DRUG NAME – METFORMIN HCL.

BRAND NAME – FORTAMET , GLUMETZA.

DRUG INFORMATION.
Metformin is used with a proper diet and exercise program and possibly with
other medications to control high blood sugar. It is used in patients with type
2 diabetes. Controlling high blood sugar helps prevent kidney damage,
blindness, nerve problems, loss of limbs, and sexual function problems.
Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Metformin works by helping to restore your body's proper response to
the insulin you naturally produce. It also decreases the amount of sugar that
your liver makes and that your stomach/intestines absorb.

ADVERSE EFFECTS.
 Nausea, vomiting, stomach upset, diarrhea, weakness, or a metallic
taste in the mouth may occur. If any of these effects last or get worse,
tell your doctor or pharmacist promptly tell your doctor right away.
Stomach symptoms that occur after the first days of your treatment may
be signs of lactic acidosis.
 Metformin does not usually cause low blood sugar (hypoglycemia). Low
blood sugar may occur if this drug is prescribed with
other diabetes medications. Talk with your doctor or pharmacist about
whether the dose of your other diabetes medication(s) needs to be
lowered
 A very serious allergic reaction to this drug is rare. However, get medical
help right away if you notice any of the following symptoms of a
serious allergic reaction: rash, itching/swelling (especially of the
face/tongue/throat), severe dizziness).
DRUG NAME – MISOPROSTOL.
BRAND NAME - CYTOTEC , ARTHROTEC.

DRUG INFORMATION.
This medication is used to prevent stomach ulcers while you
take NSAIDs (such as aspirin, ibuprofen, naproxen), especially if you are at
risk for developing ulcers or have a history of ulcers. Misoprostol helps to
decrease your risk of serious ulcer complications such as bleeding. This
medication protects your stomach lining by lowering the amount of acid that
comes in contact with it.This medication is also used in combination with
another drug (mifepristone) to end a pregnancy.

ADVERSE EFFECTS.
 Nausea or stomach cramps may occur. If any of these effects last or get
worse, tell your doctor or pharmacist promptly.
 Diarrhea is common with misoprostol and usually occurs about two
weeks after you start taking it, and lasts for about a week. Be sure to
keep up your intake of fluids and minerals/electrolytes to
prevent dehydration. Diarrhea that doesn't stop may sometimes lead to
a large loss of your body's water and minerals. Tell your doctor right
away if you develop any of these serious signs of dehydration and
mineral imbalance: dizziness, decreased urination, mental/mood
changes, muscle weakness, slow/irregular heartbeat.
 A very serious allergic reaction to this drug is rare. However, get medical
help right away if you notice any symptoms of a serious allergic
reaction, including: rash, itching/swelling (especially of the
face/tongue/throat), severe dizziness, trouble breathing.
DRUG NAME – OTEZLA.
BRAND NAME - Apremilast, Aplex.

DRUG INFORMATION.
Take this medication by mouth with or without food as directed by your
doctor, usually twice daily. The manufacturer directs not to crush, split, or
chew the tablet before taking it. However, many similar drugs (immediate-
release tablets) can be crushed, split, or chewed. Follow your doctor's
directions on how to take this medication.

ADVERSE EFFECTS.
 Diarrhea, nausea/vomiting, loss of appetite, headache, or weight
loss may occur. If any of these effects last or get worse, tell your
doctor or pharmacist promptly.
 Rarely, people who take this medication may
experience depression, suicidal thoughts/attempts, or other
mental/mood problems. Tell your doctor right away if you or your
family/caregiver notice any unusual/sudden changes in your mood,
thoughts, or behavior including signs of depression, suicidal
thoughts/attempts, thoughts about harming yourself.
 A very serious allergic reaction to this drug is rare. However, get
medical help right away if you notice any symptoms of a
serious allergic reaction, including: rash, itching/swelling (especially
of the face/tongue/throat), severe dizziness, trouble breathing.
 Database.
 MEDLINE.
MEDLINE is the National Library of Medicine’s (NLM) premier
bibliographic database that contains more than 29 million references to
journal articles in life sciences with a concentration on biomedicine. A
distinctive feature of MEDLINE is that the records are indexed with
NLM Medical Subject Headings (MeSH).

MEDLINE is the primary component of PubMed, a literature database

developed and maintained by the NLM National Center for Biotechnology
Information (NCBI). MEDLINE is the online counterpart to the MEDical
Literature Analysis and Retrieval System (MEDLARS) that originated in
1964 (see MEDLINE history).

The majority of journals are selected for MEDLINE based on the

recommendation of the Literature Selection Technical Review Committee
(LSTRC), an NIH-chartered advisory committee of external experts.

Time coverage: MEDLINE includes literature published from 1966 to

present, and selected coverage of literature prior to that period. For details
about pre-1966 citations see OLDMEDLINE Data.

Source: Currently, citations from more than 5,200 worldwide journals in

about 40 languages.

