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What You Need To Know About Vitiligo-Merged
What You Need To Know About Vitiligo-Merged
What You Need To Know About Vitiligo-Merged
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STORY AT-A-GLANCE -
Vitiligo is a skin condition that has been around for centuries and has been
It is now being listed as an autoimmune disease where the immune system a acks
and kills o the cells that are responsible for the production of melanin
Read these articles to know more about the symptoms, causes, treatment and
prevention of vitiligo
Vitiligo is a skin condition that has been around for centuries and has been
documented in various historical accounts. The clear cause for vitiligo has not yet
the immune system a acks and kills o the cells that are responsible for the
1
production of melanin.
Some of the earliest documents describing this condition go as far back as 3,000
years ago, some of which are found in Egyptian and Vedic texts. The only problem
is that there is no clear contrast between vitiligo and leprosy during those ages,
which led to the shunning of people with vitiligo from society because of the
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collective fear.
These two conditions are di erent even though both cause depigmentation.
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the two have lessened the societal stigma of vitiligo.
The loss of the melanin in select areas of the body can lead to a heightened
4
sensitivity and risk of sunburn. But aside from this intolerance to sunlight, the
This is because even though vitiligo has been proven to be noninfectious, some
people still tend to be frightened of it, and to even shame or ridicule those who
have it. The stigma of this can cause those with vitiligo to su er numerous
those who have it. A 2019 study found that while vitiligo does not typically cause
stigma among patients. Almost 97% of patients were found to have an impaired
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quality of life. To help prevent these emotional e ects, family support and
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counseling are crucial.
diseases
People with vitiligo have also been observed to have a higher chance of
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developing various autoimmune diseases, including:
• Alopecia areata — This refers to hair loss, which is caused by the immune
system’s a ack on hair follicles. It can be seen in various areas of the body,
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mostly on the scalp or the face. The risk for alopecia areata does not depend
on race, age or sex, with everyone having the same risk as anyone else in the
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population.
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processes. Having an autoimmune thyroid disease means that the immune
system is unknowingly a acking the thyroid glands, which then causes them
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include Graves’ disease and Hashimoto’s disease.
glands. Two of the important hormones these glands produce are cortisol and
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aldosterone.
13,14
volume by controlling salt and water levels.
produce enough insulin or when body cells have become insulin resistant.
There are two types of diabetes mellitus: Type 1 and Type 2, with Type 1 being
15
cells.
Read these articles to know more about the symptoms, causes, treatment and
prevention of vitiligo. You will also learn various holistic treatments and how you
Vitiligo: an
Introduction
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What is vitiligo?
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While this skin condition is not fatal, having these white patches makes a person
more prone to sunburn. There are mixed conclusions for its potential to increase
Vitiligo is much more noticeable in people with dark skin. Some of the external
stimuli usually said to in uence the occurrence of vitiligo include stress, physical
Vitiligo is a rare skin condition that a ects up to 2% of the world’s population, and
about 2 million to 5 million people in the United States are a ected by this
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disease.
Vitiligo is characterized by the loss of pigment in various areas of the skin. The
extent and severity of vitiligo varies from person to person, with some people
developing small patches, while others having large white areas that cover a
of the two, that achieve a “score” re ecting the disease’s extent, stage and
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progression.
The cause for the loss of melanocytes in the skin, however, is not yet known. A
2003 study reviewed scienti c research that back the possibility of it being an
autoimmune disease. This may be supported by the e cacy of treatment options
3
with immunosuppressive e ects.
While this skin condition is not fatal, it should be noted that having these white
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patches could make a person more prone to sunburn. As for the possibility of a
heightened risk for skin cancer, there have been mixed conclusions. While it was
rst believed that vitiligo may contribute to the development of cancer, it is now
being proposed that the preexistence of vitiligo actually protects patients from
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the development of melanoma.
The age when vitiligo becomes active largely varies among populations, although
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patients typically start showing hypopigmentation in their 20s. The risk for
developing this condition is not dictated by race or gender, with every person in
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the population having an equal chance of ge ing vitiligo. However, vitiligo is
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much more noticeable in people with dark skin.
Some of the external stimuli usually said to in uence the occurrence of vitiligo
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include stress, physical trauma and pregnancy. People a ected by autoimmune
diseases also have a higher risk of contracting vitiligo. The explanation for this
heightened risk is not yet fully understood, but it is commonly connected to how
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the immune system mistakenly a acks healthy cells.
macules (discolored skin areas) share the same appearance as other marks,
in fear that they may have contracted infectious diseases. Vitiligo is commonly
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mistaken for the following skin conditions:
• Pityriasis alba — This condition starts with the development of pink scaly
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patches, which then heal and leave white macules on the skin. The cause for
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this is not known but it is usually a ributed to atopic dermatitis.
