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1 s2.0 S0022391320304157 Main
1 s2.0 S0022391320304157 Main
a
Assistant Professor of Prosthodontics, Substitutive Dental Science Department, College of Dentistry, Taibah University, Al-Madinah, Saudi Arabia; and Assistant Professor of
Prosthodontics, Prosthodontics Department, College of Dentistry, Ibb University, Ibb, Yemen.
b
Associate Professor of Prosthodontics, Substitutive Dental Science Department, College of Dentistry, Taibah University, Al-Madinah, Saudi Arabia.
c
Assistant Professor of Prosthodontics, Prosthodontics Department, College of Dentistry, Ibb University, Ibb, Yemen.
d
Lecturer of Oral Biology, Oral Biology Department, College of Dentistry, Ibb University, IBB, Yemen.
e
Associate Professor of Crown and Bridge Department, Faculty of Dental Medicine, AlAzhar University, Cairo, Egypt; and Associate Professor of prosthodontics, substitutive
dental science Department, College of Dentistry, Taibah University, Al-Madinah, Saudi Arabia.
Cheng et al, 201831 12 40 47.9 (17 M-23 F) 73 Maxilla and Straumann (internal NR Ceramic crown 20
mandible connection)
Metal-ceramic crown 20
Hosseini et al, 201136 12 36 28.1 (18M-18F) 75 Maxilla and Astra Tech 4-6 mo Ceramic crown 18
mandible
Metal-ceramic crown 18
Mangano and 12 50 52.6 (22M- 28F) 50 Maxilla and Exacone Leone NR Ceramic crown 25
Veronesi, 201833 mandible Implants
Metal-ceramic crown 25
Weigl et al, 201934 12 42 48(19M, 23F) 42 Maxilla and Ankylos C implant 3 mo Ceramic crown 21
mandible (Dentsply Sirona)
Metal-ceramic crown 21
Zembic et al, 201235 48 27 41.3 (8M- 14F) 40 Maxilla and Branemark RP (Nobel 4-6 mo Ceramic crown 17
mandible Biocare).
Metal-ceramic crown 10
CR, cement-retained; F, female; M, male; MBL, marginal bone loss; NR, not reported; SR, screw-retained; VAS, visual analog scale.
about whether or not an article should be included for summarized by using mean differences (MDs) and
full assessment was settled by consensus. The final standard deviations. The participant was regarded as the
articles were decided on once agreement between the 2 statistical unit.
reviewers had been reached, and any conflicts were Whenever there was any relevant data missing from
resolved through discussion. If this was not possible, a the included publications, the corresponding authors
third reviewer (M.H.A.) was introduced. Each reviewer were sent a request for this information through email.
independently extracted data from the studies, These were followed up by reminder emails if no
including the authors’ ID, publication year, participants, response was received.
interventions, number of implants placed and position, The statistical tests were carried out by using a soft-
type of prosthetic materials, and the outcomes of each ware program (REVMAN v5.3; The Cochrane Collabo-
study. ration). Meta-analyses were considered when the
Two reviewers (A.Y.A., R.A.) independently con- included studies of similar comparisons revealed the
ducted the risk of bias assessment for the individual same outcome measures. The weighted means across the
studies by using the Cochrane Collaboration Tool.23 An studies were analyzed by using a fixed-effects model.
estimate of the intervention effect was expressed as risk When statistically significant (P<.1) heterogeneity was
differences (RDs) with 95% confidence intervals (CIs) found, a random-effects model evaluating the signifi-
concerning dichotomous outcomes, including prosthesis cance of treatment effects was used.
failure and complication rates. The data of each group The Cochran test for heterogeneity was used to assess
with 95% CIs regarding continuous outcomes, including the impact of any variants in the estimates of treatment
marginal bone loss and patient satisfaction, were effects from the various trials. If P<.1, the heterogeneity
was considered significant. The I2-statistic was used to selection procedure. Table 1 outlines the details of the 7
assess the heterogeneity between the studies, which eligible RCTs.
