AKANE SHIMIZU

CONTENTS
Chapter 10
The Circulatory
System

Chapter1] The Common Cold

ANOTHER
PIGGYBACK (
Chapter 12 Thymocytes

Chapter13 Acquired Immunity

Chapter14 Acne

\ oN
|_[ CARRYING
| BAD Guy
\ AROUND
 Nie’! |
Bure
i
( I’M GOING
70 GO
» THROUGH ONE
CIRCULATORY

Superior —“/~
vena cava#/

TM JUST
IN FRONT
Inferior OF THE
vena cava INFERIOR
VENA CAVA,
BO e

HAVE TO
DO IS TO
GO FROM
THE
INFERIOR
VENA CAVA,
TO THE
HEART AND
TO THE
LUNGS,
THEN BACK
AGAIN!
 I'LL STAB
ANYONE WHO
GETS IN MY

WHY DOES
THIS STUFF KEEP
HAPPENING
AROUND ME? I JUST
BARELY DECIDED
OH NO.
THIS 1S THE THAT I WAS GOING
END...I'M TO WORK EXTRA
GOING 9 TO BE HARD...
STABBED AND
Hemolysis 5 WSS
HEMOLYZED... When red blood cells
are destroyed.
GONNA DIE... SS
 rN BLOOD
piel : i hai = CELL. ARE
CELL... GON "A YOU ALL
THANK YOU REO AI IY RIGHT?
60 MUCH. mg

White Blood Cell (Neutrophil)

His main job is to destroy foreign
substances that enter the body
“i from the outside, such as bacteria
( and viruses, Neutrophils make

Se
j up more than half of the white
\ VA blood cells in the blood.
<P SS

WERE YOU
DOING IN A
| PLACE LIKE
ANO WHITE : THIS?
BLOOD CELL ; THERE'RE
GOT HURT é ONLY
LYMPH
DUCTS UP
AHEAD.

THEN LET
ME SHOW
YOU THE
WAY LIKE
 /7'S LIKE
HER ALUIRA RED
/S SAYING, BLOOD
CELL /S
‘I'M GO/NG BURNING
TO 00 THIS WITH
ALL ON MY PASSION!
OWN!”
 A-ARE
YOU ALL
RIGHT?!

(thiV I |
ody St
NCONVEN.
1'M FINE.
SO SORRY
RED BLOOD
CEU
FOR THE
TROUBLE,

THIS IS
NO.N46. TM |
GOING TO MAP( ast,
GO PATROL 6 THE
THE BODY, | Va INFERIOR
(is VENA
‘s CAVA!
GOT IT!

Inferior Vena Cava

The largest vein in the human
body. Blood from the lower
ALL RIGHTY. part of the body and other
I'M GOING TO areas flow here and then into
WANDER AROUND 2) the heart (right atrium).

NEAR THE OUD,

LIVER, THEN.
Sb LED
 =
=SHOULDERS
ARE ALL
STIFF!

Z0-4DeC0a-0
*

WHY...
WHY ARE
YOU RE-
VERSING
OREC-
TION, RED
BLOOD
CELL...?

HEY! WHY ane

YOU GOING THE
WRONG WAY?!
YOU JUST WENT
2 'o| THROUGH THIS
e VALVE!

THAD
THE MAP
uiIPSIDE
50 COW...
DumBr
Venous Valve
These prevent blood fram | wuaar!
flowing backwards. They
14 1-1 so
force the blood traffic in
the veins to be one-way,
i. SORRY!
heading toward the heart.
 »

Inferior
Va Vena Cava

TIMES
LIKE
THESE ARE
EXACTLY
WHEN I
NEED TO
STEP UP!

WHEN THE
ROADS ARE
COMPLICATED
THAT I
LOSE TIME.

ARE YOU
ALONE? DO
YOU WANT
ME TO GO
WITH YOU?

THE
INFERIOR
VENA CAVA
IS JUST ONE
BIG ROAD,
‘| SO IT'S EASY
1 BUT ENOUGH...
T HATE
THAT
I'S ALL
UPHILL.
 re ee en
One-way traffic.

Mitral Valve

Pulmonary Circulation and

Systemic Circulation
Pulmonary circulation proceeds
from the right ventricle, then to the
pulmonary artery, lungs (discarding
carbon dioxide and receiving
: : oxygen), pulmonary vein, then to
Tricuspid 7 the left atrium.It takes about 3
Valve or 4seconds per cycle. Systemic
circulation proceeds from the left
ventricle to the aorta, then to the
arteries, capillaries (dropping off
oxygen and nutrients, and receiving
carbon dioxide and other unneeded
chemicals), the veins, the superior
vena cava, then to the right atrium.
It takes about20 seconds per cycle.
INOA
‘Sulpmosd
aseajd
*s}4e>
pjo}
oL
aonpas

I ALWAYS
FOLLOWED
SENFPA/ TO

HEART...
| LE |NO MATTER
R | ee HOW MANY
Jea : ‘ TIMES
: be I COME
TO THE - HERE, I
HEART! ia : DON'T FLILLY
UNDER-
STAND IT...

at
 WELCOME
TO THE
HEAR T/

THE
TRICUSPID
ae? it
OH NO! I
DROPPED
MY
NOTES!

MY
PRECIOUS
NOTES—!!
 THIS |S THE RIGHT
ATRIUM. THERE |S
HEAVY FLOW BECAUSE OF
MERGING TRAFFIC
FROM THE INFERIOR AND
SUPERIOR VENAE CAVAE.
WE THANK YOU FOR YOUR
UNDERSTANDING.

Current 5
location
ey

Ww git N ama net

: to
"STOP,
\ AND MOVE
HUH?! THROUGH
WHA?!
WHY'D
; QUICKLY.
THEY COME
FLYING AT
 WELCOME TO
Right Ventricle THE RIGHT
Contains venous blood VENTRICLE. WE ARE
carrying large amounts UNDERGOING
of carbon dioxide. { CONTRACTION,
WE ASK YOU NOT
TO LINGER NEAR
THE TRICUSPID
VALVE.

yd Pulmonary Artery
i toBlood
the
vessels leading
lungs.

JUST A Md EAM) YO Noten a

SHORT, = i : = —
STRAIGHT
ROAD
HERE.
EASY!

’ (i
{| Lungs
Here, red blood cells
discard carbon dioxide
and receive oxygen.
a8

OKAY,
NOW TO
EXCHANGE
GASES AT
THE
ALVEOLI...

S50 THAT'S
WHAT
ALVIOL/ LOOK
LIKE FROM
FAR AWAY.
 Alveoli
Where gases are
Ou, THIS / exchanged.

IS WHERE
WHITE
| stoop
| CELL FIRST
SAVED
ME...

Pulmonary Vein
Contains arterial

r=] Aorta
From the aorta, the blood ii
--q| branches out into arteries,
| then to capillaries

Capillaries
“| Here, blood cells drop off
oY : : oxygen and nutrients, and
NOW ALL TI < oF receive carbon dioxide and
HAVE TO DO IS i other unneeded chemicals.
DELIVER THIS
OXYGEN.

The route
traveled so far.