Updates: Citations are added to PubMed 7 days a week.

Broad subject coverage: In line with the Collection and Preservation Policy
of the NLM, the subject scope of MEDLINE is biomedicine and health,
broadly defined to encompass those areas of the life sciences, behavioral
sciences, chemical sciences, and bioengineering needed by health
professionals and others engaged in basic research and clinical care, public
health, health policy development, or related educational activities.
MEDLINE also covers life sciences vital to biomedical practitioners,
researchers, and educators, including aspects of biology, environmental
science, marine biology, plant and animal science as well as biophysics and
chemistry.
The majority of the publications in MEDLINE are scholarly journals;
however, a small number of newspapers, magazines, and newsletters
considered useful to particular segments of the NLM broad user community
are also included.

Availability: Searching MEDLINE via PubMed results in a list of citations

(including authors, title, source, and often an abstract) to journal articles
and an indication of free electronic full-text availability. Searching is free of
charge and does not require registration.

NLM also supports access to MEDLINE data via download with

documentation available at MEDLINE/PubMed Data Documentation –
additional access to various MEDLINE services is often available from
medical libraries, many public libraries, and commercial sources.

MedlinePlus is a consumer-oriented health information resource from the

NLM. It contains carefully selected links to online resources with
authoritative health information on a broad range of health topics.
MedlinePlus has more information on the difference between MedlinePlus
and MEDLINE. Health consumers are encouraged to discuss search results
with their health care provider.

 Food and Drug Administration.

The Food and Drug Administration (FDA) conducts careful inspections of
regulated facilities to determine a firm's compliance with regulations and
the Food, Drug and Cosmetic Act. The Agency is disclosing inspection
information to help improve the public’s understanding of how the FDA
works to protect the public health. Disclosure of the compliance status of
firms helps to provide the public with a rationale for the Agency’s
enforcement actions and will also help to inform public and industry
decision-making, allowing them to make more informed marketplace
choices and help to encourage compliance.

The FDA Adverse Event Reporting System (FAERS) database contains

information on adverse event and medication error reports submitted to
FDA. The database is designed to support the FDA's post-marketing safety
surveillance program for drug and therapeutic biologic products. We
provide downloadable files only; you cannot search the database
online. Read more about FAERS.
To receive approval for an Abbreviated New Drug Application (ANDA), an
applicant generally must demonstrate, among other things, that its product
has the same active ingredient, dosage form, strength, route of
administration and conditions of use as the listed drug, and that the
proposed drug product is bioequivalent to the reference listed drug (RLD).
Our Bioequivalence (BE) Recommendations for Specific Products database
provides guidance.

NATIONAL SCIENCE LIBRARY.

E-journals :.
NSL has access to 4000+ journals in addition to over 2000 open access
journals, and several important Databases and Standards like Web of
Science (WOS), Derwent Innovations Index (DII), Delphion, QPAT,
Scifinder, ASTM Standards and Indian Standards.

The library is providing free access to electronic journals from 29 leading

international publishers and database providers, like Elsevier, Springer,
American Institute of Physics, Blackwell, John Wiley, Cambridge University
Press, OUP, OSA, ACS, Taylor & Francis, Scifinder, WOS, DII, Delphion,
Qpat etc. (as per details in the table).

Researchers irrespective of their affiliations may walk-in to access, browse,

download and print any article from such a valuable knowledge resource
for their scholarly work. The researchers / scholars, who walk-in to the
CSIR labs /Institutions libraries for their scholarly work are also permitted
to use these electronic resources of the consortium through the computer
terminals placed in the library free of charge/fee.

Books Collection :

NSL has an enviable collection of books, journals/periodicals on Science

and Technology from India and abroad. NSL contains more than 2,00,000
bound volumes of journals in diverse fields of knowledge like computer
software and hardware, documentation of seminars and workshops in India
and abroad, the latest works in science and technology, dictionaries in
foreign languages, database in the form of CD ROMs on various topics in
information technology, research activities, etc.
NSL has rare collections of book and other materials.

Information Science and Information Technology Resources

A rich collection of books including latest books of prominent authers.

Books in Hindi language

on Computer software, Communication technology, JournalsConference

Process.

On-line databases :
NSL provides access to over 1500 international databases through STN and
DIALOG. In addition, NSL provides access to important online
database/resources viz. Web of Science (WOS), Derwent Innovations Index
(DII), Delphion, WIPS, Questal, etc.

Web of Science (WOS)

(Web of Science) Contain information gathered from about 10,000

scholarly journals. NSL has access to: Science Citation Index Expanded
(1945 – present) Social Science Citation Index (1987 – present) WoS is a
tool to serve two purposes ;
1. Research tool for conducting literature search; and

2. for scientometric and bibliometric studies. One can search by topic,

author, source title, and address. It enables to find bibliographic
information and abstract of article that cites a previously published work.