNDER- HAS ON THEIR
TURNED STANDING SETTLED OWN.
WITH THE

Steroid Side Effects

“ V Long-term use or large doses of
‘| steroids can cause side effects.
Itis important to use them in the
manner and amounts prescribed.

GOING TO
REMEMBER
THE EVENTS
OF TODAY
FOREVER.
 RED
BLOOD CELL
UNIFORMS
ARE
REVERSIBLE

ARTERIES
Ln
The bright-colored = :
side faces out. :
Because they have
to deliver oxygen and
nutrients quickly, the Red
Blood Cells in the arteries
are in a bit of a rush.

VEINS
The deeper-colored side faces
out. Once they receive the
carbon dioxide, allithat the Red
Blood Cells in the veins have to
do is to head back to the lungs.
They,can take it a little slower.
 WHAT IS
THE DEAL
WITH THIS
TOWN?

ISN'T A
: SINGLE
: é = PERSON
: aig HERE... /

=r WHAT'S
GOING
ON...7! (fF
CHABTERTS INFLUENZA
 HLUFE!
WHEEZE!

H-HELP
MEEEEEEE!!

ft &
= : ? Vy

ME

. (
fie to fis

: | White Blood Cell (Neutrophil)

His main job is to destroy foreign
substances that enter the body from the
outside, such as bacteria and viruses.
Neutrophils make up more than half
ofall white blood cells in the blood.
 IMA
NAIVE T
CELL...
I'M THE
LOWEST
RANKED
OF THE
T CELL
FIGHTERS...

UMMMMM..,
$0 WHAT WERE
YOU DOING INA
PLACE LIKE THIS
ANYWAY?

I-I’M ON A
RECONNAISSANCE
MISSION. BUT THIS a
TOWN WAS FILLED Naive T Cell
WITH ZOMBIES... An inexperienced T
cell that has never
encountered an antigen

il | CAN WE BACK
UP? WHY DID
ave 4 le YOU COME OLIT
WERE JUST ; , OF A WALL...?
ORDINARY A b
CIVILIANS.

BUT...THEY
SEEM TO HAVE
BEEN INFECTED
BY A VIRUS.

To move freely
insidea tissue
'Y

< = =s 7) < N 6 > s “

The virus responsible for the infectious
disease Influenza. Largely divided into Types [7
A »Bandc 2 it causes symptoms such as fever
above 38 c 2 headache 2 and joint and muscle
pain. Some new strains of the virus were
previously not transmittable to humans. ”
but became that way due to mutation.
 THEY
PARASITIZE
CELL BODIES
LIKE THAT TO
MULTIPLY.

KILL THEM
BEFORE
THEY DO!
YOU BACK
ME UP AND...

TLL JUST
SIT STILL
HERE SO I

AREN'T YOU
A MEMBER OF
THE T CELL
FIGHTERS?
 TEE-HEE!
ARE YOU
GENTLE-
MEN ALL
RIGHT?

Js ee
See

Macrophage
Atype of white blood cell, these
catch and kill foreign substances
such as bacteria, and determine
antigens and information on
immune responses. They also act
as cleaners who remove debris
such as dead cells and bacteria.
SEEMS THAT
INFLUENZA
B VIRUSES
HAVE

CONTACTED
THE
ORGANS
T THROUGH
wis 7 DENDRITIC
i ceLts wit, CELL.
| RELAYED ARRIVE AS
REINFORCE-
YOUR MESsager 4a) MENTS ANY
GOOD Luck:
 THAT C-COULD
T BEAT YOU TELL
JUST ONE PEOPLE...
OF THESE
ZOMBIES?!

I-IF YOU
DON'T, THEN
MY SENPAI
WILL...

THIS THE
PLACE TO
FIND SOME
VIRUSES?!

Killer T Cells
(Cytotoxic T Cells) §
WE KILLER Deployed onthe orders §

7 CELLS of aHelperT Cell, they

kill virus-infected and
ARE GONNA cancerous cells.

KILL ’EM
 hy
HE

NAIVE! Eel
uf

YOURSELF
) AT CELL?
y HUH?!

yO, fen geus ave

HEY, STEP --
UP FOR
[Xi a3ip: TIME, Hill?
ONCE AND .
KILL JUST
ONE, WILL
HEAR
YA?!.
 LISTEN
THESE VIRAL uP,
BASTARDS LADIES!
MULTIPLY WAY DON'T
*\ FASTER THAN LET YOUR
gy ©6BACTERIA! GUARD

Memory T Cell
Amember ofthe Killer
T Cells, They stand by
so that they can attack
if the same enemy
appearsa second time. KX

ADDITIONAL
CIVILIAN
~ CASUALTY!
VIRUSIL!