Nea ae HELpr
ie ANT
This ypoT

es GV SaS\ TOD TY
ae ee Cy | ee
INE YOUR
Ve
Ve
ASNS
 TIME TO
CLAIM THAT
OXYGEN
FOR US
BACTERIA!

OUR
TARGET
IS THAT
DOPEY
ONCE IT RED
TURNS THE BLOOD
CORNER, WE'LL CELL.
BEAT IT UP
TOGETHER!!!
 po
WE APOLOGIZE =
FOR ANY
INCONVENIENCE.

WE ARGS
FOR AN
INCOROE SES See WE APOLOGIZE ae
FOR ANY 3
{ (NCONVENIENCE,
= VOLLL A
: ~O-

sO THIS
(S THE END
OF THE
BUT YM a ae ad
ALMOST ighas (ES...!
THERE...!! ROOM.
\ CANT. 5.
‘) BREATHE... [5

THANKS FOR
COMING TO SUCH A
NARROW STREET.
MUST HAVE
BN BEEN ALOT OF |}.

PROBLEM.
JUST DOING
 I
CIRCULATED
BLOOD
WITHOUT
GETTING
LOST!
 KILLER T,
WHAT ARE
YOU DOING
NEVER MIND HERE...?7
THAT. THAT
2

} BLOOD CELL
YOU SHOWED
‘eB

SHE
FINALLY
DID HER bas.
JOB ALL Tanne ft
ON HER gt EVERYTHING
OWN? you
TAUGHT Men

JUST HOW
INCOMPETENT
IS SHE?
HEY! Killer T Cells
DON'T (Cytotoxic T Cells)
TALK In the event
of aforeign
ABOUT invasion, these cells
HER LIKE act as commanders and
THAT. decide the strategic
b response. They issue
m deployment orders for
Killer T Cells.

YOU AND
I HAVE
THINGS THAT
WE DON'T DO
TOO WELL.

FOR HER,
“NOT GETTING
LOST” HAPPENS
Wave PEOPLE ' TO GIVE HER
SHOW HER TROUBLE.

geen 4 OVERCOME
PLENTY OF HER WEAK-
MISTAKES, BUT NESS.
SHE NEVER
GAVE UP.
 IT NEVER
EVEN AS SHE THOUGHT ABOUT
DOES HER JOB IT BEFORE,
EVERY DAY, SHE BUT RED BLOOD
STILL WORKS TO CELLS HAVE A
MAKE HERSELF HARD JOBTO (
BETTER. DO, TOO...

THEY CARRY
AROLIND
THOSE HEAVY
LOADS AND
RUN ALL OVER
THE BODY.

REALLY
SOME-
THING...

“ELL GOOD
FOR YOU.
BABY STEPS!

Wit
panini
YOU KNOW,
KILLER T—
THE RED BLOOD
CELLS ARE
SOMETIMES
SO THAT ONE SCARED OF
DAY, WE CAN Us IMMUNE
ALL LIVE AS Bur CELLS.
FRIENDS? WOULDN'T
IT BE GREAT
DON’T IF WE COULD
YOU THINK UNDERSTAND
$0, T00?
EACH OTHER'S
JOBS—
 you
SPINELESS
FOOL!
ZL DON'T
WANNA
HEAR THAT

LISTEN UP,
Y'HEAR?!
WE KILL
THAT'S EVEN OUR
WHAT FELLOW
CELLS IF
IMMUNE WE NEED
CELLS TO!

kz:iy
” © \- You eerteRKEEP
Ly THAT KNIFE
FSAID?! IN YOUR SOUL
= SHARPENED SO
YOU CAN USE IT
ANY TIME!! YOU WANT
TO JUMP INTO
A GROUP OF
NEIGHBOR CELLS
PLAYING CARDS
AND PULL THE OLD
MAID AND HAVE
THEM SAY,
"HAH HAH!" AND

D
TEASE YOU?

YOU WANNA
JOIN IN
WHEN THE ee
RED BLOOD
CELLS SIT
 WHOOOSH

WHITE ,
AND I'M BLOOD CELL =
$0 FULL OF 18 WORKING N ¢ Ou
“UST CONG DAN PUTTING — MB. HAPPENED WHITE
€

MY JOB RIGHT HIMSELF ON 7O YOu?! PC BLOOD

.
LIKE THIS.
CELL!
/ YOU'LL NEVER
BELIEVE WHAT
HAPPENED!

FINALLY
DID MY
JOB ALL |
ONMY ©
| , OWN
THIS ABOUT j 5 | TODAY—
DOING Any | WAIT—
YOUR JOB
ON YOUR
OWN? fol.
 I WANT TO
HEAR ALL
ALL ABOUT ABOUT IT.
THE WORK
YOU GUYS
DO.

é Pe
2
a
f feo \.

OH, AND I
DROPPED MY
NOTES AT THE
AND THEN HEART, BUT FOR

ERT IIAN
I WENT TO THE SOME REASON
LUNGS, AND THE AFTER I RAN
ALVEOLI WHEN YOU THEY CAME INTO YOU...
LOOK AT THEM FLYING AT ME
FROM THE OUTSIDE, FROM BEHIND.
Mi fo
THEY WERE ALL
LUMPY, AND THEY
HAVE THIS FUNNY
SHAPE! .-.THE FIRST
PLACE J WENT
WAS THE VENA
OH CAVA! IT’S HUGE,
REALLY? BECAUSE THAT'S
“LUMPY? WHERE ALL THE
VEINS END UP.

AND THEN,
AND THEN...
pn AND THEN
I WENT TO THE
HEART! 3 WAS
PUSHED AROUND
\) EVERY WHICH WAY,
IT WAS REALLY
TOUGH! I WAS
SQUISHED!
 *This is a fictitious setting for this manga, and does not reflect scientific fact.

Inside a Bloo d Vessel [cross section]

Cells born
. I as copies of waiting for’
ay other cells.
nutrients
i to be |
Vending
imachine for Red blood cells
isnacksStea carrying CO,
land other
| ||goodies.
Platelets Transmigrating
walking white blood cell

(i.e. nerves, etc.)

Sewage inlet
Public inlet

Sewage
(waste)

Unlike white blood cells

and other cells, red blood
cells lack mitochondria.
Because of this, they can only
utilize glucose for energy.
 inres
ergic reaction
nasal cavity, inhalation of pepper
r, or exposure to sunli

. —— .

CHAPTER ‘1: THE COMMON COLD

= -
——
ASE Abia
Sis
 LISTEN UPL!
Killer T Cells
(Cytotoxic T Cells) IT’S COLD
SEASON!!
Deployed on the order
of aHelper TCell.
Professional killers who [4 y >
recognize and destroy
foreign substances
such as transplanted
cells, virus-infected
a cells, and cancer cells.
ON
i
Ras
be a A - A

Cold ois pens eoeren

Also called the common cold, aterm
used to describe the inflammation
of respiratory organs (acute
| upper respiratory inflammation)
and related symptoms caused by
| the cald virus. The inflammation
causes symptoms such as
sneezing, runny or stuffy nose,
achy throat, phlegm, and fever.

