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Full Chapter Handbook of Clinical Anesthesia Seventh Edition Barash Paul G Cullen MD Bruce F Stoelting MD Robert K Cahalan MD Michael K Stock MD M Christine Ortega MD Rafael PDF
Full Chapter Handbook of Clinical Anesthesia Seventh Edition Barash Paul G Cullen MD Bruce F Stoelting MD Robert K Cahalan MD Michael K Stock MD M Christine Ortega MD Rafael PDF
Full Chapter Handbook of Clinical Anesthesia Seventh Edition Barash Paul G Cullen MD Bruce F Stoelting MD Robert K Cahalan MD Michael K Stock MD M Christine Ortega MD Rafael PDF
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SEVENTH EDITION
HAND B O O K O F
Clinical
Anesthesia
HAND B O O K O F
Clinical
Anesthesia
Paul G. Barash, md Michael K. Cahalan, md
Professor Professor and Chair
Department of Anesthesiology Department of Anesthesiology
School of Medicine School of Medicine
Yale University School of Medicine The University of Utah
Attending Anesthesiologist Salt Lake City, Utah
Yale-New Haven Hospital
New Haven, Connecticut M. Christine Stock, md
Professor and Chair
Bruce F. Cullen, md Department of Anesthesiology
Emeritus Professor Feinberg School of Medicine
Department of Anesthesiology Northwestern University
School of Medicine Chicago, Illinois
University of Washington
Seattle, Washington Rafael Ortega, md
Professor
Robert K. Stoelting, md Vice-Chairman of Academic Affairs
Emeritus Professor and Past Chair Department of Anesthesiology
Department of Anesthesia School of Medicine
School of Medicine Boston University
Indiana University Boston, Massachusetts
Indianapolis, Indiana
7th Edition
Copyright © 2009 by Wolters Kluwer Health/Lippincott Williams & Wilkins, 2006, 2001 by
Lippincott Williams & Wilkins. Copyright © 1997 by Lippincott-Raven Publishers. Copyright ©
1993, 1991 by J.B. Lippincott Company.
All rights reserved. This book is protected by copyright. No part of this book may be reproduced
or transmitted in any form or by any means, including as photocopies or scanned-in or other
electronic copies, or utilized by any information storage and retrieval system without written
permission from the copyright owner, except for brief quotations embodied in critical articles
and reviews. Materials appearing in this book prepared by individuals as part of their official
duties as U.S. government employees are not covered by the above-mentioned copyright. To
request permission, please contact Lippincott Williams & Wilkins at Two Commerce Square,
2001 Market Street, Philadelphia PA 19103, via email at permissions@lww.com or via website at
lww.com (products and services).
987654321
Printed in China
Handbook of clinical anesthesia / [edited by] Paul G. Barash . . . [et al.]. — 7th ed.
p. ; cm.
Includes bibliographical references and index.
Summary: “The Handbook of Clinical Anesthesia, Seventh Edition, is a companion to the parent
textbook, Clinical Anesthesia, Seventh Edition. This widely acclaimed reference parallels the
textbook and presents content in a concise outline format with additional appendices. The
Handbook makes liberal use of tables, graphics, and clinical pearls, to enhance rapid access of
the subject matter. This comprehensive, pocket-sized reference guides you through virtually every
aspect of perioperative, intraoperative, and postoperative patient care.”—Provided by publisher.
ISBN 978-1-4511-7615-5 (alk. paper)
I. Barash, Paul G. II. Clinical Anesthesia.
[DNLM: 1. Anesthesia—Handbooks. 2. Anesthetics—Handbooks. WO 231]
617.996–dc23 2012051809
Care has been taken to confirm the accuracy of the information presented and to describe
generally accepted practices. However, the authors, editors, and publisher are not responsible for
errors or omissions or for any consequences from application of the information in this book and
make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy
of the contents of the publication. Application of this information in a particular situation
remains the professional responsibility of the practitioner; the clinical treatments described and
recommended may not be considered absolute and universal recommendations.
The authors, editors, and publisher have exerted every effort to ensure that drug selection
and dosage set forth in this text are in accordance with the current recommendations and prac-
tice at the time of publication. However, in view of ongoing research, changes in government
regulations, and the constant flow of information relating to drug therapy and drug reactions, the
reader is urged to check the package insert for each drug for any change in indications and dosage
and for added warnings and precautions. This is particularly important when the recommended
agent is a new or infrequently employed drug.
