Last edited: 4/22/2022

FATTY ACID OXIDATION (PART 2)

Metabolism | Fatty Acid Oxidation: Part 2 Medical Editor: Uta Hüning

I) REVIEW QUESTIONS WITH ANSWERS

QUESTIONS ANSWERS

1) How many ATP does FA activation use? b) 2 ATP

a) 1
b) 2 Splits 1 ATP into AMP + PPi. This uses 2 bonds of an ATP
c) 3 molecule. This is equivalent to the use of 2 ATP
d) 4

2) How many ATP are produced by the oxidation of a 20C d) 163

FA? (NADH →3 ATP, FADH2 → 2 ATP)
a) 150 9 rounds of beta-oxidation: 9 NADH + 9 FADH2
b) 166 10 Krebs cycles: 30 NADH + 10 FADH2 + 10 ATP
c) 178 Total: 39 NADH + 19 FADH2 + 10 ATP
d) 163
Convert all into ATP (NADH*3, FADH2*2):
117N + 38F + 10ATP -2ATP (from activation) = 163

3) What are the end products of odd-chain FA oxidation? b) Acetyl-CoA + Propionyl-CoA

a) 2x Acetyl-CoA
b) Acetyl-CoA + Propionyl-CoA
c) Acetyl-CoA + Methylmalonyl-CoA
d) Propionyl-CoA + Methylmalonyl-CoA

4) The carboxylation of propionyl-CoA can only happen c) Biotin

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in the presence of:
a) Vit.B12 The enzyme propionyl-CoA carboxylase needs biotin as
b) ATP cofactor
c) Biotin
d) H2O2

5) FA oxidation in peroxisomes is different than in d) The first step yields FADH2 which gets reduced by H2O2 to
mitochondria because: FAD
a) The first step creates FADH2 which goes to the
electron transport chain and yields ATP
b) The second step is dependent on biotin
c) The first step yields FADH2 which gets reduced by
H2O to FAD
d) The first step yields FADH2 which gets reduced by
H2O2 to FAD

FATTY ACID OXIDATION (PART 2) METABOLISM: Note #1. 1 of 1

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