AND THIS
AREA, NEAR
THE PHARYNX,
1S ESPECIALLY
VULNERABLE <<
TO ATTACKS
FROM
VIRUSES!
I YOU SEE
AN INFECTED
CELL, AS
SOON AS THE
ORDER /S
DO THEY GIVEN, YOU
HAVE TO BE ARE TO KILL
30 LOUD IT—WITHOUT
EVERY DAY? PAILIL

AG) Ly Ga ae
 7SK... THEY'RE
TALKING ABOUT
KILLING US
NORMAL CELLS
LIKE IT’S
NOTHING.

JUST
BECALISE THEY’ THINK
THEIR Jop's THEY'RE SO
ALITTLE DiF- SPECIAL...
FERENT FROM
THE REST

Tiere

nl

C X \\
CMU
ns

REST OF US
NORMAL

COMPARED
TO WHAT
THOSE
IMMUNE
CELLS DO...

BORING
JOBS...
 THEN I ROOM WE JUST
WITH HIM AND MAKE BORING
SORTING COPIES OF
TEACH HIM STUFF MY STUFF AND
UNTIL HE'S READY OURSELVES,
THE COPY'S DAY AFTER
TO GO OFF ON STUFF, THEN
HIS OWN. AND THE TYING THEM UP
SAME THING OVER SEPARATELY...
AND OVER,
FOREVER...?!

Cell Division
A process by which a single cell
divides into two or more cells.
Acell copies its own DNA during
interphase, and then divides
during mitosis. The duration
between cell divisions marks
a single cell cycle. The number
of times a cell can divide in its
lifetime depends on its type.
i a zee

ISN'T THERE THING IS

ANYTHING SUCH A
COOL GOING
ON...7
| ) af
 WE FOUND
THIS
DELIVERED...
SQUAD
LEADERI!
TAKE A
LOOK AT
THIS!

OW...A7'S
THOSE LOUD

“THANK
YOU FOR
YOUR
HARD
WORK,” IT

I-I CAN'T N-NO,

ok EP OeE 10107? WHAT...?.A
moe GIVE IT
HERE!!
PRESENT?!
TUL OPEN IT! IT COULD

CONTAIN
HAZARD-
ous
MATERIAL,
SIR.

PLEASE ¥
BE CARE- § WE'LL
FUL! OPEN IT
OVER
HERE...
LAN
Te
en X

STOP RIGHT
THERE!
LLL KILL
YOU DEAD,
YOU STUPID
ORDER TO
DEPLOY,
YOU'RE
DEAD
MEAT!!

HAA.
HA! DID HAAH...
YOU MAKE THAT
THAT THING WAS
YOURSELF? CLOSE.

IS THAT “KEH Ju ST
SERIOUS- KEH"... you
1] WAIT!

FUN,
MANITIT \
Aa
\ a
 Receptor oe
Works like radar
to detect bacteria
and other bodies.

| HE'S TH-THAT'S
j LOOKING A WHITE
FOR 2 BLOOD
SOME- | CELL...
THING... /@W/Z\ YEEESH.
AAAHE :

I-IS HE
AFTER

di
White Blood Cell
(Neutrophil)
His main job is to destroy
foreign substances that
enter the body from
the outside, such as Mer.
bacteria and viruses.
 —
So NZJee
LU
 THERE'S
AN ENEMY

GO PRANK
SOME
MORE
CELLS!!
 AHHH. OFFICE SHOOT,
WORK IS THE SOMEONE'S
BEST, DON'T
NO . YOU THINK,
PHYSICAL 1 AAR REGULATORY
LABOR, NO T CELL?
DANGER. ,
Bp

CAN HAVE
DELICIOUS

BeSe
a
aa
Helper T Cell
In the event of a foreign invasion, these cells
act as commanders. They determine the
appropriate strategic response based on the
intelligence on the nature of the invaders. They
issue deployment orders for Killer T Cells.

AND WHO
SWITCHED
THE SALT AND
SUGAR?! DID You
SEE AN
ANTIGEN
IN HERE?!

Regulatory T Cell
‘| Controls the activity of T
4 cells to prevent them from
triggering anomalous
immune responses.
 BUT I
I HATE HOW SHOULD
THOSE IMMUNE GET BACK
CELLS ARE SO FULL TO WORK AH HA HAL
OF THEMSELVES, SOON. BOY, THAT
AND VIOLENT, TOO!
PICKING ON WAS FUN!!
ya THEM WAS SO
na MUCH PLIN!
WAL

WHY
NOT? SIT
DOWN FOR
BY THE WAY, A CUP OF
HOW DID You
COME UP WITH ee
ALL THOSE ;
PRANKS?

IT'S LIKE
YOU AREN'T
SCARED OF
ANYTHING.
AREN'T YOU
AFRAID OF
GETTING IN
TROUBLE?

sot
DON'T HAVE
ANY FRIENDS... I
AND T HAVE ONLY JUST
NO IDEA WHAT STARTED
KIND OF CELL LIVING ON
ANYONE IS.

WE
SHOULD HANG
OUT MORE, IF
YOU'RE OKAY
WITH THAT.
 KEHH?;) f xey

A HAT? THIS?

—
ma ee
ge

NO THANKS.
T CAN'T
TAKE THIS...
HEY.
 TTTA
TL
TL

A
A
A
uf
G
Hf
f
 THEY'RE
AlL OVER
THE
PLACE?!!
 P
STAY AWAY
FROM THE
DIVIDING
MACHINE!

ARE YOU
TRYING
TO TAKE
IT OVER?!
 JUST WHEN 7
HE WAS I THOUGHT VIRUS
JUST L'D FINALLY IN-
TRYING TO MADE A FECTED
USE ME... FRIEND...

YOU GOT
ME GOOD
EARLIER.
 UATE
EVAC
THE
WITH RS!
OTHE

itt
a
aa

USED
CONF
 WE ANALYZED
THE RNA YOU
LEFT ON THIS,
IDENTIFIED THE
ANTIGEN, AND
GOT PERMISSION
TO DEPLOY!

Consists of four bases: adenine,

guanine, cytosine, and uracil. RNA
plays many roles in protein synthesis
inside the cell. Some viruses store
their genetic information in RNA.
WE'RE DONE
ALREADY.

e
 THE VIRUS WAS
IDENTIFIED AS A
RHINOVIRUS, A
CARRIER OF THE
COMMON COLP.

Rhinovirus
A representative carrier
of the common cold. In
most cases, causes light
respiratory symptoms (runny
or stuffy nose, sneezing).
z..) The saliva and mucus of an
=| infected person contain large
numbers of rhinoviruses,
and are highly infectious.
 IF YOU'D
BEEN
INFECTED,
“ye TROUBLE!
“£2 MORON!!
vr

YOU SHOULD
LEARN MORE
ABOUT
VIRUSES AND

. 1 pont
2 FY} PLAY PRANKS4
ON OTHERS!
 OH,
SQUAD
LEADER!

WELL, WE'RE
NEIGHBORS,
$0 I THOUGHT
WE SHOULD
HANG OUT...

