Homeostatic imbalances Myasthenia Gravis (My =

Muscle , asthenia-weakness , gravi-heavy) it's an autoimmune disease characterized by 0 Drooping eyeleds & difficulty swallowing an talking

③Generalized
G
What for MG ? an autoimmune disease
S

① Shortage of ACh receptors is the reason which the immune system destroys
T

muscle weakness in

-
(
an -

ACh receptors (so Ap

can't transfer to muscles from

-Y motorens)
nor
O -

~
g
&
i

Excitation-contraction coupling - sequence of events by which transmission of an AP along the sarcolemma leads to the sliding
of myofilaments
-

Acheceptors
SOMAP triggered by the binding of ACh to ↓ Of -
he e

nei
propagates along the Sarcolemma ad Down the T-tubules .

> Terminal cistern channels that

release cat into the cytosol

↳Transmission of AP along the T-tubules causes the voltage

Sensitive proteins to change shape which
Opens ,
the Cat -
-

channels on the TC c releases ca into the cytosol

Listern

↳ the cat released binds to troponin Ca

protein that has 3 binding sites : to action to cast to tropomyosin)
When Ca binds to troponin , troponin changes shape ,
attach to tropomyosin al moving it exposing the Myosin-binding sites on

actin O OO O
OO
>
000O
-

&O
: O
- cat
OG O -

> in a relaxed 000 O

jOf ↑OC +
O

- muscle · SO
·
- Of
·O
·
O

&
G 00 OO
.

(no contraction) OO -
roo
000
O muscle ready to
· ⑳

tropomyosin blocks >a

-

myosin binding site

.

=> contract, myosin binding

sites are open

A contraction Begins
↳ Myosin binding to actin CBTW not all gosin heads will be able to bind to actin afonce a s of the
,

difference of what
way facing v the actin is
o
O
Our
0 .
.
as in here only two will bind to acting forms Cross
&
,
-& &

Bridges and contraction (cross bridge Cycling) at this point ,

E-C coupling is over

The after math 8-

↳ as the muscle's AP Ceases , Voltage-sensitive tubule proteins on t-tubules chang back to their
original shape closing, the

cat release channels of the terminal cisterns

.

↳ Ca Levels in the sarcoplasm fall as the Ca is pumped back into the TC via ACTIVE TRASPORT
↳ without Ca binding it could block myosin-binding actin again
troponin , troponin releases tropomyosin
to so sites on

↳ RELAXATION OCCURS .

* Latent period >

-
Excitation-Contraction Coupling -
> Relaxation