Some drugs and medical devices presented in this publication have Food and Drug
Administration (FDA) clearance for limited use in restricted research settings. It is the responsi-
bility of the health care provider to ascertain the FDA status of each drug or device planned for
use in his or her clinical practice.
LWW.COM
The authors would like to gratefully acknowledge the efforts of the con-
tributors to the seventh edition of the textbook Clinical Anesthesia.
vii
Paul G. Barash MD
Bruce F. Cullen MD
Robert K. Stoelting MD
Michael K. Cahalan MD
M. Christine Stock MD
Rafael Ortega, MD
ix
SECTION I Introduction to
Anesthesiology
APPENDICES
A Formulas 1003
B Atlas of Electrocardiography 1009
C Pacemaker and Implantable Cardiac Defibrillator
Protocols 1041
D American Heart Association (AHA) Resuscitation
Protocols 1057
E American Society of Anesthesiologists Standards,
Guidelines, and Statements 1078
F The Airway Approach Algorithm and Difficult Airway
Algorithm 1095
G Malignant Hyperthermia Protocol 1097
H Herbal Medications 1100
Index 1109
C H A P T E R
1
The History of Anesthesia
Introduction to Anesthesiology
of metal laryngeal tubes, which he inserted blindly between
the vocal cords of children having diphtheritic crises.
3. In 1895 in Berlin, Alfred Kirstein devised the first direct-
vision laryngoscope.
4. Before the introduction of muscle relaxants in the 1940s,
intubation of the trachea could be challenging. This chal-
lenge was made somewhat easier, however, with the advent
of laryngoscope blades specifically designed to increase
visualization of the vocal cords.
5. In 1926, Arthur Guedel began a series of experiments that
led to the introduction of the cuffed tube.
6. In 1953, single-lumen tubes were supplanted by double-
lumen endobronchial tubes.
C. Advanced Airway Devices. Conventional laryngoscopes
proved inadequate for patients with difficult airways. Dr. A. I. J.
“Archie” Brain first recognized the principle of the laryngeal
mask airway in 1981.
D. Early Anesthesia Delivery Systems. John Snow created ether
inhalers, and Joseph Clover was the first to administer chloro-
form in known concentrations through the “Clover bag.”
Critical to increasing patient safety was the development of a
machine capable of delivering calibrated amounts of gas and
volatile anesthetics (also carbon dioxide absorption, vaporiz-
ers, and ventilators).
E. Two American surgeons, George W. Crile and Harvey
Cushing, advocated systemic blood pressure monitoring dur-
ing anesthesia. In 1902, Cushing applied the Riva Rocci cuff
for blood pressure measurements to be recorded on an anes-
thesia record.
1. The widespread use of electrocardiography, pulse oximetry,
blood gas analysis, capnography, and neuromuscular
blockade monitoring have reduced patient morbidity and
mortality and revolutionized anesthesia practice.
2. Breath-to-breath continuous monitoring and waveform
display of carbon dioxide (infrared absorption) concentra-
tions in the respired gases confirms endotracheal intuba-
tion (rules out accidental esophageal intubation).
F. Safety Standards. The introduction of safety features was
coordinated by the American National Standards Institute
Committee Z79, which was sponsored from 1956 until 1983
by the American Society of Anesthesiologists. Since 1983,
representatives from industry, government, and health care
professions have met as the Committee Z79 of the American
Society for Testing and Materials. This organization establishes
the Nobel laureate Daniel Bovet in 1949 and was in wide inter-
Introduction to Anesthesiology
national use before historians noted that the drug had been
synthesized and tested in the early 1900s. Recognition that
atracurium and cis-atracurium undergo spontaneous degrada-
tion by Hoffmann elimination has defined a role for these
muscle relaxants in patients with liver and renal insufficiency.
F. Antiemetics. Effective treatment of patients with postoperative
nausea and vomiting (PONV) evolved relatively recently and
has been driven by incentives to limit hospitalization expenses
and improve patient satisfaction. The antiemetic effects of
corticosteroids were first recognized by oncologists treating
patients with intracranial edema from tumors. Recognition of
the role of the serotonin 5-HT3 pathway in PONV has led to a
unique class of drugs (including ondansetron in 1991) devoted
only to addressing this particular problem.