I DO THE
KILLING! AND Y-YOu
YOU MIGHT BE IDIOT! WE'RE
KILLED BY ME! KILLERS,
WE HAVE TO SET DON'T YOU
BOUNDARIES... GET IT?! WE
DON'T “HANG
Our"!

WE'VE
HEARD THAT
A MILLION
TIMES ALREADY,
SQUAD
LEADER.
 oe ( eS aap STOP
flirecses seca t : f BEING SO
‘ee i } x UPTIGHT, SIR!
SOCIALIZING
Wer'g,12: \ {6 IMPORTANT,
oor! 00.

ES THIS ONCE, ~~ [4
GOT THAT,
IDIOTS...?

Bsa

HOW'D I
GET STUCK
KEEPING
SCORE...7
 *This is a fictitious setting for this manga and does not reflect scientific fact.

SCISSORS AND OTHER

EVERYDAY TOOLS
Synthesized from

SPINDLE
Genetic ae
informations
storedjhere s/jup belongings
during amove
{cell division}

ABED FOR RESTING

Used to,take abreak and Used to divide the >

siton like a sofa’ The room living space between
% pane ee 4: Ap A
feels ‘empty, without it the original'andthe) —
net) tl er

TT)
TOILET
Oxidize, break
down and cook Anecessity in
nutrients (to \home:
convert energy
LE

BATH
iy

-Used to freshen (
upvaftertrouble
in the cell.
 T CELLS, Ws I DON'T
THEY ARE KNOW BUT
MIGHTY : I'VE BEEN

shun ges, THUMP

HEY,
PICK IT
UP, YOU
FEET-
DRAGGING
MAGGOTS!

A £ 2. AED Wie

Killer T Cells (Cytotoxic T Cells)

Nel Deployed onthe order of a HelperT
ell. Professional killers who recognize
»| and destroy foreign substances
m™ such as transplanted cells, virus-
|) infected cells, and cancer cells.
 WE DON’T NEED
WIMPS IN THE
T CELL SQUAD!!!
T CELLS ARE THE .
LAST RESORT OF me \ . 4
THE IMMUNE SYSTEM! yr WADAK\ \ 4S THERE
DO YOU TAKE A (Zars\\ N NOTHING
THAT SERIOUSLY, JENS BUT WEAK-
MAGGOTS!!?! “a, | ASS CELLS
IN THIS
Ze ‘ yo OUTFIT?
YOU THINK A 1 YOU THINK
LAST RESORT a \ T CELLS
CAN BE WEAK?! : F bs ARE A
TRAIN HARD, ps “ JOKE?!
YOU MORONS!!!
 IT SPOILS
OUR PRECIOUS
TEA BREAK—
DON'T YOU <|
AGREE,
REGULATORY
T CELL?3+

Helper T Cell
In the event of a foreign
invasion, these cells act as
commanders and decide
the strategic response.
They issue deployment
TEA BREAK SAY SO, , orders for Killer T Cells.
RIGHT allt:
\ UGH,
THEY'RE SO
LOUD AND
WE CAN SWEATY.
HEAR THEM
i ALL THE
WAY OUT
HERE.

Regulatory T Cell }
Controls the activity
of T cells to prevent
| them from triggering
4 anomalous immune
responses.
”

\\
SNANANNE
SANNA
SN
 OOPS, SORRY
COMMANDER.
T PUT A LITTLE
TOO MUCH
INTO THAT

KILLER T
CELL...
 I'VE
WANTED
TO SAY
THIS
FOR A
WHILE.
LOOK...
DOIN’ MY
YOU'RE JOB, SIR.
THE ONE I HAVE TO YOU DO
WHO'LL BE TRAIN THEM YOUR JOB A
IN TROUBLE SO THAT LITTLE MORE
IF WE'VE WE'RE READY CALMLY? BUT
ONLY GOT WHEN YOu I GUESS YOU
WIMPS FOR GIVE US THE NEVER COULD
FIGHTERG... ORDER. THINK ABOUT
WOULDN'T DOING THINGS
YOU AGREE? EFFICIENTLY,
COULD YOU?

I'M JUST
THE MOST ASKING
IMPORTANT YOU TO
PART OF THINK
TRAINING IS ABOUT
TO BUILD YOUR
THEIR SPIRIT. APPROACH!
j WHAT'RE
YOU CAN'T you
TEACH GUTS TALKING
FROM A ABOUT?
MANUALI!

HAHA, ‘~
you}
WANT TO |
KNOW? <4

WHAT'S
THE DEAL
BETWEEN
Dendritic Cells THE TWO
, OF THEM?
These cells take fragments of
q@ =THEY'RE NOT
bacterial cells and virus-infected BOSS AND
cells, presenting them as antigens SUBORDINATE?
for other cells in the immune
system. They’re also involved
in the development of T cells.
 THEY WERE
IN THE SAME
GRADUATING
CLASS
AT THYMUS
SCHOOL.

KILLER T
SENPAI
a eon)IS ONETH-THE
IN THE
GLASSES.

16 THAT
COMMANDER
HELPER T...7!
HE SEEMS
Hne's
CRYING. |\ Cprirer-
JUST
UKE US.
 ZL DON'T i
KNOW
BUT IT'S
BEEN
7 CELL SAID)
TRAINEES

Alymphoid organ that

differentiates and
matures precursor T cells
into full-fledged T cells.
 -«/S WHERE
WE FIND OUT WELCOME
WHICH OF 70 HELL, te
YOU WE CAN you é
USE, AND USELESS =
WHICH ONES RUNTSI!
WE CAN'T!

LISTEN
UP! THE
THYMUS...
Thymocytes
Precursors of T cells.

ae

WE DON'T
NEED
BLOCKHEADS
THAT CAN'T
20 THEIR
PART WHEN
THE TIME
COMES!

ATTACK THE
ONES YOU Thymic Epithelial Cells
THINK ARE Cells that make up the
thymus. They nurse
ANTIGENS!
THAIS WILL lymphocytes and help the
differentiation of T cells.
DETERMINE
IF YOU CAN
RESPOND TO
ANTIGENS
ANYONE OR NOTI!
WHO ATTACKS
ORDINARY CELLS
AND ANYONE WHO
DOESN'T ATTACK A
SINGLE ANTINGEN
WILL BE FAILED
ON THE SPOTIL YOu'LL
START BY
TAKING A
TESTI!
 S3S88
eSES=

It
BUS

AN
ANTIGEN
ze, | CUTOUT?!
 \ ABOUT THAT.
I USED
YOU FOR
FOOTING.

I THINK
WE'LL HAVE
TO BE AT
LEAST THIS WAY TO THE
FAST TO CUTOUT.
BECOME AND You /7
FULL-GROWN STEPPED
T CELLS. ON My
HEAD...
 CAN YOU
NOT MAKE ME
USE ENERGY
NEEDLESSLY?

D-DID
THAT FINGER
FLICK REALLY
HURT THAT
MUCH?

HIM. WHY
WASTE
ENERGY
HELPING
HIM?

; SEEMS 70 BE
A BIG GAP
e*ae BETWEEN THE
CADETS...
GOOD ONES
: , AND THE BAD
 WHAT'RE
THE
CHANCES
WE'D BE
ROOM-
MATES?