IMA
7 CELL, TOO,
AFTER ALL... H-HE'S
JUST LIKE MY RIGHT.
SENPA/...1f LT HAVE
70 VO
MY PART,
700...
 TSK...
FORGET HIM!
WE'VE GOT
VIRUSES TO
WORRY ABOUT!!
 AREN’T
YOU ONE
OF THE
T CELLS
IS THAT WAS
SOME- FIGHTING
THING THE VIRUS
WRONG
fh
EARLIER?

Dendritic Cells
These cells take fragments of
| bacterial cells and virus-infected
cells, and present them as antigens
/] for other cellsin the immune

geea
}] system. As their name suggests,
4 ! they extend finger-like appendages.

A
2

THERE'S
NO WAY T
CAN FIGHT
THOSE SCARY
THINGS.

I-I'M NOT
LIKE WHITE
Z’M NOT BLOOD CELL
OR
STRONG MACROPHAGE
LIKE OR MY
SENPA/...
THEM!!!
 EVERYONE
WOULD BE
BETTER OFF
WITHOUT A
WIMP LIKE
ME AROUND!

THAT'S
NOT
TRUE,
NAIVE T
CELL...

NO ONE
STARTS
OUT BEING
STRONG
FROM THE
START.
 A-ARE
THESE...
OLD
PICTURES
OF MY
SENPA/?!

T Cell Differentiation
Upon recognizing an antigen,
naive T cells activate to
become effector T cells. They
subsequently differentiate to
become killerT cells, helper
T cells, and other types.

SENPAI
WERE ONCE
NAIVE T
CELLS JUST
LIKE YOU.

INFECTED
BY THE
VIRUS?
I FEEL AS
IF A SEALED
DARK HISTORY
HAS BEEN
REVEALED...
A NASTY
CHILL...
 COULD IT
BE THAT
THE OTHER
T CELLS ARE
HARSH ON
you...

..-BECAUSE
THERE'S THEY SEE
NOTHING THEIR OLD
TO BE SELVES IN
AFRAID OF,
LITTLE

WHITE
BLOOD CELL
PATROLS THE
BODY TO FIND
ENEMIES...
MACROPHAGE
RELAYS
INFORMATION
ABOUT THEM.

THAT'S
WHY HELPER
T CELL CAN
GIVE THE
ORDERS.

YOU HAVE
FRIENDS +0380
WHO WORK THAT KILLER
TOGETHER... T CELLS
AND DO CAN DEFEAT
THEIR JOBS THEM.
WITH PRIDE!
 AND
YOU KNOW
WHAT YOU
HAVE TO
DO...

a q :
el

ENCOURAGING
AND
ACTIVATING
The Dendritic 7 CELLS LIKE
Cells’ Power
They can activate
naive T Cells
 THERE'S...
: NO END
Sa TO THESE
' THINGS.

| , iN
As H

‘ \
\\
 .
le ye Nien
a / ate |

Vo “lg
yp" ome" oral
A >
 MY FRIENDS...
I'M SORRY
THAT YOU HAD
TO SEE MY
SHAMEFUL
BEHAVIOR
EARLIER.

BUT I WAS
ABLE TO
OVERCOME
THE OLD,
WEAK ME...

..-AND
RETURN
HERE,
ACTIVATED.
 I'M THE
FORMER
NAIVE

ZEEE
Effector T Cell
Anaive T cell that
has been activated.

I’VE ALSO
UNDER-
 NOW WE'RE A
HUNDRED CELLS
STRONG—
LITERALLY!!!

if
Ay ip
{ff
yyMe p
We yA

we ye

4 B Cell (Antibody-
Producing Cell)
Atype of lymphocyte
that makes weapons
E
called antibodies to
A fight antigens such as :
AV bao 7 | bacteria and viruses.
(en | | WE'LL
7 WIPE
ae THEM
HE.
\, anty OuT

AT YOUR
WITH SERVICE!
THESE, I CAME
YOU'VE | BACK WITH
GOT
NOTHING
70 FEAR!

Do It...
TOGETHER,
.-EXTER-
GONNA.
MINATE
THE
Raising the body temperature ‘
suppresses the multiplication
of bacteria and viruses. It
also prompts activation of
immune response cells,

YO! THIS
AIN'T NO
TIME TO BE
COOKING,
TELL THEM
TO USE
ENERGY Z aS
Kora Aad Loss of Appetite
Areaction in which
the energy usually
used for digestion is
spent to fight illness.

