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Lymph Angio Lei o Myoma To Sis
Lymph Angio Lei o Myoma To Sis
Concept Mapping
Lymphangioleiomyomatosis
Davao Doctors College, Inc.
College of Allied Health Sciences
Nursing Program
Davao Doctors College, Inc.
College of Allied Health Sciences
Nursing Program
Narrative
Lung Association (2022), these nodules and cysts disrupt normal lung tissue
architecture and impede the flow of air and fluids, leading to symptoms such as
shortness of breath, coughing, and recurrent pneumothorax (collapsed lung). Over
time, the progressive growth of LAM cells causes further damage to lung tissue,
leading to the development of fibrosis (scarring) and a decline in lung function (Lee,
2023). The abnormal proliferation of LAM cells can also affect lymphatic vessels,
leading to lymphatic obstruction and fluid accumulation in the chest and abdomen.
The first medication approved by the US FDA for LAM was sirolimus, also
known as Rapamune, in May 2015. It has been shown to improve lung function in
LAM patients. Moreover, sirolimus shrinks lymphangioleiomyomas, chylous
effusions, and angiomyolipomas. Simvastatin and sirolimus combined therapy
prevented tumor recurrence even after both medications were stopped. It has also
been demonstrated that simvastatin lessens the expansion of the alveolar space in a
mouse model of LAM. Further, combined with sirolimus, simvastatin blocked matrix
metalloproteinase up-regulation and prevented alveolar destruction.
Davao Doctors College, Inc.
College of Allied Health Sciences
Nursing Program
Since LAM primarily affects women who are not yet menopausal, estrogens
have been linked to the disease's pathogenesis from the beginning. Progesterone,
gonadotropin-releasing hormone (GnRH) analogs, and oophorectomy have all been
used to treat LAM. (Taveira-DaSilva & Moss, 2014) Changes such as tachypnea,
dyspnea, and the use of accessory muscles may indicate the progression of
respiratory involvement and compromise requiring prompt intervention. A
comfortable position maximizes lung expansion, decreases the work of breathing,
and reduces the risk of aspiration. Exercise, in moderation, promotes general
well-being. Overall nursing responsibilities for patients with LAM include providing
emotional support and ensuring the patient's safety.
References
https://www.lung.org/lung-health-diseases/lung-disease-lookup/lymphangioleiomyom
atosis-lam/learn-about-lymphangioleiomyomatosis-lam#:~:text=What%20Causes%2
0LAM,not%20linked%20to%20tuberous%20sclerosis.
(LAM).
https://www.lung.org/lung-health-diseases/lung-disease-lookup/lymphangioleiomyom
atosis-lam/symptoms-diagnosis
Ataya, A., Brantly, M., & Riley, L. (2023). Lymphangioleiomyomatosis (LAM). American
Thoracic Society.
https://www.thoracic.org/patients/patient-resources/resources/lymphangioleiomyomat
osis-lam.pdf
Facts.
https://www.brighamandwomens.org/medicine/pulmonary-and-critical-care-medicine/
center-for-lymphangioleiomyomatosis/lam-overview-and-facts-for-patients
https://www.brighamandwomens.org/medicine/pulmonary-and-critical-care-medicine/
center-for-lymphangioleiomyomatosis/lam-signs-and-symptoms
https://www.news-medical.net/health/What-is-LymLphangioleiomyomatosis-(LAM).as
px
Davao Doctors College, Inc.
College of Allied Health Sciences
Nursing Program
https://www.msdmanuals.com/professional/pulmonary-disorders/interstitial-lung-disea
ses/lymphangioleiomyomatosis
National Heart Lung and Blood Institute. (2023). LAM Causes and Risk Factors.
https://www.nhlbi.nih.gov/health/lam/causes#:~:text=Researchers%20believe%20the
%20hormone%20estrogen,LAM%20sometimes%20stops%20getting%20worse.
https://my.clevelandclinic.org/health/diseases/16022-lymphangioleiomyomatosis-lam
Shah J M, Patel J T, Shah H, et al. (2023) The Epidemiology and Clinical Features of
Laput, Daniela John Mary - Signs and Symptoms, Diagnostic tools, and Narrative