13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

Informe de laboratorio PhysioEx

Ejercicio 4: Fisiología del sistema endocrino
Actividadsesión- 4e952205-457c-7c84-5f79-d8790bd9a45bID de sesión: 13 de diciembre de
2023Fecha: KATHERINE POR CORREGIR
Nombre: Metabolismo y hormona tiroidea: 1

Prueba previa al laboratorio Resultados

Obtuviste una puntuación del 67% al responder correctamente 4 de 6 preguntas.

1 ¿Cuál de las siguientes afirmaciones sobre el metabolismo es falsa?

Tu respuesta: El anabolismo se refiere a reacciones químicas que forman moléculas más

grandes y complejas.

Respuesta correcta: Toda la energía del metabolismo se almacena en última instancia en

los enlaces químicos del ATP.

2 La tiroxina es

Respondiste correctamente: la hormona más importante para mantener la tasa

metabólica y la temperatura corporal.

3 La hormona estimulante de la tiroides (TSH) es

Respondiste correctamente: producida en la glándula pituitaria.

4 ¿Una inyección de TSH a un animal por lo demás normal provocará cuál de las siguientes
situaciones?

Tu respuesta: hipotiroidismo.

Respuesta correcta: desarrollo del bocio.

5 La hormona liberadora de tirotropina (TRH) es

Respondiste correctamente: secretada por el hipotálamo.

6 ¿Cuál de las siguientes afirmaciones es verdadera?

Respondiste correctamente: El hipotálamo secreta principalmente hormonas trópicas

que estimulan la secreción de otras hormonas.

ExperimentoResultados
Predecir preguntas

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 1/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

1 Pregunta de predicción 1: Haga una predicción sobre la tasa metabólica basal (TMB) de
las ratas restantes en comparación con la TMB de la rata normal que acaba de medir.

No respondiste esta pregunta.

2 Predice la pregunta 2: ¿Qué crees que sucederá después de inyectar tiroxina a las tres
ratas?

No respondiste esta pregunta.

3 Predice la pregunta 3: ¿Qué crees que sucederá después de inyectar TSH a las tres ratas?

No respondiste esta pregunta.

4 Pregunta de predicción 4: El propiltiouracilo (PTU) es un fármaco que inhibe la

producción de tiroxina al bloquear la unión del yodo a los residuos de tirosina en las
células foliculares de la glándula tiroides (las tirosinas yodadas se unen para formar
tiroxina). ¿Qué crees que pasará después de inyectar PTU a las tres ratas?

No respondiste esta pregunta.

Detener y Preguntas para pensar

1 Calcule el consumo de oxígeno por hora para esta rata usando la siguiente ecuación.

ml O2 consumido/1 minuto x 60 minutos/hora = ml O2/hora

Ingrese el consumo de oxígeno por hora.

No respondiste esta pregunta.

2 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

3 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 2/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

You did not answer this question.

4 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

5 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

6 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

7 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800).

The normal rat is

You did not answer this question.

Correct answer: euthyroid.

8 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800).

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 3/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

The thyroidectomized (Tx) rat is

You did not answer this question.

Correct answer: hypothyroid.

9 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800).

The hypophysectomized (Hypox) rat is

You did not answer this question.

Correct answer: hypothyroid.

10 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

11 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

12 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

13 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 4/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

14 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

15 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

16 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the thyroxine injection.

The normal rat is

You did not answer this question.

Correct answer: hyperthyroid.

17 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the thyroxine injection.

The thyroidectomized (Tx) rat is

You did not answer this question.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 5/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

Correct answer: hyperthyroid.

18 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the thyroxine injection.

The hypophysectomized (Hypox) rat is

You did not answer this question.

Correct answer: hyperthyroid.

19 Which of the rats developed a goiter after injection with thyroxine?

You did not answer this question.

Correct answer: None of the rats developed a goiter with this injection.

20 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

21 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

22 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 6/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

23 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

24 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

25 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

26 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the TSH injection.

The normal rat is

You did not answer this question.

Correct answer: hyperthyroid.

27 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the TSH injection.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 7/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

The thyroidectomized (Tx) rat is

You did not answer this question.

Correct answer: hypothyroid.

28 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the TSH injection.

The hypophysectomized (Hypox) rat is

You did not answer this question.

Correct answer: hyperthyroid.

29 Which of the rats did not develop a goiter after injection with TSH?

You did not answer this question.

Correct answer: the thyroidectomized rat.

30 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

31 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

32 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 8/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

Enter the oxygen consumption per hour.

You did not answer this question.

33 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

34 Calculate the oxygen consumption per hour for this rat using the following equation.

ml O2 consumed/1 minute x 60 minutes/hour = ml O2/hour

Enter the oxygen consumption per hour.

You did not answer this question.

35 Now that you have calculated the oxygen consumption per hour for this rat, you can
calculate the metabolic rate per kilogram of body weight with the following equation
(note that you need to convert the weight data from grams to kilograms to use this
equation).

Metabolic rate = (ml O2/hr)/(weight in kg) = ml O2/kg/hr

Enter the metabolic rate.

You did not answer this question.

36 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the PTU injection.

The normal rat is

You did not answer this question.