I GUESS
THEY DON’T
DON'T MAKE ; : CHOOSE
ME EXPLAIN ROOMMATES
EVERYTHING. F : As ~ BASED ON
IK ABILITY.

TI DON'T
WANT YOU TO
DISRUPT MY GO UP AND
REST. YOU DOWN MORE
COULD SLEEP THAN YOU
ON THE NEED TO.
FLOOR, IF YOU
WANT.

WANT TO
WASTE
ENERGY
2 JUST WHO wee CLIMBING
laid DO You were uP AND
DOWN.

po You NOT
THINK YOU
ARE!2!
QNDERSTAND
WORDS?
 YOU TWO
SEEM TO
HAVE A LOT
OF TIME

JUST
PASSING
BY.

I WAS
WONDERING
IF YOU GUYS
WANTED
TO GET IN
TROUBLE AND
FLUNK.
NO WAY!
ARE YOU
KIDDING?!

«THE
CADETS WHO
USED THE
BED ACROSS
FROM YOURS
FLUNKED OUT
IN TODAY'S
TEST.

I'M GONNA
MAKE SURE
THAT
DOESN'T
HAPPEN
 THE CHAL-
4 LENGES To |
| SOMEHOW
§ ESCAPE
FAILURE,

YOU THERE!
QUIT YOUR WAILING!
IF YOU WANT TO
DROP OUT, PUT IN
YOUR NOTICE AND
STOP TAKING UP
SPACE!

DROPPING
OUT, SIR.

QUIT BEIN’
SO STUB-
BORN. THE
HE'S JUST RESULT'S
NOT T CELL THE SAME IN fj
QUALITY. THE END.
 --ARE THE THE
ONES AT ONLY ONES
THE TOP OF WHO'LL
THE CLASS, MAKE THE
LIKE Us— cur...
RIGHT?
YOU'RE
RIGHT...
Aa» ty!
4
 Wai
\\et

YAAAAHT!
KILLER T
IMMUNITY PUNCH,
SUPER 42
DISSOLVING STRIKES!
FISTI!

HE MUST
BE ON THE
VERGE OF
—ANO WHAT COLLAPSE
"SECRET AFTER
TECHNIQUE"? TODAY'S
TRAINING.

WHATEVER...
NOTHING TO
20 WITH ME.
 AH,
YOUTH!
AMT
RIGHT?

DO THEY
INTEREST
you,

HA HA,
NOW IF THEY
FOUGHT HERE,
: THAT WOULD
IT'D BE REALLY BE
NICE IF FUN.
THEY MADE
THE CUT,
DON'T YOU
THINK?
 WE'RE
DOING A
SURPRISE
TEST
TODAY!!

THE
RULES ARE
THE SAME
AS USUAL!
JUST ATTACK .
THE ANTIGEN %
CUTOUTS!
BUT
ALMOST
ALL OF YOU
WILL FAIL
THIS TEST!
FOR
THOSE OF 7
You WHO Pi
HAVEN'T
PROPERLY TELL
TRAINED YSITS
upunTi. PLANS
you Now,
JUST HAVE TODAY
TO DO WILL BE
WHAT YOU Goop-
USUALLY BYE!
DO!
wuar's \A/\
aS
ITIVE
SELEC-
TION"?

I'M SO
NERVOUS,
Im
GETTING
SICK...
 YOU'LL NOW
TAKE THE
POSITIVE
SELECTION
TESTI!

Positive and Negative Selection

The thymus preserves useful T cells by “positive selection,” and removes
harmful T cells that attack the body by “negative selection.” This process selects
lymphocytes that are able to accurately discern cells of the body and foreign ones
| such as pathogens. It is said that only a few percent become Tcells in the end.

YOU HAVE
A HABIT OF
CLOSING
YOUR EYES
WHEN
ATTACKING.

= eiatoas YOU'LL NEVER

HIT ANYTHING
THAT WAY. WHEN
ATTACKING YOUR
TARGETS, KEEP
YOUR EYES OPEN
UNTIL THE
VERY END!
 ATTACK
oe ; a THE ANTIGEN
JUST LIKE a’ “,| CUTOUTS...
ALWAYS... Le. “a AND LEAVE
I’M READY! ("YU THE ORDINARY
- _ S-1 CELL cutouts
x a ee
y
 ae

AAAUGH! AAAUGH!
IT WAS AN TI THOUGHT IT
ORDINARY WAS A VIRUS,
CELL WEARING BUT IT WAS
A PADDED
Hoop! JUST A FANCY
HAT!

ANP SO,
THE T CELL
CADETS
FAILED ONE
BY ONE...

ZZ

IT'S MY
 YOU HAVE
\
A HABIT OF
CLOSING YOUR ) THERE!!
EYES WHEN
ATTACKING.

KEEP
YOUR EYES

SHEESH...
MAKING
ME
NERVOUS
 LY,
SHON REN

may

BEHIND
you!

SNAP
OUT OF IT,
YOU IDIOT!
your
OTHER
RIGHT!

NO,
ABOVE }\RIGHT!
YOU! +19 YOUR
RIGHT

BEHIND
YOu 1S
BEHIND
YOU!
 YOU'RE

(
LUCKY... THEY
SAID YOU HAVE
THE POTENTIAL
TO BE A KILLER, dhe pis
A HELPER, ORA LUCK...
REGULATORY.

TO BE
HONEST, I
DON'T KNOW IF
T CAN CUT IT...
WILL I REALLY
MAKE IT AS A
T CELL?
 YOU DON'T
KNOW IF You
CAN CUT IT?
THEN QUIT! IT'S NOT
TOO LATE TO
SUBMIT YOUR
WITHDRAWAL
PAPERS.

EDAD tp DNA PO nt NI WERT

He HE

NO ONE HAS
THE TIME TO
CARE ABOUT
THEM. THE
WORLD... AHERE'S
FREE WH-
LESSON. WHAT
ALL THOSE DID You
DUMB SAY...7!
FEELINGS

THE WORLD
OF CELLS
ISN'T THAT
EASY!

A “DUMB
GIFTED FEEL-
TERK
LIKE
NGS"?
you...
is
ee Wee
Ly
NOW IT’S
TIME TO Ne
HARDEN YOU FACED
YOUR YOUR OWN
RESOLVE. WEAKNESS.

is YOU'VE
ae ay
GOT NO
CHOICE WAKE
NOW BUT uP.
TO GIVE
IT YOUR
BEST.

EVEN IF
YOUR EFFORTS
LOOK USELESS
TO OTHERS...
YOU KEEP AT
IT ON YOUR
OWN.

THAT'S
YOUR
STRENGTH,
ISN'T IT?
 OKAY!
I'M DONE
WHINING.

L’M...GOING
7O BECOME
STRONGER!