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melanocytes at certain areas of the body. It is commonly observed in the
forelock or the frontal part of the head. Other areas that may be a ected by
this condition include the chin, trunk and eyebrows. While there have been
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reassume color, unlike with vitiligo.
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in the skin. This causes small white patches on the trunk, back and arms.
• Leprosy — One of the common mistakes that people commit when talking
there is a fear of people who have vitiligo because of the belief that these two
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conditions are the same.
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Mycobacterium leprae, while vitiligo is an autoimmune disease and cannot
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be transmi ed from person to person.
through the variations in the extent of the a ected skin. Albinism, a congenital
disorder, a ects the whole body, while vitiligo a ects only a portion of the
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skin.
Albinism is not a condition that is acquired through time. On the contrary, it is
genetic and is not caused by the destruction of the melanocytes found in the
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skin.
Vitiligo: an
Introduction
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What are the causes of vitiligo?
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STORY AT-A-GLANCE -
While vitiligo has been widely studied by researchers and professionals, the
primary cause for this condition has not yet been determined
There have been numerous instances where chemicals deemed safe for human
use or consumption have led to the death of the essential pigment-making cells in
While vitiligo has been widely studied by researchers and professionals, the
primary cause of this condition has not yet been determined. The wide range of
external and internal factors in uencing the development of this disease has
Some of the factors that have been linked to the progression of vitiligo include
the following:
the melanocytes in the skin, researchers have linked vitiligo to the immune
study from The New England Journal of Medicine, the risk of numerous
1
vitiligo, are dependent on the innate immune system of individuals.
in families, with people having a higher risk for the disease if another family
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member has it. Having a rst-degree relative with vitiligo increases a person’s
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risk by about seven- to 10-fold.
Although genetics is one of the leading factors for the development of vitiligo,
studies have also shown that people with a genetic predisposition to this
shows that environmental factors still play a part in the development of the
4
disease, but the genetic factor still contributes a 23% increase in their risk.
• Oxidative stress — Studies suggest that oxidative stress may trigger the
have been observed to interact with each other and produce a pathway that
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eventually leads to the destruction of the melanocytes.
• Skin trauma — Vitiligo may also be caused by a wide variety of skin trauma,
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autoimmune response against the melanocytes in the area.
• Stress — A 2015 study from the journal, Cutis, points to emotional distress as
a possible trigger for vitiligo. 1,541 patients were evaluated to determine the
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disease’s assessment.
use or consumption have led to the death of these essential pigment-making cells
of certain parts of the skin. Two male patients exhibited depigmented patches
8
on their neck, wrists and legs a er exposure to dimethyl sulfate.
depigmentation was reported in workers who used gloves with MBEH with
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depigmentation therapy for patients who have extensive vitiligo.
Vitiligo: an
Introduction
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Di erent types of vitiligo
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Vitiligo has been divided into various groups and subgroups depending on the
Nonsegmental vitiligo is the most common type of vitiligo, a ecting almost 80% of
circumscribed
The behavior of this disease widely varies across the population, and due to the
Vitiligo has been divided into various groups and subgroups depending on the
1
extent and the location of the depigmentation.
Two of the general groups of vitiligo are nonsegmental and segmental. These
categories largely depend on the location and the extent of the skin condition.
Segmental refers to when the macules respect the body’s midline, and the
condition’s progression does not exceed or cross over to the other side of the
2
body.
Nonsegmental vitiligo is the most common type of vitiligo, a ecting almost 80%
well-circumscribed. This type can begin in any part of the skin, but is usually rst
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observed in the ngers and the face. Nonsegmental vitiligo can further be
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divided into subgroups, namely:
Acrofacial — Macules are o en found on the hands, feet and face, typically in
Mucosal — Depigmented areas are typically found on the lips, mouth or the
genitalia.
Universal — The depigmented areas make up almost 80% to 90% of the skin.
chemicals that can destroy the melanocytes in the skin. These chemicals usually
noted that contact vitiligo may be a subtype of generalized vitiligo because of the
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progression of depigmentation.
While mixed vitiligo is not yet part of the classi cation, there have been numerous
cases where both segmental and nonsegmental vitiligo are observed in a single
generalized vitiligo in a span of months or years. Some of the risk factors that
researchers have noted were the presence of halo nevi, or moles surrounded by
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depigmented patches, and leukotrichia, or the gradual loss of pigment in hair.