Correct answer: hypothyroid.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 9/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

37 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the PTU injection.

The thyroidectomized (Tx) rat is

You did not answer this question.

Correct answer: hypothyroid.

38 Judging from their basal metabolic rates (an indicator of thyroid function), categorize the
rats as hypothyroid (low thyroid levels; BMR below 1600), euthyroid ("good," or normal,
thyroid levels; BMR = 1650-1750), or hyperthyroid (high thyroid levels; BMR above 1800)
after the PTU injection.

The hypophysectomized (Hypox) rat is

You did not answer this question.

Correct answer: hypothyroid.

39 Which of the rats developed a goiter after injection with PTU?

You did not answer this question.

Correct answer: the normal rat.

Experiment Data

Post-lab Quiz Results

You scored 14% by answering 1 out of 7 questions correctly.

1 How would you treat a thyroidectomized animal so that it functions like a "normal"
animal?

Your answer: Provide the animal TSH supplements.

Correct answer: Provide the animal T4 supplements.

2 As a result of the missing hormone(s) in the hypophysectomized rat, what would be an

expected symptom?

Your answer: high body temperature.

Correct answer: decreased basal metabolic rate.

3 An injection of thyroxine to an otherwise normal rat will cause which of the following?

Your answer: development of a goiter.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 10/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

Correct answer: hyperthyroidism.

4 Why didn't any of the rats develop a goiter after thyroxine injection?

Your answer: In all cases, the thyroid gland response to TRH was lost.

Correct answer: In all cases, TSH levels were not elevated by the thyroxine injection.

5 Why did the normal rat develop a palpable goiter with the TSH injection?

Your answer: The amount of T4 secretion by the thyroid gland became excessive.

Correct answer: The TSH receptors on the thyroid gland were excessively stimulated.

6 An injection of propylthiouracil to an otherwise normal animal will cause which of the

following?

Your answer: excessive amounts of T4 secretion.

Correct answer: goiter development.

7 Why did the normal rat develop a palpable goiter with the propylthiouracil injection?

You correctly answered: The injection decreased the negative feedback mechanism on
TSH.

Review Sheet Results

1 Part 1: Determining the Basal Metabolic Rates

Which rat had the fastest basal metabolic rate (BMR)?

You did not answer this question.

2 ¿Por qué las tasas metabólicas diferían entre la rata normal y las ratas alteradas
quirúrgicamente? ¿Qué tan bien se compararon los resultados con su predicción?

No respondiste esta pregunta.

3 Si un animal ha sido tiroidectomizado, ¿qué hormona(s) le faltarían en la sangre?

No respondiste esta pregunta.

4 Si un animal ha sido hipofisectomizado, ¿qué efecto esperaría observar en los niveles

hormonales de su cuerpo?

No respondiste esta pregunta.

5 Parte 2: Determinación del efecto de la tiroxina sobre la tasa metabólica

¿Cuál fue el efecto de las inyecciones de tiroxina sobre la TMB de la rata normal?

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 11/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

No respondiste esta pregunta.

6 ¿Cuál fue el efecto de las inyecciones de tiroxina en la TMB de la rata tiroidectomizada?

¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿La dosis de
tiroxina en la jeringa era demasiado grande, demasiado pequeña o la adecuada?

No respondiste esta pregunta.

7 ¿Cuál fue el efecto de las inyecciones de tiroxina en la TMB de la rata hipofisectomizada?

¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿La dosis de
tiroxina en la jeringa era demasiado grande, demasiado pequeña o la adecuada?

No respondiste esta pregunta.

8 Parte 3: Determinación del efecto de la TSH en la tasa metabólica

¿Cuál fue el efecto de las inyecciones de hormona estimulante de la tiroides (TSH) en la

TMB de ratas normales?

No respondiste esta pregunta.

9 ¿Cuál fue el efecto de las inyecciones de TSH sobre la TMB de la rata tiroidectomizada?
¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿Por qué se
observó este efecto?

No respondiste esta pregunta.

10 ¿Cuál fue el efecto de las inyecciones de TSH sobre la TMB de la rata hipofisectomizada?
¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿La dosis de TSH
en la jeringa era demasiado grande, demasiado pequeña o la adecuada?

No respondiste esta pregunta.

11 Parte 4: Determinación del efecto del propiltiouracilo en la tasa metabólica

¿Cuál fue el efecto de las inyecciones de propiltiouracilo (PTU) en la TMB de ratas

normales? ¿Por qué esta rata desarrolló un bocio palpable?

No respondiste esta pregunta.

12 ¿Cuál fue el efecto de las inyecciones de PTU sobre la TMB de la rata tiroidectomizada?
¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿Por qué se
observó este efecto?

No respondiste esta pregunta.

13 ¿Cuál fue el efecto de las inyecciones de PTU sobre la TMB de la rata hipofisectomizada?
¿Cómo se compara la TMB en este caso con la TMB de una rata normal? ¿Por qué se

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 12/13
13/12/23, 21:42 PhysioEx Ejercicio 4 Actividad 1

observó este efecto?

No respondiste esta pregunta.

https://media.pearsoncmg.com/bc/bc_0media_ap/physioex/10/ex4/act1/ 13/13