THE STRONG |’
| PERFORMANCE }, WE'VE
OF EACH TAKEN IN
PLENTY OF
FLUIDS!
SWEAT!!
COOL THE
SURFACE!!

inal HE
INFLUENZA
WIRUS WAS
ERADICATED
 A Hea
TTY

I DID MOST OF
THE WORK IN
THE SECOND
HALF OF THE
FIGHT...
ME AND MY
ANTIBODY...

BACTERILIM
OR VIRUS
STANDS
A CHANCE
AGAINST
 HEH...
WHAT FOLLY...
WHEN TENS OF
THOUSANDS OF
/TS BRETHREN
ALREADY LAY

LET US AT
LEAST K/LL
/T QUICKLY,
SO THAT /T
DOES NOT
SUFFER.
WAQTS! Be
R
ey

gRas
a
so) Bd
oe * fe
y
 COULD
IT BE A...
TYPE A
INFLUENZA
WIRUS?
9

Type Alnfluenza Virus [= ~

Many viruses ofthis type tf
mutate inside the body
and are more likely to
cause pandemics.

I'M GONNA
GO BACK TO
MAKE A NEW
W-WAIT, |
ANTIBODY, SO...
WE'RE GOOD LUCK,
COMPLETELY T CELLS-
EXHAUSTED...

i\
wZ, aS,

\U}|
 ¢ Transports nutrients
and oxygen, and collects
waste and carbon dioxide.
« The workplace for white
blood cells, red blood
cells, and platelets.

LYMPHATIC y
VESS E LS ae if — * Collect excess water and fat,
as well as germs. They are
patrolled by an army known
as lymphocytes, who are
prepared for any emergency.

KILLER
T CELL
Platelet
Acellular constituent
of blood. They gather
when blood vessels are
damaged and close the
wound to stop bleeding.
 THINGS
HAVE BEEN
PEACEFUL
INSIDE
THE BLOOD
Red Blood Cell
Carries oxygen and carbon
dioxide throughout the body
through blood circulation.

IT'S
BEEN SO
PEACEFUL
LATELY,
SENPAI!

THE BLOOD
I VESSELS
qn¢ AROUND HERE SHOULD BE
ARE PRETTY CAREFUL
CLOSE TO THE WHEN
WALKING UP
AHEAD!

EVEN A
SLIGHT IMPACT
WILL GIVE A
HUGE—
 HUH?
WHAT
H-HEY,
ioe THAT
THAT
“i ae IMPA
A | THERE! oo

YYARELES
 IT’S
PULL-
ING
IN?! Ve
 White Blood Cell (Neutrophil)
His main job is to destroy foreign
es substances that enter the body
Gy h from the outside, such as bacteria
’ i and viruses. Neutrophils have cell
Hh adhesion molecules called L-selectin
that allows them to stick to the
inside of vascular endothelial cells.

OUTER
Es .-DUE WALLS
ji
y Pel eee TO AN OF THE
Wo TUE BLOOD. MPACT BLOOD
Y <ifa— CELLS To. FROM THE VESSEL
“1 eae our. OUTSIDE... BROKE...
y : d IN OTHER
2
yf woRDS— ]44
 FALL FROM THIS
OPENING, IT'S
ALL OVER. YOU'LL Scrape Wound
NEVER BE ABLE TO (Abrasive Injury)
MAKE IT BACK TO An injury made by
scraping, no deeper
THIS WORLD. than the epidermis.

IT'S ALL
REALLY OVER
SERIOUS! IF WE
WE HAVE TO FALL...?
DO SOME-

THERE'S
SOMETHING
WE HAVE
TO WORRY
ABOUT
BEFORE
THAT.
 BAC-
TERIA
I]

IVS JUST
LIKE THE
STORIES
SAY. A
PERFECT
PLACE TO
MULTIPLY. £

THAT
DIDN'T
TAKE
LONG...
 THIS
ISN'T Staphylococcus Aureus
BAD... A bacterium that lives on the skin and
in the pores. Highly virulent, and can
cause skin infections, pneumonia,
meningitis and septicimia when it enters
through the trauma (injury) site. Can also
cause food poisoning when ingested.
 WORRY
AGOUT ME! WHITE
BLOOD
JUST GO! CELL,
SHOULDN'T
YOU FIGHT
OVER
HERE?!

YOU'LL
GET
SUCKED

Q
ad
/
Cc
K
/

SS
 WHAT'S THIS?
VASOCON-
STRICTION
UNDERWAY?