Introduction
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Symptoms of vitiligo
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STORY AT-A-GLANCE -
macules, which are small discolored spots on the skin. Depigmentation usually
starts in areas of the body that are more commonly exposed to the sun, including
The rst signs of vitiligo usually manifest in people before they reach their 20s
The main symptom of vitiligo is the loss of pigment in certain portions of the skin.
Due to the contrast in color, cases of vitiligo are more observable in people who
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have tanned or dark skin. The white patches are also more pronounced in
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summer when people usually get tans from sun exposure.
The rst signs of vitiligo usually manifest in people before they reach their 20s.
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However, this does not mean that vitiligo is limited to people in this age bracket.
Vitiligo usually starts with the loss of color on the sun-exposed portions of the
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skin. While the color of these parts changes drastically, the texture and sensation
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are usually preserved.
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by this skin condition.
Aside from skin depigmentation, some other symptoms of vitiligo include the
following:
in the skin may be accompanied by the loss of bulbar melanocytes, which are
responsible for hair color. This may cause the gradual depigmentation of your
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eyelashes, eyebrows or some patches on your head.
Depigmentation of the tissues inside the mouth — The loss of melanin can
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also be observed in mucous membranes and mouth tissues. White vitiligo
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patches may develop on the lips as well.
Color changes in the eyes — There are cases in which the eyes, speci cally
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the choroid, may exhibit some hypopigmentation in vitiligo patients.
macules, which are small discolored spots on the skin. Some accounts claim that
depigmentation usually starts in areas of the body that are more commonly
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exposed to the sun, including the face, hands, arms and feet.
There is no clear course for the progression of this condition because of the
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variations in the occurrence of vitiligo in patients. However, guring out the type
13,14
unpredictable. The patches typically spread symmetrically.
The timeframe for the spread of this skin condition is unpredictable, too. As a
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pace.
Vitiligo: an
Introduction
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Vitiligo treatment options to consider
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Conventional techniques for vitiligo help reintroduce pigment to the skin. It should
be noted that these conventional treatments may lead to numerous side e ects
properties. It also helps in decreasing oxidative stress, which is one of the factors
The treatment for vitiligo incorporates varying approaches on dealing with the
gradual depigmentation. Most of these treatments focus on evening out the skin
tone and minimizing the obvious e ects of vitiligo on the appearance of patients.
1
products to decrease the noticeability of their vitiligo.
Conventional techniques for vitiligo help reintroduce pigment to the a ected skin.
• Phototherapy — This procedure helps even out the skin tone by exposing
the skin to UVB light, causing the skin to produce pigment. Two types of
phototherapies that are now being used to treat vitiligo are targeted
which concentrates the treatment to the a ected area alone. This procedure
is said to help repigment almost 75% of the vitiligo patches, with some
patients even achieving full repigmentation. However, this process may cause
2
some minimal blistering and ulcerations.
The other type of light therapy is psoralen and ultraviolet A (PUVA) treatment.
plant chemicals, onto the skin and exposing it to UVA light. While this has
patients have also been observed to have a heightened risk for developing
3
skin cancer in the long term.
universal and widespread vitiligo. The procedure entails the removal of any
remaining melanocytes to even out the skin color of the vitiligo patient by the
4
pigmented skin. But because of the removal of the remaining pigment, the
patient will have a much higher sensitivity to sunlight and will need to take
5
extra care for the rest of their lives.
• Surgery — This is o en the last resort for vitiligo patients when other
conventional treatments fail. This is done on people who have had stable
vitiligo for a couple of years. Skin gra ing or cellular gra ing is the most
common surgical technique and involves gra ing healthy skin onto the white
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vitiligo patches to reintroduce melanocytes to the depigmented regions.
It should be noted that these conventional treatments for vitiligo may lead to
numerous side e ects that may a ect your lifestyle and skin health. Most of the
treatments that contain chemicals eventually lead to skin atrophy, which is the
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gradual deterioration of the treated skin.
protein called IL-15. Researchers announced in March 2019 that they had
discovered in a trial with mice that just two weeks of the treatment caused their
scientists are still developing a clinical trial if the same thing might work in
8
humans. Thus, you should consider natural remedies rst to address the
A safe way to treat vitiligo is to use natural and holistic techniques, including the
one of the factors that in uence the development of vitiligo. Researchers note
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phototherapy.
