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Week 13 14 Part2 GeneStemCellTherapy
Week 13 14 Part2 GeneStemCellTherapy
Outcomes to:
1 DIFFERENT FORMS Describe gene therapy and stem cell and its forms.
STEM
❑ What are Stem Cells
❑ Characteristics and
Properties
❑ Types of Stem Cells
CELLS
❑ Stem Cell Therapy
❑ Uses of Stem Cells
THERAPY
WHAT ARE STEM CELLS?
These inner cell mass from a blastocyst. These stem cells
can become any tissue in the body. for example: neuron,
chondrocyte, enterocytes, red blood cells, muscle, fat or
epithelial cells
Stem cells are cells from which all other cells with
specialized functions are generated. Under the right
conditions in the body or a laboratory, stem cells divide
to form more cells called daughter cells.
Tissue regeneration
Tissue regeneration is probably the most important use of stem cells. Until
now, a person who needed a new kidney, for example, had to wait for a donor
and then undergo a transplant. There is a shortage of donor organs but, by
instructing stem cells to differentiate in a certain way, scientists could use them
to grow a specific tissue type or organ.
STEM
❑ Importance of this therapy
❑ Planarians
❑ Where do Stem Cells
naturally come from?
CELLS
❑ Donating or Harvesting
Stem Cells
THERAPY
IMPORTANCE OF STEM CELLS
Stem cells can be used to test different substances (drugs and chemicals)
3
PLANARIANS USED IN STEM CELLS STUDIES
Planarians are flatworms that are capable of
profound regenerative feats dependent upon a
population of self-renewing adult stem cells called
neoblasts.
Regeneration in planarians offers a paradigm for
understanding the molecular and cellular control of
the repair and regeneration of animal tissues, and
could provide valuable insights for the safe use of
stem cells to repair damaged, diseased and ageing
human tissues with little or no regenerative
capacities.
The goal of stem cell research to know the
fundamental stem cell concepts of regeneration
using Planaria as a model organism.
WHERE DO STEM CELLS NATURALLY COME FROM?
B. Therapeutic Cloning: is a
technique used to create stem cells
that are a genetic match to a donor.
It has been used to clone non-human
animals, the most famous being the
sheep, Dolly. Therapeutic
cloning has been negatively
associated with the idea of human
reproductive cloning, but the majority
of scientists do not support the
reproductive uses of this procedure in
humans.
DONATING OR HARVESTING STEM CELLS
STEM
❑ Issues Concerning Stem
Cells
❑ Controversy
CELLS
THERAPY
ISSUES CONCERNING STEM CELLS
Ethical and Social Issues. It's a topic that brings up some big questions such as:
• When does human life begin?
• Can we have the benefits of stem cell research without using embryos?
• Might stem cell research make human cloning more likely and does this matter?
• Is it a good idea to do stem cell research at all when there are people suffering
from preventable diseases (like TB) in developing countries?
• We need to decide what we think and feel about embryos.
• Is an embryo just a ball of cells?
• Does it have the potential to be human but is not yet human?
• Or is an embryo a human being right from fertilization?
In the UK, stem cell research is regulated by the Human Fertilization and Embryology
Authority (HFEA). They allow limited research to do with fertility treatment relating to
IVF (In Vitro Fertilization), and research into 'serious diseases'
CONTROVERSY ON STEM CELLS
There has been some controversy about stem cell research. This mainly relates to
work on embryonic stem cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724388/pdf/jbra-23-03-0197.pdf
https://media-exp1.licdn.com/dms/document/C4E1FAQEBDNi_terjBA/feedshare-document-
pdf-
analyzed/0/1618896996327?e=2147483647&v=beta&t=Wl4IKLCtw1GvaWvlBECtxLvmlflxjJM-
_bcGIBoRUmY
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987258/pdf/btt-15-67.pdf
https://www.medicalnewstoday.com/articles/323343#uses
https://www.nwabr.org/sites/default/files/STEM_CELL_CURRICULUM_1109.pdf
https://www.pnas.org/doi/pdf/10.1073/pnas.1306562110
https://stemcellres.biomedcentral.com/track/pdf/10.1186/scrt474.pdf
https://www.medicalnewstoday.com/articles/323343#controversy
https://medlineplus.gov/genetics/understanding/basics/gene/#:~:text=A%20gene%20is%20th
e%20basic,more%20than%202%20million%20bases.
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