MUST HAVE
HAPPENED 8
OVER THAT

Vasoconstriction
Damaged blood vessels attempt
to slow bleeding by constricting.
= ——a" 7 ml

AND IT’S AN
BACTERIA ARE EMER-
SWARMING GENCY!!
IN FROM THE A BIG
OPENING!!! SCRAPE
WOUND
OPENED
OVER
THERE!
 Pseudomonas Aeruginosa
Arepresentative common
bacteria that lives in the
natural environment. Causes
pseudomonas infections.

GWA HA HA
HA HA HAL!
THIS BODY
BELONGS TO
US NOW!

RED BLOOD
CELLS CARRYING Streptococcus Pyogenes
Lives in the pharynx, the
NUTRIENTS, LINE digestive organs, and the skin
among other places. Itisa
UP RIGHT THERE! commonplace bacterium but
WE'LL KILL THE can cause many diseases.

ONES WHO
AREN'T CARRYING
ANYTHING!!
Venous Valve
These prevent
blood from flowing
backwards. They
force the blood traffic
in the veins to be
one-way, heading
toward the heart.

BEEEK!
i's
GOING
TO KILL
ME!!
 THE WHITE
BLOOD
L CELLS...

WHERE'RE
THE
WHERE BACTERIA?!
=a WHERE ARE
WOLIND?! THEEEEEY?!

T THINK
IT'S TOO EARLY
TO SAY THAT.
AREN'T THERE
TONS OF GERMS
COMING IN?

AND FALLING
INTO THE
WOUND IS
THE END.

WELL...
T GUESS
WE HAVE TO
COUNT ON
THEM TO
DO THEIR
BEST...
 Lz

ENS
OS
S
ae=

PIN HIM
/ DOWN! |,

HA HA HA,
’ CAN'T
MOVE WHEN
ay YOU'RE SUR-
ROUNDED BY
BLADE-LIKE
SPIKES!
 THIS IS
STRANGE...

We'LL 2046 IS INA N46,

GO, T00, TOUGH SPOT! COME IN/
ONCE WE = HE'S CLOSE
TAKE CARE TO YOu! ARE YOU
OF THE — THESE GUYS
pacterla EAU EVER
COULD HAVE
RUN DEEPER
INTO THE BODY
INSTEAD OF
THING'S NOT}, FA FIGHTING ME...
RIGHT! THE | KAW
BACTERIA ARE
ATTACKING
LIKE THERE'S
NO TOMOR-
ROW! BE
CAREFUL!
THANKS
FOR THE /
HELP! I

NOT
BAD...
THERE'S
MORE
OF US
COM/NG
FROM
OUT-
SIDE!
 y y
Be A Vd
C'S
YOU'RE
SUPPOSED TO
TURN ON THE
POWER FOR YOUR
L-SELECTIN!!

pied

MUCH HELP,
ARE THEY?!
 HO HO
HO HO! |
WHAT A | BA
an PATHETIC |f/

AFTER
DAY, YOU
BUT WHEN FIGHT TO
YOU'RE PROTECT
THE
IN NEED, OTHER
NOT A SOUL cells...
COMES TO
YOUR AID. art

AREN'T YOU
EXHAUSTED
BY NOW7!
IT'S ALL You
CAN DO TO
CALL US HOLD ON
“NEUTROPHILS” AND NOT
INSTEAD OF FALL IN/!
“WHITE BLOOD
CELLS’?
 I HEARD OH, voune
pst ee
unt {O08 ABOUT SOME NATLIE
“sro 4 PNEUMOCOCCUS CT RALLY. DONE
> \ WHO GOT HIMSELF 1 . YOUR
KILLED BY TRYING = HOME-
. TO INVADE HERE WORK.
~ =| WITHOUT DOING
: ANY RESEARCH
4 a FIRST.
— 5

.-AND THAT
THE STRONGER
ONES LIKE
MACROPHAGES
} AND
\ MONOCYTES
i COME LATER!
a
i Wi \N rdr, ;

MW WN RR
(eas ‘A A I KNOW THAT
MT} THE FIRST TO
KK APA RESPOND TO
ALVES BACTERIA ENTERING
= A WOUND ARE
SMALL FRY CALLED
NEUTROPHILS...

IT ALSO KNOW
THAT THE ARMY
KNOWN AS THE
LYMPHOCYTES
ARRIVE EVEN
LATER.

ey

‘X

.AND
ALL WE HAVE
TO 00 1S TAKE
VICTORY IS CURE OF YOU
OURS!!! NEUTROPHILS...
 WHA-
you
BLOCKED IT?!
HOW COULD
YOU HAVE
THAT KIND OF
WILLPOWER
LEFT. ..?