21
Scope of Practice
Introduction to Anesthesiology
T a b l e 2 - 2 Examples of Anesthesiologists as
Participants in Medical Staff Activities
Credentialing
Peer review
Transfusion review
Operating room management
Medical direction of same-day surgery units
Medical direction of postanesthesia care units
Medical direction of intensive care units
Medical direction of pain management services and clinics
Introduction to Anesthesiology
ing room.
1. Service. Equipment maintenance and service may be pro-
vided by factory representatives or in-house engineers.
2. Replacement of obsolete anesthesia machines (10 years
often cited as the estimated useful life) and monitoring
equipment is a key element in a risk-modification program.
J. Malpractice Insurance
1. Occurrence means that if the insurance policy was in force
at the time of the occurrence of an incident resulting in a
claim, the physician will be covered.
2. Claims made provide coverage only for claims that are
filed when the policy was in force. (“Tail coverage” is
needed if the policy is not renewed annually.)
3. A new approach in medical risk management and insur-
ance is advocating immediate full disclosure to the victim
or survivors. This shifts the culture of blame with punish-
ment to a just culture with restitution.
K. Response to an Adverse Event
1. Despite the decreased incidence of anesthesia catastrophes,
even with the very best practice, it is statistically likely
that an anesthesia professional will be involved in a major
anesthesia accident at least once in his or her professional
life.
2. A movement to implement immediate disclosure and apol-
ogy reflects as shift from the “culture of blame” with pun-
ishment to a “just culture” with restitution. Laudable as the
policy of immediate full disclosure and apology may
sound, it is recommended for the anesthesia professional to
confer with the involved liability insurance carrier, the
practice group, and the facility administration before pur-
suing this policy.
Introduction to Anesthesiology
providers in the managed care organization receives a fixed
amount per member per month and agrees, except in unusual
circumstances (“carve-outs”), to provide care.
C. Changing Paradigm. There is an emerging trend for private
contracting organizations to tie their payments for profes-
sional services to the government’s Medicare rate for specific
CPT-4 codes.
D. Pay for performance is the concept supported by commercial
indemnity insurance carriers and the Centers for Medicaid and
Medicare Services to reduce health care costs by decreasing
expensive complications of medical care.
1. Accountable Care Organizations were created by the
Patient Protection and Affordable Care Act that was signed
into law in 2010. To ensure the importance of preoperative
care of the surgical patient in these provisions, the ASA is
advocating a “surgical home” model of care.
2. Management Intricacies. The complexities of modern
medical practice have spawned management consultants
that offer their services to anesthesiology group practices.
3
Occupational Health
The health care industry has the dubious distinction of being one of the
most hazardous places to work in the United States (health care is sec-
ond only to manufacturing in the number of occupational illnesses and
injuries sustained by their workers (Katz JD, Holzman RS. Occupational
health. In: Barash PG, Cullen BF, Stoelting RK, Cahalan MK, Ortega R,
Stock MC, eds. Clinical Anesthesia. Philadelphia: Lippincott Williams
& Wilkins; 2013: 61–89).
I. PHYSICAL HAZARDS
A. Anesthetic Gases
1. Concerns about the possible toxic effects of occupational
exposure to inhalational anesthetics have been expressed
since their introduction into clinical practice.
2. Several studies testing for chromosomal aberrations, sister
chromatid exchanges, or changes in peripheral lympho-
cytes have found no evidence of cellular damage among
clinicians exposed to the levels of anesthetic gases that are
encountered in an adequately ventilated operating room
(OR).
3. Nitrous oxide exposure is a special situation as this gas can
irreversibly oxidize the cobalt atom of vitamin B12 to an
inactive state. This inhibits methionine synthetase and pre-
vents the conversion of methyltetrahydrofolate to tetrahy-
drofolate, which is required for DNA synthesis, assembly of
the myelin sheath, and methyl substitutions in neurotrans-
mitters. At adequate clinically used concentrations of
nitrous oxide, this inhibition could result in anemia and
polyneuropathy. As with the halogenated hydrocarbon
anesthetics, these effects with nitrous oxide have not been
demonstrated in adequately scavenged ORs with effective
waste gas scavenging.
B. Reproductive Outcomes
1. There is no increased risk of spontaneous abortion in stud-
ies of personnel who work in scavenged environments
where waste gases were scavenged.
2. It is likely that other job-associated conditions (e.g., stress,
infections, long work hours, shift work, radiation exposure)
15