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Caspi 2003
Caspi 2003
Caspi 2003
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REPORTS
Fig. 4. PPI of the right 22. G. R. Fink et al., Brain 122, 497 (1999).
ACC. (A) All areas are 23. C. Büchel, K. J. Friston, Cereb. Cortex 7, 768 (1997).
shown that receive a sig- 24. A. K. Engel, P. Fries, W. Singer, Nature Rev. Neurosci.
nificant context-depen- 2, 704 (2001).
dent contribution from 25. A. R. McIntosh et al., J. Neurosci. 14, 655 (1994).
right ACC during visuo- 26. G. Bush, P. Luu, M. I. Posner, Trends Cogn. Sci. 4, 215
spatial decisions, pro- (2000).
jected on the same ren- 27. K. J. Friston et al., NeuroImage 6, 218 (1997).
dered brain as in Fig. 1. 28. C. Cavada, P. S. Goldman-Rakic, J. Comp. Neurol.
Right ACC significantly 287, 393 (1989).
29. D. N. Pandya, G. W. Van Hoesen, M. M. Mesulam, Exp.
increased its influence
Brain Res. 42, 319 (1981).
on posterior (28/–72/48,
30. This work was supported by the Deutsche For-
t max ⫽ 4.49, P ⬍ 0.015, schungsgemeinschaft (K.Z., G.R.F), the U.K. Medical
corrected) and anterior Research Council ( J.C.M), and the Wellcome Trust
parts of the right IPS (K.E.S., K.J.F). Additional support for this Human Brain
(42/–42/44, t max ⫽ Project/Neuroinformatics research was provided
4.63, P ⬍ 0.034, correct- jointly by the National Institute of Mental Health,
ed) during visuospatial decisions. Note the specificity of this result: Even when the threshold was National Institute of Neurological Disorders and
reduced to P ⬍ 0.05, uncorrected, no other significant clusters were found throughout the brain. Stroke, National Institute on Drug Abuse, and the
National Cancer Institute. We thank our volunteers,
(B) This schema summarizes the negative findings for right ACC: As indicated by the gray dashed
K. Amunts for helpful anatomical discussions, and the
lines, right ACC shows no context-dependent contributions to any left-hemispheric area during radiographers at the Research Center Jülich for tech-
visuospatial decisions and none to any left- or right-hemispheric area at all during letter decisions.