. Hun...
A
PRETTY
CG LAME
a PLAN.

NOT
MACROPHAGES
_..BUT A OR YOU'VE
POWER- MONOCYTES OVERLOOKED
FUL ALLY OR KILLER ONE TYPE OF
IN OUR T CELLS OR BLOOD CELL.
FIGHT. B CELLS...
eee
TO

i} P
ei

nen
{

Aji, ih |
 THANK
YOU FOR
YOUR
HARD
WORK!!
 ty

iT MAKE SURE
TO USE
OM EIENY S
dats ae
we
; a
AYE

Ny aN
in
wyWK

‘a
AY}
 FINISHED
GATHERING 4
uP THE
FIBRIN!

‘i : a Ve

GREAT! By Nee ND
TAKE OLIT afe Z LP O
YOUR : " 7 ae
ee =. é fi bell involvedin ft
PLEASE J LP y, coagulating blood. :
: bes K , T 4

USE THE
COAGULATION
FACTORS TO PATCH
= TOGETHER
ms THE FIBRIN.
 a
=
“ee (itn ae : i.
a : es a

NOW eee, y
WHAA?! WE CAN
BEGIN THE &@
oar Se oy
& Rad? %
CLEANUP.
MG ge
4

=
ae |
i
Vr
i THROMBUS, Thrombus (Blood Clot)

“TA COMPLETE!
Activated platelets aggregate
to close the wound. They do so
4 with a protein called the “von
Willebrand factor”, which acts
like super-glue. Then, proteins in

a the blood known as “coagulation

factors” work to coat the clot

ty
[| |
with a net of fibrin, hardening it.
 ei
fo! +} ; =
|am
|
T 1
a + A NET TO
‘= re CLOSE THE
WOUND?!

ee Ze
“sureosen
70 LET MORE
||_\__\_\\_S
GERMS IN?!

NOW THAT
WE DON'T HAVE
TO WORRY

NO
ABOUT FALLING,
WE'VE GOT THE
UPPER HAND.

TIME TO
KILL US

YOU'RE
THE LAST
ONE LEFT.
 ZENON
S an

Fai, LN
} VP
 UM...
THANK
YOU 60
MUCH...
REALLY.

f 13 . q . ES ul

We OYC\)ACN eeBECALe,
- \ oe ISE I so
MN Bat eae
Bese (
 ve ant
BUT WE RED
BLOOD CELLS YOUR
COULDN'T DO FRIENDS
ANYTHING BUT AND THE FOUGHT
RUN AWAY. PLATELETS THE
CLOSED THE BACTERIA.
. WOUND. ..YOU
y ALL WORKED
eo is TO KEEP THE Lh. =
BLOOD ’ S
VESSELS es

THE LEAST
IT COULD
DO IS TO
THANK YOU
PROPERLY.
 THAT'S
NOT
TRUE,
ACTU-
ALLY...

MY HUH?! /A |
SENPAI ARE |
TIED UP IN
FIBRIN AND
BEING LED
AWAY BY
THE LITTLE
PLATELETS!
UM, BY
WHY [6 IT THE WAY,
THAT YOU WHITE
HAVEN'T BLOOD
MOVED A CELL...

WHAT?!
MOVES! wm stuck |
TO THE
FIBRIN!
 THE CELLS
MAKING UP
THE OUTER
WALL CAN BE
HEALED...

BODIES OF
THIS ds BLOOD
UH, THAT'S IS CALLED CELLS ARE
GREAT AND t seeGnbAey USED TO
ALL, WHITE THROMBO- PLUG UP
BLOOD CELL, THE HOLE.

HOW LONG
ARE WE
a t SUPPOSED
a ° TO STAY
LIKE THIS?! /-

TISSUE FLUID
LEAKS OUTSIDE
THE BLOOD
VESSEL THROUGH
THE WALL OF
CELLS AND DRIES,
IT MAKES A
SCAB, SEE?

oe,
CELLS AT WORK! VOLUME 1: END | ==
+ AND HOW DO THEY REACH THEIR FULL POTENTIAL AS CELLS?

ANTIGEN

NEXT VOLUME!
WHITE BLOOD CELLS, RED BLOOD CELLS-WHERE ARE THEY BORN...

I WANNA
GROW UP
TO BE AN
AWESOME
RED BLOOD
CELL,

THE YOUNG CELLS WILL COME OF AGE AND

FACE THEIR MYSTERIOUS DESTINY!!