THE
WORLD NEEDS AS FOR T’LL LIFT I'M
SOMEONE TO ME...T WEIGHTS LIKE GOING TO
GIVE ORDERS KNOW NOW CRAZY...I'M WORK OUT
TO CLUMSY WHAT I’M GONNA DO UNTIL I CAN
GUYS LIKE SUPPOSED WHATEVER BEAT ANY
you. TO DO. I CAN! ENEMY WITH
ONE HIT!
 HEH HEH...
IF YOU'RE
YOU'LL GOING
SCARE THE TO BEA
CELLS YOU COMMANDER,
LEAD. LOOSEN
UP A BIT.

HMPH...
TI DON'T
you NEED YOU TO
WANT ME TO TELL ME THE
LOOSEN UP? opvious!
JUST WAIT
AND SEE...

THOSE
GUYS
ARE SO
SILLY...

$0 THAT'S
WHAT
HAPPENED.
 THAT'S
WHY...
THOSE TWO
ARE THE WAY
THEY ARE

WHAT'RE
YOU GUYS
LOOKING
AT OVER
THERE?
 GIVE
THOSE
TO MEL!
BURN
THOSE
PICTURES
RIGHT
NOWw—

HEY,
WHAT'RE
YOU DOING?
THESE ARE
IMPORTANT
RECORDS

Tr
HAVEN a

CHANGED
A G/T...
(-1UT-Yelsg
eltreyd") Life of a Killer T Cell

WHAT
HAPPENED
IN HERE?!
 ee
aig

ae icy
7 Bub RN

a%
‘eye!chee

Aeee
a
u/
oh
HO
Lied

Te
LLELE tae

_ ARE THESE
ee > gin
Ane MY ie 3 Panad
IMAGES...? ~

.. INTOM Yes = Ss THEY'RE

sO =z aa FLOWING...

sant

PELE
See
ie a
ae
Wee
Memory Cell
Alymphocyte that
remembers the immune
responses to antigens.
TS
They are prepared against
invasion by the same °“~
ia or viruses,

CHAPTERSi
-CHAP: 3
i
F
fl
fi
/ If
np
t
q | AAW AAP
i
HAAH HAAH
HAAH HAAH

B Cell (Antibody-
producing Cell)
Atype of lymphocyte
that makes weapons
called antibodies to
fight antigens such as
bacteria and viruses.
 j THE
JUMPING MATTER,
uP MEMORY
SUDDENLY CELL?
LIKE
THAT.

I'M NOTA WHAT.

PHAGOCYTE. WERE THOSE 3
WHY. WOULD. =IMAGES...?. GAR
LT HAVE
SUCH GORY,
a PL.
17. DOESN'T:
MAKE SENSE!

Phagocytosis
A process by which cells called phagocytes—such as
monocytes, macrophages, and neutrophils—engulf
and break down bacteria and foreign substances.
zs ——

THAT IETHAT'S’ “DIDI. SEE THAT.

DREAM THE CASE.... AMOMENT DEFINITELY.
°°" DIDI SEE THE FROMTHE WASN'TAN
FUTUREOF END OF THE ORDINARY
THIS BODY?! WORLD?! DREAM...
THEN... THAT.
MEANS...
}
0) 4
ACQUIRED
la
AGILITY TO
SEE THE
FUTURE,
700...1!

CAN YOU
STOP THAT
RAMBLING
AND
WHETHER FOCUS ON
OR NOT I RECORDING THAT MEANS
CAN DO MY INFORMATION THAT WHEN
PART INA () THAT VIRUS
FIGHT AGAINST ANTIGENS?
APPEARS...
ANTIGENS
DEPENDS ON
YOUR THE
KNOWLEDGE,
MEMORY WORLD... I
CELL! Qs)
 WE'VE JUST
DETECTED
A VIRAL
INFECTION IN
A PAROTID
GLAND.

IMMUNE
CELLS IN
THE AREA,
PLEASE
HEAD TO
THE SITE
RIGHT
AWAY.

SEE? IT'S
T DON'T THAT ONE
ipiaghit
WHAT KIND éIN THE
OF VIRUS HADOW
THERE.
It Is, BUT
LET'S GET
OUT OF
HERE!

C'MON,
LET'S GO!
IF IT’S AN
ANTIGEN

TIME TO CAN BEAT

work! [Win
IT WITH

BODIES.
Antibodies
Antibodies are made up of proteins
called immunoglobluins (Ig). They bind
to antigens in foreign substances so
VECBVUICE that immune cells can eradicate them.
 w) 0
|

WHAT IS
THAT? WHAT
AN ODD
VIRUS.

ANYTHING
.- HELLO? IN YOUR
MEMORY? MEMORIES,
MEMORY?
 TAS fi

So
[COMEZON...
COME ON™!//

WHOA
WHOA...!!
 THERE'S
A TON OF
THEM ALL
OF A
SUDDENI!

REE ti
e Blood Cell (Neutrophil)
His main job is to destroy foreign '

outside, such as bacteria and viruses.

Neutrophils make up more than half
of the white blood cells in the blood.
MEMORY
HUH? HEY,
WHAT'S THE
MATTER,
s
MEMORY
é/ 3 WHAT'S VISION...
WRONG...2, COME
MY THIRD ON...
EYE... COME
OPEN ON...!I
Now!!!
(Sf
YAR
{ « TF La

NAL LOD AB
 YOU CAN
BEAT THEM
ALL WITH
MAKE
ANTIBODIES | << > ANTIBODIES,
ache
WITHOUT et a8 2)
DATA ON ts ane
ANTIGENS!
IT NEED
ANTIGEN
PRESENTA-

uSE
WITHOUT YOUR
ANTI- ANTI-
BODIES!! - BODIES
>| AND SAVE

T CAN'T
PHAGO-
CYTOGE...1
SPECIALIZE
ON ATTACKS
USING ANTI-
BODIES...
 COME ON!!
DVO SOME-
THING, YOU
USELESS
BUM!!

AND A AN ODP.
a SOMETHING... WAR... VIRUS...
SOMETHING
FALLING FROM 4
THE SKV.2

I CAN'T FIGURE ©
IT OUT AT ALLIS fE
COME ON,
MIRACULOUS —
FUTURE VISION =
POWERIT! Z
 Macrophage
Atype of white blood cell, these catch
and kill foreign substances such as
bacteria, and determine antigens and
information on immune responses.
fd They also act as cleaners who remove
debris such as dead cells and bacteria.

TLL BE I'M GOING

TO GO TO
RIGHT BACK.
ANTIGEN COMMANDER
TAKE CARE,
PRESENTA- EVERYONE! HELPER T TO
TION WILL PRESENT THE
LEAD TO ANTIGEN.
REINFORCE-
MENTS...

BUT CAN
WE HOLD
OUT THAT

2,
Daa
 COME ON,
8 CELL!
HELP ME
LOOK!

\S oy
v peS pont- \
Ve LiImre
L AUT ACL QiUT anti
nen i
aN. merce?
1) |
GOTTA FIND
SOME CLUE!
TALK TO ME, \uu ! i) Some vieus
LIKE THE
ONES WE'RE
FIGHTING!

ISN'T
ANYTHING?!
ALMOST...
ALMOST
We70HAVE
0O
SEE THE SOMETHING!
FUTURE!!
 .- AND
4 REMEM-
BER THE
PAST!!!
 CAME”
-
<A GIANT
PIPE...
,

HOA?! : , =
 COMING
Out OF Bag |
CAPSULE,..!/

ORBLE
WHAT'RE
THESE?!
THEY'RE
WEAK!