explains the variation percentage as a result of hetero- In total, 241 participants (123 ceramic, 118 MC) were
geneity rather than chance.23 An I2-statistic of more than included in the 7 trials. Five trials30,33-36 used a titanium
50% was regarded as moderate to high heterogeneity. abutment with the MC and a zirconia abutment with the
ceramic restoration, whereas 2 trials31,32 used a titanium
RESULTS
abutment for both groups. Five trials30,32,34-36 used ven-
The database search produced 347 papers. An additional 2 eered zirconia, and 2 trials31,33 used monolithic zirconia.
records were identified through a manual search. Once all For more details regarding the characteristics of the
duplicates had been removed, 285 potentially relevant included studies, see Table 1.
articles were selected. After the early screening, 14 articles The 7 included RCTs were assessed for risk of bias,
that fulfilled the eligibility criteria were chosen for further summarized in Figure 2. Four studies30,31,34,35 were
assessment of the full-text versions. Seven articles11,24-29 considered to have unclear risk of bias, and 3
were excluded for various reasons: 5 trials11,24-27 studies32,33,36 were at low risk of bias.
were not RCTs, 1 trial28 was a retrospective study The prosthesis failure was reported in the 7 trials.30-36
design, and 1 trial29 compared the abutments, not the The pooled result found no statistically significant dif-
superstructure. The remaining 7 studies30-36 were ference between the ceramic and MC crowns (P=.86; RD:
selected for data analysis. Figure 1 summarizes the study 0.000; 95% CI: -0.05 to 0.06; heterogeneity: P=.92; I2: 0%)
DISCUSSION
Other bias
The prosthesis failure rate for both types of restora-
tions was low, and the pooled data did not show a sig-
nificant difference. Prosthesis failure can result from
Bosch et al 2018 + ? + + + + + implant loss after infection, overload, excess cement,31,35
or an unrestorable prosthesis fracture.30
Cheng et al 2018 + ? + ? + + + The ceramic restoration experienced a mechanical
Gallucci et al 2010 + + + + + + + complication rate similar to that of the MC restorations as
indicated by the meta-analysis. The similar performance
Hosseini et al 2011 + + + + + + +
may be attributed to the use of zirconia that is charac-
Mangano and Veronesi 2018 + + + + + + + terized by high flexural strength and fracture tough-
ness.31,33 Another explanation is that most of the selected
Weigl et al 2019 + ? + ? + + +
studies had a short follow-up, which may hide
Zembic et al 2012 + ? + ? + + + differences.
The most frequent complication associated with
Figure 2. Quality assessment of included randomized clinical trials. ceramic crowns was veneer chipping.30,32,33 The precise
cause of chipping is unknown, as noted by Anusavice,18
(Fig. 3). With regard to marginal bone loss, the pooled and multiple reasons may be in play. For example, the
data from 5 trials30,33-36did not show differences between interface bond between copings and ceramic is believed
the 2 restorations (P=.37; MD: -0.02; 95% CI: -0.07 to to be a contributing factor,38 as too is the residual stress
0.03; heterogeneity: P=.55; I2: 0%) (Fig. 4). resulting from the cooling of zirconia and the phenom-
With respect to the mechanical complications re- enon of aging.39 The material property, design, and
ported in all of the included trials,30-36 the most com- thickness of the ceramic veneer should all be sufficient;
mon reported complication was the minor chipping of otherwise, the use of monolithic zirconia is preferred to
veneered ceramics. The meta-analysis of overall me- bilayered ceramic restoration to avoid ceramic chipping.40
chanical complication revealed a nonsignificant differ- The results of 1 included study31 by using monolithic
ence between the ceramic and MC crown (P=.86; RD: zirconia as ceramic material reported a high occurrence of
-0.06; 95% CI: -0.18 to 0.07; heterogeneity: P=.005; I2: mechanical complications with MC restorations. Ac-
67%) (Fig. 5). As for biological complications, 5 trials32- cording to the authors, this result maybe because of the
36
compared implant-supported MC versus ceramic different MC prosthesis types included. However, this
crowns, and the forest plot did not show statistically finding is not related only to the type of material because
significant difference (P=.70; RD: 0.02; 95% CI: -0.07 to the authors reported that most of the complications were
0.11; heterogeneity: P=.44; I2: 0%) (Fig. 6). The most found in bruxers.