Cells at
«a WOOP!
RED
BLOOD
CELL
TRANSLATIO
Bye-bye, Germs
Page il
“Bye-bye, Germs,” or “Baibai-
kin” in the original Japanese,
is the parting line of the main
villain Baikin Man (Germ
Man) from the popular, long-
runnning children’s cartoon
Anpan Man. |t is a pun
combining the English phrase
“Bye-bye” and the Japanese
word “baikin,” meaning Ce a
“germ.” In the original Lala ny
ni
Japanese, the sign is written a ap es ttl
in the 5-7-5 meter of a haiku i I? Her re os
poem, which is a common
practice in educational messages for
children as well as in public service slogans.

Senpai
I-lE YOu Page 115
DON'T, THEN The Japanese word “senpa/” roughly
translates to “upperclassman” or
cial “senior.” While it is used by students
or to refer to their older peers, it is not
necessarily an academic term, and can
be used to refer to anyone in a given
situation who’s more experienced than
the speaker but not necessarily ina
position of authority over them, as
opposed to a teacher or a boss, who
would not be considered a senpa?/. It
often connotes respect and admiration.

A Body Strong Against Stress

Page 50
This is a parody of popular municipal slogans—e.g. “A Town Strong Against
Crime” for Yokohama City. The slogans usually seeks to promote a set of policies
or infrastructure designed to combat a specific problem.
 KODANSHA)|
|
comics:
y “The word
heartwarming
was made for
manga like this.”

and biting social i

commentary... delivers [7,)CO:#CGery powerful
in its depth of char- a ao story about being
acter and emotional | different and the con-
strength. Comics sequences of childhood
Bulletin Ny), bullying... Read it.”
<= | -Anime News
Network

=, —\\

= = - '

Ea _ —y ] a if ;

Shoya is a bully. When Shoko, a girl who can’t hear, enters his ele-
mentary school class, she becomes their favorite target, and Shoya
and his friends goad each other into devising new tortures for her.
But the children’s cruelty goes too far. Shoko is forced to leave the
school, and Shoya ends up shouldering all the blame. Six years lat-
er, the two meet again. Can Shoya make up for his past mistakes,
or is it too late?
Available now in print and digitally!
© Yoshitoki Oima/Kodansha Ltd. All rights reserved.
ae Fl Very, funny manga Ww
with a
fe /OL Of.heart éand. character, ye
=Adventures iin Poor, Taste

rN A
K169?: ai l
im WW,
Wr/)
‘4
PewapeeD WITHA
Class troublemaker Ryu Yamada is already having a bad day when he
stumbles down a staircase along with star student Urara Shiraishi.
When he wakes up, he realizes they have switched bodies—and that
Ryu has the power to trade places with anyone just by kissing themn/
Ryu and Urara take full advantage of the situation to improve their
lives, but with such an oddly amazing power, just how long will they be
able to keep their secret under wraps?
Available now in print and digitally/
© Miki Yoshikawa/Kodansha Ltd. All nghts reserved.
 DON’T MISS THE MOST ACCLAIMED
ACTION MANGA OF 2013!
“Gripping doesn't begin to describe Vinland Saga.
Satay —ICv2
“Deeply engrossing... If you have any interest at
allin Vikings, the Medieval period, or pirates, this
is not a series you want to miss.”
—Anime News Network
“The art is gorgeous, a combination of beautiful
cartooning and realistic backgrounds, Yukimura
is also a master of pacing, both in frenetic battle
scenes and charged emotional moments,”
—Faith Erin Hicks, Friends With Boys
“For those who love Berserk, you'll love this too...
Worth the long wait.”
—A Case Suitable for Treatment

“Tt will be impossible to stop watching this story

unfold,” —Japan Media Arts Awards jury

/
Yukimura
Makoto
©
reserved.
rights
All
Ltd.
Kodansha
 N

OMICS ag

Sen | Ny
i -
| 2E

When Takeru adopts a new pet, he’s in for a surprise—the dog is

none other than the reincarnation of Sherlock Holmes. With no
one else able to communicate with Holmes, Takeru is roped into
becoming Sherdog’s assistant, John Watson. Using his sleuthing
skills, Holmes uncovers clues to solve the trickiest crimes.
© Yuma Ando and Yuki Sato /Kodansha Ltd. All rights reserved.
 Praise for the anime:

“The show provides a plea

touching, just: lain batter than yo

going to be.”