THEY WERE
~ REALLY
7 CAA Gilt DY WEAK.
WE SHOULD
FOLLOW
PROTOCOL...

WHAT THE
HECK WAS
.- AND THAT?
PRESENT THE
ANTIGEN AND
PRESERVE
THE DATA ON
THE SAMPLE.
 PLEASE
RECORD THE
INFORMATION
ON THIS
ANTIGEN...
.»- MEMORY
CELL!

BUT
WHAT
I SAW
IN THE
PAST!!
 ini
Gn
SO

Ti
il
ULE aU (idl thE
ET

Administering pathogens (bacteria or

VITUSeS. ) or toxins with reduced toxicity
lets the body acquire immunity,
thus making future infections less
likely. The antigens administered in
this manner are called vaccines.
 CELL CELL CELL CELL

THEY'RE
GOING TO
FALL ON
US ALL AT
ONCE!!

X
‘\
i
SORRY TO
KEEP YOU
WAITING!
 IDENTIFYING
ANTIGEN TARGET..
LOCKED

ENERGY
CHARGE,
a
eej o |
COM-

M
U
M
P
ra!
THIS Is
THE
 q”q
-
Se
yy ..- OF
B y;} ACQUIRED
Wait IMMUNITY
Ou) I
ere IG |
4 On"

: Immunity that is acquired

fter birth by infection
 ay
Sy
Py) . k \ f
i J At ~ / ? | ae

.
 THANKS
THE 70 THE
ANTIGENS POWER
WERE OF ANT/-
WIPED OUT BOVIES...
WITHOUT A
TRACE, WITHOUT
Rl EVEN PRE-
SENTING
ANTIGENS!

BOVIES |
ROCKI!

.. WITHOUT
ANTIGEN El
PRESENTA- bshie
TION. ANTI-
BODIES...

ALL OF THIS
wy eA HAPPENED |_-<5
yi CY BECAUSE— /
“~~
’ Ny S
 YOU KEPT
AND FORGOT RAMBLING
ALL ABOUT ON ABOUT
THE VIRUS THAT FUTURE
WAS PROPERLY VISION...
RECORDED As
AN ANTIGEN!

osese

IT'S
RECORDED
$O CLEARLY!
A VIRUS The Mumps Virus
THAT CAUSES The viral pathogen of mumps, a.k.a.

MUMPS!
epidemic parotitis. Infection causes one
or both parotid glands (one ofthe large
salivary glands) under the ear to swell.
 ISN'T
THAT SO
STUPID?!
AND
WE ALL

peteds
IT’S

Po Troncer, THIS STUEFI!

HAPPENED!

OH...7
SHOULD T
NOT HAVE
SAID ANY-
TM TIRED THING?
NOW...
ee
| \| White Blood Cell (Neutrophil)
| His main job is to destroy foreign substances
that enter the body from the outside, such as
bacteria and viruses. Neutrophils make up more
than half of the white blood cells in
== ec OE:
SS Gs
¥ The part of the hair SO THERE’S
under the skin, from TROUBLE AT
which the hair grows. THIS HAIR

THIS 15 NO
ORDINARY
AMOUNT OF Vy.
INFLAMMA- 1 ;
Hi}
ey

WHAT /N
THE WORLD
/S GOING ON
 ANYONE
SLACKING
OFF GETS
Sebum
“sf An oily semifluid secretion
A HUNDRED
of the sebaceous LASHES!!
glands. It protects and
1 moisturizes hair and skin.

HMMM, DO
WE HAVE
A SLACKER
HERE?
HEH
2) HEH
 dD

COMES
THE
HUNDRED-
LASH—

DON’T
HURT THE
ELDERI!

D-DON'T
,
CHILD...
!

Hair Matrix Cel

Creates hair
l
through
cell division.

SUKCEHH PHOEIHNTHLEHE.
RESISTANCE |S —
SS

m uy)j
Y “nal!
 I'M A WHITE
BLOOD CELL
WITH THE
NEUTROPHIL
DIVISION.

Wy

CAN YOU
TELL ME
WHO You
ARE?

year te Nah a4 { WE'RE CELLS

HAPPENED ° 3 4) WORKING IN
HERE? : 3“ SABAS |
= THIS PORE.
| CEOUS
A GLAND |_!
CELL.

pst SSUES LIKE BEFORE,

BUT ONE : MAKING tipOUR
DAY, WE Sebaceous Gland Cell SEBLIM AND JOBS.
WERE INVADED Produces sebum. SKIN es
BY THE ACNE y PIGMENTA-
BACTERIA
AND TAKEN
OVER...

THIS IS NOT
A NORMAL
PORE ANY
MORE, BUT A
PIMPLE!

Pimple
An inflammatory disorder of the skin. The
: Sak : : Melanocyte
inflammationis caused by sebum clogging Makesskiacni a
the pore. Common where sebum production jire ayPigments fi
is high. Often accompanied by pus and pain. eee tSHy
 You
HAD TO GET
YOURSELF
INVOLVED...

l-1T'S
THE ACNE
BACTERIA!!
Acne
Acommon bacterium that can
cause pimples. Its scientific name

ACNE?! \:

THERE'S
A SO MANY
AN OF THEM!
Ke Xe
 CH-
CHILD,
DON’T
y uf

y A 5, MR. WHITE
BLOOD CELL,
: G I'M GOING
TO FIGHT,

NOW, GET A
BACK |. A
Le) TO YOUR KX BWA HA A
| POSTSI! HA HA
HA HA! A
u
G
H
i
 I'M SORRY
ABOUT WHAT
HAPPENED!
IT’S ALL
BECAUSE OF
ME...

DIDN'T DO
ANYTHING
WRONG.

WHAT ARE
THOSE

THE PIPES
TO SEND
SEBUM TO THE
EPIDERMIS GOT
CLOGGED WITH
DIRT...

| THE ACNE Germs |

CAME FOR THE «THEN THE
SEBUM AND GREW
STRONGER. WHOLE PORE
BECAME
FULL OF

BEFORE WE
KNEW IT, THEY
TOOK OVER THE
WHOLE PORE
AND TURNED
us INTO
 WHY DID
, YOU LEAVE
behel e
ANYONE THEM UNTIL
ELS THEY
THEY GAVE MULTIPLIED
UP...THEY COME TO $0 MUCH?!
ALL DID. HELP?!

THEY'RE
CORPSES
OF WHITE X| Pus
An opaque slime that
BLOOD suppurates from inflamed

CELLS LIKE tissue. Itis made up of a

= serum made of white blood
ME...f! A cells (mostly neutrophils),
4 aswellas broken-down
tissue and dead bacteria.
 THEY WERE
BUT... ALL BRAVE
LOOK AT WARRIORS
THEM LIKE YOU,
MISTER.