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Brassica juncea, Nigella glandulifera and Vernonia anthelmintic. It helps by
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promoting melanogenesis in depigmented areas of the body.
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heightened risk for skin cancer a er treatment.
Before using these natural remedies for vitiligo, it is best that you consult a health
professional for the right dosage and proper application. It should also be noted
that the use of these herbs show varying e ectivity on each individual.
For vitiligo patients who are pregnant or breastfeeding, it is strongly advised that
you consult with a health practitioner about the safest vitiligo treatment methods
Vitiligo: an
Introduction
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Vitiligo diet tips to remember
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A healthy and balanced diet that helps regulate the immune system is
recommended for anyone who has or is at risk of contracting vitiligo. There are
also speci c vitamins and minerals that can help in promoting the production of
melanin
People with vitiligo should not eat certain types of food to avoid aggravating the
A healthy and balanced diet that helps regulate the immune system is
have shown that this skin condition can be directly a ected by di erent
components in the environment, including diet. There are also speci c vitamins
Some of the essential vitamins and minerals that can help you deal with vitiligo
• Vitamin B12 and folate — A 1997 study found that vitamin B12 and folic acid
(the synthetic form of folate), together with regular sun exposure, may help
1
promote repigmentation. Nutritional de ciency in both these nutrients have
also been found to cause hypopigmentation by inhibiting the tyrosinase
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enzyme. Some examples of foods rich in vitamin B12 are grass fed beef, raw
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milk, homemade yogurt and pasture-raised, organic eggs.
found to inhibit Th17 cytokine production while promoting Th2, which assists
been linked to a heightened risk for multiple sclerosis and systemic lupus
4
erythematosus.
Sun exposure can also help optimize your vitamin D levels naturally, but
instead get vitamin D from foods like eggs, shiitake mushrooms, wild
alternative.
been linked to B-cell proliferation and T-cell activation, which may help
5
regulate and manage autoimmunity. Some good sources of vitamin A include
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grass fed beef liver, carrots, spinach and broccoli.
• Zinc — A 2011 study from the Indian Journal of Dermatology suggested the
possibility of zinc having a protective mechanism that may be bene cial for
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crucial component in melanogenesis. Foods rich in zinc include grass fed
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beef, veal, lamb and cheese.
Wheat and other grain products — They contain gluten, which has been
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a ack your melanocytes. A 2014 study from the Case Reports of Dermatology
gluten-free diet was put in place. Rapid repigmentation happened with the
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depigmented patches within four months.
Sugar-loaded foods — Diets high in re ned sugar were found to promote the
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its symptoms.
oxygen free radicals in the body may worsen vitiligo. Likewise, patients
should avoid fast food and other processed foods because they lack the
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nutrients they need to promote be er health.
Vitiligo: an
Introduction
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Vitiligo prevention: Can you avoid this skin
condition?
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STORY AT-A-GLANCE -
For vitiligo patients, the prevention of vitiligo progression is also important. Here
are some of the tips that physicians and health professionals have recommended
While there have been numerous papers and studies focusing on vitiligo, there is
still no clear-cut solution to how you can decrease your risk of contracting it,
transmi able disease. This mistake arises from the idea that vitiligo is the same as
leprosy or other transmi able diseases. But even if you maintain your distance
from vitiligo patients, this will not guarantee protection against this disease, as it
1
is not a contagious disease.
Avoid injuring your skin — Vitiligo has been observed in areas of incisions,
trauma and lacerations that are otherwise una ected by this skin condition. It
3
may also be seen in areas that are subjected to mild friction on a daily basis.
Avoiding skin injury may lower your risk of developing vitiligo by decreasing
4
the possibility of melanocyte death.
development of vitiligo, so you should always monitor it. Vitiligo patients have
which play an important role in the production of melanin in the skin. These
5
include vitamins D, B12 and folate. A well-balanced diet not only ensures that
the person has a lower risk of contracting vitiligo, but it may also help ght
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various diseases.
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stress, which may give rise to numerous problems. Oxidative stress is one of
8
that’s responsible for the death of melanocytes.
remember
For vitiligo patients, preventing vitiligo from progressing is also important. Some
of the tips that physicians and health professionals have recommended include:
been identi ed as one of the possible triggers for the faster progression of
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this disease. This is o en a ributed to the direct impact of stress on the
10
immune system, which may trigger an autoimmune response. By avoiding
events or instances that may cause stress, you can minimize or slow down the
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spread of your vitiligo patches.
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contribute to the progression of vitiligo. If you have macules on frequently
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use natural skin protection.
Vitiligo: an
Introduction
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