Nhs
KODANSHA
COMICS}
Mei Tachibana has no friends — and says she doesn’t need them!
But everything changes when she accidentally roundhouse kicks the most
popular boy in school! However, Yamato Kurosawa isn’t angry in the slightest—
lames (oie al=Walial.comalrsme)cellar=lava lic merel0|(eMUtcs-Mr=|gmUlalOciOr=1 Mella (CoM U(clem sIULMnlalaliare)
Mei’s trust will be a tough task. How long will she refuse to say, “I love you”?

© Kanae Hazuki / Kodansha Ltd. All rights reserved.

 PRAISE FOR THEJANIME!
“This series never fails to “A very funny look at what happens when
put a smile on my face.” two strange and strangely well-suited people
-Dramatic Reviews try to navigate the thorny path to true love
gptogether.”
fl nime News Network

OPPOSITES ATTRACT...MAYBE? |
Haru Yoshida is feared as an unstable and violent “monster.”
Mizutani Shizuku is a grade-obsessed student with no friends.
Fate brings these two together to form the most unlikely pair Haru
firmly believes he’s in love with Mizutani and she firmly believes
he's insane. KODANSHA
© Robico / Kodansha Ltd. All rights reserved. COMICS
 eee.

// Be f afA
| fiHce faye yi
é Td | |
TE
CG ae ts
tise f 4 jie

Chihiro has an unusual connection to zombie movies. He doesn’t feel bad for
the survivors - he wants to comfort the undead girls they slaughter! When
his pet passes away, he brews a resurrection potion. He’s discovered by
local heiress Sanka Rea, and she serves as his first test subject!

© Mitsuru Hattori / Kodansha Ltd. All rights reserved.

 The VIRGINGCITCD

“Maria's brand of righteous

justice, passion and plain talking
make for one of the freshest
manga series of 2015. |dare any
other book to top it.”
—UK Anime Network

As a war to determine the rightful ruler of f

medieval France ravages the land, the witch
Maria decides she will not stand idly by as
men kill each other in the name of Godand /
glory. Using her powerful magic, she summons
various beasts and demons —even going as far o-_
as using a succubus to seduce soldiers into sub- a
mission under the veil of night— all to stop thes
needless slaughter. However, after the Arch- ~
| angel Michael puts an end to her meddling, he :
| curses her to lose her powers if she ever gives
) Tor
YY A st pe
Wve>
| up her virginity. Will she forgo the forbidden —{¢ ae ae
| fruit of adulthood in order to bring an end to te Ss a KODANSHA
| the merciless machine of war? ~ i ee ae (HI TES
. . . oe | = — =

Available now in pial and digitally! ©Mayasuki Ishikawa /Kodanstia, Ltd.Allrights reserved.
 Battle Avgel Alita is
1 OK2.0f the greatest
st andzpossibly the
» greatest) of all sci-fi
it action manga series.”
Nn

inc Anime News Network 77

LA
lj

SFA | syy6u
peniesal
BYsuepo
pr]
O1INA
O4IYSIY
©/|Iy

The Cyberpunk Legend is Back!

Tame (=U <-Molarlalieletcm-vellt(e)at-Mey moll 02amor-le(-t-m
including ALL-NEW original stories by
Alita creator Yukito Kishiro!
 ICHIRO INUYASHIKI IS DOWN ON HIS LUCK. HE LOOKS MUCH
OLDER THAN HIS 58 YEARS, HIS CHILDREN DESPISE HIM, AND
HIS WIFE THINKS HE’S A USELESS COWARD. SO WHEN HE’S
DIAGNOSED WITH STOMACH CANCER AND GIVEN THREE MONTHS
TO LIVE, IT SEEMS THE ONLY ONE WHO’LL MISS HIM IS HIS DOG.

THEN A BLINDING LIGHT FILLS THE SKY, AND THE OLD MAN
IS KILLED... ONLY TO WAKE UP LATER IN A BODY HE ALMOST
RECOGNIZES AS HIS OWN. CAN IT BE THAT ICHIRO INUYASHIKI
IS NO LONGER HUMAN?

COMES IN EXTRA-LARGE EDITIONS WITH COLOR PAGES!