CANNOT ALLOW THIS HAIR

ANY MORE ROOT /S OUR
SACRIFICES TO HOME, AND
BE MADE FOR THE PLACE
THE SAKE OF WHERE WE
ONE PORE. WORK,

THE BEST
PLEASE THING 1S FOR THE REST
UNDERSTAND, WS TO MEET OF THE BODY,
CHILD, OUR END 11'S BUTA
QUIETLY. SINGLE PORE.

WORKED SO
HARD!

iF IT ONLY...

ONSNIFE
iF I ONLY HAD

If
THE COURAGE
OF WHITE
BLOOD CELLS

GETTING RID
OF WASTE...
REGULATING Small openings on the surface of
THE BODY the skin from which hairs grow.
TEMPERA- It also outputs sebum, sweat
and waste, playing an important
TURE... role in thermoregulation
and moisture retention
 THIS
REQUEST- z IS NO.
ING RE- | <a
Tia 1146.
\ INForce-
MENT |
FROM
ANYONE I FOUND
IN THE A NEST OF
AREA. ACNE BACTERIA
NO MATTER AT THE PORE
HOW SMALL IN QUESTION.
THE IMPACT...
YOU
GOT IT."
PLL BE A |!
BIT LATE.

AEN
Ss

SSS
../F THERE'S
A GERM
W
Xs a
INFESTATION
IN THIS BODY,
Sang

} I WON'T
Zz STAND BY AND
yy WATCH.

MY JOB—
OUR JOB —
/S TO NOT
LET THAT
HAPPEN.

i
 EEEEK!
PLEASE
DON'T!

t THOUGHT \’
YOU WERE
DEAD, WHITE
LOO
CELL.
 I, THE
ACNE KING,
you'le ||, WILL ADD
BECOME }. YOU TO MY
COLLECTION
APART (/\¥ OF WHI
OF THE } ] “corpses!
PUSI!
YOU'VE
YET TO
SEE MY

YOU'LL
KNOW ENDLESS
SUFFERING, IT'S HARD
JUST LIKE YOUR TO SEE HOW
COLLEAGUES...!! YOU COULD HAVE
KILLED SO MANY
WHAT
WHITE BLOOD
CHEAP TRICK CELLS WITH THAT
DID YOU USE, SLOW, FAT BODY
ACNE KING? OF YOURS.
 THERE'S
AN
ENDLESS
SUPPLY OF
OUR FOOD,
TH-THIS
ISN'T
GOOD.

JUST
AST
THOUGHT...
IT'S NO
USE.

THAT ONE
IS ALSO
DESTINED
FOR THE
Pus...

/GTO MY JOB— ~/E THERE'S NOMATTER

NOT LET OUR JOB... £4.GERM HOW SMALL
THAT e \ THE IMPACT...
HAPPEN. i
 WHA?!
ey
LT

CH-CHILD?!
HOW COULD
YOU DO
THAT TO THE
?

THAT
WHITE
BLOOD
CELL SAID
EVEN THAT HE'D
IF IT'S FIGHT NO
JUST ONE MATTER
HAIR... HOW
THIS SMALL THE

NOT RIGHT
IS OUR IMPACT!
PRECIOUS BECALISE
HOME! THAT'S HIS

FOR US TO JOB!

GIVE UPL!
I'M SORRY,
ELDER, BUT

CHILD...

ELDER...
WE
ALSO...
. FEEL
THE SAME
WAy!
 MY DEAR
VILLAGERS...
 IMPRES- \/
I DIDN'T ive... f°
EXPECT
YOu TO
LAST THIS «
LONG...
 NOW, LET
ME ADD HIS
CORPSE TO
MY COLLEC-
 TURN
1T WITH
EVERY-

Pe;

LPEUTSHTHUESM

MORE...!

WE'RE GOING
TECT
70 PROOWN
OUR
WORKPLACE! eG
 WHAT...
W-

i +My A
y

ee
r aia
pie *
Wee
5 ae;

YOU WANT
SEBUM?
HAVE ALL
YOU WANT!
 A Me we % A : \ZN i

\E
Fie SOAS AEN TH-THIS IS
y ONY
EN
AN 6 aeY
LAY
Z ; \\e \Y XS
NO
:
GOOD! |
T'LL DROWN
Zp AN aw

rs

Lp
2)
wa
ee
cF

fit
Vi

DPDD~<H
ae
 WE DON'T
KNOW WHAT
BECAME OF
THAT WHITE
BLOOD CELL
AFTER
THAT...

iy AE
Leer
<
ise ie
ee
“
se

GONE...?
 UNTIL . wee THIS SINGLE
SOMEDAY. PROTECT IT HAIR THAT
'T FALLS ~ 4h YOU SAVED
OUT... é
A THAT'S A |\
| NeUTRO-
PHIL...
RIGHT?

DID You
HAVE A
CAREER
BHANGE
 YOU SHOULD
REALLY
TAKE BETTER
THOSE WHO CARE OF
CAN'T LOVE YOURSELF.
THEMSELVES
CAN'T LOVE
OTHERS,
YOU KNOW!

Je sp, o SH nts
es,an tes
lags

oe.
Medical Editor: Saha Harada
 Knives (two types)

| Six knives equipped at the legs and hip. Throwing knives equipped at the belt.

Designed in the Rarely used. Practice is required

style of aRussian so as to not hit allies when
“antiterror” knife. they have to be used.

AN 4

White Blood Cells and Their Friends

From an early age, white blood

cells play swords, tag, and
hide-and-seek to learn how to
both work with their comrades
and to battle their enemies.
 *This is a fictitious setting for this manga, and does not reflect scientific fact.

KI White Blood Cell (Neutrophil) [schematic illustration]

Receptor Under their

They wear white to FReceptor |
: shirts,
tecope i Reacts to bacteria they wear
and other enemies. a receptor
ey an The ones assigned and inner
to neutrophils have wear made of
a clunky design. The L-selectin.
range and volume
can be adjusted, but
WBC (White it cannot determine , Water
Blood Cell) direction. Resistant
badge. Velcro.

The receptor cable is

connected here.
There are two kinds
of circuits; the Fe
receptor and another
for thé C3 receptor.

It zips on
the side.
L-Selectin Adhesion
ke} Cexel 10

Used to communicate with

colleagues, the limbic system,
and the headquarters’of the
blood forming organs:

It responds
to the floor
(endothelial
cells) to tether
their bodies to
the ground.
bacterial corpses
and other things.

switch on
the inside
of the belt.
Cells at Work! 3

KODANSHA COMICS Digital Edition

Cells at Work! volume 3 copyright © 2017 Akane Shimizu

English translation copyright © 2017 Akane Shimizu

All rights reserved.

First published in Japan in 2017 by Kodansha Ltd., Tokyo.

Electronic Publishing rights for this English edition arranged through
Kodansha Ltd., Tokyo.

No portion of this book may be reproduced or transmitted in any form or

by any means without written permission from the copyright holders.

English digital edition published by Kodansha Advanced Media, LLC,

San Francisco.

www.kodanshacomics.com

ISBN: 9781682336250
Digital Edition: 1.0.0

Translation: Yamato Tanaka

Lettering: Abigail Blackman
Editing: Paul Starr
Kodansha Comics edition cover design: Phil Balsman