common reported biological complication was In the present review, the type of crown material did
suppuration. not affect the rate of biological complications or marginal
The quantitative analysis of patient satisfaction in 3 bone loss, and the meta-analysis did not show a statis-
trials32,33,36 reported no difference between the 2 resto- tically significant difference. The most commonly
ration types (P=.22; MD: 4.86; 95% CI: -2.86 to 12.58; encountered biological complication of both restorations
heterogeneity: P=.02; I2: 75%) (Fig. 7). As only 7 articles was suppuration on probing. The ceramic restoration
were involved in this review, the sample size was not recorded an overall biological complication rate of 11%
adequate to assess publication bias. compared with 9.5% for the MC restorations.
Figure 3. Forest plot of prosthesis failure of ceramic compared with MC implant-supported crown. CI, confidence interval; MC, metal-ceramic.
Bosch et al 2018 0.05 0.05 12 0.28 0.77 16 1.8% –0.23 [–0.61, 0.15]
Hosseini et al 2011 0.08 0.2 18 0.1 0.17 18 17.5% –0.02 [–0.14, 0.10]
Mangano and Veronesi 2018 0.47 0.31 25 0.39 0.29 25 9.3% 0.08 [–0.09, 0.25]
Weigl et al 2019 0.17 0.1 21 0.2 0.1 21 70.5% –0.03 [–0.09, 0.03]
Zembic et al 2012 1.8 0.5 17 2 0.8 10 0.9% –0.20[–0.75, 0.35]
Figure 4. Forest plot of marginal bone loss of ceramic compared with MC implant-supported crown. CI, confidence interval; MC, metal-ceramic; SD,
standard deviation.
Figure 5. Forest plot of mechanical complications of ceramic compared with MC implant-supported crown. CI, confidence interval; MC, metal-ceramic.
Figure 6. Forest plot of biological complications of ceramic compared with MC implant-supported crown. CI, confidence interval; MC, metal-ceramic.
Gallucci et al 2010 91.78 10.04 10 91.81 5.94 10 33.1% –0.03 [–7.26, 7.20]
Hosseini et al 2011 84.9 18.4 18 83.1 18.8 18 21.6% 1.80 [–10.35, 13.95]
Mangano and Veronesi 2018 93.5 3.3 25 83.6 4 25 45.2% 9.90 [7.87, 11.93]
Figure 7. Forest plot of patient satisfaction of ceramic compared with MC implant-supported crown. CI, confidence interval; MC, metal-ceramic; SD,
standard deviation.
A high incidence of biological complications with 3. Well-designed RCTs with long-term assessments
ceramic restorations was reported in 1 of the included are needed to gain further insight.
studies.36 The authors clarified that this finding might be
related to the poor marginal fit of ceramic crowns,
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3-year randomized controlled prospective clinical trial on different CAD- Prosthodontics Department
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CRediT authorship contribution statement
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randomized clinical trial. Clin Oral Implants Res 2011;22:62-9. Writing - original draft, Visualization. Ahmad Abdulkareem Alnazzawi:
Conceptualization, Writing - review & editing. Radwan Algabri: Writing - review
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restoration of single implants: a randomized controlled trial with 1 year of & editing. Afaf N. Aboalrejal: Formal analysis, Data curation, Writing - review &
editing. Mohammed Hosny AbdElaziz: Writing - review & editing,
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34. Weigl P, Trimpou G, Grizas E, Hess P, Nentwig GH, Lauer HC, et al. All- Visualization.
ceramic versus titanium-based implant supported restorations: preliminary
12-months results from a randomized controlled trial. J Adv Prosthodont Copyright © 2020 by the Editorial Council for The Journal of Prosthetic Dentistry.
2019;11:48-54. https://doi.org/10.1016/j.prosdent.2020.06.011