 EDITIONO
ONTAINS VOLUMES 1-5
ONLY $39.99!

bhi Fairy Tail sete place in

ina world filled with magic. 17-year-old Lucy iis a5
a wizard-in-training who wants to join: a magic guild so that she can ve
become a full:
nae wizard. She dreams of joining the, most famous wy

his dragon father. When Natsu pipe Lucy out of a tricky :situation, shewilt
discovers that he is a member. of Fairy Tail, and our heroes’ adventure
Pg YM Se

© Hiro Mashima/Kodansha Ltd. All rights reserved. | ASTER'S isp) eple)\|

fairy tail masters ad.indd 4 @ B15 14:54 AM |

 AFTER DEMONS BREAK
THROUGH INTO THE HUMAN
WORLD, TOKYO MUST BE
QUARANTINED. WITHOUT
POWER AND STUCK INA
SUPERNATURAL WARZONE,
17-YEAR-OLD KAZUYA HAS
ONLY ONE HOPE: HE MUST
USE THE “COMP,” A DEVICE
CREATED BY HIS COUSIN
NAOYA CAPABLE OF SUM-
MONING AND SUBDUING
DEMONS, TO DEFEAT THE
INVADERS AND TAKE BACK

| PF BASED ON THE ahr

| VIDEO. GAME FRAN MaArs
UL
CHISE ay
TLUS | lig \an

| devil survivor ad.indd 1

© 1A38AN6 11:44AM |
 BLUE MISTRAL
The new adventures of
everyone's favorite Sky / fa \e

Dragon Slayer, Wendy

Marvell, and her faithful gh
yous | = ZA | \ |
friend Carlal, Fe Wes :
id fi] /, y SN Ye
\\ . MAN oN

\ \ : . ENN ‘ SS " a a aN \

\ & .

OQ
j = : at Ch oh CAS Nog

Tae LNow
ae fe | |

(HULU ITE A. Oo
i
irosMashima/RuiVVa anabe/Kodansha,LtdAIl rights reserved.
wy Of
 ARSLA
THE HEROIC LEGEND OF

READ THE NEW SERIES FROM THE |CREATOR OF

— ALCHEMIST, HIROMU ARAKAWA!
cinne A HIT TV SERIES!

H 1ovels Pate] fans’ of

Mieitelaters| Kelp epic, fantasy.
will be quite pleased with
the resulting book.”
-Anime News Network

ECBATANA IS BURNING!
Arslaniis the young and {curious prince of Pars who, despite his best efforts doesn't seem
to have what it takes to be a proper king like his father. At the age of 14, Arslan goes to
his first battle and loses everything as the blood-soaked mist of war gives way to scorching
flames, bringing him to face the demise of his once glorious kingdom. However, it is Arslan’s
destiny to be a ruler, and despite the trials that face him, he must now embark on a journey
to reclaim his fallen kingdom.

Available now in print and digitally!

© Hiromu Arakawa/ Yoshiki Tanaka/Kodansha Ltd. All rights reserved.
Cells at Work! 1

KODANSHA COMICS Digital Edition

Cells at Work! volume 1 copyright © 2015 Akane Shimizu

English translation copyright © 2016 Akane Shimizu

All rights reserved.

First published in Japan in 2015 by Kodansha Ltd., Tokyo.

Electronic Publishing rights for this English edition arranged through
Kodansha Ltd., Tokyo.

No portion of this book may be reproduced or transmitted in any form or

by any means without written permission from the copyright holders.

English digital edition published by Kodansha Advanced Media, LLC,

San Francisco.

www.kodanshacomics.com

ISBN: 9781682334638
Digital Edition: 1.0.0

Translation: Yamato Tanaka

Lettering: Abigail Blackman
Editing: Paul Starr
Kodansha Comics edition cover design: Phil Balsman
 HOW TO READ MANGA
Japanese is written right to left and top to bottom. This
means that for a reader accustomed to Western languages,
Japanese books read “backwards.” Since most manga
published in English now keeps the Japanese page order,
it can take a little getting used to—but once you learn how,
it’s a snap. Here’s a handy guide!

Here you can see pages 10-11 from this book. The speech
balloons have been numbered in the order you should read
them in.

Start here, at
Page 10—read this one first! the top right
corner of the
right hand
page.

Read right to
left, then top to
bottom. In this
panel, the leftmost
speech balloon
comes before the
one in the top left
corner.

Now continue on to
the top right corner
of Page 11.
 Page fl
On this page,
the top two
panels are
read first.

This panel is the top

right-most after the
first two, so it’s next.

If you go to this
panel next, you
would have to
move backwards
Cright) to read
balloons 6 and 7.

Instead, after
reading balloon
5, you move
down to 6 and
7, then left...

..and then you

arrive at the end
of the page!

After a few pages, you’ll be reading manga

like a pro—Japanese-style!
(That
means
STOP)
You’re about to
read a manga—a
Japanese comic—
presented in its
original page order,
which means you
start at the other
end of the book. If
you need a quick
guide on how to
read manga the way
it was meant to be
read, flip to the next
page—otherwise,
turn the book over
and enjoy!